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The map label for this gene is ptpA [H]

Identifier: 50843548

GI number: 50843548

Start: 2284487

End: 2284963

Strand: Direct

Name: ptpA [H]

Synonym: PPA2110

Alternate gene names: 50843548

Gene position: 2284487-2284963 (Clockwise)

Preceding gene: 50843546

Following gene: 50843549

Centisome position: 89.23

GC content: 63.52

Gene sequence:

>477_bases
GTGAGCAACCAGAACACTTCCTCCGTTATTTTCGTGTGCTGGGGAAACATCTGTCGTTCCCCGATGGCCGAATTCGTCGC
CAGGAAAGTCTTCTCCGACGAAGGCTTGGACGCCCGCATCACCAGCGCCGGTGTCAGCGATGAGGAGCACGGCGGCCCGA
TGGATTCGCGAGCCAGGTCCGTCCTGAAGTCCCACGGATACCCCTGCTCGGGCCACAACGCTCACCAGATCGACGAGTCC
GAGATCATGTCCGCCGACCTCGTCATAGCCGCCGAGCCACGCCACATCCAGATGATGAAGCGGATGGCCCCCGACGCCGA
CAACCTCCGTCTCATCCGCGACTACGACCCCAAATGCACCCCTGGCACCTCCCTGCCGGACCCCTGGTATGGCTCGGCCG
ACGGGTTCGAGGACACCCTCGACGCCATCGAGGCCGCAATGCCCGGAATCGTTGACGAGGTGCGCTCACTGGCCTGA

Upstream 100 bases:

>100_bases
TTTCTTGACAGCTCCGTGTAGTTCGCCGCAAGTATGAACCCTGGCAAGGCCCTCCCCACACCAGGCAGACTGGACCCACC
GATCATGGGAGGAACCCCCT

Downstream 100 bases:

>100_bases
TCAGTTCCCCGCCATGGCGCTGGTCCCCCGAGACCAATCGTTGCGGCACTATAGGCTGTTCCCATGAGTTTGTTCTTGGT
CGGCGGAGGGTACGACGACT

Product: low molecular weight protein-tyrosine-phosphatase

Products: NA

Alternate protein names: PTPase; Small, acidic phosphotyrosine protein phosphatase; PY protein phosphatase [H]

Number of amino acids: Translated: 158; Mature: 157

Protein sequence:

>158_residues
MSNQNTSSVIFVCWGNICRSPMAEFVARKVFSDEGLDARITSAGVSDEEHGGPMDSRARSVLKSHGYPCSGHNAHQIDES
EIMSADLVIAAEPRHIQMMKRMAPDADNLRLIRDYDPKCTPGTSLPDPWYGSADGFEDTLDAIEAAMPGIVDEVRSLA

Sequences:

>Translated_158_residues
MSNQNTSSVIFVCWGNICRSPMAEFVARKVFSDEGLDARITSAGVSDEEHGGPMDSRARSVLKSHGYPCSGHNAHQIDES
EIMSADLVIAAEPRHIQMMKRMAPDADNLRLIRDYDPKCTPGTSLPDPWYGSADGFEDTLDAIEAAMPGIVDEVRSLA
>Mature_157_residues
SNQNTSSVIFVCWGNICRSPMAEFVARKVFSDEGLDARITSAGVSDEEHGGPMDSRARSVLKSHGYPCSGHNAHQIDESE
IMSADLVIAAEPRHIQMMKRMAPDADNLRLIRDYDPKCTPGTSLPDPWYGSADGFEDTLDAIEAAMPGIVDEVRSLA

Specific function: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. May be involved in the regulation of sulfur amino acid metabolism [H]

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family [H]

Homologues:

Organism=Homo sapiens, GI4757714, Length=143, Percent_Identity=36.3636363636364, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI6005988, Length=143, Percent_Identity=34.965034965035, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI96304457, Length=79, Percent_Identity=49.3670886075949, Blast_Score=74, Evalue=8e-14,
Organism=Escherichia coli, GI1788375, Length=139, Percent_Identity=30.9352517985612, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI87081812, Length=149, Percent_Identity=30.2013422818792, Blast_Score=64, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6325330, Length=142, Percent_Identity=32.3943661971831, Blast_Score=74, Evalue=9e-15,
Organism=Drosophila melanogaster, GI78706770, Length=155, Percent_Identity=29.0322580645161, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI78706772, Length=155, Percent_Identity=29.0322580645161, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000106
- InterPro:   IPR017867 [H]

Pfam domain/function: PF01451 LMWPc [H]

EC number: =3.1.3.48 [H]

Molecular weight: Translated: 17227; Mature: 17096

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNQNTSSVIFVCWGNICRSPMAEFVARKVFSDEGLDARITSAGVSDEEHGGPMDSRARS
CCCCCCCCEEEEECCHHHCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCHHHHHHH
VLKSHGYPCSGHNAHQIDESEIMSADLVIAAEPRHIQMMKRMAPDADNLRLIRDYDPKCT
HHHHCCCCCCCCCCCCCCHHHHHCCCEEEEECCHHHHHHHHHCCCCCCEEEEECCCCCCC
PGTSLPDPWYGSADGFEDTLDAIEAAMPGIVDEVRSLA
CCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCC
>Mature Secondary Structure 
SNQNTSSVIFVCWGNICRSPMAEFVARKVFSDEGLDARITSAGVSDEEHGGPMDSRARS
CCCCCCCEEEEECCHHHCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCHHHHHHH
VLKSHGYPCSGHNAHQIDESEIMSADLVIAAEPRHIQMMKRMAPDADNLRLIRDYDPKCT
HHHHCCCCCCCCCCCCCCHHHHHCCCEEEEECCHHHHHHHHHCCCCCCEEEEECCCCCCC
PGTSLPDPWYGSADGFEDTLDAIEAAMPGIVDEVRSLA
CCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8550407; 12000953 [H]