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The map label for this gene is argS

Identifier: 50843566

GI number: 50843566

Start: 2303771

End: 2305441

Strand: Reverse

Name: argS

Synonym: PPA2128

Alternate gene names: 50843566

Gene position: 2305441-2303771 (Counterclockwise)

Preceding gene: 50843568

Following gene: 50843553

Centisome position: 90.05

GC content: 60.68

Gene sequence:

>1671_bases
ATGTCGTCTCTTCCCTCTCGGCTTGCTGCCCGCATCGAGTCCGCCATCGGAGTTGATCCGCAGTTGCGCCCGGCCACTAA
GCCACAGTTCGGACATTTCCAATCCAACGTCGCCCTGCGCCTGGCCAAGGAGGAGAAACGTCCACCTCGCGACGTTGCCG
CAGACATTGTTGCCAAGCTAGATATCGAGGATCTGTGCGAAACCCCCGAGATCGCCGGGCCCGGATTCATCAACTTGCGC
CTGCGCGCCGACGTTCTGGCTCGGGTGGCCTCTGATTTCGTCACCGATCCCAACGCCGGGATCGCCCAGGCTGAGAAACC
CGAGCGTGTCGTCATCGACTATTCGGCCCCTAATGTCGCCAAACAGATGCACGTCGGTCACCTACGTTCCACCATCATCG
GCGACTGCTTCAACCGTGTCTTGAGCGCTCAAGGGCACACCGTTATCCCGCAGAACCACATCGGTGACTGGGGCACCCAG
TTCGGCATGCTCATCGAGTACATCGTCGAGAAGCGGATGGACGTCGAAGATTTCGACCTGTCCGGTGTCGAGCAGCTCTA
CCAGGATTCCAAGAAGACCTTTGATGCCGATCCTCAGTTTGCTGACCGTGCGCGCCGCCGCGTTGTCAAACTGCAGGGTG
GAGACGCCGAGACTCTGCGGATCTGGCGGACTCTCATTGACATCTCCCTGGAGGGATTCAACGCCACCTACTCCCGTCTG
TCGGTGCTGCTGACTGACGAGGACGTGGCCGGCGAGTCCAGCTACAACGACGACCTGCCGCGAGTTGTGGACGAGCTCGT
GGCTGACGGCCTGGCTGTCGAGGACAACGGCGCACTGTGCGTTTTCGTCGAGGGGCAGGACGCCCCAATGATCGTGCGTA
AGAGGGACGGTGGCTTCGGATATGACGCCACCGATCTCGCTGCGATTCGTCGTCGCGTTGGCAAACTCAAGGCCGACCGC
ATTATTTACGTCACCGACGTGCGCCAGAGCCATCACTTTGAGGTGCTGTTCCAGGTGGCCCGGATGGCCGGGTTCCTGCC
TGACGACGTCGAGGCCGAGCACGTTGGCTACGGCATGGTGCTTGGCCCGGATGGCCGTCCTTTCAAGACTCGTGAGGGTG
GCACAGTGTCGTTGTCGGATCTGCTCGACGAGGCCGAGACGCACGCGGCCCCGAATATCGCCTTGGCTGCCATTAAATAC
GCCGACCTGTCCAACGGCTTGCAGAAGGACTATGTTTTTGACGCTGAGCGGATGGTGCAGACCACCGGTGACACTGGCCC
ATATCTGCAGTACGCTCACGCCCGCGTCTCACAGATCTTGCGCAAAGCGGCCGCTGAGGCCAACCCGAACGTCGATCCTG
AGGCTGACCTGGATGCGATGGATTGGGGTCGCATCAGCGTCCTCGACGAGCCAGCCGAGCAACAGTTGGCCCTGTTGTTG
TCGAGGTTCGGAGAGATCGTCGAGGTTGTTGCTACCGACCTAACTCCGCACAAGCTGTGCACTTACCTCTACGAATTGGC
TGGCGCTTACTCGGTGTTTTATGAGCAGTGCCCGGTGTTGCGTAGTACCGGCGAGGTTCGCGGATCGCGTCTGGCCTTGT
GCGCGGCTACTCGTCGGGTGCTTGGCCGAGGCCTTGACCTGCTGGGTATTGATGCCCCAGATCGGATGTGA

Upstream 100 bases:

>100_bases
GCAAACGTCTTTGCAGCGGTGTTTGTTCCAAAAACGTCACTACGGGGCCTGTGGCGCCTCCGACTGTGACGAGCTGGCCC
TCTCGTGGGATAATGCCGCC

Downstream 100 bases:

>100_bases
CCTGTCGAGTCCAGAACGGGAATGATCTACCCGAGCTGCCCCCGGGATCGACGATATCTTGACCATATCGGTGCCGTACA
CGGTGTGGTGAAAACCCAGA

Product: arginyl-tRNA synthetase

Products: NA

Alternate protein names: Arginine--tRNA ligase; ArgRS

Number of amino acids: Translated: 556; Mature: 555

Protein sequence:

>556_residues
MSSLPSRLAARIESAIGVDPQLRPATKPQFGHFQSNVALRLAKEEKRPPRDVAADIVAKLDIEDLCETPEIAGPGFINLR
LRADVLARVASDFVTDPNAGIAQAEKPERVVIDYSAPNVAKQMHVGHLRSTIIGDCFNRVLSAQGHTVIPQNHIGDWGTQ
FGMLIEYIVEKRMDVEDFDLSGVEQLYQDSKKTFDADPQFADRARRRVVKLQGGDAETLRIWRTLIDISLEGFNATYSRL
SVLLTDEDVAGESSYNDDLPRVVDELVADGLAVEDNGALCVFVEGQDAPMIVRKRDGGFGYDATDLAAIRRRVGKLKADR
IIYVTDVRQSHHFEVLFQVARMAGFLPDDVEAEHVGYGMVLGPDGRPFKTREGGTVSLSDLLDEAETHAAPNIALAAIKY
ADLSNGLQKDYVFDAERMVQTTGDTGPYLQYAHARVSQILRKAAAEANPNVDPEADLDAMDWGRISVLDEPAEQQLALLL
SRFGEIVEVVATDLTPHKLCTYLYELAGAYSVFYEQCPVLRSTGEVRGSRLALCAATRRVLGRGLDLLGIDAPDRM

Sequences:

>Translated_556_residues
MSSLPSRLAARIESAIGVDPQLRPATKPQFGHFQSNVALRLAKEEKRPPRDVAADIVAKLDIEDLCETPEIAGPGFINLR
LRADVLARVASDFVTDPNAGIAQAEKPERVVIDYSAPNVAKQMHVGHLRSTIIGDCFNRVLSAQGHTVIPQNHIGDWGTQ
FGMLIEYIVEKRMDVEDFDLSGVEQLYQDSKKTFDADPQFADRARRRVVKLQGGDAETLRIWRTLIDISLEGFNATYSRL
SVLLTDEDVAGESSYNDDLPRVVDELVADGLAVEDNGALCVFVEGQDAPMIVRKRDGGFGYDATDLAAIRRRVGKLKADR
IIYVTDVRQSHHFEVLFQVARMAGFLPDDVEAEHVGYGMVLGPDGRPFKTREGGTVSLSDLLDEAETHAAPNIALAAIKY
ADLSNGLQKDYVFDAERMVQTTGDTGPYLQYAHARVSQILRKAAAEANPNVDPEADLDAMDWGRISVLDEPAEQQLALLL
SRFGEIVEVVATDLTPHKLCTYLYELAGAYSVFYEQCPVLRSTGEVRGSRLALCAATRRVLGRGLDLLGIDAPDRM
>Mature_555_residues
SSLPSRLAARIESAIGVDPQLRPATKPQFGHFQSNVALRLAKEEKRPPRDVAADIVAKLDIEDLCETPEIAGPGFINLRL
RADVLARVASDFVTDPNAGIAQAEKPERVVIDYSAPNVAKQMHVGHLRSTIIGDCFNRVLSAQGHTVIPQNHIGDWGTQF
GMLIEYIVEKRMDVEDFDLSGVEQLYQDSKKTFDADPQFADRARRRVVKLQGGDAETLRIWRTLIDISLEGFNATYSRLS
VLLTDEDVAGESSYNDDLPRVVDELVADGLAVEDNGALCVFVEGQDAPMIVRKRDGGFGYDATDLAAIRRRVGKLKADRI
IYVTDVRQSHHFEVLFQVARMAGFLPDDVEAEHVGYGMVLGPDGRPFKTREGGTVSLSDLLDEAETHAAPNIALAAIKYA
DLSNGLQKDYVFDAERMVQTTGDTGPYLQYAHARVSQILRKAAAEANPNVDPEADLDAMDWGRISVLDEPAEQQLALLLS
RFGEIVEVVATDLTPHKLCTYLYELAGAYSVFYEQCPVLRSTGEVRGSRLALCAATRRVLGRGLDLLGIDAPDRM

Specific function: Unknown

COG id: COG0018

COG function: function code J; Arginyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI15149476, Length=568, Percent_Identity=38.556338028169, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI197100773, Length=570, Percent_Identity=30.8771929824561, Blast_Score=216, Evalue=3e-56,
Organism=Escherichia coli, GI1788184, Length=565, Percent_Identity=44.2477876106195, Blast_Score=459, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI71985061, Length=605, Percent_Identity=37.1900826446281, Blast_Score=346, Evalue=1e-95,
Organism=Caenorhabditis elegans, GI71985068, Length=567, Percent_Identity=37.2134038800705, Blast_Score=327, Evalue=1e-89,
Organism=Caenorhabditis elegans, GI17532153, Length=485, Percent_Identity=26.5979381443299, Blast_Score=143, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6320548, Length=547, Percent_Identity=30.8957952468007, Blast_Score=222, Evalue=9e-59,
Organism=Saccharomyces cerevisiae, GI6321883, Length=494, Percent_Identity=28.3400809716599, Blast_Score=190, Evalue=5e-49,
Organism=Drosophila melanogaster, GI18859963, Length=571, Percent_Identity=34.6760070052539, Blast_Score=330, Evalue=2e-90,
Organism=Drosophila melanogaster, GI28571570, Length=483, Percent_Identity=31.055900621118, Blast_Score=191, Evalue=8e-49,

Paralogues:

None

Copy number: 789 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYR_PROAC (Q6A5X8)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_056793.1
- ProteinModelPortal:   Q6A5X8
- SMR:   Q6A5X8
- GeneID:   2932484
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA2128
- NMPDR:   fig|267747.1.peg.2070
- HOGENOM:   HBG695395
- OMA:   HMGFGTM
- ProtClustDB:   CLSK2764372
- BioCyc:   PACN267747:PPA2128-MONOMER
- BRENDA:   6.1.1.19
- GO:   GO:0005737
- HAMAP:   MF_00123
- InterPro:   IPR001412
- InterPro:   IPR001278
- InterPro:   IPR015945
- InterPro:   IPR005148
- InterPro:   IPR008909
- InterPro:   IPR014729
- InterPro:   IPR009080
- Gene3D:   G3DSA:3.30.1360.70
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11956
- PRINTS:   PR01038
- SMART:   SM00836
- TIGRFAMs:   TIGR00456

Pfam domain/function: PF03485 Arg_tRNA_synt_N; PF05746 DALR_1; PF00750 tRNA-synt_1d; SSF55190 Arg-tRNA-synth_Ic_N; SSF47323 tRNAsyn_1a_bind

EC number: =6.1.1.19

Molecular weight: Translated: 61179; Mature: 61048

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLPSRLAARIESAIGVDPQLRPATKPQFGHFQSNVALRLAKEEKRPPRDVAADIVAKL
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHEEEEHHHCCCHHHHHHHHHHHC
DIEDLCETPEIAGPGFINLRLRADVLARVASDFVTDPNAGIAQAEKPERVVIDYSAPNVA
CHHHHHCCCCCCCCCEEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCHHH
KQMHVGHLRSTIIGDCFNRVLSAQGHTVIPQNHIGDWGTQFGMLIEYIVEKRMDVEDFDL
HHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCH
SGVEQLYQDSKKTFDADPQFADRARRRVVKLQGGDAETLRIWRTLIDISLEGFNATYSRL
HHHHHHHHHHHHCCCCCCHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHCCCCCCCCHHE
SVLLTDEDVAGESSYNDDLPRVVDELVADGLAVEDNGALCVFVEGQDAPMIVRKRDGGFG
EEEEECCCCCCCCCCCCCHHHHHHHHHHCCEEEECCCEEEEEEECCCCCEEEEECCCCCC
YDATDLAAIRRRVGKLKADRIIYVTDVRQSHHFEVLFQVARMAGFLPDDVEAEHVGYGMV
CCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHCCEEEE
LGPDGRPFKTREGGTVSLSDLLDEAETHAAPNIALAAIKYADLSNGLQKDYVFDAERMVQ
ECCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCEEEEEEEHHHHHCCCHHHHHHHHHHHHH
TTGDTGPYLQYAHARVSQILRKAAAEANPNVDPEADLDAMDWGRISVLDEPAEQQLALLL
HCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHH
SRFGEIVEVVATDLTPHKLCTYLYELAGAYSVFYEQCPVLRSTGEVRGSRLALCAATRRV
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHHH
LGRGLDLLGIDAPDRM
HHCCCCEEECCCCCCC
>Mature Secondary Structure 
SSLPSRLAARIESAIGVDPQLRPATKPQFGHFQSNVALRLAKEEKRPPRDVAADIVAKL
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHEEEEHHHCCCHHHHHHHHHHHC
DIEDLCETPEIAGPGFINLRLRADVLARVASDFVTDPNAGIAQAEKPERVVIDYSAPNVA
CHHHHHCCCCCCCCCEEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCHHH
KQMHVGHLRSTIIGDCFNRVLSAQGHTVIPQNHIGDWGTQFGMLIEYIVEKRMDVEDFDL
HHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCH
SGVEQLYQDSKKTFDADPQFADRARRRVVKLQGGDAETLRIWRTLIDISLEGFNATYSRL
HHHHHHHHHHHHCCCCCCHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHCCCCCCCCHHE
SVLLTDEDVAGESSYNDDLPRVVDELVADGLAVEDNGALCVFVEGQDAPMIVRKRDGGFG
EEEEECCCCCCCCCCCCCHHHHHHHHHHCCEEEECCCEEEEEEECCCCCEEEEECCCCCC
YDATDLAAIRRRVGKLKADRIIYVTDVRQSHHFEVLFQVARMAGFLPDDVEAEHVGYGMV
CCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHCCEEEE
LGPDGRPFKTREGGTVSLSDLLDEAETHAAPNIALAAIKYADLSNGLQKDYVFDAERMVQ
ECCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCEEEEEEEHHHHHCCCHHHHHHHHHHHHH
TTGDTGPYLQYAHARVSQILRKAAAEANPNVDPEADLDAMDWGRISVLDEPAEQQLALLL
HCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHH
SRFGEIVEVVATDLTPHKLCTYLYELAGAYSVFYEQCPVLRSTGEVRGSRLALCAATRRV
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHHH
LGRGLDLLGIDAPDRM
HHCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA