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The map label for this gene is gltA2 [H]

Identifier: 50843709

GI number: 50843709

Start: 2462927

End: 2464213

Strand: Direct

Name: gltA2 [H]

Synonym: PPA2272

Alternate gene names: 50843709

Gene position: 2462927-2464213 (Clockwise)

Preceding gene: 50843708

Following gene: 50843710

Centisome position: 96.2

GC content: 57.89

Gene sequence:

>1287_bases
ATGGGTTCGAGTGCAAGGTTCGTCGACGAAGACACTCACCTCGATTTCAGCAAGGTTGTCGCTACTGACGGCCAGGTGGG
TTACGACGTCGCGGGTCTGCTCAACAAGACCGGCAACGTCATGATCGACCCGGGATTCGTCAACACGGCATCCTGCGAGT
CACAGATCACCTACATTGACGGTGAGCAGGGAGTTTTGCGTTACCGCGGCTACCCGATTGAGCAGCTCGCTGAACAGTCG
ACCTTCCTTGAGACCGCCTACCTTGTCCTCTATGGGGAACTGCCAAGCAAGGCCCAATTGGACGGCTTCGAGGAGCGTAT
TCGTCGCACTACCCTCATCGACGAGCGGATGCGTGACCTCTTCCGATGCTTCCCCCGTCGGTCCCACCCGATGCCTGTGT
TGGCTGCGGGCATCATGGCCCTGTCGACCTTCTCACAGAAATCCTCCGGCACTGATCCCGACCAAATCGAGGCGGCCACC
ACTCGCCTCATCGCCAAGGTCCCCACCCTGGCCGCCTTCGGCTACAAGAACTCGATGGGCCAGCCGACCCTCTACCCCGA
TAACTCCCTGAGCTACGTCCAGAACTTCATCCGGATGAGCTTCGGCTTCCCGACTGAACCCTACGAGTTCAATGACGAAA
TCACCCGCGCTCTGGAAACCCTGCTCATCCTGCACGTTGATCACGAGCAGAACTGTTCAACCTCGACGGTCCGTATGGTC
GCGTCGTCGGGTGCCAACATGTACGCGGCGGTTGCCGCAGGCGTCAACGCCCTGTCCGGCCCGAAGCACGGTGGCGCAAA
CCAGGCCGTCCTCGAAATGCTGCAATTTATTCGCGACTCCGGCATGACCACTAAGGAGTTCGTCCGTAAGGTCAAGGACA
AAGAATCCGACATCAAGCTGATGGGCTTTGGCCACCGGATCTACAAGAACTACGATCCACGCGCCGCCATCATCAAGAAA
CATGCCGACCGCATTATGGAACTCCATACCGGTCGTGAGGACCTTCTCGAGATCGCCAAGGAACTTGAAGAGACCGCGCT
AAACGATGACTACTTCAAGGAGCGCAAGCTCTACCCGAACGTTGATTTCTATACCGGCCTCATCTACGAGGCCATGGGCT
TCCCGATGAATATGTTCACCGTGCTGTTCGCACTGGGACGTCTGCCCGGGTGGATCGCCCAGTACCGAGAGCAAGTTGCC
AGCGGAGGCAACAAGATTTGGCGTCCGCGTCAGATCTTCACCGGGTCTGACAAGCGAGATTACGTACCACTCAACAAGCG
TGCCTGA

Upstream 100 bases:

>100_bases
CACCGTGGTGACGCTCGGGAACGAACCCGCAGTGCCACCCGTCCACGTATGTCCGGCCACCGGTGATTGTCCGGACGAGG
CCGCCAGGAAGGAACGCACG

Downstream 100 bases:

>100_bases
CGTAAACCGGCCTGGGAGGAAACTCGACCTCCCAGGCCGGTGTGTCTAAGGACTCGTATGTGTCTCTGGCCCTCGCATAC
GCCCCGTACCGATATCCGAT

Product: citrate synthase 1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MGSSARFVDEDTHLDFSKVVATDGQVGYDVAGLLNKTGNVMIDPGFVNTASCESQITYIDGEQGVLRYRGYPIEQLAEQS
TFLETAYLVLYGELPSKAQLDGFEERIRRTTLIDERMRDLFRCFPRRSHPMPVLAAGIMALSTFSQKSSGTDPDQIEAAT
TRLIAKVPTLAAFGYKNSMGQPTLYPDNSLSYVQNFIRMSFGFPTEPYEFNDEITRALETLLILHVDHEQNCSTSTVRMV
ASSGANMYAAVAAGVNALSGPKHGGANQAVLEMLQFIRDSGMTTKEFVRKVKDKESDIKLMGFGHRIYKNYDPRAAIIKK
HADRIMELHTGREDLLEIAKELEETALNDDYFKERKLYPNVDFYTGLIYEAMGFPMNMFTVLFALGRLPGWIAQYREQVA
SGGNKIWRPRQIFTGSDKRDYVPLNKRA

Sequences:

>Translated_428_residues
MGSSARFVDEDTHLDFSKVVATDGQVGYDVAGLLNKTGNVMIDPGFVNTASCESQITYIDGEQGVLRYRGYPIEQLAEQS
TFLETAYLVLYGELPSKAQLDGFEERIRRTTLIDERMRDLFRCFPRRSHPMPVLAAGIMALSTFSQKSSGTDPDQIEAAT
TRLIAKVPTLAAFGYKNSMGQPTLYPDNSLSYVQNFIRMSFGFPTEPYEFNDEITRALETLLILHVDHEQNCSTSTVRMV
ASSGANMYAAVAAGVNALSGPKHGGANQAVLEMLQFIRDSGMTTKEFVRKVKDKESDIKLMGFGHRIYKNYDPRAAIIKK
HADRIMELHTGREDLLEIAKELEETALNDDYFKERKLYPNVDFYTGLIYEAMGFPMNMFTVLFALGRLPGWIAQYREQVA
SGGNKIWRPRQIFTGSDKRDYVPLNKRA
>Mature_427_residues
GSSARFVDEDTHLDFSKVVATDGQVGYDVAGLLNKTGNVMIDPGFVNTASCESQITYIDGEQGVLRYRGYPIEQLAEQST
FLETAYLVLYGELPSKAQLDGFEERIRRTTLIDERMRDLFRCFPRRSHPMPVLAAGIMALSTFSQKSSGTDPDQIEAATT
RLIAKVPTLAAFGYKNSMGQPTLYPDNSLSYVQNFIRMSFGFPTEPYEFNDEITRALETLLILHVDHEQNCSTSTVRMVA
SSGANMYAAVAAGVNALSGPKHGGANQAVLEMLQFIRDSGMTTKEFVRKVKDKESDIKLMGFGHRIYKNYDPRAAIIKKH
ADRIMELHTGREDLLEIAKELEETALNDDYFKERKLYPNVDFYTGLIYEAMGFPMNMFTVLFALGRLPGWIAQYREQVAS
GGNKIWRPRQIFTGSDKRDYVPLNKRA

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=369, Percent_Identity=27.10027100271, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1786939, Length=421, Percent_Identity=50.3562945368171, Blast_Score=421, Evalue=1e-119,
Organism=Escherichia coli, GI1786527, Length=382, Percent_Identity=31.151832460733, Blast_Score=190, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17555174, Length=383, Percent_Identity=26.8929503916449, Blast_Score=105, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6324328, Length=384, Percent_Identity=27.8645833333333, Blast_Score=110, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6319850, Length=390, Percent_Identity=27.1794871794872, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6325257, Length=383, Percent_Identity=23.4986945169713, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24640124, Length=393, Percent_Identity=27.4809160305344, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24640126, Length=394, Percent_Identity=27.4111675126904, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI21356863, Length=343, Percent_Identity=26.2390670553936, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 48131; Mature: 48000

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSSARFVDEDTHLDFSKVVATDGQVGYDVAGLLNKTGNVMIDPGFVNTASCESQITYID
CCCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHCCCCCEEECCCCCCCCCCCCEEEEEE
GEQGVLRYRGYPIEQLAEQSTFLETAYLVLYGELPSKAQLDGFEERIRRTTLIDERMRDL
CCCCEEEECCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHH
FRCFPRRSHPMPVLAAGIMALSTFSQKSSGTDPDQIEAATTRLIAKVPTLAAFGYKNSMG
HHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
QPTLYPDNSLSYVQNFIRMSFGFPTEPYEFNDEITRALETLLILHVDHEQNCSTSTVRMV
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHEECCCCCCCCHHHHHHH
ASSGANMYAAVAAGVNALSGPKHGGANQAVLEMLQFIRDSGMTTKEFVRKVKDKESDIKL
HHCCCCHHHHHHHCCHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEE
MGFGHRIYKNYDPRAAIIKKHADRIMELHTGREDLLEIAKELEETALNDDYFKERKLYPN
EECCHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCC
VDFYTGLIYEAMGFPMNMFTVLFALGRLPGWIAQYREQVASGGNKIWRPRQIFTGSDKRD
CHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCC
YVPLNKRA
CCCCCCCC
>Mature Secondary Structure 
GSSARFVDEDTHLDFSKVVATDGQVGYDVAGLLNKTGNVMIDPGFVNTASCESQITYID
CCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHCCCCCEEECCCCCCCCCCCCEEEEEE
GEQGVLRYRGYPIEQLAEQSTFLETAYLVLYGELPSKAQLDGFEERIRRTTLIDERMRDL
CCCCEEEECCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHH
FRCFPRRSHPMPVLAAGIMALSTFSQKSSGTDPDQIEAATTRLIAKVPTLAAFGYKNSMG
HHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
QPTLYPDNSLSYVQNFIRMSFGFPTEPYEFNDEITRALETLLILHVDHEQNCSTSTVRMV
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHEECCCCCCCCHHHHHHH
ASSGANMYAAVAAGVNALSGPKHGGANQAVLEMLQFIRDSGMTTKEFVRKVKDKESDIKL
HHCCCCHHHHHHHCCHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEE
MGFGHRIYKNYDPRAAIIKKHADRIMELHTGREDLLEIAKELEETALNDDYFKERKLYPN
EECCHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCC
VDFYTGLIYEAMGFPMNMFTVLFALGRLPGWIAQYREQVASGGNKIWRPRQIFTGSDKRD
CHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCC
YVPLNKRA
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]