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The map label for this gene is nuoL [H]

Identifier: 50843375

GI number: 50843375

Start: 2085126

End: 2087012

Strand: Reverse

Name: nuoL [H]

Synonym: PPA1924

Alternate gene names: 50843375

Gene position: 2087012-2085126 (Counterclockwise)

Preceding gene: 50843376

Following gene: 50843374

Centisome position: 81.52

GC content: 60.04

Gene sequence:

>1887_bases
GTGACTGTCTTGGAAACCGGCTTGTTCAACGTGGCCTGGTTCATGATTGCGGTGCCACTGGTGGTTGCCGCGCTGCTATT
GGTGTTGGGACGCCGCAGCGACGCGTGGGGACATGTGTTGGCCACTGTGGCCCCAATCGTCGCCTTTGTTATCGGGTTGG
TCCTGTTTATCGACCTGCTCGGACGTGGCGGCGCGTCTCGTGCCGTCGACGTGGGGGTCTACCGATTTATCGACGTCGGG
GCGTGGGATCTGCGAGTGGGGCTGCTTATTGACCAGCTCTCGATCCTGTTTGTGCTGCTCATCACCTTCGTGGGCTCGCT
GATCCACATCTACGCGATCGGGTATATGGCCCATGACACCGATCGTCGTCGGTTCTTCGCCTATCTCAACCTCTTCATTG
CCGCGATGCTGACGTTGGTGTTGGCCGATAACTACCTCATCCTGTTTGTCGGCTGGGAGGGTGTCGGTCTGGCCTCCTAC
CTGCTTATCGGGTTCTGGTTTGGTCGTCCCGCTGCTGCCCGCGCCGGTAATAAGGCTTTCATCATGAACCGCATCGGCGA
CCTCGGTTTGACGATGGCGATCTTTACGATGCTCGCCCAGTTCGGCAGCGTGCGCTTCTCCGATGTTTCAGCTAAAGCGT
CGGGGCTGACGTCAACCTGGGCCACGTTGCTCGGCTTCATGCTGCTGCTGGCTGCTTGTGGTAAGTCCGCTCAGGTGCCG
TTGCAAGCCTGGCTGCTTGACGCCATGGAGGGCCCGACGCCGGTCTCAGCCCTGATCCACGCTGCGACGATGGTTACCGC
TGGTGTTTACCTGGTGGTACGTTCTCACGAGATCTATGCCCACACGGGTGCAGCCTCGTTGGCAGTGGCGATCATCGGCA
CCGTTACCTTGTTGTTCGGCGCCTGGATCGGTTCGGCGAAGAAGGACATCAAGAAGGTCCTCGCCGGATCGACGATGAGC
CAGATCGGCTACATGATGCTGGCTGCAGGTTTGGGACCGGCTGGTGCGGCTCTGGCGATTTTCCACCTGCTCACCCACGG
TTTCTTTAAGGCGAACATGTTCCTTGGGGCCGGCTCGGTGATGCACGGTACCGGTGACGACACGGACATGTACCACTTTG
GTGCGCTGTCCAAGGTGATGCCTATGACCTTCTGGACCTTCGCGTGCGGTTACCTCGCCATTATCGGTATCCCTGGTACC
TCCGGCTACTTCTCCAAAGACCACATCATCGAGGCCGCCTTCGATAAGGGCGCGGTCTTCGGGGTGCTGGCCCTTATCGG
CGCTGGAATCACCGCCTACTACATGACTCGCCTCATGATGCTGACCTTCTTGGGGACTAAGCGTTGGCGCGCGGACGTCC
ACCCGCACGAGTCTCCGGCAGTCATGACGATCCCTCTCATCGTGTTGGCTATTTTGTCGATCTTCGCCGGTGCTTTTATG
AACAACTGGATCGGCGACTGGTTGGCTCCAGCTACGGGCGCTGAGGTTGAGCACGTCGGTATGTGGCATATGGGCGTGAT
TGGGGTTGTCACCCTCGTCGTGGTGATCCTCGGCATCGTGGCAGGCTGGTTGCTCAACCGTCACAATGTGCCGAACGAGG
AGCCCGAGACTCACGATCCGCTGCTTGTCGCTGGTCGTCACGACATCTACGGCGACGACATCAACGATGTTGTCGTGGTG
AAGCCGGGGCGTTGGCTGGCCGGCGGTGTCGCGGGCTTCGATCGGTCGGTGGTCGACGGTCTGGTTAACGGCGCTGGCTC
CGTCACCACGGCTTGTTCCCAGATCATCCGCAAAGTCCAAAACGGCTACGTGCGCAGTTACGGCCTCATGATGGTCGTCG
GCGTGGTGGTCGTCGGACTCGTCGTCGTCCTGGGCCGGATGGCCTGA

Upstream 100 bases:

>100_bases
GAGGTGGTCGTCGGTTTGGCGATCATCGTCACCATTTTCCGTTCCCGTCGCACCACTTCGGTGGACGACACCAACCTGCT
GAAGTTCTGAGGGAGGTACC

Downstream 100 bases:

>100_bases
GCGCTGGAGGAGCTGACATGTCTTTCCCGATCCTCACAGTGATCGCGCTGCTGCCGTTCGTCGGCGGCGTTATCACCATG
ATGCTGCGCGGGGCTGCGGC

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 628; Mature: 627

Protein sequence:

>628_residues
MTVLETGLFNVAWFMIAVPLVVAALLLVLGRRSDAWGHVLATVAPIVAFVIGLVLFIDLLGRGGASRAVDVGVYRFIDVG
AWDLRVGLLIDQLSILFVLLITFVGSLIHIYAIGYMAHDTDRRRFFAYLNLFIAAMLTLVLADNYLILFVGWEGVGLASY
LLIGFWFGRPAAARAGNKAFIMNRIGDLGLTMAIFTMLAQFGSVRFSDVSAKASGLTSTWATLLGFMLLLAACGKSAQVP
LQAWLLDAMEGPTPVSALIHAATMVTAGVYLVVRSHEIYAHTGAASLAVAIIGTVTLLFGAWIGSAKKDIKKVLAGSTMS
QIGYMMLAAGLGPAGAALAIFHLLTHGFFKANMFLGAGSVMHGTGDDTDMYHFGALSKVMPMTFWTFACGYLAIIGIPGT
SGYFSKDHIIEAAFDKGAVFGVLALIGAGITAYYMTRLMMLTFLGTKRWRADVHPHESPAVMTIPLIVLAILSIFAGAFM
NNWIGDWLAPATGAEVEHVGMWHMGVIGVVTLVVVILGIVAGWLLNRHNVPNEEPETHDPLLVAGRHDIYGDDINDVVVV
KPGRWLAGGVAGFDRSVVDGLVNGAGSVTTACSQIIRKVQNGYVRSYGLMMVVGVVVVGLVVVLGRMA

Sequences:

>Translated_628_residues
MTVLETGLFNVAWFMIAVPLVVAALLLVLGRRSDAWGHVLATVAPIVAFVIGLVLFIDLLGRGGASRAVDVGVYRFIDVG
AWDLRVGLLIDQLSILFVLLITFVGSLIHIYAIGYMAHDTDRRRFFAYLNLFIAAMLTLVLADNYLILFVGWEGVGLASY
LLIGFWFGRPAAARAGNKAFIMNRIGDLGLTMAIFTMLAQFGSVRFSDVSAKASGLTSTWATLLGFMLLLAACGKSAQVP
LQAWLLDAMEGPTPVSALIHAATMVTAGVYLVVRSHEIYAHTGAASLAVAIIGTVTLLFGAWIGSAKKDIKKVLAGSTMS
QIGYMMLAAGLGPAGAALAIFHLLTHGFFKANMFLGAGSVMHGTGDDTDMYHFGALSKVMPMTFWTFACGYLAIIGIPGT
SGYFSKDHIIEAAFDKGAVFGVLALIGAGITAYYMTRLMMLTFLGTKRWRADVHPHESPAVMTIPLIVLAILSIFAGAFM
NNWIGDWLAPATGAEVEHVGMWHMGVIGVVTLVVVILGIVAGWLLNRHNVPNEEPETHDPLLVAGRHDIYGDDINDVVVV
KPGRWLAGGVAGFDRSVVDGLVNGAGSVTTACSQIIRKVQNGYVRSYGLMMVVGVVVVGLVVVLGRMA
>Mature_627_residues
TVLETGLFNVAWFMIAVPLVVAALLLVLGRRSDAWGHVLATVAPIVAFVIGLVLFIDLLGRGGASRAVDVGVYRFIDVGA
WDLRVGLLIDQLSILFVLLITFVGSLIHIYAIGYMAHDTDRRRFFAYLNLFIAAMLTLVLADNYLILFVGWEGVGLASYL
LIGFWFGRPAAARAGNKAFIMNRIGDLGLTMAIFTMLAQFGSVRFSDVSAKASGLTSTWATLLGFMLLLAACGKSAQVPL
QAWLLDAMEGPTPVSALIHAATMVTAGVYLVVRSHEIYAHTGAASLAVAIIGTVTLLFGAWIGSAKKDIKKVLAGSTMSQ
IGYMMLAAGLGPAGAALAIFHLLTHGFFKANMFLGAGSVMHGTGDDTDMYHFGALSKVMPMTFWTFACGYLAIIGIPGTS
GYFSKDHIIEAAFDKGAVFGVLALIGAGITAYYMTRLMMLTFLGTKRWRADVHPHESPAVMTIPLIVLAILSIFAGAFMN
NWIGDWLAPATGAEVEHVGMWHMGVIGVVTLVVVILGIVAGWLLNRHNVPNEEPETHDPLLVAGRHDIYGDDINDVVVVK
PGRWLAGGVAGFDRSVVDGLVNGAGSVTTACSQIIRKVQNGYVRSYGLMMVVGVVVVGLVVVLGRMA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton transloca

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=506, Percent_Identity=33.9920948616601, Blast_Score=254, Evalue=2e-67,
Organism=Escherichia coli, GI1788614, Length=571, Percent_Identity=39.4045534150613, Blast_Score=330, Evalue=1e-91,
Organism=Escherichia coli, GI1788829, Length=425, Percent_Identity=33.1764705882353, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1788827, Length=437, Percent_Identity=27.6887871853547, Blast_Score=117, Evalue=3e-27,
Organism=Escherichia coli, GI1788831, Length=349, Percent_Identity=28.3667621776504, Blast_Score=113, Evalue=5e-26,
Organism=Escherichia coli, GI2367154, Length=456, Percent_Identity=23.9035087719298, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788613, Length=430, Percent_Identity=25.1162790697674, Blast_Score=84, Evalue=4e-17,
Organism=Escherichia coli, GI145693160, Length=407, Percent_Identity=25.0614250614251, Blast_Score=73, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 66998; Mature: 66867

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVLETGLFNVAWFMIAVPLVVAALLLVLGRRSDAWGHVLATVAPIVAFVIGLVLFIDLL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GRGGASRAVDVGVYRFIDVGAWDLRVGLLIDQLSILFVLLITFVGSLIHIYAIGYMAHDT
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DRRRFFAYLNLFIAAMLTLVLADNYLILFVGWEGVGLASYLLIGFWFGRPAAARAGNKAF
HHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHCCCCHHHCCCCCCH
IMNRIGDLGLTMAIFTMLAQFGSVRFSDVSAKASGLTSTWATLLGFMLLLAACGKSAQVP
HHHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHCCCHHHHHHHHHHHHHHHHCCCCCCCH
LQAWLLDAMEGPTPVSALIHAATMVTAGVYLVVRSHEIYAHTGAASLAVAIIGTVTLLFG
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEEECCEEEEECCHHHHHHHHHHHHHHHHH
AWIGSAKKDIKKVLAGSTMSQIGYMMLAAGLGPAGAALAIFHLLTHGFFKANMFLGAGSV
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCCE
MHGTGDDTDMYHFGALSKVMPMTFWTFACGYLAIIGIPGTSGYFSKDHIIEAAFDKGAVF
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHCCCHHH
GVLALIGAGITAYYMTRLMMLTFLGTKRWRADVHPHESPAVMTIPLIVLAILSIFAGAFM
HHHHHHHCCHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
NNWIGDWLAPATGAEVEHVGMWHMGVIGVVTLVVVILGIVAGWLLNRHNVPNEEPETHDP
HHHHHHHCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
LLVAGRHDIYGDDINDVVVVKPGRWLAGGVAGFDRSVVDGLVNGAGSVTTACSQIIRKVQ
EEEECCCCCCCCCCCCEEEECCCCEEECCHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHH
NGYVRSYGLMMVVGVVVVGLVVVLGRMA
CCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TVLETGLFNVAWFMIAVPLVVAALLLVLGRRSDAWGHVLATVAPIVAFVIGLVLFIDLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GRGGASRAVDVGVYRFIDVGAWDLRVGLLIDQLSILFVLLITFVGSLIHIYAIGYMAHDT
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DRRRFFAYLNLFIAAMLTLVLADNYLILFVGWEGVGLASYLLIGFWFGRPAAARAGNKAF
HHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHCCCCHHHCCCCCCH
IMNRIGDLGLTMAIFTMLAQFGSVRFSDVSAKASGLTSTWATLLGFMLLLAACGKSAQVP
HHHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHCCCHHHHHHHHHHHHHHHHCCCCCCCH
LQAWLLDAMEGPTPVSALIHAATMVTAGVYLVVRSHEIYAHTGAASLAVAIIGTVTLLFG
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEEECCEEEEECCHHHHHHHHHHHHHHHHH
AWIGSAKKDIKKVLAGSTMSQIGYMMLAAGLGPAGAALAIFHLLTHGFFKANMFLGAGSV
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCCE
MHGTGDDTDMYHFGALSKVMPMTFWTFACGYLAIIGIPGTSGYFSKDHIIEAAFDKGAVF
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHCCCHHH
GVLALIGAGITAYYMTRLMMLTFLGTKRWRADVHPHESPAVMTIPLIVLAILSIFAGAFM
HHHHHHHCCHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
NNWIGDWLAPATGAEVEHVGMWHMGVIGVVTLVVVILGIVAGWLLNRHNVPNEEPETHDP
HHHHHHHCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
LLVAGRHDIYGDDINDVVVVKPGRWLAGGVAGFDRSVVDGLVNGAGSVTTACSQIIRKVQ
EEEECCCCCCCCCCCCEEEECCCCEEECCHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHH
NGYVRSYGLMMVVGVVVVGLVVVLGRMA
CCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]