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The map label for this gene is guaB [C]

Identifier: 50843227

GI number: 50843227

Start: 1928704

End: 1929807

Strand: Reverse

Name: guaB [C]

Synonym: PPA1767

Alternate gene names: 50843227

Gene position: 1929807-1928704 (Counterclockwise)

Preceding gene: 50843228

Following gene: 50843226

Centisome position: 75.38

GC content: 63.32

Gene sequence:

>1104_bases
ATGTACGACATCGGACGCAGCAAGCGTGCCACCCGGGCCTACAGCCTGGACGACATCGCCCTCATTCCCTCCCGGCGCAC
CCGTGGCACCGAGATGGTGAACCTGGAGTGGCGCATCGACGCACTCACCTTCGACTTCCCCATCATGGCCGCCCCCATGG
ACTCGGTTATGAGCCCTGCAACGGCTATTGAGTTTGGGCGTTTGGGCGGCCTTGGTGTGCTCAACCTTGAGGGTTTGTGG
ACCCGTTACGAGGATCCCACCCCGTACCTCGAGGAGCTAGCCGGGTTGAGCGACGATGTCGCCACCACCCGTCGGATGCA
AGAGATTTACGCCGAGCCGATCAAGGCTGAGCTCATCACCGAACGGATGGCTGAGATTCGGGCCGCCGGGGTGCCGGTGG
CGGGGTCGCTGTCACCGAAGAATGCCTCGCGTTTCTCCGAGACGGTGGTCAATGCCGGGGCGGACTTTTTCGTCATCCGT
GGCACGACGGTGTCGGCGGAGCACGTGGCCAACGGTGACGACGTTCTCGACCTGCGTAAGTTCATTTACGATCTCGACGT
CCCCGTGATCGTTGGCGGCTGCGCCACCTACCAGGCAGCCCTGCATCTCATGCGCACCGGTGCTGCTGGCGTCCTCGTGG
GTTTCGGTGGGGGAGCGACCCATACCACCCGCCAGGTGCTGGGCATTCAGGTGTCGATGGCATCTGCGATCGCCGACGTC
GCTGAGGCGCGTCGTGACTACATGGATGAGTCGGGGGGACGCTACGTTCACGTCATCGCTGATGGTTCAGTGGGTCGTTC
TGGCGACATTGCCAAGGCCATCGCCTGCGGTGCTGACGCTGTCATGGTCGGTTCTCCGTTAGCTCGGGCTACTGAGGCTC
CCGGCAGGGGTTGGCACTGGGGAGCGGAGGCATGGCACCCCGACCTGCCGCGTGGTGCCCGGGTTCACTTTGAGCCGGTG
GGGACCCTCGCTGAGGTCCTTAATGGCCCTTCTCGTGTCCCGGACGGCACCATGAACCTTGTTGGTGGGCTGCGTCAGGC
TATGGCCACCACTGGTTACTCGGAGGTCAAAGAGTTCCAGCGCATCGAGCTGACGATTCGCTAA

Upstream 100 bases:

>100_bases
CCTGCGCGAATCTCATCCGCACGACATTCAGATGACGGTCGAAGCCCCTAATTACTCTGCCCATTGACGGGCGAGCCGGA
TATCCGGCAGGAAAGGAATC

Downstream 100 bases:

>100_bases
CCGTCCCACCACGCAGAATGTTGTTCCGGTGAGCGGGTGGATAGCTAGCCTTCGGCCATGAGTGAAGTGCCCAATGAATT
GGTCGTGTTGCGTGGCGCGA

Product: inosine 5-monophosphate dehydrogenase

Products: xanthosine 5'-phosphate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MYDIGRSKRATRAYSLDDIALIPSRRTRGTEMVNLEWRIDALTFDFPIMAAPMDSVMSPATAIEFGRLGGLGVLNLEGLW
TRYEDPTPYLEELAGLSDDVATTRRMQEIYAEPIKAELITERMAEIRAAGVPVAGSLSPKNASRFSETVVNAGADFFVIR
GTTVSAEHVANGDDVLDLRKFIYDLDVPVIVGGCATYQAALHLMRTGAAGVLVGFGGGATHTTRQVLGIQVSMASAIADV
AEARRDYMDESGGRYVHVIADGSVGRSGDIAKAIACGADAVMVGSPLARATEAPGRGWHWGAEAWHPDLPRGARVHFEPV
GTLAEVLNGPSRVPDGTMNLVGGLRQAMATTGYSEVKEFQRIELTIR

Sequences:

>Translated_367_residues
MYDIGRSKRATRAYSLDDIALIPSRRTRGTEMVNLEWRIDALTFDFPIMAAPMDSVMSPATAIEFGRLGGLGVLNLEGLW
TRYEDPTPYLEELAGLSDDVATTRRMQEIYAEPIKAELITERMAEIRAAGVPVAGSLSPKNASRFSETVVNAGADFFVIR
GTTVSAEHVANGDDVLDLRKFIYDLDVPVIVGGCATYQAALHLMRTGAAGVLVGFGGGATHTTRQVLGIQVSMASAIADV
AEARRDYMDESGGRYVHVIADGSVGRSGDIAKAIACGADAVMVGSPLARATEAPGRGWHWGAEAWHPDLPRGARVHFEPV
GTLAEVLNGPSRVPDGTMNLVGGLRQAMATTGYSEVKEFQRIELTIR
>Mature_367_residues
MYDIGRSKRATRAYSLDDIALIPSRRTRGTEMVNLEWRIDALTFDFPIMAAPMDSVMSPATAIEFGRLGGLGVLNLEGLW
TRYEDPTPYLEELAGLSDDVATTRRMQEIYAEPIKAELITERMAEIRAAGVPVAGSLSPKNASRFSETVVNAGADFFVIR
GTTVSAEHVANGDDVLDLRKFIYDLDVPVIVGGCATYQAALHLMRTGAAGVLVGFGGGATHTTRQVLGIQVSMASAIADV
AEARRDYMDESGGRYVHVIADGSVGRSGDIAKAIACGADAVMVGSPLARATEAPGRGWHWGAEAWHPDLPRGARVHFEPV
GTLAEVLNGPSRVPDGTMNLVGGLRQAMATTGYSEVKEFQRIELTIR

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=125, Percent_Identity=37.6, Blast_Score=65, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71994385, Length=224, Percent_Identity=29.9107142857143, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71994389, Length=215, Percent_Identity=30.2325581395349, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6323464, Length=126, Percent_Identity=32.5396825396825, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323585, Length=126, Percent_Identity=32.5396825396825, Blast_Score=63, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24641071, Length=145, Percent_Identity=35.1724137931034, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24641073, Length=145, Percent_Identity=35.1724137931034, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28571163, Length=142, Percent_Identity=35.9154929577465, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001093
- InterPro:   IPR005992 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: 1.1.1.205

Molecular weight: Translated: 39366; Mature: 39366

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYDIGRSKRATRAYSLDDIALIPSRRTRGTEMVNLEWRIDALTFDFPIMAAPMDSVMSPA
CCCCCCCCCCHHCCCCCCEEECCCCCCCCCEEEEEEEEEEEEEECCCEEECCHHHHHCCH
TAIEFGRLGGLGVLNLEGLWTRYEDPTPYLEELAGLSDDVATTRRMQEIYAEPIKAELIT
HHHHHHCCCCCEEEECCCCEECCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHH
ERMAEIRAAGVPVAGSLSPKNASRFSETVVNAGADFFVIRGTTVSAEHVANGDDVLDLRK
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCEECHHHCCCCCHHHHHHH
FIYDLDVPVIVGGCATYQAALHLMRTGAAGVLVGFGGGATHTTRQVLGIQVSMASAIADV
HHHHCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHEEHHHHHHHHHH
AEARRDYMDESGGRYVHVIADGSVGRSGDIAKAIACGADAVMVGSPLARATEAPGRGWHW
HHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHCCCCEEEECCCHHHHCCCCCCCCCC
GAEAWHPDLPRGARVHFEPVGTLAEVLNGPSRVPDGTMNLVGGLRQAMATTGYSEVKEFQ
CCCCCCCCCCCCCEEEECHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHH
RIELTIR
HEEEEEC
>Mature Secondary Structure
MYDIGRSKRATRAYSLDDIALIPSRRTRGTEMVNLEWRIDALTFDFPIMAAPMDSVMSPA
CCCCCCCCCCHHCCCCCCEEECCCCCCCCCEEEEEEEEEEEEEECCCEEECCHHHHHCCH
TAIEFGRLGGLGVLNLEGLWTRYEDPTPYLEELAGLSDDVATTRRMQEIYAEPIKAELIT
HHHHHHCCCCCEEEECCCCEECCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHH
ERMAEIRAAGVPVAGSLSPKNASRFSETVVNAGADFFVIRGTTVSAEHVANGDDVLDLRK
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCEECHHHCCCCCHHHHHHH
FIYDLDVPVIVGGCATYQAALHLMRTGAAGVLVGFGGGATHTTRQVLGIQVSMASAIADV
HHHHCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHEEHHHHHHHHHH
AEARRDYMDESGGRYVHVIADGSVGRSGDIAKAIACGADAVMVGSPLARATEAPGRGWHW
HHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHCCCCEEEECCCHHHHCCCCCCCCCC
GAEAWHPDLPRGARVHFEPVGTLAEVLNGPSRVPDGTMNLVGGLRQAMATTGYSEVKEFQ
CCCCCCCCCCCCCEEEECHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHH
RIELTIR
HEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: inosine 5'-phosphate; NAD+; H2O

Specific reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA