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The map label for this gene is 50843454

Identifier: 50843454

GI number: 50843454

Start: 2180077

End: 2181570

Strand: Reverse

Name: 50843454

Synonym: PPA2008

Alternate gene names: NA

Gene position: 2181570-2180077 (Counterclockwise)

Preceding gene: 50843455

Following gene: 50843453

Centisome position: 85.21

GC content: 61.04

Gene sequence:

>1494_bases
ATGAGTCCACGAAAGATTGGCGTTACCGAGCTCGTGCTCCGCGACGCGCATCAGAGCCTGCTTGCCACTCGCATGGCCAT
GGAGGACATGGTTGATGCCTGTGCCGACATTGATGCGGCAGGCTTCTGGTCCGTTGAATGCTGGGGCGGAGCTACCTTCG
ATTCTTGCATCCGATTCCTCAACGAAGACCCATGGGAGCGTCTGCGTACTTTCCGCAAGCTGCTGCCGAACTCCCGGTTG
CAGATGCTGCTGCGTGGCCAAAACCTTCTGGGCTACCGCCACTACAACGACGAGGTCGTCGACAAGTTTGTCGAGAAGTC
GGCCGAGAACGGCATGGACGTGTTCCGGGTGTTCGACGCTCTGAACGATCCTCGCAACCTTGAGCACGCGATGGCAGCCG
TCAAGAAGACCGGCAAGCACGCCCAGGGCACCATCTGCTACACCACTTCCCCGATTCACACCCCAGAGAGCTTCGTCAAG
CAGGCCGATCGTCTCATCGACATGGGTGCCGACTCGATCGCCTTCAAGGACATGGCTGCTTTGCTCAAGCCGCAGCCTGC
CTACGACATCATCAAGGGCATTAAGGAGAACCATCCGGACGTGCAGATCAACCTGCACTGCCACTCCACCACGGGCGTCA
CCCTGGTCACCCTGCAGAAGGCCATCGAGGCTGGTGTCGACGTCGTCGGCACCGCTATCTCGTCGATGTCGCTCGGCCCG
GGGCACAACCCAACCGAGTCTTTGGTCGAGATGCTCGAGGGCACCGAGTACATCACCGGCCTCGACATGGATCGCCTGCT
CAAGATCCGCGACCACTTCAAGAAGGTGCGTCCGAAGTACAAGAAGTTCGAGTCGAAGACGCTGGTCAACACCAACATCT
TCCAGTCCCAGATCCCGGGCGGAATGCTCTCCAACATGGAGTCCCAGCTCGAGGCCCAGGGTGCTGGAGACCGCATGGAT
GAGGTCATGAAGGAGGTGCCGCGCGTTCGTAAGGATGCCGGCTACCCGCCGCTGGTCACCCCGTCCTCCCAGATCGTGGG
AACCCAGGCGGTGTTCAACGTCCTGATGGGCAATGGTTCGTACAAGAACCTCACTGCCGAGTTTGCCGACCTCATGCTTG
GCTACTACGGCAAGCCCATTGGCGAGCTCAATCCCGAGATCGTTGAGATGGCCAAGAAGCAGACCGGCAAGGAGCCGATC
GACTGCCGTCCCGCCGACCTGCTCGAGCCTGAGTGGGACCAGCTGGTCGAGCAGGCCAAGAGTCTTGAGGGCTTCGACGG
CTCCGACGAGGACGTTCTTACCAACGCCCTGTTCCCGGGAGTTGCCCCGAAGTTCCTCAAGGAACGCGCACAGGGCCCGA
AGAGCGTCGCGATGACCGAGGCACAGCTGAAGGCCGAGAAGGAAGGCACCGGCGCTGCCGGCATCGCCGGACCGGTCAAC
TACAACGTGACGGTCGGTGGCAACAGCCACCAGGTGACCGTCGAGCCTGCGTGA

Upstream 100 bases:

>100_bases
GTGTCCTCAGGTGAACGCCTTCGTGGCTGAACACTGTTAGGGTGTGGAACTTTGACCCCAAGTCGGTGAAAGCTTCGGGG
AAGGTGCAAAGATTAGATTC

Downstream 100 bases:

>100_bases
GGATGATCGCCAACTATGGCTGAGAAGAAACCAATCAAGCTGGCCGATACCATGGCCGGCCGGATCGAGCAGCTCGCCGA
CGAGCGCCACGCTGTGGAGC

Product: oxaloacetate decarboxylase

Products: NA

Alternate protein names: Transcarboxylase 5S subunit [H]

Number of amino acids: Translated: 497; Mature: 496

Protein sequence:

>497_residues
MSPRKIGVTELVLRDAHQSLLATRMAMEDMVDACADIDAAGFWSVECWGGATFDSCIRFLNEDPWERLRTFRKLLPNSRL
QMLLRGQNLLGYRHYNDEVVDKFVEKSAENGMDVFRVFDALNDPRNLEHAMAAVKKTGKHAQGTICYTTSPIHTPESFVK
QADRLIDMGADSIAFKDMAALLKPQPAYDIIKGIKENHPDVQINLHCHSTTGVTLVTLQKAIEAGVDVVGTAISSMSLGP
GHNPTESLVEMLEGTEYITGLDMDRLLKIRDHFKKVRPKYKKFESKTLVNTNIFQSQIPGGMLSNMESQLEAQGAGDRMD
EVMKEVPRVRKDAGYPPLVTPSSQIVGTQAVFNVLMGNGSYKNLTAEFADLMLGYYGKPIGELNPEIVEMAKKQTGKEPI
DCRPADLLEPEWDQLVEQAKSLEGFDGSDEDVLTNALFPGVAPKFLKERAQGPKSVAMTEAQLKAEKEGTGAAGIAGPVN
YNVTVGGNSHQVTVEPA

Sequences:

>Translated_497_residues
MSPRKIGVTELVLRDAHQSLLATRMAMEDMVDACADIDAAGFWSVECWGGATFDSCIRFLNEDPWERLRTFRKLLPNSRL
QMLLRGQNLLGYRHYNDEVVDKFVEKSAENGMDVFRVFDALNDPRNLEHAMAAVKKTGKHAQGTICYTTSPIHTPESFVK
QADRLIDMGADSIAFKDMAALLKPQPAYDIIKGIKENHPDVQINLHCHSTTGVTLVTLQKAIEAGVDVVGTAISSMSLGP
GHNPTESLVEMLEGTEYITGLDMDRLLKIRDHFKKVRPKYKKFESKTLVNTNIFQSQIPGGMLSNMESQLEAQGAGDRMD
EVMKEVPRVRKDAGYPPLVTPSSQIVGTQAVFNVLMGNGSYKNLTAEFADLMLGYYGKPIGELNPEIVEMAKKQTGKEPI
DCRPADLLEPEWDQLVEQAKSLEGFDGSDEDVLTNALFPGVAPKFLKERAQGPKSVAMTEAQLKAEKEGTGAAGIAGPVN
YNVTVGGNSHQVTVEPA
>Mature_496_residues
SPRKIGVTELVLRDAHQSLLATRMAMEDMVDACADIDAAGFWSVECWGGATFDSCIRFLNEDPWERLRTFRKLLPNSRLQ
MLLRGQNLLGYRHYNDEVVDKFVEKSAENGMDVFRVFDALNDPRNLEHAMAAVKKTGKHAQGTICYTTSPIHTPESFVKQ
ADRLIDMGADSIAFKDMAALLKPQPAYDIIKGIKENHPDVQINLHCHSTTGVTLVTLQKAIEAGVDVVGTAISSMSLGPG
HNPTESLVEMLEGTEYITGLDMDRLLKIRDHFKKVRPKYKKFESKTLVNTNIFQSQIPGGMLSNMESQLEAQGAGDRMDE
VMKEVPRVRKDAGYPPLVTPSSQIVGTQAVFNVLMGNGSYKNLTAEFADLMLGYYGKPIGELNPEIVEMAKKQTGKEPID
CRPADLLEPEWDQLVEQAKSLEGFDGSDEDVLTNALFPGVAPKFLKERAQGPKSVAMTEAQLKAEKEGTGAAGIAGPVNY
NVTVGGNSHQVTVEPA

Specific function: The 5S subunit specifically catalyzes the transfer of the carboxyl group from biotin of the 1.3S subunit to pyruvate to form oxaloacetate and 1.3S biotin [H]

COG id: COG5016

COG function: function code C; Pyruvate/oxaloacetate carboxyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI106049528, Length=456, Percent_Identity=34.2105263157895, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI106049295, Length=456, Percent_Identity=34.2105263157895, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI106049292, Length=456, Percent_Identity=34.2105263157895, Blast_Score=238, Evalue=7e-63,
Organism=Caenorhabditis elegans, GI17562816, Length=467, Percent_Identity=36.6167023554604, Blast_Score=271, Evalue=8e-73,
Organism=Saccharomyces cerevisiae, GI6319695, Length=453, Percent_Identity=33.5540838852097, Blast_Score=248, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6321376, Length=453, Percent_Identity=33.5540838852097, Blast_Score=247, Evalue=3e-66,
Organism=Drosophila melanogaster, GI24652212, Length=471, Percent_Identity=34.1825902335456, Blast_Score=248, Evalue=7e-66,
Organism=Drosophila melanogaster, GI24652210, Length=471, Percent_Identity=34.1825902335456, Blast_Score=248, Evalue=7e-66,
Organism=Drosophila melanogaster, GI24652214, Length=471, Percent_Identity=34.1825902335456, Blast_Score=248, Evalue=7e-66,
Organism=Drosophila melanogaster, GI19921944, Length=471, Percent_Identity=34.1825902335456, Blast_Score=248, Evalue=7e-66,
Organism=Drosophila melanogaster, GI24652216, Length=471, Percent_Identity=34.1825902335456, Blast_Score=248, Evalue=7e-66,
Organism=Drosophila melanogaster, GI281363050, Length=471, Percent_Identity=34.1825902335456, Blast_Score=248, Evalue=7e-66,
Organism=Drosophila melanogaster, GI24652224, Length=471, Percent_Identity=34.1825902335456, Blast_Score=248, Evalue=7e-66,
Organism=Drosophila melanogaster, GI24652222, Length=471, Percent_Identity=34.1825902335456, Blast_Score=248, Evalue=7e-66,
Organism=Drosophila melanogaster, GI24652220, Length=471, Percent_Identity=34.1825902335456, Blast_Score=248, Evalue=7e-66,
Organism=Drosophila melanogaster, GI24652218, Length=471, Percent_Identity=34.1825902335456, Blast_Score=248, Evalue=7e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR003379
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like; PF02436 PYC_OADA [H]

EC number: =2.1.3.1 [H]

Molecular weight: Translated: 54645; Mature: 54514

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00165 DEHYDRATASE_SER_THR ; PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPRKIGVTELVLRDAHQSLLATRMAMEDMVDACADIDAAGFWSVECWGGATFDSCIRFL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHH
NEDPWERLRTFRKLLPNSRLQMLLRGQNLLGYRHYNDEVVDKFVEKSAENGMDVFRVFDA
CCCHHHHHHHHHHHCCCHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCHHHHHHHHH
LNDPRNLEHAMAAVKKTGKHAQGTICYTTSPIHTPESFVKQADRLIDMGADSIAFKDMAA
HCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHH
LLKPQPAYDIIKGIKENHPDVQINLHCHSTTGVTLVTLQKAIEAGVDVVGTAISSMSLGP
HHCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHCHHHHHHHHHHCCCCC
GHNPTESLVEMLEGTEYITGLDMDRLLKIRDHFKKVRPKYKKFESKTLVNTNIFQSQIPG
CCCHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHCHHHHHHHCCHHCCCHHHHHHCCC
GMLSNMESQLEAQGAGDRMDEVMKEVPRVRKDAGYPPLVTPSSQIVGTQAVFNVLMGNGS
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCC
YKNLTAEFADLMLGYYGKPIGELNPEIVEMAKKQTGKEPIDCRPADLLEPEWDQLVEQAK
CHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
SLEGFDGSDEDVLTNALFPGVAPKFLKERAQGPKSVAMTEAQLKAEKEGTGAAGIAGPVN
HCCCCCCCCHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCE
YNVTVGGNSHQVTVEPA
EEEEECCCCCEEEEECC
>Mature Secondary Structure 
SPRKIGVTELVLRDAHQSLLATRMAMEDMVDACADIDAAGFWSVECWGGATFDSCIRFL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHH
NEDPWERLRTFRKLLPNSRLQMLLRGQNLLGYRHYNDEVVDKFVEKSAENGMDVFRVFDA
CCCHHHHHHHHHHHCCCHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCHHHHHHHHH
LNDPRNLEHAMAAVKKTGKHAQGTICYTTSPIHTPESFVKQADRLIDMGADSIAFKDMAA
HCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHH
LLKPQPAYDIIKGIKENHPDVQINLHCHSTTGVTLVTLQKAIEAGVDVVGTAISSMSLGP
HHCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHCHHHHHHHHHHCCCCC
GHNPTESLVEMLEGTEYITGLDMDRLLKIRDHFKKVRPKYKKFESKTLVNTNIFQSQIPG
CCCHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHCHHHHHHHCCHHCCCHHHHHHCCC
GMLSNMESQLEAQGAGDRMDEVMKEVPRVRKDAGYPPLVTPSSQIVGTQAVFNVLMGNGS
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCC
YKNLTAEFADLMLGYYGKPIGELNPEIVEMAKKQTGKEPIDCRPADLLEPEWDQLVEQAK
CHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
SLEGFDGSDEDVLTNALFPGVAPKFLKERAQGPKSVAMTEAQLKAEKEGTGAAGIAGPVN
HCCCCCCCCHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCE
YNVTVGGNSHQVTVEPA
EEEEECCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8365490 [H]