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The map label for this gene is hemY [H]

Identifier: 50843534

GI number: 50843534

Start: 2270288

End: 2271658

Strand: Direct

Name: hemY [H]

Synonym: PPA2095

Alternate gene names: 50843534

Gene position: 2270288-2271658 (Clockwise)

Preceding gene: 50843527

Following gene: 50843535

Centisome position: 88.67

GC content: 64.26

Gene sequence:

>1371_bases
GTGGCAGTCATCGGTGCCGGAATGACGGGCCTGGCAGCCGCACACCACCTGCACAGCCACGGCTGTCGTCCCGTCGTCCT
CGAAGCGGGGCAGGGCGTTGGCGGCCAGGTCAGGTCCCGTCGTCTTGGTTCTGATGTGGTCGACATGGGACCTGAAGCCG
TGCCTCTTCGCGCCCCGGGCGTCGCCGCACTCGTTGCGGAGCTGGGACTGACGGACTCCATGCGTCATCCCGTTCCTGGG
CGCGTCTTATTGTCGAGCCGGCGTGGAGTCGTGGAGATGCCGTCCGGCGTAACACCAGTAGGGCCCACGAAGCTCCTCCC
CACTATTGCCTCGCGCATCCTCTCCCCTGCCGGACTGTTACGGGCCGGGCTCGAACCTTTCAACGCTCGCCCGCACCTTG
ACGACGTCAGCGTCGGCCAATTCATCGCCGAAAGGTTTGGTGACGAGGTGAGCCGCGCCGTCGTCGACCCGCTACTGGGG
GGTATTCACGCCGCCGACCTCAACACGTTCTCGCTAGCAGTTGCCGCCCCCGCTTTGGAGCAGACGGTCAGGAACGGCGA
CTCCATCGTCGCCGGAACTCTCAAACGCAATGCTGCCGGACGCTGGTCGCAGCTCCGCCATCGTTCACAGCGATCCGGTC
CGCGCACCCCCGCCACCGCCACCTGGAAACACGGCCTGATGATGTTGCCGGAAGCATTGGCTAGGGAGCTCACCATTCAT
ACGAATACCCGTGCCAGGGGAATCCGTCAGGTCGGCCACGAATGGGTAGTCGATGTCACTGGTCCGCATGGCGTTGGATC
GGTTGCTGTTGATGACGTCATCATTGCCACCCCCGCCAGGGTTGCGGGTGCCCTGCTTGCTACCGCATGCCCGCGAGCTT
CCGAGCTGCTGTCGCAGTGTGAAAGCACTACCGTTGCCACGCTGGTTATGCAGGCTGACCTTACTGACCACCCGATCGCT
ACGGCCCAAACGTGGTTCATTGGTTCGGCATGGTCTGCCCTGGTGCGTCAGGTGACCAATCTCTCGACGACGTGGCACCT
CGCCAAACCCACCTTTCGGATCGCCATGGGTCGGCAGCGTGGAACCCCCATCGACGATCTATCTGACGACGACCTCGTCG
CCATGAGCGTGGCAGAGTTGAGACGTCTCGGACTGGCTCTTGACCCCCACGACTACGTCATTGAGCGACACCGCGGCGCC
ATGCCGCAACCAGCTCCTGGCCACCGGGAGCGCATGGCCCAGCTCGCCGCGACCCTCAACGGCACCGGTCTCCATGTGGG
AGGGGCCGGTATCGACGGTGCCGGAGTTGGCACCGCAATTGCTGCTGGACGCCGTCTCGCACGCCACATCACCTCGAAGG
AGGAGAATTAG

Upstream 100 bases:

>100_bases
CACCAAAGATGAGGTTACCGTTGCGTAGGTTGTTCCTGGTTCCTACCCCGGACTTCGATTGGTGCCAGAACGTGCGTACC
CTCAAACGGTGAGCAAAACA

Downstream 100 bases:

>100_bases
TGACCATCACTGAGCACCCTGACCACCTGACCCGGCCCGGCAGTGCGCCCACAGGACACCCCGGCGGCCATCCGGGAGGT
CATCCAGGCCACAGCCCGCT

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: PPO [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MAVIGAGMTGLAAAHHLHSHGCRPVVLEAGQGVGGQVRSRRLGSDVVDMGPEAVPLRAPGVAALVAELGLTDSMRHPVPG
RVLLSSRRGVVEMPSGVTPVGPTKLLPTIASRILSPAGLLRAGLEPFNARPHLDDVSVGQFIAERFGDEVSRAVVDPLLG
GIHAADLNTFSLAVAAPALEQTVRNGDSIVAGTLKRNAAGRWSQLRHRSQRSGPRTPATATWKHGLMMLPEALARELTIH
TNTRARGIRQVGHEWVVDVTGPHGVGSVAVDDVIIATPARVAGALLATACPRASELLSQCESTTVATLVMQADLTDHPIA
TAQTWFIGSAWSALVRQVTNLSTTWHLAKPTFRIAMGRQRGTPIDDLSDDDLVAMSVAELRRLGLALDPHDYVIERHRGA
MPQPAPGHRERMAQLAATLNGTGLHVGGAGIDGAGVGTAIAAGRRLARHITSKEEN

Sequences:

>Translated_456_residues
MAVIGAGMTGLAAAHHLHSHGCRPVVLEAGQGVGGQVRSRRLGSDVVDMGPEAVPLRAPGVAALVAELGLTDSMRHPVPG
RVLLSSRRGVVEMPSGVTPVGPTKLLPTIASRILSPAGLLRAGLEPFNARPHLDDVSVGQFIAERFGDEVSRAVVDPLLG
GIHAADLNTFSLAVAAPALEQTVRNGDSIVAGTLKRNAAGRWSQLRHRSQRSGPRTPATATWKHGLMMLPEALARELTIH
TNTRARGIRQVGHEWVVDVTGPHGVGSVAVDDVIIATPARVAGALLATACPRASELLSQCESTTVATLVMQADLTDHPIA
TAQTWFIGSAWSALVRQVTNLSTTWHLAKPTFRIAMGRQRGTPIDDLSDDDLVAMSVAELRRLGLALDPHDYVIERHRGA
MPQPAPGHRERMAQLAATLNGTGLHVGGAGIDGAGVGTAIAAGRRLARHITSKEEN
>Mature_455_residues
AVIGAGMTGLAAAHHLHSHGCRPVVLEAGQGVGGQVRSRRLGSDVVDMGPEAVPLRAPGVAALVAELGLTDSMRHPVPGR
VLLSSRRGVVEMPSGVTPVGPTKLLPTIASRILSPAGLLRAGLEPFNARPHLDDVSVGQFIAERFGDEVSRAVVDPLLGG
IHAADLNTFSLAVAAPALEQTVRNGDSIVAGTLKRNAAGRWSQLRHRSQRSGPRTPATATWKHGLMMLPEALARELTIHT
NTRARGIRQVGHEWVVDVTGPHGVGSVAVDDVIIATPARVAGALLATACPRASELLSQCESTTVATLVMQADLTDHPIAT
AQTWFIGSAWSALVRQVTNLSTTWHLAKPTFRIAMGRQRGTPIDDLSDDDLVAMSVAELRRLGLALDPHDYVIERHRGAM
PQPAPGHRERMAQLAATLNGTGLHVGGAGIDGAGVGTAIAAGRRLARHITSKEEN

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. Also oxidizes the pathway intermediate coproporphyrinogen-III [H]

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family [H]

Homologues:

Organism=Homo sapiens, GI170650615, Length=505, Percent_Identity=25.1485148514851, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI4506001, Length=505, Percent_Identity=25.1485148514851, Blast_Score=79, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002937
- InterPro:   IPR016040
- InterPro:   IPR004572 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: =1.3.3.4 [H]

Molecular weight: Translated: 47935; Mature: 47803

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVIGAGMTGLAAAHHLHSHGCRPVVLEAGQGVGGQVRSRRLGSDVVDMGPEAVPLRAPG
CEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHCCCHHHHCCCCCCCCCCCC
VAALVAELGLTDSMRHPVPGRVLLSSRRGVVEMPSGVTPVGPTKLLPTIASRILSPAGLL
HHHHHHHHCCCCCCCCCCCCCEEECCCCCEEECCCCCCCCCHHHHHHHHHHHHCCHHHHH
RAGLEPFNARPHLDDVSVGQFIAERFGDEVSRAVVDPLLGGIHAADLNTFSLAVAAPALE
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHH
QTVRNGDSIVAGTLKRNAAGRWSQLRHRSQRSGPRTPATATWKHGLMMLPEALARELTIH
HHHHCCCCEEEEHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHEEEE
TNTRARGIRQVGHEWVVDVTGPHGVGSVAVDDVIIATPARVAGALLATACPRASELLSQC
CCHHHHHHHHCCCEEEEEECCCCCCCCHHHCCEEEECCHHHHHHHHHHHCCCHHHHHHHH
ESTTVATLVMQADLTDHPIATAQTWFIGSAWSALVRQVTNLSTTWHLAKPTFRIAMGRQR
HHHHHHHHEEECCCCCCCCCCHHHEEHHHHHHHHHHHHHCCCCEEEECCCEEEEEECCCC
GTPIDDLSDDDLVAMSVAELRRLGLALDPHDYVIERHRGAMPQPAPGHRERMAQLAATLN
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCC
GTGLHVGGAGIDGAGVGTAIAAGRRLARHITSKEEN
CCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AVIGAGMTGLAAAHHLHSHGCRPVVLEAGQGVGGQVRSRRLGSDVVDMGPEAVPLRAPG
EEECCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHCCCHHHHCCCCCCCCCCCC
VAALVAELGLTDSMRHPVPGRVLLSSRRGVVEMPSGVTPVGPTKLLPTIASRILSPAGLL
HHHHHHHHCCCCCCCCCCCCCEEECCCCCEEECCCCCCCCCHHHHHHHHHHHHCCHHHHH
RAGLEPFNARPHLDDVSVGQFIAERFGDEVSRAVVDPLLGGIHAADLNTFSLAVAAPALE
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHH
QTVRNGDSIVAGTLKRNAAGRWSQLRHRSQRSGPRTPATATWKHGLMMLPEALARELTIH
HHHHCCCCEEEEHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHEEEE
TNTRARGIRQVGHEWVVDVTGPHGVGSVAVDDVIIATPARVAGALLATACPRASELLSQC
CCHHHHHHHHCCCEEEEEECCCCCCCCHHHCCEEEECCHHHHHHHHHHHCCCHHHHHHHH
ESTTVATLVMQADLTDHPIATAQTWFIGSAWSALVRQVTNLSTTWHLAKPTFRIAMGRQR
HHHHHHHHEEECCCCCCCCCCHHHEEHHHHHHHHHHHHHCCCCEEEECCCEEEEEECCCC
GTPIDDLSDDDLVAMSVAELRRLGLALDPHDYVIERHRGAMPQPAPGHRERMAQLAATLN
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCC
GTGLHVGGAGIDGAGVGTAIAAGRRLARHITSKEEN
CCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1459957; 9579061; 9384377; 8288631 [H]