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The map label for this gene is hutH

Identifier: 50843607

GI number: 50843607

Start: 2351598

End: 2353133

Strand: Direct

Name: hutH

Synonym: PPA2170

Alternate gene names: 50843607

Gene position: 2351598-2353133 (Clockwise)

Preceding gene: 50843606

Following gene: 50843608

Centisome position: 91.85

GC content: 65.3

Gene sequence:

>1536_bases
ATGAACCCAACCACCGTTGACGCCGGTGCCCCGCTCACTCCCCGCGACGTCGTCGCAGTCGCTCGGCTGGGAGCCCAAGT
GACCGTGGGAGAGGACGCGATAGAGCGGGTCAAACGGGCCTCTGACCTCGTCGAGAGCCTGGCCGACGACCCCACCCCTC
ATTACGGCATCTCCACCGGCTTCGGTGCGCTGGCCTCGACCCGGGTGCCGCGTGACTACCGCGTGGCTCTGCAGCATTCA
CTCATCCGTTCTCACGCCGCGTCGACCGGACCGCGGGTCGAGAGCGAGGTCATCCGCGCCATGATGACCCTGCGCCTCAA
GACGATGGCATCTGGCCACACCGGCGTACGTCCGAAGGTCGTCACTGCCTACGCCGATCTGCTTAACTCCGGGCTCGTCC
CAGTCGTGGGGGAATATGGGTCTCTTGGCTGTTCGGGCGACCTCGCCCCGCTAGCCCACTGTGCCCTCGTCCTGACCGGC
GAAGGGACCGTCCTCACCCCTGACGGTGACGAAGTCGATGCGGCTACCGGCCTGGCCCAGGCCGGGCTGAAGCCTGTGTC
CCTGCGCGAGAAGGAGGGGCTGGCCCTCATTAACGGCACTGACGGCATGCTCAGCCAGCTCATCATGGCCCTAGCTGACC
TCGACGTTCTCGTTCCGACGGCTGATCTGGCGACCGCAATGACCGTCCAGGCGCTGTGCGGCATTGATCGGGTCTTCGCC
CCTGACCTTCAGGCCCTGCGGCCCCATCCAGGCCAGGCCACCTCGGCCGCCAACATTCTCGCTTTGCTAGAAGGTTCTGA
CCTCATCCAGGCCGGTCGTGAAGGTGCCGCCAAGCGAGTCCAAGACGCCTACTCCTTGCGCTGTGCCCCACAGGTCCACG
GCGCCGTCCGCGACACGATGGCCCATGCCCTGCAGGTAGCGAAGGTCGAGTTGGCCTCGGCTGTCGACAACCCAGTCATC
ACCGACGACATGAGGGTAGAGTCCAATGGCAACTTCCACGGCGCCCCCGTGGCGTATGTGCTTGACTTCTTGGCGATTGC
TGCAGCCGACCTCGCGTCGATGAGTGAGCGCCGCACCGACCGCATGCTCGACCCGGCCCGCAACCGTGACCTACATCCCT
TCCTGGCCGACGATCCCGGCGTCGACTCCGGGCATATGATCGCTCAGTACACTCAGGCCGGCATCGTCTCGGACATGAAG
CGACTGGCCGTACCGGCCTCAGTGGACTCCATTCCAACCTCAGCCATGCAGGAAGACCACGTCTCGATGGGATGGTCGGC
TGCCCGCAAACTGCGCCGCGCCATCGACGGTATGGGAGCAGTCATTGGTATCGAGATCCTGACCGCCGCCAAAGCCATCC
AAATGCGCGGTTTGGAGCCCTCGAAGCTGGTGGCCGACGTCATCGAACGAATGCGCCAGACCATTCCTGGCCCCGGGCCA
GACCGCTTCCTCGCCCCCGAAATCGACGAAGCCCACCGCCTGGTGGCCTCCGGCGAGCTCCTCGAGGTCGCCCGTCAGAG
CGTGGAAGTGAGTTAA

Upstream 100 bases:

>100_bases
TTCGGCAGCGGATCGGCCACGTTGGTTGCATCGGAGACGACGGGCCCTGACCATCACAGACACAATCGCCACGACGACGT
GGCTCCAAGAAAGGATGACC

Downstream 100 bases:

>100_bases
CCACGCACGATTCGTGTACATGGCTCCGGTAGCCTGGGGCGTGCTCTGCCCATGCAGAGGTGAGCCAGTTGAGTTGCGTG
TCGTCCGCATCTCGAGTGTC

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MNPTTVDAGAPLTPRDVVAVARLGAQVTVGEDAIERVKRASDLVESLADDPTPHYGISTGFGALASTRVPRDYRVALQHS
LIRSHAASTGPRVESEVIRAMMTLRLKTMASGHTGVRPKVVTAYADLLNSGLVPVVGEYGSLGCSGDLAPLAHCALVLTG
EGTVLTPDGDEVDAATGLAQAGLKPVSLREKEGLALINGTDGMLSQLIMALADLDVLVPTADLATAMTVQALCGIDRVFA
PDLQALRPHPGQATSAANILALLEGSDLIQAGREGAAKRVQDAYSLRCAPQVHGAVRDTMAHALQVAKVELASAVDNPVI
TDDMRVESNGNFHGAPVAYVLDFLAIAAADLASMSERRTDRMLDPARNRDLHPFLADDPGVDSGHMIAQYTQAGIVSDMK
RLAVPASVDSIPTSAMQEDHVSMGWSAARKLRRAIDGMGAVIGIEILTAAKAIQMRGLEPSKLVADVIERMRQTIPGPGP
DRFLAPEIDEAHRLVASGELLEVARQSVEVS

Sequences:

>Translated_511_residues
MNPTTVDAGAPLTPRDVVAVARLGAQVTVGEDAIERVKRASDLVESLADDPTPHYGISTGFGALASTRVPRDYRVALQHS
LIRSHAASTGPRVESEVIRAMMTLRLKTMASGHTGVRPKVVTAYADLLNSGLVPVVGEYGSLGCSGDLAPLAHCALVLTG
EGTVLTPDGDEVDAATGLAQAGLKPVSLREKEGLALINGTDGMLSQLIMALADLDVLVPTADLATAMTVQALCGIDRVFA
PDLQALRPHPGQATSAANILALLEGSDLIQAGREGAAKRVQDAYSLRCAPQVHGAVRDTMAHALQVAKVELASAVDNPVI
TDDMRVESNGNFHGAPVAYVLDFLAIAAADLASMSERRTDRMLDPARNRDLHPFLADDPGVDSGHMIAQYTQAGIVSDMK
RLAVPASVDSIPTSAMQEDHVSMGWSAARKLRRAIDGMGAVIGIEILTAAKAIQMRGLEPSKLVADVIERMRQTIPGPGP
DRFLAPEIDEAHRLVASGELLEVARQSVEVS
>Mature_511_residues
MNPTTVDAGAPLTPRDVVAVARLGAQVTVGEDAIERVKRASDLVESLADDPTPHYGISTGFGALASTRVPRDYRVALQHS
LIRSHAASTGPRVESEVIRAMMTLRLKTMASGHTGVRPKVVTAYADLLNSGLVPVVGEYGSLGCSGDLAPLAHCALVLTG
EGTVLTPDGDEVDAATGLAQAGLKPVSLREKEGLALINGTDGMLSQLIMALADLDVLVPTADLATAMTVQALCGIDRVFA
PDLQALRPHPGQATSAANILALLEGSDLIQAGREGAAKRVQDAYSLRCAPQVHGAVRDTMAHALQVAKVELASAVDNPVI
TDDMRVESNGNFHGAPVAYVLDFLAIAAADLASMSERRTDRMLDPARNRDLHPFLADDPGVDSGHMIAQYTQAGIVSDMK
RLAVPASVDSIPTSAMQEDHVSMGWSAARKLRRAIDGMGAVIGIEILTAAKAIQMRGLEPSKLVADVIERMRQTIPGPGP
DRFLAPEIDEAHRLVASGELLEVARQSVEVS

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=507, Percent_Identity=39.8422090729783, Blast_Score=348, Evalue=5e-96,
Organism=Caenorhabditis elegans, GI17567831, Length=503, Percent_Identity=37.375745526839, Blast_Score=295, Evalue=4e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 53733; Mature: 53733

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00387 PPASE ; PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPTTVDAGAPLTPRDVVAVARLGAQVTVGEDAIERVKRASDLVESLADDPTPHYGISTG
CCCCCCCCCCCCCHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
FGALASTRVPRDYRVALQHSLIRSHAASTGPRVESEVIRAMMTLRLKTMASGHTGVRPKV
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHH
VTAYADLLNSGLVPVVGEYGSLGCSGDLAPLAHCALVLTGEGTVLTPDGDEVDAATGLAQ
HHHHHHHHHCCCCEECCCCCCCCCCCCHHHHHHEEEEEECCCEEECCCCCCHHHHHHHHH
AGLKPVSLREKEGLALINGTDGMLSQLIMALADLDVLVPTADLATAMTVQALCGIDRVFA
HCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHCCHHHHC
PDLQALRPHPGQATSAANILALLEGSDLIQAGREGAAKRVQDAYSLRCAPQVHGAVRDTM
CCHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AHALQVAKVELASAVDNPVITDDMRVESNGNFHGAPVAYVLDFLAIAAADLASMSERRTD
HHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RMLDPARNRDLHPFLADDPGVDSGHMIAQYTQAGIVSDMKRLAVPASVDSIPTSAMQEDH
HHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
VSMGWSAARKLRRAIDGMGAVIGIEILTAAKAIQMRGLEPSKLVADVIERMRQTIPGPGP
HHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCC
DRFLAPEIDEAHRLVASGELLEVARQSVEVS
CCCCCCCHHHHHHHHHCHHHHHHHHHHHCCC
>Mature Secondary Structure
MNPTTVDAGAPLTPRDVVAVARLGAQVTVGEDAIERVKRASDLVESLADDPTPHYGISTG
CCCCCCCCCCCCCHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
FGALASTRVPRDYRVALQHSLIRSHAASTGPRVESEVIRAMMTLRLKTMASGHTGVRPKV
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHH
VTAYADLLNSGLVPVVGEYGSLGCSGDLAPLAHCALVLTGEGTVLTPDGDEVDAATGLAQ
HHHHHHHHHCCCCEECCCCCCCCCCCCHHHHHHEEEEEECCCEEECCCCCCHHHHHHHHH
AGLKPVSLREKEGLALINGTDGMLSQLIMALADLDVLVPTADLATAMTVQALCGIDRVFA
HCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHCCHHHHC
PDLQALRPHPGQATSAANILALLEGSDLIQAGREGAAKRVQDAYSLRCAPQVHGAVRDTM
CCHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AHALQVAKVELASAVDNPVITDDMRVESNGNFHGAPVAYVLDFLAIAAADLASMSERRTD
HHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RMLDPARNRDLHPFLADDPGVDSGHMIAQYTQAGIVSDMKRLAVPASVDSIPTSAMQEDH
HHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
VSMGWSAARKLRRAIDGMGAVIGIEILTAAKAIQMRGLEPSKLVADVIERMRQTIPGPGP
HHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCC
DRFLAPEIDEAHRLVASGELLEVARQSVEVS
CCCCCCCHHHHHHHHHCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1537807; 1612436 [H]