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The map label for this gene is fumC

Identifier: 50843729

GI number: 50843729

Start: 2486987

End: 2488393

Strand: Direct

Name: fumC

Synonym: PPA2292

Alternate gene names: 50843729

Gene position: 2486987-2488393 (Clockwise)

Preceding gene: 50843726

Following gene: 50843733

Centisome position: 97.14

GC content: 61.27

Gene sequence:

>1407_bases
ATGGCAGAGATGCGCATTGAGAAAGACAGCATGGGCGAGGTCGAAGTACCCGCCGAGCATTACTGGGGAGCCCAGACACA
GCGTTCCCTCCACAACTTCGAGATCGGCCGTGACACCTTCGTTTGGGGCCGAGACATGATCCGTGCTCTCGGAACTCTCA
AGAAGTCCGCGGCACTAGCCAACAAGGAACTGGGTGAGTTGCCGGGCGACGTTGCCGACCTCATCGTCCAGGCCGCCGAC
GAGGTCATCGCCGGAAAACTCGATGACGAGTTCCCGCTGGTGGTCTTCCAGACCGGTTCGGGCACCCAGTCCAACATGAA
CACCAACGAGGTCATCAGCAACCGTGCGATTGAGTTGGCCGGTGGCGAACGCGGGTCGAAGAAACCCGTCCACCCCAACG
ACCACGTCAACCGTGGCCAATCTTCCAACGATACCTTCCCGACGGCCATGCACATCGCCGTTGTGTGTGCCCTCAATAAG
CGCCTCTACCCCGCCGTCCAGCAGCTTCGCGACACTCTCGACGAGAAGGCCAAAAAGTACGACGACGTCGTGATGGTCGG
CCGCACCCACCTGCAGGACGCAACGCCGATCCGCCTCGGCCAGGTCATTAGTGGCTGGGTCGCCCAAATCGATTTCGCCC
TCGACGGCATCCGCTACGCCGATTCACGCGCCCGTGAACTAGCCATCGGCGGCACCGCCGTCGGCACCGGCCTCAACGCC
CACCCTGATTTCGGCCCGACCGTCGCTAAGCACGCGACCGAGGAGACTGGCATTGAGTTCAAGCAGGCCGACAACCTTTT
CGCCGCGCTGAGCGCCCACGACGCCCTAGTACAAGTTTCGGGGTCGCTGCGTGTCCTCGCCGACGCCCTCATGAAGATTG
CCAATGACGTCCGCTGGTACGCGTCTGGCCCCCGCAACGGTATCGGCGAACTCCTGATCCCCGAAAACGAGCCCGGCTCT
TCGATCATGCCTGGCAAAGTCAATCCGACCCAGTGCGAGGCCATGACGATGGTCGCCACCCGCGTGTTCGGTAACGACGC
GACAGTCGGCTTTGCCGGTTCTCAAGGCAACTTCCAGCTCAACGTGTTCAAGCCCGTCATGGCCCATGCCTGCCTGGAGT
CGATCCGCCTTATCGCCGATTCGTGCATCAGCTTCGACAAACATTGCGCCTACGGCATCGAGCCAAACCCCGACAAAATC
AAGGAGAACCTCGACAAGAACCTCATGCAGGTCACGGCTCTCAACCGTCACATCGGTTACGACCTGGCTTCGAAGATCGC
TAAGAACGCTCACCATAAGGGCATCAGCCTGCGGGAGTCCGCTCTGACGGTCGGCGGCATGAGCGAGGAGGATTTCGACA
AGTGGGTCGTCCCCGCCGACATGACTCACCCCAGCGCCGCTGAATGA

Upstream 100 bases:

>100_bases
TCCCCGGCCGCACCCTCCCCCTATGTGTCCGCGACCTCCCTGACCAAAAATCCCACCACCCCGCCACCTGTGACATCCCC
GTGCAAAGTAGGCTTGCGAC

Downstream 100 bases:

>100_bases
TTTTCATCGCCACGACGACACGTCGGGCCGGTCACTGCATCGACAGTGACCGGCCCGACGTTTTTGTGCACAGAGAGGAG
GAAAACCCGGGACACGGACC

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MAEMRIEKDSMGEVEVPAEHYWGAQTQRSLHNFEIGRDTFVWGRDMIRALGTLKKSAALANKELGELPGDVADLIVQAAD
EVIAGKLDDEFPLVVFQTGSGTQSNMNTNEVISNRAIELAGGERGSKKPVHPNDHVNRGQSSNDTFPTAMHIAVVCALNK
RLYPAVQQLRDTLDEKAKKYDDVVMVGRTHLQDATPIRLGQVISGWVAQIDFALDGIRYADSRARELAIGGTAVGTGLNA
HPDFGPTVAKHATEETGIEFKQADNLFAALSAHDALVQVSGSLRVLADALMKIANDVRWYASGPRNGIGELLIPENEPGS
SIMPGKVNPTQCEAMTMVATRVFGNDATVGFAGSQGNFQLNVFKPVMAHACLESIRLIADSCISFDKHCAYGIEPNPDKI
KENLDKNLMQVTALNRHIGYDLASKIAKNAHHKGISLRESALTVGGMSEEDFDKWVVPADMTHPSAAE

Sequences:

>Translated_468_residues
MAEMRIEKDSMGEVEVPAEHYWGAQTQRSLHNFEIGRDTFVWGRDMIRALGTLKKSAALANKELGELPGDVADLIVQAAD
EVIAGKLDDEFPLVVFQTGSGTQSNMNTNEVISNRAIELAGGERGSKKPVHPNDHVNRGQSSNDTFPTAMHIAVVCALNK
RLYPAVQQLRDTLDEKAKKYDDVVMVGRTHLQDATPIRLGQVISGWVAQIDFALDGIRYADSRARELAIGGTAVGTGLNA
HPDFGPTVAKHATEETGIEFKQADNLFAALSAHDALVQVSGSLRVLADALMKIANDVRWYASGPRNGIGELLIPENEPGS
SIMPGKVNPTQCEAMTMVATRVFGNDATVGFAGSQGNFQLNVFKPVMAHACLESIRLIADSCISFDKHCAYGIEPNPDKI
KENLDKNLMQVTALNRHIGYDLASKIAKNAHHKGISLRESALTVGGMSEEDFDKWVVPADMTHPSAAE
>Mature_467_residues
AEMRIEKDSMGEVEVPAEHYWGAQTQRSLHNFEIGRDTFVWGRDMIRALGTLKKSAALANKELGELPGDVADLIVQAADE
VIAGKLDDEFPLVVFQTGSGTQSNMNTNEVISNRAIELAGGERGSKKPVHPNDHVNRGQSSNDTFPTAMHIAVVCALNKR
LYPAVQQLRDTLDEKAKKYDDVVMVGRTHLQDATPIRLGQVISGWVAQIDFALDGIRYADSRARELAIGGTAVGTGLNAH
PDFGPTVAKHATEETGIEFKQADNLFAALSAHDALVQVSGSLRVLADALMKIANDVRWYASGPRNGIGELLIPENEPGSS
IMPGKVNPTQCEAMTMVATRVFGNDATVGFAGSQGNFQLNVFKPVMAHACLESIRLIADSCISFDKHCAYGIEPNPDKIK
ENLDKNLMQVTALNRHIGYDLASKIAKNAHHKGISLRESALTVGGMSEEDFDKWVVPADMTHPSAAE

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=461, Percent_Identity=55.9652928416486, Blast_Score=522, Evalue=1e-148,
Organism=Escherichia coli, GI1787896, Length=461, Percent_Identity=57.2668112798265, Blast_Score=529, Evalue=1e-151,
Organism=Escherichia coli, GI87082375, Length=463, Percent_Identity=39.3088552915767, Blast_Score=329, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI17553882, Length=464, Percent_Identity=57.1120689655172, Blast_Score=530, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI32565146, Length=325, Percent_Identity=54.1538461538462, Blast_Score=361, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6324993, Length=463, Percent_Identity=57.0194384449244, Blast_Score=536, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24640177, Length=463, Percent_Identity=53.9956803455724, Blast_Score=508, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24640179, Length=463, Percent_Identity=53.9956803455724, Blast_Score=507, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24662684, Length=465, Percent_Identity=54.4086021505376, Blast_Score=507, Evalue=1e-144,
Organism=Drosophila melanogaster, GI78710009, Length=463, Percent_Identity=54.4276457883369, Blast_Score=500, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24583245, Length=462, Percent_Identity=48.4848484848485, Blast_Score=433, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50706; Mature: 50575

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEMRIEKDSMGEVEVPAEHYWGAQTQRSLHNFEIGRDTFVWGRDMIRALGTLKKSAALA
CCCCCCCCCCCCCEECCHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
NKELGELPGDVADLIVQAADEVIAGKLDDEFPLVVFQTGSGTQSNMNTNEVISNRAIELA
HHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHCCEEEEE
GGERGSKKPVHPNDHVNRGQSSNDTFPTAMHIAVVCALNKRLYPAVQQLRDTLDEKAKKY
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DDVVMVGRTHLQDATPIRLGQVISGWVAQIDFALDGIRYADSRARELAIGGTAVGTGLNA
CCEEEECCHHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHCCHHHEEEECCHHCCCCCCC
HPDFGPTVAKHATEETGIEFKQADNLFAALSAHDALVQVSGSLRVLADALMKIANDVRWY
CCCCCCHHHHHCCHHHCCCHHHHCCHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHCEEE
ASGPRNGIGELLIPENEPGSSIMPGKVNPTQCEAMTMVATRVFGNDATVGFAGSQGNFQL
ECCCCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCEEE
NVFKPVMAHACLESIRLIADSCISFDKHCAYGIEPNPDKIKENLDKNLMQVTALNRHIGY
EEHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCH
DLASKIAKNAHHKGISLRESALTVGGMSEEDFDKWVVPADMTHPSAAE
HHHHHHHHHHHHCCCCCHHHHEEECCCCHHHHCCEECCCCCCCCCCCC
>Mature Secondary Structure 
AEMRIEKDSMGEVEVPAEHYWGAQTQRSLHNFEIGRDTFVWGRDMIRALGTLKKSAALA
CCCCCCCCCCCCEECCHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
NKELGELPGDVADLIVQAADEVIAGKLDDEFPLVVFQTGSGTQSNMNTNEVISNRAIELA
HHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHCCEEEEE
GGERGSKKPVHPNDHVNRGQSSNDTFPTAMHIAVVCALNKRLYPAVQQLRDTLDEKAKKY
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DDVVMVGRTHLQDATPIRLGQVISGWVAQIDFALDGIRYADSRARELAIGGTAVGTGLNA
CCEEEECCHHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHCCHHHEEEECCHHCCCCCCC
HPDFGPTVAKHATEETGIEFKQADNLFAALSAHDALVQVSGSLRVLADALMKIANDVRWY
CCCCCCHHHHHCCHHHCCCHHHHCCHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHCEEE
ASGPRNGIGELLIPENEPGSSIMPGKVNPTQCEAMTMVATRVFGNDATVGFAGSQGNFQL
ECCCCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCEEE
NVFKPVMAHACLESIRLIADSCISFDKHCAYGIEPNPDKIKENLDKNLMQVTALNRHIGY
EEHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCH
DLASKIAKNAHHKGISLRESALTVGGMSEEDFDKWVVPADMTHPSAAE
HHHHHHHHHHHHCCCCCHHHHEEECCCCHHHHCCEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]