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The map label for this gene is aroP [H]

Identifier: 50843477

GI number: 50843477

Start: 2205917

End: 2207275

Strand: Direct

Name: aroP [H]

Synonym: PPA2033

Alternate gene names: 50843477

Gene position: 2205917-2207275 (Clockwise)

Preceding gene: 50843475

Following gene: 50843487

Centisome position: 86.16

GC content: 60.71

Gene sequence:

>1359_bases
GTGACCGAACCCGACCAGCAACTGCATCGCAGTCTGCGCAACCGACACATCCAACTCATCGCCTTGGGTGGCGCAATCGG
AACCGGTCTGTTCTACGGAGCAGCCGACTCTATCGCGGCCGCCGGACCGGCGGTCATCGTCAGTTACCTCATTGGTGGCG
TAGTGATCTATCTCATCATGCGAGCTCTTGGCGAAATGAGCGTCCACAACCCGACTTCGGGTGCCTTCAGTGAGTACGCG
CACCAGTGGTGGGGAGATCTCCCCGGGTTCATCTCCGGCTGGAACTACTGGTTCAACTACATCTTCGTGTCGATGGCCGA
GCTCTCGGTGGTCGGGATCTACATCAACTATTGGTTCCCTGTCGTCCCCCGGTGGGTGTCAGCGGCGGTACTGCTTGCCA
TCGTCACAACCGTCAATCTCCTCCACGTCCGCGCCTACGGAGAAGTGGAGTTCTGGTTCGCCATCATCAAGGTCGTCGCG
ATTATTGCCATGATCGTCCTGGGCCTGTGGATTATATTCTTCGGCACCGGCTCCACCCCGGCGACTGGCATCGGCAATCT
GTGGCGCAATGGCGGATTTTTGCCTCACGGCGTCACCGGGATGCTCGCCGGGATCATCGTCGTCATGTTCTCCTTTGGCG
GCACCGAGCTCATCGGCATCACCGCCGGTGAGGCCGAAGATCCGCAGCGCTCCATCCCCAGGGCCATTAACCGAGTCGTC
GGGCGCATCCTGCTGTTCTACGTCGGTGCGCTCATCGTCATGGTGGCGATTGTCCCGTGGACGAAGATCGACGGAAATGC
CAGCCCCTTCGTCCAGATTTTCGACCTCGTCGGGATCCCGGGAGCGGCAGCCATCCTCAACCTCGTCGTTCTCACCGCAG
CGATCTCGGCGTATAACTCTGGTCTGTACGCCAATGGACGCATGCTCCACGCCCTGGCCCATCAAGGGGATGCCCCCGCC
TTCCTCGGCAAGGTAAATAAGGCCGGGTCGCCGTGGGCCGGGGTACTTCTGTCTAGCGCCGTAACAGCTATTGCAGTGGT
CGTCGTCGGGCTGCTACCGGAACAGGCGTTCGTGTACATCATGTCGATCGCCATGATCGCCGCAATCATCAACTGGGCGA
CGATCATCATCACCCAGATGCTCTTTCGTCGCCGTCTCGATCCTGAATCCCGCTCCGAGCTGCGTTTCACGATGCCGGGA
GCCCCCGTCACCAACTGGATCGTGCTGGCCTTCCTGGTACTCATGGTCGTCGTCATGACAACCATGCCGCCCTACCGGAT
CGCGGTGGCTATCGGCCCCATCTGGCTGGCTGTCCTGGGCCTAGGGTGGCGGGTGTCACGGCGCCGTCAGACTTTGTAA

Upstream 100 bases:

>100_bases
TCCCGCCAGGTCACCACACACTGGACGGACGGCGCCACGTCGCGCCCACCCTTCGATCAACACCGGTTCCCATCGACACC
CGCCTCTAAACTCACAGACC

Downstream 100 bases:

>100_bases
ACGATCGGGTAAAACGACCGATAGGCGGTGACCCGAGGCTGTTTAGACCAGCACAATCACCTGTACTAGCAGGATTTTGA
CGACGGTTCCTAACGCGAAA

Product: aromatic amino acid transport permease AroP

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MTEPDQQLHRSLRNRHIQLIALGGAIGTGLFYGAADSIAAAGPAVIVSYLIGGVVIYLIMRALGEMSVHNPTSGAFSEYA
HQWWGDLPGFISGWNYWFNYIFVSMAELSVVGIYINYWFPVVPRWVSAAVLLAIVTTVNLLHVRAYGEVEFWFAIIKVVA
IIAMIVLGLWIIFFGTGSTPATGIGNLWRNGGFLPHGVTGMLAGIIVVMFSFGGTELIGITAGEAEDPQRSIPRAINRVV
GRILLFYVGALIVMVAIVPWTKIDGNASPFVQIFDLVGIPGAAAILNLVVLTAAISAYNSGLYANGRMLHALAHQGDAPA
FLGKVNKAGSPWAGVLLSSAVTAIAVVVVGLLPEQAFVYIMSIAMIAAIINWATIIITQMLFRRRLDPESRSELRFTMPG
APVTNWIVLAFLVLMVVVMTTMPPYRIAVAIGPIWLAVLGLGWRVSRRRQTL

Sequences:

>Translated_452_residues
MTEPDQQLHRSLRNRHIQLIALGGAIGTGLFYGAADSIAAAGPAVIVSYLIGGVVIYLIMRALGEMSVHNPTSGAFSEYA
HQWWGDLPGFISGWNYWFNYIFVSMAELSVVGIYINYWFPVVPRWVSAAVLLAIVTTVNLLHVRAYGEVEFWFAIIKVVA
IIAMIVLGLWIIFFGTGSTPATGIGNLWRNGGFLPHGVTGMLAGIIVVMFSFGGTELIGITAGEAEDPQRSIPRAINRVV
GRILLFYVGALIVMVAIVPWTKIDGNASPFVQIFDLVGIPGAAAILNLVVLTAAISAYNSGLYANGRMLHALAHQGDAPA
FLGKVNKAGSPWAGVLLSSAVTAIAVVVVGLLPEQAFVYIMSIAMIAAIINWATIIITQMLFRRRLDPESRSELRFTMPG
APVTNWIVLAFLVLMVVVMTTMPPYRIAVAIGPIWLAVLGLGWRVSRRRQTL
>Mature_451_residues
TEPDQQLHRSLRNRHIQLIALGGAIGTGLFYGAADSIAAAGPAVIVSYLIGGVVIYLIMRALGEMSVHNPTSGAFSEYAH
QWWGDLPGFISGWNYWFNYIFVSMAELSVVGIYINYWFPVVPRWVSAAVLLAIVTTVNLLHVRAYGEVEFWFAIIKVVAI
IAMIVLGLWIIFFGTGSTPATGIGNLWRNGGFLPHGVTGMLAGIIVVMFSFGGTELIGITAGEAEDPQRSIPRAINRVVG
RILLFYVGALIVMVAIVPWTKIDGNASPFVQIFDLVGIPGAAAILNLVVLTAAISAYNSGLYANGRMLHALAHQGDAPAF
LGKVNKAGSPWAGVLLSSAVTAIAVVVVGLLPEQAFVYIMSIAMIAAIINWATIIITQMLFRRRLDPESRSELRFTMPGA
PVTNWIVLAFLVLMVVVMTTMPPYRIAVAIGPIWLAVLGLGWRVSRRRQTL

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI258645169, Length=399, Percent_Identity=24.0601503759398, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI258614005, Length=400, Percent_Identity=23.75, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI258614003, Length=400, Percent_Identity=23.75, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI181337167, Length=401, Percent_Identity=25.4364089775561, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI4507047, Length=450, Percent_Identity=23.1111111111111, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI110347453, Length=333, Percent_Identity=24.3243243243243, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1786302, Length=446, Percent_Identity=50, Blast_Score=456, Evalue=1e-129,
Organism=Escherichia coli, GI1786789, Length=448, Percent_Identity=47.7678571428571, Blast_Score=441, Evalue=1e-125,
Organism=Escherichia coli, GI1786602, Length=449, Percent_Identity=46.9933184855234, Blast_Score=390, Evalue=1e-110,
Organism=Escherichia coli, GI1790653, Length=450, Percent_Identity=39.7777777777778, Blast_Score=357, Evalue=1e-99,
Organism=Escherichia coli, GI48994972, Length=439, Percent_Identity=42.8246013667426, Blast_Score=348, Evalue=3e-97,
Organism=Escherichia coli, GI87081915, Length=451, Percent_Identity=40.1330376940133, Blast_Score=341, Evalue=6e-95,
Organism=Escherichia coli, GI87081708, Length=458, Percent_Identity=37.5545851528384, Blast_Score=293, Evalue=1e-80,
Organism=Escherichia coli, GI1789017, Length=429, Percent_Identity=36.1305361305361, Blast_Score=292, Evalue=2e-80,
Organism=Escherichia coli, GI1788480, Length=387, Percent_Identity=37.2093023255814, Blast_Score=266, Evalue=3e-72,
Organism=Escherichia coli, GI87082250, Length=352, Percent_Identity=25, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87081869, Length=191, Percent_Identity=26.1780104712042, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI87082023, Length=368, Percent_Identity=22.0108695652174, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI2367353, Length=329, Percent_Identity=23.4042553191489, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532491, Length=428, Percent_Identity=22.8971962616822, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17531343, Length=394, Percent_Identity=24.1116751269036, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17540018, Length=353, Percent_Identity=25.7790368271955, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17533459, Length=410, Percent_Identity=22.4390243902439, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6324061, Length=471, Percent_Identity=32.6963906581741, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6320772, Length=435, Percent_Identity=34.4827586206897, Blast_Score=236, Evalue=6e-63,
Organism=Saccharomyces cerevisiae, GI6324924, Length=485, Percent_Identity=33.1958762886598, Blast_Score=216, Evalue=5e-57,
Organism=Saccharomyces cerevisiae, GI6322892, Length=414, Percent_Identity=34.0579710144928, Blast_Score=206, Evalue=6e-54,
Organism=Saccharomyces cerevisiae, GI6324059, Length=437, Percent_Identity=33.1807780320366, Blast_Score=205, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6324553, Length=400, Percent_Identity=32, Blast_Score=198, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6319824, Length=412, Percent_Identity=29.3689320388349, Blast_Score=193, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6324990, Length=444, Percent_Identity=29.0540540540541, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6320251, Length=405, Percent_Identity=29.6296296296296, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6321629, Length=439, Percent_Identity=27.7904328018223, Blast_Score=182, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6320717, Length=407, Percent_Identity=27.2727272727273, Blast_Score=180, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6319542, Length=403, Percent_Identity=29.2803970223325, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6321053, Length=425, Percent_Identity=28.4705882352941, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6319543, Length=402, Percent_Identity=29.6019900497512, Blast_Score=167, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6322967, Length=405, Percent_Identity=29.1358024691358, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6324981, Length=403, Percent_Identity=27.7915632754342, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6319608, Length=438, Percent_Identity=24.8858447488584, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6320364, Length=469, Percent_Identity=24.9466950959488, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI221512776, Length=410, Percent_Identity=23.4146341463415, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24666159, Length=410, Percent_Identity=23.4146341463415, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24668806, Length=414, Percent_Identity=24.8792270531401, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21356285, Length=414, Percent_Identity=24.8792270531401, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24668802, Length=414, Percent_Identity=24.8792270531401, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24667468, Length=418, Percent_Identity=23.6842105263158, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI161077963, Length=333, Percent_Identity=24.9249249249249, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI281366235, Length=414, Percent_Identity=23.9130434782609, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI116007820, Length=414, Percent_Identity=23.9130434782609, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 48888; Mature: 48756

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPDQQLHRSLRNRHIQLIALGGAIGTGLFYGAADSIAAAGPAVIVSYLIGGVVIYLIM
CCCCHHHHHHHHHHCCEEEEEECCHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHH
RALGEMSVHNPTSGAFSEYAHQWWGDLPGFISGWNYWFNYIFVSMAELSVVGIYINYWFP
HHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVPRWVSAAVLLAIVTTVNLLHVRAYGEVEFWFAIIKVVAIIAMIVLGLWIIFFGTGSTP
HHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ATGIGNLWRNGGFLPHGVTGMLAGIIVVMFSFGGTELIGITAGEAEDPQRSIPRAINRVV
CCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHH
GRILLFYVGALIVMVAIVPWTKIDGNASPFVQIFDLVGIPGAAAILNLVVLTAAISAYNS
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
GLYANGRMLHALAHQGDAPAFLGKVNKAGSPWAGVLLSSAVTAIAVVVVGLLPEQAFVYI
CCEECCHHHHHHHCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
MSIAMIAAIINWATIIITQMLFRRRLDPESRSELRFTMPGAPVTNWIVLAFLVLMVVVMT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHH
TMPPYRIAVAIGPIWLAVLGLGWRVSRRRQTL
CCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCC
>Mature Secondary Structure 
TEPDQQLHRSLRNRHIQLIALGGAIGTGLFYGAADSIAAAGPAVIVSYLIGGVVIYLIM
CCCHHHHHHHHHHCCEEEEEECCHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHH
RALGEMSVHNPTSGAFSEYAHQWWGDLPGFISGWNYWFNYIFVSMAELSVVGIYINYWFP
HHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVPRWVSAAVLLAIVTTVNLLHVRAYGEVEFWFAIIKVVAIIAMIVLGLWIIFFGTGSTP
HHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ATGIGNLWRNGGFLPHGVTGMLAGIIVVMFSFGGTELIGITAGEAEDPQRSIPRAINRVV
CCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHH
GRILLFYVGALIVMVAIVPWTKIDGNASPFVQIFDLVGIPGAAAILNLVVLTAAISAYNS
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
GLYANGRMLHALAHQGDAPAFLGKVNKAGSPWAGVLLSSAVTAIAVVVVGLLPEQAFVYI
CCEECCHHHHHHHCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
MSIAMIAAIINWATIIITQMLFRRRLDPESRSELRFTMPGAPVTNWIVLAFLVLMVVVMT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHH
TMPPYRIAVAIGPIWLAVLGLGWRVSRRRQTL
CCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]