Click here to switch to the map view.

The map label for this gene is purL

Identifier: 50843424

GI number: 50843424

Start: 2143587

End: 2145839

Strand: Reverse

Name: purL

Synonym: PPA1977

Alternate gene names: 50843424

Gene position: 2145839-2143587 (Counterclockwise)

Preceding gene: 50843426

Following gene: 50843422

Centisome position: 83.81

GC content: 62.67

Gene sequence:

>2253_bases
GTGGCAGACACAGTGGAGAACGCCGTCAGCACCCCCGACGTTGAGCAGCCCTGGGCTGAGTTGGGGTTGTCCGCCGACGA
GTACCAGCGCATCCGGGAGATCCTGGGACGCCGCCCGACCGGCGGCGAGCTCGCCATGTACTCGGTGATGTGGTCGGAGC
ATTGCTCCTACAAATCATCGAAGAAATACCTGCGCCGATTCGGTGACCTGCCTCAGCAGACGCCGCTCGGCCCGCTGCTA
GCTGGCATCGGGGACAATGCTGGTGTCGTCGATATTGGCAACGGACTGGCCGTCACTTTTAAGGCGGAGTCCCACAACCA
CCCCTCCTACGTCGAGCCCCACCAGGGCGCAGCTACCGGAGTCGGTGGCATCGTTCGCGACATCATGGCGATGGGTGCTC
GCCCGGTCGGCGTCATGAATGCTTTGGCTTTCGGCCCGCTGGATGCTCCAGATACCGCACGTGTGCTGCCCGGTGTTGTT
TCTGGGATCGCCGACTATGGCAACTGCCTCGGCCTGCCCACGATCGGCGGCCAGACCCTCTTCGACCCCACCTATTACGG
CAATCCGCTCGTCAACGCCCTGTGCGTCGGGGTGCTGCGTCATGAGGACCTACAGTTCGCCAAAGCCTCGGGTGTAGGCA
ATCTCGTCGTTCTCTTTGGTGCGGCCACCGGTGGCGACGGTATCGGTGGCGCGTCGATCCTTGCCTCGGAATCTTTCGCT
GCAGAGGGCGAGTCGAAGCGACCCAGCGTCCAGGTGGGCGACCCGTTCATGGAGAAGCTGCTCATCGAGTGCACCCTTGA
CCTCTTCAACGCCGGGGTAGTTGAGGCTTTGCAGGATTTCGGTGCCGCCGGAATCTCCTGTGCCACCTCCGAGCTGGCCA
GTGCTGGCGACGGTGGCATGCACGTCGAGCTCGACCGCGTTCCGCTGCGCGACCCGAACCTCGCCCCTGAAGAGATCCTC
ATGAGCGAGTCCCAGGAGCGGATGGCGGCGGTGGTGCGCCCCGATCAGCTTGACCGCTTCATGGAGATCTGCGCCCATTG
GGGTGTCGCTGCCACTGTCATTGGCGAGGTCACCGATACCGGTCGACTTCACATTGATTGGCAGGGCGAGCGGATTGTCG
ACGTCGATCCGCGGACGGTTGCTCACGACGGACCTGTTCTCGACATGCCGGCCGCCCGTCCGTGGTGGATTGATGAGCTC
AACGAGGACGACGCCAACGCGTTGCCGCGCGATAACTCTGGTGAGGGTCTTGCCGGGGCCCTGCTGGCCCTTGTTGGCTC
CGCCCAGCTGTGCGACCGTTCCTGGATCACCGACCAGTATGACCGGTTCGTGCGTGGCAATACTGTGCTCGCTCAGCCGA
ACGATGCCGGCATGATTCGTATTGACGACAACCTCGGCATCGCGCTGTCCTTGGACGCTAACGGACGCCAGACCACCCTT
AACCCGTATCTTGGCGCCCAGCTGGCTCTTTGCGAGGCTTACCGGAATGTGGCTGTCTCTGGCGCAACTCCGGTGGCTGT
CACTGATTGCCTCAATTATGGCTCCCCGTACGATCCCGATGTCATGTGGCAATTCGACGAGACCATCCTTGGTCTGGTTG
ACGGCTGCCGCGAGCTTGGCGTGCCGGTTACGGGCGGTAACGTTTCCCTGCACAACCGCACTGGAGATGAGTCGATTCGG
CCTACTCCGCTCGTTGGTGTGCTCGGCGTTATTGATGACGTGCATCGTCGTATCCCGTCGGCCTTCGCACACGACGGCGA
CGCTGTCTTGCTGCTAGGAACGACGAAGTGCGAGTTCGGCGGATCGGTCTATGAGGACGTCATCCACGCTGGCCACCTAG
GTGGTATGCCCCCGATGCCCGACCTGAATGCCGAGAAGGCTCTGGCCGCGGTGATGGTGGAAGCGTCGAAGCGCGGCCTG
CTGTCTAGCGCTCACGACCTGTCCGACGGTGGCCTGGCGCAGGCGCTTGTGGAAAGCTGCCTACAGGGGGGTCTTGGCGT
GTCGGTGAGTCTGCCCGAGGGTGAACCGTCGGTGATGTTGTTCTCTGAGACCCCGGCCCGAGCGATCGTTTCGCTGTGCG
GTAACGGCTACCGTGAGTTCAAGGAGCTGTGCCAGGAGCACGGTGTGCCGACTGCCCGTATTGGCGAGGTCATAGATCAC
GGTGAGATCGAGGTTAACGGTCTGTTCAGCCTCCCCCTTGACGAGATCGAACGAGCCTGGCGCAAGCCGATTCCAACTGC
TATGGGGGAGTGA

Upstream 100 bases:

>100_bases
CTGGCTCATGGTAAGACGTTCTGTCACTCCGATGCGCCTTGAGTGACCTGCATCTGTGGTCGAGGCGGCAATGACGTCGC
TCAACGGCTAGATTTGTCCT

Downstream 100 bases:

>100_bases
CGGGAATTCCTGGCCCGGCTGACAGCGTCAGCGCAGCCAACGGTGCCGCCGCTTTGAGGTTCTTCTCGCGCCACTCCTCG
TCAGGCTGGGAAGCTGCGAC

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 750; Mature: 749

Protein sequence:

>750_residues
MADTVENAVSTPDVEQPWAELGLSADEYQRIREILGRRPTGGELAMYSVMWSEHCSYKSSKKYLRRFGDLPQQTPLGPLL
AGIGDNAGVVDIGNGLAVTFKAESHNHPSYVEPHQGAATGVGGIVRDIMAMGARPVGVMNALAFGPLDAPDTARVLPGVV
SGIADYGNCLGLPTIGGQTLFDPTYYGNPLVNALCVGVLRHEDLQFAKASGVGNLVVLFGAATGGDGIGGASILASESFA
AEGESKRPSVQVGDPFMEKLLIECTLDLFNAGVVEALQDFGAAGISCATSELASAGDGGMHVELDRVPLRDPNLAPEEIL
MSESQERMAAVVRPDQLDRFMEICAHWGVAATVIGEVTDTGRLHIDWQGERIVDVDPRTVAHDGPVLDMPAARPWWIDEL
NEDDANALPRDNSGEGLAGALLALVGSAQLCDRSWITDQYDRFVRGNTVLAQPNDAGMIRIDDNLGIALSLDANGRQTTL
NPYLGAQLALCEAYRNVAVSGATPVAVTDCLNYGSPYDPDVMWQFDETILGLVDGCRELGVPVTGGNVSLHNRTGDESIR
PTPLVGVLGVIDDVHRRIPSAFAHDGDAVLLLGTTKCEFGGSVYEDVIHAGHLGGMPPMPDLNAEKALAAVMVEASKRGL
LSSAHDLSDGGLAQALVESCLQGGLGVSVSLPEGEPSVMLFSETPARAIVSLCGNGYREFKELCQEHGVPTARIGEVIDH
GEIEVNGLFSLPLDEIERAWRKPIPTAMGE

Sequences:

>Translated_750_residues
MADTVENAVSTPDVEQPWAELGLSADEYQRIREILGRRPTGGELAMYSVMWSEHCSYKSSKKYLRRFGDLPQQTPLGPLL
AGIGDNAGVVDIGNGLAVTFKAESHNHPSYVEPHQGAATGVGGIVRDIMAMGARPVGVMNALAFGPLDAPDTARVLPGVV
SGIADYGNCLGLPTIGGQTLFDPTYYGNPLVNALCVGVLRHEDLQFAKASGVGNLVVLFGAATGGDGIGGASILASESFA
AEGESKRPSVQVGDPFMEKLLIECTLDLFNAGVVEALQDFGAAGISCATSELASAGDGGMHVELDRVPLRDPNLAPEEIL
MSESQERMAAVVRPDQLDRFMEICAHWGVAATVIGEVTDTGRLHIDWQGERIVDVDPRTVAHDGPVLDMPAARPWWIDEL
NEDDANALPRDNSGEGLAGALLALVGSAQLCDRSWITDQYDRFVRGNTVLAQPNDAGMIRIDDNLGIALSLDANGRQTTL
NPYLGAQLALCEAYRNVAVSGATPVAVTDCLNYGSPYDPDVMWQFDETILGLVDGCRELGVPVTGGNVSLHNRTGDESIR
PTPLVGVLGVIDDVHRRIPSAFAHDGDAVLLLGTTKCEFGGSVYEDVIHAGHLGGMPPMPDLNAEKALAAVMVEASKRGL
LSSAHDLSDGGLAQALVESCLQGGLGVSVSLPEGEPSVMLFSETPARAIVSLCGNGYREFKELCQEHGVPTARIGEVIDH
GEIEVNGLFSLPLDEIERAWRKPIPTAMGE
>Mature_749_residues
ADTVENAVSTPDVEQPWAELGLSADEYQRIREILGRRPTGGELAMYSVMWSEHCSYKSSKKYLRRFGDLPQQTPLGPLLA
GIGDNAGVVDIGNGLAVTFKAESHNHPSYVEPHQGAATGVGGIVRDIMAMGARPVGVMNALAFGPLDAPDTARVLPGVVS
GIADYGNCLGLPTIGGQTLFDPTYYGNPLVNALCVGVLRHEDLQFAKASGVGNLVVLFGAATGGDGIGGASILASESFAA
EGESKRPSVQVGDPFMEKLLIECTLDLFNAGVVEALQDFGAAGISCATSELASAGDGGMHVELDRVPLRDPNLAPEEILM
SESQERMAAVVRPDQLDRFMEICAHWGVAATVIGEVTDTGRLHIDWQGERIVDVDPRTVAHDGPVLDMPAARPWWIDELN
EDDANALPRDNSGEGLAGALLALVGSAQLCDRSWITDQYDRFVRGNTVLAQPNDAGMIRIDDNLGIALSLDANGRQTTLN
PYLGAQLALCEAYRNVAVSGATPVAVTDCLNYGSPYDPDVMWQFDETILGLVDGCRELGVPVTGGNVSLHNRTGDESIRP
TPLVGVLGVIDDVHRRIPSAFAHDGDAVLLLGTTKCEFGGSVYEDVIHAGHLGGMPPMPDLNAEKALAAVMVEASKRGLL
SSAHDLSDGGLAQALVESCLQGGLGVSVSLPEGEPSVMLFSETPARAIVSLCGNGYREFKELCQEHGVPTARIGEVIDHG
EIEVNGLFSLPLDEIERAWRKPIPTAMGE

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Homo sapiens, GI31657129, Length=744, Percent_Identity=26.2096774193548, Blast_Score=110, Evalue=6e-24,
Organism=Escherichia coli, GI48994899, Length=745, Percent_Identity=24.8322147651007, Blast_Score=127, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17553022, Length=742, Percent_Identity=23.8544474393531, Blast_Score=100, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6321498, Length=844, Percent_Identity=23.3412322274882, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24582111, Length=659, Percent_Identity=23.9757207890744, Blast_Score=96, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24582109, Length=659, Percent_Identity=23.9757207890744, Blast_Score=96, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17137292, Length=659, Percent_Identity=23.9757207890744, Blast_Score=96, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_PROAC (Q6A6C0)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_056651.1
- ProteinModelPortal:   Q6A6C0
- SMR:   Q6A6C0
- GeneID:   2933231
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA1977
- NMPDR:   fig|267747.1.peg.1928
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- ProtClustDB:   PRK01213
- BioCyc:   PACN267747:PPA1977-MONOMER
- BRENDA:   6.3.5.3
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 79364; Mature: 79233

Theoretical pI: Translated: 4.27; Mature: 4.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADTVENAVSTPDVEQPWAELGLSADEYQRIREILGRRPTGGELAMYSVMWSEHCSYKSS
CCCCHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHCCCHHH
KKYLRRFGDLPQQTPLGPLLAGIGDNAGVVDIGNGLAVTFKAESHNHPSYVEPHQGAATG
HHHHHHHCCCCCCCCCHHHHHCCCCCCCEEECCCCEEEEEEECCCCCCCCCCCCCCCHHH
VGGIVRDIMAMGARPVGVMNALAFGPLDAPDTARVLPGVVSGIADYGNCLGLPTIGGQTL
HHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
FDPTYYGNPLVNALCVGVLRHEDLQFAKASGVGNLVVLFGAATGGDGIGGASILASESFA
ECCCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHCCCCHH
AEGESKRPSVQVGDPFMEKLLIECTLDLFNAGVVEALQDFGAAGISCATSELASAGDGGM
CCCCCCCCCEEECCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCE
HVELDRVPLRDPNLAPEEILMSESQERMAAVVRPDQLDRFMEICAHWGVAATVIGEVTDT
EEEECCCCCCCCCCCHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHCCCC
GRLHIDWQGERIVDVDPRTVAHDGPVLDMPAARPWWIDELNEDDANALPRDNSGEGLAGA
CEEEEEECCCEEEECCCCEECCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
LLALVGSAQLCDRSWITDQYDRFVRGNTVLAQPNDAGMIRIDDNLGIALSLDANGRQTTL
HHHHHCCHHHHHHHCCHHHHHHHHCCCEEEECCCCCCEEEECCCCCEEEEECCCCCEEEC
NPYLGAQLALCEAYRNVAVSGATPVAVTDCLNYGSPYDPDVMWQFDETILGLVDGCRELG
CCHHHHHHHHHHHHHHEEECCCCCHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHCC
VPVTGGNVSLHNRTGDESIRPTPLVGVLGVIDDVHRRIPSAFAHDGDAVLLLGTTKCEFG
CEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHCCCCCEEEEEECCCCCCC
GSVYEDVIHAGHLGGMPPMPDLNAEKALAAVMVEASKRGLLSSAHDLSDGGLAQALVESC
CHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHH
LQGGLGVSVSLPEGEPSVMLFSETPARAIVSLCGNGYREFKELCQEHGVPTARIGEVIDH
HCCCCCEEEECCCCCCCEEEECCCHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHCC
GEIEVNGLFSLPLDEIERAWRKPIPTAMGE
CCEEEEEEEECCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
ADTVENAVSTPDVEQPWAELGLSADEYQRIREILGRRPTGGELAMYSVMWSEHCSYKSS
CCCHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHCCCHHH
KKYLRRFGDLPQQTPLGPLLAGIGDNAGVVDIGNGLAVTFKAESHNHPSYVEPHQGAATG
HHHHHHHCCCCCCCCCHHHHHCCCCCCCEEECCCCEEEEEEECCCCCCCCCCCCCCCHHH
VGGIVRDIMAMGARPVGVMNALAFGPLDAPDTARVLPGVVSGIADYGNCLGLPTIGGQTL
HHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
FDPTYYGNPLVNALCVGVLRHEDLQFAKASGVGNLVVLFGAATGGDGIGGASILASESFA
ECCCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHCCCCHH
AEGESKRPSVQVGDPFMEKLLIECTLDLFNAGVVEALQDFGAAGISCATSELASAGDGGM
CCCCCCCCCEEECCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCE
HVELDRVPLRDPNLAPEEILMSESQERMAAVVRPDQLDRFMEICAHWGVAATVIGEVTDT
EEEECCCCCCCCCCCHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHCCCC
GRLHIDWQGERIVDVDPRTVAHDGPVLDMPAARPWWIDELNEDDANALPRDNSGEGLAGA
CEEEEEECCCEEEECCCCEECCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
LLALVGSAQLCDRSWITDQYDRFVRGNTVLAQPNDAGMIRIDDNLGIALSLDANGRQTTL
HHHHHCCHHHHHHHCCHHHHHHHHCCCEEEECCCCCCEEEECCCCCEEEEECCCCCEEEC
NPYLGAQLALCEAYRNVAVSGATPVAVTDCLNYGSPYDPDVMWQFDETILGLVDGCRELG
CCHHHHHHHHHHHHHHEEECCCCCHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHCC
VPVTGGNVSLHNRTGDESIRPTPLVGVLGVIDDVHRRIPSAFAHDGDAVLLLGTTKCEFG
CEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHCCCCCEEEEEECCCCCCC
GSVYEDVIHAGHLGGMPPMPDLNAEKALAAVMVEASKRGLLSSAHDLSDGGLAQALVESC
CHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHH
LQGGLGVSVSLPEGEPSVMLFSETPARAIVSLCGNGYREFKELCQEHGVPTARIGEVIDH
HCCCCCEEEECCCCCCCEEEECCCHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHCC
GEIEVNGLFSLPLDEIERAWRKPIPTAMGE
CCEEEEEEEECCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA