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The map label for this gene is guaB [H]

Identifier: 50843228

GI number: 50843228

Start: 1929841

End: 1931355

Strand: Reverse

Name: guaB [H]

Synonym: PPA1768

Alternate gene names: 50843228

Gene position: 1931355-1929841 (Counterclockwise)

Preceding gene: 50843229

Following gene: 50843227

Centisome position: 75.44

GC content: 59.93

Gene sequence:

>1515_bases
ATGACCTCGGATTCCCGCCCGACCACGATTGAGGAGTTGGCACCGCTGGCCCTCACCTTCGATGACGTCCTGCTCCAGCC
AGTCGAGAGTAACGTCATTCCCTCCCAGGTCAAGACGACGACGAGGGTTTCTCGCAACATTTCCATCGCGATTCCGCTCG
TCAGCGCGGCGATGGATACCGTCACCGAGACCCGGATGGCGGTTGCTATGGCGCGTGAAGGTGGCCTTGGCATCCTGCAC
CGCAACCTGTCTATTGAGGATCAGGCTGCCATGGTCGATCAGGTGAAGCGTTCTGAGGCGGGCATGATTGATGAGCCCAT
CACGATCTCCCCGAATGCCACCCTGGCTGACGCCGAGGAGCTTTGCCACACTTACCGGATCTCCGGGGTGCCCGTCGTCG
ACGACAAGGAAAACCTGGTCGGTATCATCACGAACCGTGACATGCGCTTTGAGGACAATCCACAGCGTCCTATCTGCGAG
GTCATGACCGCAGCCCCACTCGTCACCGCTCCAGTGGGAACCAGTCCATCTGACGCTCTTTCTTTGCTGGCTGCCCACAA
GATTGAGAAGCTGCCGCTTGTCGACGCCGACGGTAAGTTGCGTGGGCTGTTCACTCTCAAAGACTTCGTCAAGACTGACA
AGTACCCCAACGCCACTAAGGATCCGCAAGGACGGCTACGTGTGGGTGCTGCGATCGGGTTCTTCGGCAACTCGTGGGAT
CGCGCTATGGCCCTGGTTGAGGAGGGGGTTGACCTCATCGTCGTCGACACCGCTCATGGTCACACCCAGGGTGTTTTTGA
CATGATCGCCCGGCTGAAGGCCGAGCCAGCTGCTCAGGGGGTTGACGTCGTTGCCGGCAATATCGCTACCTATGAGGCAG
CTAAGGCGCTGTGTGCGGCCGGGGTTGACGGCATCAAAGTCGGTATTGGGCCGGGGTCAATCTGCACTACCCGCGTCGTT
GCCGGGGTGGGCGTCCCGCAAGTGACCGCGATTTTTGAAGCTTCCAAGGCTGCTCGTCAGTATGATGTGCCGGTTATCGG
TGACGGTGGGTTGCAATACTCTGGTGACATCGCCAAGGCCCTGGTCGCCGGAGCTGATTCCGTCATGCTTGGCTCTTTAC
TGGCTGGTTGCGAAGAGTCTCCGGGTGAGCTCGCCTTCATCAACGGTAAACAGTTCAAGACTTACCGTGGTATGGGATCG
ATGGGAGCCATGTCGGCGCGCGGCGAGAAGCTGTCCTACTCCAAGGACCGCTATTTCCAGGGCGATGTCACGACCAACGA
CAAGATCGTCCCGGAGGGCATCGAGGGCCAGGTCGCTTACCGCGGGCCCCTTGGCGCAGTGGCCTACCAGTTGGTTGGTG
GGCTGCGTCAGTCGATGTTCTACACCGGGGCTCGCACTATCGACGAGTTGCACGAGCGGGGCCGCTTCGTGCGCATCACC
TCGGCGGGCCTGCGCGAATCTCATCCGCACGACATTCAGATGACGGTCGAAGCCCCTAATTACTCTGCCCATTGA

Upstream 100 bases:

>100_bases
TGACGGGGGCACCTCGCTTAAGGCCGGAGACCAGGCCACGGGTGAAGGCCGCCGACGCGAGCGGCGATAGGATAGCGAGC
ATCCCGGCGAAAGGTGGCTT

Downstream 100 bases:

>100_bases
CGGGCGAGCCGGATATCCGGCAGGAAAGGAATCATGTACGACATCGGACGCAGCAAGCGTGCCACCCGGGCCTACAGCCT
GGACGACATCGCCCTCATTC

Product: IMP dehydrogenase / GMP reductase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MTSDSRPTTIEELAPLALTFDDVLLQPVESNVIPSQVKTTTRVSRNISIAIPLVSAAMDTVTETRMAVAMAREGGLGILH
RNLSIEDQAAMVDQVKRSEAGMIDEPITISPNATLADAEELCHTYRISGVPVVDDKENLVGIITNRDMRFEDNPQRPICE
VMTAAPLVTAPVGTSPSDALSLLAAHKIEKLPLVDADGKLRGLFTLKDFVKTDKYPNATKDPQGRLRVGAAIGFFGNSWD
RAMALVEEGVDLIVVDTAHGHTQGVFDMIARLKAEPAAQGVDVVAGNIATYEAAKALCAAGVDGIKVGIGPGSICTTRVV
AGVGVPQVTAIFEASKAARQYDVPVIGDGGLQYSGDIAKALVAGADSVMLGSLLAGCEESPGELAFINGKQFKTYRGMGS
MGAMSARGEKLSYSKDRYFQGDVTTNDKIVPEGIEGQVAYRGPLGAVAYQLVGGLRQSMFYTGARTIDELHERGRFVRIT
SAGLRESHPHDIQMTVEAPNYSAH

Sequences:

>Translated_504_residues
MTSDSRPTTIEELAPLALTFDDVLLQPVESNVIPSQVKTTTRVSRNISIAIPLVSAAMDTVTETRMAVAMAREGGLGILH
RNLSIEDQAAMVDQVKRSEAGMIDEPITISPNATLADAEELCHTYRISGVPVVDDKENLVGIITNRDMRFEDNPQRPICE
VMTAAPLVTAPVGTSPSDALSLLAAHKIEKLPLVDADGKLRGLFTLKDFVKTDKYPNATKDPQGRLRVGAAIGFFGNSWD
RAMALVEEGVDLIVVDTAHGHTQGVFDMIARLKAEPAAQGVDVVAGNIATYEAAKALCAAGVDGIKVGIGPGSICTTRVV
AGVGVPQVTAIFEASKAARQYDVPVIGDGGLQYSGDIAKALVAGADSVMLGSLLAGCEESPGELAFINGKQFKTYRGMGS
MGAMSARGEKLSYSKDRYFQGDVTTNDKIVPEGIEGQVAYRGPLGAVAYQLVGGLRQSMFYTGARTIDELHERGRFVRIT
SAGLRESHPHDIQMTVEAPNYSAH
>Mature_503_residues
TSDSRPTTIEELAPLALTFDDVLLQPVESNVIPSQVKTTTRVSRNISIAIPLVSAAMDTVTETRMAVAMAREGGLGILHR
NLSIEDQAAMVDQVKRSEAGMIDEPITISPNATLADAEELCHTYRISGVPVVDDKENLVGIITNRDMRFEDNPQRPICEV
MTAAPLVTAPVGTSPSDALSLLAAHKIEKLPLVDADGKLRGLFTLKDFVKTDKYPNATKDPQGRLRVGAAIGFFGNSWDR
AMALVEEGVDLIVVDTAHGHTQGVFDMIARLKAEPAAQGVDVVAGNIATYEAAKALCAAGVDGIKVGIGPGSICTTRVVA
GVGVPQVTAIFEASKAARQYDVPVIGDGGLQYSGDIAKALVAGADSVMLGSLLAGCEESPGELAFINGKQFKTYRGMGSM
GAMSARGEKLSYSKDRYFQGDVTTNDKIVPEGIEGQVAYRGPLGAVAYQLVGGLRQSMFYTGARTIDELHERGRFVRITS
AGLRESHPHDIQMTVEAPNYSAH

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=461, Percent_Identity=39.0455531453362, Blast_Score=297, Evalue=1e-80,
Organism=Homo sapiens, GI34328930, Length=461, Percent_Identity=39.0455531453362, Blast_Score=297, Evalue=2e-80,
Organism=Homo sapiens, GI66933016, Length=461, Percent_Identity=39.4793926247288, Blast_Score=297, Evalue=2e-80,
Organism=Homo sapiens, GI34328928, Length=461, Percent_Identity=39.0455531453362, Blast_Score=297, Evalue=2e-80,
Organism=Homo sapiens, GI156616279, Length=461, Percent_Identity=39.0455531453362, Blast_Score=297, Evalue=2e-80,
Organism=Homo sapiens, GI217035152, Length=457, Percent_Identity=38.9496717724289, Blast_Score=291, Evalue=1e-78,
Organism=Homo sapiens, GI217035148, Length=461, Percent_Identity=38.3947939262473, Blast_Score=288, Evalue=9e-78,
Organism=Homo sapiens, GI217035150, Length=461, Percent_Identity=36.6594360086768, Blast_Score=265, Evalue=8e-71,
Organism=Homo sapiens, GI156104880, Length=265, Percent_Identity=33.2075471698113, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI50541956, Length=338, Percent_Identity=30.7692307692308, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI50541954, Length=338, Percent_Identity=30.7692307692308, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI50541952, Length=338, Percent_Identity=30.7692307692308, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI50541948, Length=338, Percent_Identity=30.7692307692308, Blast_Score=142, Evalue=8e-34,
Organism=Escherichia coli, GI1788855, Length=491, Percent_Identity=49.4908350305499, Blast_Score=436, Evalue=1e-123,
Organism=Escherichia coli, GI1786293, Length=230, Percent_Identity=37.8260869565217, Blast_Score=146, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71994385, Length=480, Percent_Identity=34.375, Blast_Score=260, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI71994389, Length=429, Percent_Identity=35.8974358974359, Blast_Score=250, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17560440, Length=286, Percent_Identity=35.3146853146853, Blast_Score=159, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6322012, Length=485, Percent_Identity=38.5567010309278, Blast_Score=317, Evalue=2e-87,
Organism=Saccharomyces cerevisiae, GI6323585, Length=485, Percent_Identity=36.9072164948454, Blast_Score=306, Evalue=3e-84,
Organism=Saccharomyces cerevisiae, GI6323464, Length=485, Percent_Identity=37.9381443298969, Blast_Score=306, Evalue=4e-84,
Organism=Saccharomyces cerevisiae, GI6319352, Length=339, Percent_Identity=38.9380530973451, Blast_Score=231, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6319353, Length=116, Percent_Identity=39.6551724137931, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24641071, Length=486, Percent_Identity=38.477366255144, Blast_Score=309, Evalue=2e-84,
Organism=Drosophila melanogaster, GI24641073, Length=486, Percent_Identity=38.477366255144, Blast_Score=309, Evalue=2e-84,
Organism=Drosophila melanogaster, GI28571163, Length=446, Percent_Identity=39.6860986547085, Blast_Score=288, Evalue=6e-78,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 53585; Mature: 53454

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSDSRPTTIEELAPLALTFDDVLLQPVESNVIPSQVKTTTRVSRNISIAIPLVSAAMDT
CCCCCCCCCHHHHCCHHEEHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEHHHHHHHHH
VTETRMAVAMAREGGLGILHRNLSIEDQAAMVDQVKRSEAGMIDEPITISPNATLADAEE
HHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHH
LCHTYRISGVPVVDDKENLVGIITNRDMRFEDNPQRPICEVMTAAPLVTAPVGTSPSDAL
HHHHHCCCCCEEECCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCEEEECCCCCHHHHH
SLLAAHKIEKLPLVDADGKLRGLFTLKDFVKTDKYPNATKDPQGRLRVGAAIGFFGNSWD
HHHHHHHHHHCCEECCCCCEEEEHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCHH
RAMALVEEGVDLIVVDTAHGHTQGVFDMIARLKAEPAAQGVDVVAGNIATYEAAKALCAA
HHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHC
GVDGIKVGIGPGSICTTRVVAGVGVPQVTAIFEASKAARQYDVPVIGDGGLQYSGDIAKA
CCCCEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEECCCCEECCHHHHH
LVAGADSVMLGSLLAGCEESPGELAFINGKQFKTYRGMGSMGAMSARGEKLSYSKDRYFQ
HHHCCCHHHHHHHHHCCCCCCCCEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEE
GDVTTNDKIVPEGIEGQVAYRGPLGAVAYQLVGGLRQSMFYTGARTIDELHERGRFVRIT
CCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
SAGLRESHPHDIQMTVEAPNYSAH
CCCCCCCCCCCEEEEEECCCCCCC
>Mature Secondary Structure 
TSDSRPTTIEELAPLALTFDDVLLQPVESNVIPSQVKTTTRVSRNISIAIPLVSAAMDT
CCCCCCCCHHHHCCHHEEHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEHHHHHHHHH
VTETRMAVAMAREGGLGILHRNLSIEDQAAMVDQVKRSEAGMIDEPITISPNATLADAEE
HHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHH
LCHTYRISGVPVVDDKENLVGIITNRDMRFEDNPQRPICEVMTAAPLVTAPVGTSPSDAL
HHHHHCCCCCEEECCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCEEEECCCCCHHHHH
SLLAAHKIEKLPLVDADGKLRGLFTLKDFVKTDKYPNATKDPQGRLRVGAAIGFFGNSWD
HHHHHHHHHHCCEECCCCCEEEEHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCHH
RAMALVEEGVDLIVVDTAHGHTQGVFDMIARLKAEPAAQGVDVVAGNIATYEAAKALCAA
HHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHC
GVDGIKVGIGPGSICTTRVVAGVGVPQVTAIFEASKAARQYDVPVIGDGGLQYSGDIAKA
CCCCEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEECCCCEECCHHHHH
LVAGADSVMLGSLLAGCEESPGELAFINGKQFKTYRGMGSMGAMSARGEKLSYSKDRYFQ
HHHCCCHHHHHHHHHCCCCCCCCEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEE
GDVTTNDKIVPEGIEGQVAYRGPLGAVAYQLVGGLRQSMFYTGARTIDELHERGRFVRIT
CCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
SAGLRESHPHDIQMTVEAPNYSAH
CCCCCCCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]