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The map label for this gene is gabP [H]

Identifier: 50843688

GI number: 50843688

Start: 2439139

End: 2440545

Strand: Reverse

Name: gabP [H]

Synonym: PPA2254

Alternate gene names: 50843688

Gene position: 2440545-2439139 (Counterclockwise)

Preceding gene: 50843689

Following gene: 50843685

Centisome position: 95.32

GC content: 60.98

Gene sequence:

>1407_bases
ATGGCAGTAGCGGCCACGGGCATCCCGGCGGAATCCGGCGAACCCGCTATGGACAAACCCCGCATGAAGGGTCGTCACCT
GGTGATGATGAGCCTTGGCTCGGCCATCGGAACCGGACTCTTCGTAGGGTCTGGCAAGGGTGTGGCTGCAGCTGGACCAG
CAACCTTGGTGGCGTATATCGTCGCCGGGTTACTCGTCATCGCCATCATGTACATGCTCGGCGAGATGGTTGCAGCCCAT
CCCGACTCCGGGGCGTTTTCGGTCTACACATCCCGAGCCATGGGCTCAGCAGCTGGCTTTGCGATGGGGTGGGTCTGGTG
GATCGAACTAGTCGTCGTCGTCGCGGCCGAGGCGATCGCGGCGGCGTCGACCCTTGTTGCTATGTGGCCAATAGCCCCTG
TCTGGCTGCTTACCCTCATCTTCCTGGTCGTCCTCACCGCAATCAACCTGCTGGGAGCCGACAGATTCGGAGAGTTCGAG
TTCTGGTTTGCCCTGCTTAAAGTGGTCGCCGTCGTCGTCTTCCTTACCATCGGTGTGCTGCTTATTTGCGGAGTCTTGGC
GGCTCCCGCGGCGGGAACATCCAACCTCGTCGGCCACGGCGGATTCCTGCCCAATGGGTGGTCTGGGGTGGCGACAGCCC
TGCTTTTGGTCGCCTTCAGCTTCGGTGGCATCGAGATCATGGCGGTGGCGGCCGCCGAGACCGAAGACCCTGCCCACAAT
GTCTCCCGGGCTGTGCGCACCATCGTTTGGCGAATCCTGGTGTTCTACATGGGTTCAGTAGCCATCATGGTTATCGCGGT
GCCTTGGGACGACCCCGAACTCGGCGCTTCCCCCTTCGTGGCCGTCCTTAACCGGGCCGGTATCCCAGCAGCCTCCGAGG
TCATGACCTTGGTCATTGTGTTGGCCTTGCTGAGTTCCCTCAATGCCAATCTTTATGGGGCTGCCCGGATGCTTGGCTCT
TTAGCGGAACGCGGCATGGCCCCTCGCGTCGCCATGCGAACCAGGGGACGCTCGGTGCCGACGGTTGCGGTGCTGGCCAG
CGTCGCCTTTGGATTCTGTTGTGTGCTGGCTACTTTCGAATGGGGCGACGCCGTACTCGGTACTCTGCTTAATATCGTCG
GTTCAACCATCATCGTTACCTACTTCTTCACCATCTGCTCTCACTACGTGCTGCGTCGCCGCGCTGAGAAGGAGGGCGCC
CCGCTGCCGATGCGGTTGAAAGGGTTTCCGGTGGTGAACTGGGCAGCAATGATCCTGCTGATTGGCATCGTTGTACTGGG
CATGTTTTCCCCCGACGTACGAGCTCAACTGATGTCAACGGGGGCGCTCGTCGTCATCCTCTATGTCATTGGAGTGGGAT
GGTCCCATCACGCCGGACGCAGCCCCTTCCATCCCACGACCGACTGA

Upstream 100 bases:

>100_bases
CCGTGTCACGTCACGTCTTGTCCCACCTAGGGAAACGGTCACATCCGCGGGACCGTACCAGCTTTATCATCAGCCCCACC
GACGCAGATGAGGAGCACAT

Downstream 100 bases:

>100_bases
ACTCAAGCGGATGACGGTCCCGGGTCGTTCGGGGGTTTGGGGGACCGAGCGAGCAGCTCGTGTTTACGGTCTTTGGCCCG
AATAATTTCCGGGACGATCC

Product: amino acid permease, putative GABA permease

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MAVAATGIPAESGEPAMDKPRMKGRHLVMMSLGSAIGTGLFVGSGKGVAAAGPATLVAYIVAGLLVIAIMYMLGEMVAAH
PDSGAFSVYTSRAMGSAAGFAMGWVWWIELVVVVAAEAIAAASTLVAMWPIAPVWLLTLIFLVVLTAINLLGADRFGEFE
FWFALLKVVAVVVFLTIGVLLICGVLAAPAAGTSNLVGHGGFLPNGWSGVATALLLVAFSFGGIEIMAVAAAETEDPAHN
VSRAVRTIVWRILVFYMGSVAIMVIAVPWDDPELGASPFVAVLNRAGIPAASEVMTLVIVLALLSSLNANLYGAARMLGS
LAERGMAPRVAMRTRGRSVPTVAVLASVAFGFCCVLATFEWGDAVLGTLLNIVGSTIIVTYFFTICSHYVLRRRAEKEGA
PLPMRLKGFPVVNWAAMILLIGIVVLGMFSPDVRAQLMSTGALVVILYVIGVGWSHHAGRSPFHPTTD

Sequences:

>Translated_468_residues
MAVAATGIPAESGEPAMDKPRMKGRHLVMMSLGSAIGTGLFVGSGKGVAAAGPATLVAYIVAGLLVIAIMYMLGEMVAAH
PDSGAFSVYTSRAMGSAAGFAMGWVWWIELVVVVAAEAIAAASTLVAMWPIAPVWLLTLIFLVVLTAINLLGADRFGEFE
FWFALLKVVAVVVFLTIGVLLICGVLAAPAAGTSNLVGHGGFLPNGWSGVATALLLVAFSFGGIEIMAVAAAETEDPAHN
VSRAVRTIVWRILVFYMGSVAIMVIAVPWDDPELGASPFVAVLNRAGIPAASEVMTLVIVLALLSSLNANLYGAARMLGS
LAERGMAPRVAMRTRGRSVPTVAVLASVAFGFCCVLATFEWGDAVLGTLLNIVGSTIIVTYFFTICSHYVLRRRAEKEGA
PLPMRLKGFPVVNWAAMILLIGIVVLGMFSPDVRAQLMSTGALVVILYVIGVGWSHHAGRSPFHPTTD
>Mature_467_residues
AVAATGIPAESGEPAMDKPRMKGRHLVMMSLGSAIGTGLFVGSGKGVAAAGPATLVAYIVAGLLVIAIMYMLGEMVAAHP
DSGAFSVYTSRAMGSAAGFAMGWVWWIELVVVVAAEAIAAASTLVAMWPIAPVWLLTLIFLVVLTAINLLGADRFGEFEF
WFALLKVVAVVVFLTIGVLLICGVLAAPAAGTSNLVGHGGFLPNGWSGVATALLLVAFSFGGIEIMAVAAAETEDPAHNV
SRAVRTIVWRILVFYMGSVAIMVIAVPWDDPELGASPFVAVLNRAGIPAASEVMTLVIVLALLSSLNANLYGAARMLGSL
AERGMAPRVAMRTRGRSVPTVAVLASVAFGFCCVLATFEWGDAVLGTLLNIVGSTIIVTYFFTICSHYVLRRRAEKEGAP
LPMRLKGFPVVNWAAMILLIGIVVLGMFSPDVRAQLMSTGALVVILYVIGVGWSHHAGRSPFHPTTD

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=348, Percent_Identity=25.8620689655172, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI33286428, Length=452, Percent_Identity=25.8849557522124, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI1789017, Length=437, Percent_Identity=38.4439359267735, Blast_Score=300, Evalue=1e-82,
Organism=Escherichia coli, GI1786302, Length=436, Percent_Identity=34.4036697247706, Blast_Score=279, Evalue=3e-76,
Organism=Escherichia coli, GI1786789, Length=423, Percent_Identity=33.5697399527187, Blast_Score=258, Evalue=8e-70,
Organism=Escherichia coli, GI1788480, Length=424, Percent_Identity=36.5566037735849, Blast_Score=256, Evalue=3e-69,
Organism=Escherichia coli, GI87081708, Length=445, Percent_Identity=33.0337078651685, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1786602, Length=439, Percent_Identity=32.3462414578588, Blast_Score=234, Evalue=9e-63,
Organism=Escherichia coli, GI87081915, Length=399, Percent_Identity=34.0852130325814, Blast_Score=225, Evalue=5e-60,
Organism=Escherichia coli, GI1790653, Length=467, Percent_Identity=30.6209850107066, Blast_Score=224, Evalue=7e-60,
Organism=Escherichia coli, GI48994972, Length=445, Percent_Identity=32.3595505617978, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI87081869, Length=246, Percent_Identity=24.7967479674797, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320772, Length=460, Percent_Identity=30.2173913043478, Blast_Score=209, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6324061, Length=469, Percent_Identity=28.1449893390192, Blast_Score=176, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6322892, Length=396, Percent_Identity=30.3030303030303, Blast_Score=176, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6324553, Length=393, Percent_Identity=32.0610687022901, Blast_Score=173, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6321053, Length=426, Percent_Identity=28.6384976525822, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6319543, Length=408, Percent_Identity=30.6372549019608, Blast_Score=171, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6324924, Length=475, Percent_Identity=31.7894736842105, Blast_Score=170, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6320717, Length=418, Percent_Identity=29.9043062200957, Blast_Score=169, Evalue=7e-43,
Organism=Saccharomyces cerevisiae, GI6324990, Length=414, Percent_Identity=30.1932367149758, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6324059, Length=458, Percent_Identity=29.6943231441048, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6319824, Length=422, Percent_Identity=27.7251184834123, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6319542, Length=406, Percent_Identity=29.3103448275862, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6320251, Length=417, Percent_Identity=28.0575539568345, Blast_Score=154, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6321629, Length=389, Percent_Identity=27.5064267352185, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6322967, Length=387, Percent_Identity=28.1653746770026, Blast_Score=136, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6319608, Length=445, Percent_Identity=24.2696629213483, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6324981, Length=401, Percent_Identity=29.1770573566085, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6320364, Length=511, Percent_Identity=21.1350293542074, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24666159, Length=343, Percent_Identity=22.4489795918367, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI221512776, Length=343, Percent_Identity=22.4489795918367, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 48997; Mature: 48866

Theoretical pI: Translated: 8.00; Mature: 8.00

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVAATGIPAESGEPAMDKPRMKGRHLVMMSLGSAIGTGLFVGSGKGVAAAGPATLVAYI
CCEECCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHH
VAGLLVIAIMYMLGEMVAAHPDSGAFSVYTSRAMGSAAGFAMGWVWWIELVVVVAAEAIA
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
AASTLVAMWPIAPVWLLTLIFLVVLTAINLLGADRFGEFEFWFALLKVVAVVVFLTIGVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LICGVLAAPAAGTSNLVGHGGFLPNGWSGVATALLLVAFSFGGIEIMAVAAAETEDPAHN
HHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHH
VSRAVRTIVWRILVFYMGSVAIMVIAVPWDDPELGASPFVAVLNRAGIPAASEVMTLVIV
HHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHH
LALLSSLNANLYGAARMLGSLAERGMAPRVAMRTRGRSVPTVAVLASVAFGFCCVLATFE
HHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
WGDAVLGTLLNIVGSTIIVTYFFTICSHYVLRRRAEKEGAPLPMRLKGFPVVNWAAMILL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHH
IGIVVLGMFSPDVRAQLMSTGALVVILYVIGVGWSHHAGRSPFHPTTD
HHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AVAATGIPAESGEPAMDKPRMKGRHLVMMSLGSAIGTGLFVGSGKGVAAAGPATLVAYI
CEECCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHH
VAGLLVIAIMYMLGEMVAAHPDSGAFSVYTSRAMGSAAGFAMGWVWWIELVVVVAAEAIA
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
AASTLVAMWPIAPVWLLTLIFLVVLTAINLLGADRFGEFEFWFALLKVVAVVVFLTIGVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LICGVLAAPAAGTSNLVGHGGFLPNGWSGVATALLLVAFSFGGIEIMAVAAAETEDPAHN
HHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHH
VSRAVRTIVWRILVFYMGSVAIMVIAVPWDDPELGASPFVAVLNRAGIPAASEVMTLVIV
HHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHH
LALLSSLNANLYGAARMLGSLAERGMAPRVAMRTRGRSVPTVAVLASVAFGFCCVLATFE
HHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
WGDAVLGTLLNIVGSTIIVTYFFTICSHYVLRRRAEKEGAPLPMRLKGFPVVNWAAMILL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHH
IGIVVLGMFSPDVRAQLMSTGALVVILYVIGVGWSHHAGRSPFHPTTD
HHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8951816; 8969499; 9384377 [H]