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The map label for this gene is accD [C]

Identifier: 50843453

GI number: 50843453

Start: 2178487

End: 2180061

Strand: Reverse

Name: accD [C]

Synonym: PPA2007

Alternate gene names: 50843453

Gene position: 2180061-2178487 (Counterclockwise)

Preceding gene: 50843454

Following gene: 50843452

Centisome position: 85.15

GC content: 61.59

Gene sequence:

>1575_bases
ATGGCTGAGAAGAAACCAATCAAGCTGGCCGATACCATGGCCGGCCGGATCGAGCAGCTCGCCGACGAGCGCCACGCTGT
GGAGCTTGGCGGGGGCGAGGATCGCCTGCAAAAGCAGCGTGACAGGGGCAAGCAGACAGCCCGTGAACGGATCGACAACC
TCGTTGATGCTTATTCCTTCGATGAGGTGGGTGCGTTCCGTAAGCACCGCACCACCCTTTTCGGCATGGACAAGGCCGAA
GTTCCCGCCGACGGCGTAGTCACCGGTCGTGCGACCATCCATGGTCGCCCGGTCCACATCGCGTCTCAGGACTTCACCGT
CATGGGTGGGTCGGCTGGCGAGACCCAGTCGACGAAGGTCGTCGAGACGATGGAACAGTCCCTGCTGACCGGCACTCCGT
TTCTGTTCTTCTATGACTCGGGCGGCGCCCGAATTCAAGAAGGCATCGACTCGCTGTCCGGGTACGGCAAGATGTTCTAC
GCGAACGTCAAGCTGTCGGGCGTCGTGCCGCAGATCGCCATCATTGCTGGCCCCTGCGCCGGCGGCGCCTCCTATTCCCC
GGCCCTGACCGACTTCATCATCATGACGAAGAAGGCCCACATGTTCATTACGGGCCCCGGAGTCATCAAGTCGGTTACCG
GTGAGGAGGTGACTGCTGACGACCTGGGTGGTGCGGATGCGCACATGTCCACCTCGGGCAATATCCACTTCGTGGCCGAA
GATGACGACGCCGCAGTGCTCATCGCGCAGAAGTTGCTGAGCTTCCTGCCGCAAAACAACACTGAGGACGCCCAGATCTC
CAACCCCAATGACGATGTCTCCCCGCAGCCTGAGCTGCGCGACATCGTTCCGCTGGATGGTAAGAAGGGCTACGACGTCC
GCGACGTCATCTCCAAGATCGTCGACTGGGGCGACTACCTAGAGGTCAAGGCCGGTTGGGCGACCAACATCGTCACCGCC
TTTGCCCGGGTCAATGGTCGTACCGTCGGCATCGTGGCCAACCAGCCGAAGGTGATGTCGGGTTGCCTTGACATCAATGC
TTCGGACAAGGCTGCCGAGTTCATTACCTTCTGCGACTCGTTCAATATTCCGTTGGTGCAGTTGGTTGACGTTCCTGGCT
TCCTGCCTGGTGTCCAGCAGGAGTACGGCGGCATCATCCGCCACGGCGCGAAGATGCTGTATGCCTACTCCGAGGCCACC
GTCCCGAAGATCACCGTGGTGCTGCGTAAGGCTTACGGCGGCTCCTACCTGGCCATGTGCAACCGTGACCTGGGTGCTGA
CGCCGTCTATGCCTGGCCGAGCGCGGAGATTGCGGTGATGGGTGCCGATGGCGCTGCCAACGTCATTTTCCGTCGCCAGA
TCAAGGACTCTGAGGATCCCGCAGCCACCCGTGCCGCGAAGATCGAGGAGTACCGCAACGCCTTCAACACGCCTTACGTG
GCTGCCGCCCGTGGACAGGTTGACGACGTGATCGATCCCGCGGACACCCGTCGCAAGATCACCGCCGCTCTGGAGACCTA
CGCCACTAAGCGTCAGTCCCGTCCGGCCAAGAAGCACGGCGTCATGCCTTGCTGA

Upstream 100 bases:

>100_bases
CGGCGCTGCCGGCATCGCCGGACCGGTCAACTACAACGTGACGGTCGGTGGCAACAGCCACCAGGTGACCGTCGAGCCTG
CGTGAGGATGATCGCCAACT

Downstream 100 bases:

>100_bases
GCGAAGAAGGCTGATGGGAGGACAAGATGAGTGAGAACAATGAACTCGTCATCGAGACGCTGAACAAGCGACTCGCGGCG
CTGGAAGCCGAGGTTTCCCG

Product: methylmalonyl-CoA carboxyltransferase

Products: NA

Alternate protein names: Transcarboxylase 12S subunit [H]

Number of amino acids: Translated: 524; Mature: 523

Protein sequence:

>524_residues
MAEKKPIKLADTMAGRIEQLADERHAVELGGGEDRLQKQRDRGKQTARERIDNLVDAYSFDEVGAFRKHRTTLFGMDKAE
VPADGVVTGRATIHGRPVHIASQDFTVMGGSAGETQSTKVVETMEQSLLTGTPFLFFYDSGGARIQEGIDSLSGYGKMFY
ANVKLSGVVPQIAIIAGPCAGGASYSPALTDFIIMTKKAHMFITGPGVIKSVTGEEVTADDLGGADAHMSTSGNIHFVAE
DDDAAVLIAQKLLSFLPQNNTEDAQISNPNDDVSPQPELRDIVPLDGKKGYDVRDVISKIVDWGDYLEVKAGWATNIVTA
FARVNGRTVGIVANQPKVMSGCLDINASDKAAEFITFCDSFNIPLVQLVDVPGFLPGVQQEYGGIIRHGAKMLYAYSEAT
VPKITVVLRKAYGGSYLAMCNRDLGADAVYAWPSAEIAVMGADGAANVIFRRQIKDSEDPAATRAAKIEEYRNAFNTPYV
AAARGQVDDVIDPADTRRKITAALETYATKRQSRPAKKHGVMPC

Sequences:

>Translated_524_residues
MAEKKPIKLADTMAGRIEQLADERHAVELGGGEDRLQKQRDRGKQTARERIDNLVDAYSFDEVGAFRKHRTTLFGMDKAE
VPADGVVTGRATIHGRPVHIASQDFTVMGGSAGETQSTKVVETMEQSLLTGTPFLFFYDSGGARIQEGIDSLSGYGKMFY
ANVKLSGVVPQIAIIAGPCAGGASYSPALTDFIIMTKKAHMFITGPGVIKSVTGEEVTADDLGGADAHMSTSGNIHFVAE
DDDAAVLIAQKLLSFLPQNNTEDAQISNPNDDVSPQPELRDIVPLDGKKGYDVRDVISKIVDWGDYLEVKAGWATNIVTA
FARVNGRTVGIVANQPKVMSGCLDINASDKAAEFITFCDSFNIPLVQLVDVPGFLPGVQQEYGGIIRHGAKMLYAYSEAT
VPKITVVLRKAYGGSYLAMCNRDLGADAVYAWPSAEIAVMGADGAANVIFRRQIKDSEDPAATRAAKIEEYRNAFNTPYV
AAARGQVDDVIDPADTRRKITAALETYATKRQSRPAKKHGVMPC
>Mature_523_residues
AEKKPIKLADTMAGRIEQLADERHAVELGGGEDRLQKQRDRGKQTARERIDNLVDAYSFDEVGAFRKHRTTLFGMDKAEV
PADGVVTGRATIHGRPVHIASQDFTVMGGSAGETQSTKVVETMEQSLLTGTPFLFFYDSGGARIQEGIDSLSGYGKMFYA
NVKLSGVVPQIAIIAGPCAGGASYSPALTDFIIMTKKAHMFITGPGVIKSVTGEEVTADDLGGADAHMSTSGNIHFVAED
DDAAVLIAQKLLSFLPQNNTEDAQISNPNDDVSPQPELRDIVPLDGKKGYDVRDVISKIVDWGDYLEVKAGWATNIVTAF
ARVNGRTVGIVANQPKVMSGCLDINASDKAAEFITFCDSFNIPLVQLVDVPGFLPGVQQEYGGIIRHGAKMLYAYSEATV
PKITVVLRKAYGGSYLAMCNRDLGADAVYAWPSAEIAVMGADGAANVIFRRQIKDSEDPAATRAAKIEEYRNAFNTPYVA
AARGQVDDVIDPADTRRKITAALETYATKRQSRPAKKHGVMPC

Specific function: The 12S subunit specifically catalyzes the transfer of the carboxyl group of methylmalonyl CoA to the biotin of the 1.3S subunit forming propanoyl-CoA and carboxylated 1.3S-biotin [H]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=512, Percent_Identity=51.3671875, Blast_Score=519, Evalue=1e-147,
Organism=Homo sapiens, GI295821216, Length=532, Percent_Identity=49.4360902255639, Blast_Score=507, Evalue=1e-143,
Organism=Homo sapiens, GI11545863, Length=500, Percent_Identity=36.4, Blast_Score=274, Evalue=2e-73,
Organism=Homo sapiens, GI134142062, Length=345, Percent_Identity=22.3188405797101, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI38679977, Length=349, Percent_Identity=24.0687679083095, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI38679967, Length=349, Percent_Identity=24.0687679083095, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI38679971, Length=349, Percent_Identity=23.2091690544413, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI38679960, Length=349, Percent_Identity=24.0687679083095, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI38679974, Length=349, Percent_Identity=24.0687679083095, Blast_Score=73, Evalue=6e-13,
Organism=Escherichia coli, GI1788655, Length=188, Percent_Identity=33.5106382978723, Blast_Score=87, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI25147362, Length=528, Percent_Identity=49.6212121212121, Blast_Score=523, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI25147359, Length=523, Percent_Identity=49.7131931166348, Blast_Score=519, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI17552936, Length=525, Percent_Identity=35.6190476190476, Blast_Score=292, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI71997163, Length=293, Percent_Identity=25.938566552901, Blast_Score=86, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI133931226, Length=289, Percent_Identity=25.6055363321799, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24586065, Length=526, Percent_Identity=35.5513307984791, Blast_Score=272, Evalue=5e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =2.1.3.1 [H]

Molecular weight: Translated: 56463; Mature: 56331

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEKKPIKLADTMAGRIEQLADERHAVELGGGEDRLQKQRDRGKQTARERIDNLVDAYSF
CCCCCCCHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCH
DEVGAFRKHRTTLFGMDKAEVPADGVVTGRATIHGRPVHIASQDFTVMGGSAGETQSTKV
HHHHHHHHHCCEEEECCCCCCCCCCEEECCEEECCCEEEEECCCEEEECCCCCCCCHHHH
VETMEQSLLTGTPFLFFYDSGGARIQEGIDSLSGYGKMFYANVKLSGVVPQIAIIAGPCA
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEEEEECCCCCEEEEEECCCC
GGASYSPALTDFIIMTKKAHMFITGPGVIKSVTGEEVTADDLGGADAHMSTSGNIHFVAE
CCCCCCHHHHHEEEEEECCEEEEECCCCEEECCCCCCCHHCCCCCCCEECCCCCEEEEEC
DDDAAVLIAQKLLSFLPQNNTEDAQISNPNDDVSPQPELRDIVPLDGKKGYDVRDVISKI
CCCCHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
VDWGDYLEVKAGWATNIVTAFARVNGRTVGIVANQPKVMSGCLDINASDKAAEFITFCDS
HCCCCEEEEECCCHHHHHHHHHHCCCEEEEEEECCCHHHHHEECCCCCCHHHHHHHHHCC
FNIPLVQLVDVPGFLPGVQQEYGGIIRHGAKMLYAYSEATVPKITVVLRKAYGGSYLAMC
CCCCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEHHCCCCEEEEE
NRDLGADAVYAWPSAEIAVMGADGAANVIFRRQIKDSEDPAATRAAKIEEYRNAFNTPYV
CCCCCCCEEEECCCCCEEEEECCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEE
AAARGQVDDVIDPADTRRKITAALETYATKRQSRPAKKHGVMPC
EECCCCCHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCCC
>Mature Secondary Structure 
AEKKPIKLADTMAGRIEQLADERHAVELGGGEDRLQKQRDRGKQTARERIDNLVDAYSF
CCCCCCHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCH
DEVGAFRKHRTTLFGMDKAEVPADGVVTGRATIHGRPVHIASQDFTVMGGSAGETQSTKV
HHHHHHHHHCCEEEECCCCCCCCCCEEECCEEECCCEEEEECCCEEEECCCCCCCCHHHH
VETMEQSLLTGTPFLFFYDSGGARIQEGIDSLSGYGKMFYANVKLSGVVPQIAIIAGPCA
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEEEEECCCCCEEEEEECCCC
GGASYSPALTDFIIMTKKAHMFITGPGVIKSVTGEEVTADDLGGADAHMSTSGNIHFVAE
CCCCCCHHHHHEEEEEECCEEEEECCCCEEECCCCCCCHHCCCCCCCEECCCCCEEEEEC
DDDAAVLIAQKLLSFLPQNNTEDAQISNPNDDVSPQPELRDIVPLDGKKGYDVRDVISKI
CCCCHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
VDWGDYLEVKAGWATNIVTAFARVNGRTVGIVANQPKVMSGCLDINASDKAAEFITFCDS
HCCCCEEEEECCCHHHHHHHHHHCCCEEEEEEECCCHHHHHEECCCCCCHHHHHHHHHCC
FNIPLVQLVDVPGFLPGVQQEYGGIIRHGAKMLYAYSEATVPKITVVLRKAYGGSYLAMC
CCCCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEHHCCCCEEEEE
NRDLGADAVYAWPSAEIAVMGADGAANVIFRRQIKDSEDPAATRAAKIEEYRNAFNTPYV
CCCCCCCEEEECCCCCEEEEECCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEE
AAARGQVDDVIDPADTRRKITAALETYATKRQSRPAKKHGVMPC
EECCCCCHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8366018 [H]