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The map label for this gene is mrsA [C]

Identifier: 50843183

GI number: 50843183

Start: 1876421

End: 1878097

Strand: Direct

Name: mrsA [C]

Synonym: PPA1723

Alternate gene names: 50843183

Gene position: 1876421-1878097 (Clockwise)

Preceding gene: 50843182

Following gene: 50843185

Centisome position: 73.29

GC content: 62.73

Gene sequence:

>1677_bases
ATGACCACCACCCGCCCTGAAAGGCTTAGCCCCGAACTCGTCGCAGAAGTTCAGTCCTGGCTCGACCAAGACCCCGACGA
GGCCACGCGCACCGAACTGTCCGATGTGCTCGTCCGCGCCCAGTCTGGTGAAGCTGAAGCCATCGTAGCGGTGGAGTCGG
CCTTCGCCGGACCATTGACCTTCGGCACCGCTGGTCTACGCGCGGCGCTCGGCCCCGGCCCGTCCCGCATGAACCGAGTC
GTTGTCCAGCGTGCCGCTGCCGGTTTCGCTTCCTGGTTGCGCTCCCACAGCAGCCGAGGAGGAACCGTCGTCATCGGTTT
CGACGCTCGTCACAATTCTGACGTCTTCGCCCGCGATACCGCCGAGATCATGGCCGGGGCAGGTTTCCACGCCCTGTTGG
CCGACTCCCCTATTCCGACCCCGGTGACGGCTTTCGCTATTAAGCACTATGGGGCAGTTGCCGGTGTCATGGTGACGGCC
TCCCACAATCCTCCCGCTGATAACGGGTACAAGGTCTATCTGGGAGACGGTTCCCAGATCGTTCCACCCACCGACGCCGA
GATTGCCCACGAAATCGAGGTCGCGTCTGAAGAGCCCGTGGGTGCGATTGTTCGCGGTGACGACATTGAGTTCATCGGCG
ACGAGCTCATTGATGCCTATGTCTGTCGCGCCGCCAAGCTGACTACGGCCAATCCCGACGTCACCTGGGTTTATACCGCC
ATGCACGGGGTCGGAACACGGGTCGTGCGTCGTCTCGTTGAGAAGGCTGGCTTATCCGAATTTATCGGGGTGACCGAGCA
GCTCAATCCAGACCCGGACTTCCCGACTGTAGCCTTCCCGAACCCCGAGGAGCCCGGCGCCATCGATCTGGCCATTGCTC
AAGCCCGCAAGCACGACGCCGACGTCGTTATCGCCTCTGACCCCGACGCCGACCGCTGCGCCGTAGCAGCCGTTATTGAC
GGGGACTGGCGGATGCTTACCGGCGACGAACTGGGCACTCTTCTTGGTGACGATGCCCTGCGTCGTGGTCTCGACGGTGT
TTACGCCAACTCGGTGGTTTCATCGACCTGTCTGGGACGGATGGCTAAGGCTGCCGGACGCGAACACCACATGACCTTGA
CCGGGTTCAAGTGGATCGGCCGTGTGCCTGGACTCGTCTTCGGCTATGAGGAAGCCATTGGTTACTGCTGCGATCCTTCC
CACGTACCCGACAAGGACGGCATCACCGCCTTGGCGACGATCCTGCGTCTGGTCGGTGAACTCAAGGCCTCCGGCACCAC
CATAGCCGAACGTCTCGACGAGATCTGGGCCACCCATGGTCTACACCGCACTTCCCAGCTCGCGGTGCGCGTCACCACCA
TGTCGATCATCTCCCAGGCCATGGACCGCTTGCGCAACCAGCCCCCCGCAACCCTGCTAGGTGATCGCGTCGATGTCTGC
GACCTCGACGATCCCAGCAATGGGTCCGGGCTACCACAGCAGAACGCGATCGAGCTGACCGGACCTCGCGTTCACGTCGT
CACTCGTCCCTCAGGCACCGAGCCGAAGCTCAAGTGCTACCTCGAGGTACGCGCAGCCCCAGCGGAATCGGCCGCCGATC
TGTCAGCCACCAAGGCCCGTCTTGACGCAGACATGACGACCCTACGAGACGAGATGTCCCAGGCTCTCGGAATCTGA

Upstream 100 bases:

>100_bases
AAGTTATCGCTGCTGGCAAGCAGGCCGCCCCTCGACTAGCTAGCCTTCTCGCCGATATCACGGCTGCCATCTGATCCATC
CCACAGCCCATCGAGGAACC

Downstream 100 bases:

>100_bases
GCGTCCCTGCGACCCGGACGATGCGTCCTCGTCAGTAATGACGGGGACGCACGAATGTGTCGGCCTCCCGGCATGCCATA
GCGGTTGCCTCAACATGCTT

Product: phosphoglucomutase/phosphomannomutase

Products: NA

Alternate protein names: PMM [H]

Number of amino acids: Translated: 558; Mature: 557

Protein sequence:

>558_residues
MTTTRPERLSPELVAEVQSWLDQDPDEATRTELSDVLVRAQSGEAEAIVAVESAFAGPLTFGTAGLRAALGPGPSRMNRV
VVQRAAAGFASWLRSHSSRGGTVVIGFDARHNSDVFARDTAEIMAGAGFHALLADSPIPTPVTAFAIKHYGAVAGVMVTA
SHNPPADNGYKVYLGDGSQIVPPTDAEIAHEIEVASEEPVGAIVRGDDIEFIGDELIDAYVCRAAKLTTANPDVTWVYTA
MHGVGTRVVRRLVEKAGLSEFIGVTEQLNPDPDFPTVAFPNPEEPGAIDLAIAQARKHDADVVIASDPDADRCAVAAVID
GDWRMLTGDELGTLLGDDALRRGLDGVYANSVVSSTCLGRMAKAAGREHHMTLTGFKWIGRVPGLVFGYEEAIGYCCDPS
HVPDKDGITALATILRLVGELKASGTTIAERLDEIWATHGLHRTSQLAVRVTTMSIISQAMDRLRNQPPATLLGDRVDVC
DLDDPSNGSGLPQQNAIELTGPRVHVVTRPSGTEPKLKCYLEVRAAPAESAADLSATKARLDADMTTLRDEMSQALGI

Sequences:

>Translated_558_residues
MTTTRPERLSPELVAEVQSWLDQDPDEATRTELSDVLVRAQSGEAEAIVAVESAFAGPLTFGTAGLRAALGPGPSRMNRV
VVQRAAAGFASWLRSHSSRGGTVVIGFDARHNSDVFARDTAEIMAGAGFHALLADSPIPTPVTAFAIKHYGAVAGVMVTA
SHNPPADNGYKVYLGDGSQIVPPTDAEIAHEIEVASEEPVGAIVRGDDIEFIGDELIDAYVCRAAKLTTANPDVTWVYTA
MHGVGTRVVRRLVEKAGLSEFIGVTEQLNPDPDFPTVAFPNPEEPGAIDLAIAQARKHDADVVIASDPDADRCAVAAVID
GDWRMLTGDELGTLLGDDALRRGLDGVYANSVVSSTCLGRMAKAAGREHHMTLTGFKWIGRVPGLVFGYEEAIGYCCDPS
HVPDKDGITALATILRLVGELKASGTTIAERLDEIWATHGLHRTSQLAVRVTTMSIISQAMDRLRNQPPATLLGDRVDVC
DLDDPSNGSGLPQQNAIELTGPRVHVVTRPSGTEPKLKCYLEVRAAPAESAADLSATKARLDADMTTLRDEMSQALGI
>Mature_557_residues
TTTRPERLSPELVAEVQSWLDQDPDEATRTELSDVLVRAQSGEAEAIVAVESAFAGPLTFGTAGLRAALGPGPSRMNRVV
VQRAAAGFASWLRSHSSRGGTVVIGFDARHNSDVFARDTAEIMAGAGFHALLADSPIPTPVTAFAIKHYGAVAGVMVTAS
HNPPADNGYKVYLGDGSQIVPPTDAEIAHEIEVASEEPVGAIVRGDDIEFIGDELIDAYVCRAAKLTTANPDVTWVYTAM
HGVGTRVVRRLVEKAGLSEFIGVTEQLNPDPDFPTVAFPNPEEPGAIDLAIAQARKHDADVVIASDPDADRCAVAAVIDG
DWRMLTGDELGTLLGDDALRRGLDGVYANSVVSSTCLGRMAKAAGREHHMTLTGFKWIGRVPGLVFGYEEAIGYCCDPSH
VPDKDGITALATILRLVGELKASGTTIAERLDEIWATHGLHRTSQLAVRVTTMSIISQAMDRLRNQPPATLLGDRVDVCD
LDDPSNGSGLPQQNAIELTGPRVHVVTRPSGTEPKLKCYLEVRAAPAESAADLSATKARLDADMTTLRDEMSQALGI

Specific function: Unknown

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=606, Percent_Identity=33.1683168316832, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI31377548, Length=575, Percent_Identity=31.8260869565217, Blast_Score=242, Evalue=9e-64,
Organism=Escherichia coli, GI1789566, Length=305, Percent_Identity=27.5409836065574, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71993870, Length=581, Percent_Identity=31.84165232358, Blast_Score=257, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI71993878, Length=319, Percent_Identity=33.8557993730408, Blast_Score=173, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6323934, Length=607, Percent_Identity=33.4431630971993, Blast_Score=280, Evalue=5e-76,
Organism=Drosophila melanogaster, GI20129809, Length=599, Percent_Identity=33.7228714524207, Blast_Score=279, Evalue=4e-75,
Organism=Drosophila melanogaster, GI24651977, Length=526, Percent_Identity=34.0304182509506, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24653722, Length=579, Percent_Identity=29.8791018998273, Blast_Score=213, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.8 [H]

Molecular weight: Translated: 59290; Mature: 59159

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTRPERLSPELVAEVQSWLDQDPDEATRTELSDVLVRAQSGEAEAIVAVESAFAGPLT
CCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEHHHCCCCHH
FGTAGLRAALGPGPSRMNRVVVQRAAAGFASWLRSHSSRGGTVVIGFDARHNSDVFARDT
CCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEHHHH
AEIMAGAGFHALLADSPIPTPVTAFAIKHYGAVAGVMVTASHNPPADNGYKVYLGDGSQI
HHHHHCCCCCEECCCCCCCCCHHHHHHHHHCCEEEEEEEECCCCCCCCCEEEEECCCCEE
VPPTDAEIAHEIEVASEEPVGAIVRGDDIEFIGDELIDAYVCRAAKLTTANPDVTWVYTA
CCCCCHHHHHHEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHEEECCCCCEEEEEHH
MHGVGTRVVRRLVEKAGLSEFIGVTEQLNPDPDFPTVAFPNPEEPGAIDLAIAQARKHDA
HHHHHHHHHHHHHHHCCHHHHHCHHHHCCCCCCCCEEECCCCCCCCEEEHEEHHHCCCCC
DVVIASDPDADRCAVAAVIDGDWRMLTGDELGTLLGDDALRRGLDGVYANSVVSSTCLGR
CEEEECCCCCCCEEEEEEECCCEEEECCCHHHHHHCHHHHHHCCCHHHHHHHHHHHHHHH
MAKAAGREHHMTLTGFKWIGRVPGLVFGYEEAIGYCCDPSHVPDKDGITALATILRLVGE
HHHHCCCCCEEEEEHHHHHHCCCCCEEEHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
LKASGTTIAERLDEIWATHGLHRTSQLAVRVTTMSIISQAMDRLRNQPPATLLGDRVDVC
HHCCCHHHHHHHHHHHHHCCCCCCHHHEEEHHHHHHHHHHHHHHHCCCCCHHHCCCCCEE
DLDDPSNGSGLPQQNAIELTGPRVHVVTRPSGTEPKLKCYLEVRAAPAESAADLSATKAR
CCCCCCCCCCCCCCCCEEECCCEEEEEECCCCCCCCEEEEEEEECCCCCCHHHHHHHHHH
LDADMTTLRDEMSQALGI
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TTTRPERLSPELVAEVQSWLDQDPDEATRTELSDVLVRAQSGEAEAIVAVESAFAGPLT
CCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEHHHCCCCHH
FGTAGLRAALGPGPSRMNRVVVQRAAAGFASWLRSHSSRGGTVVIGFDARHNSDVFARDT
CCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEHHHH
AEIMAGAGFHALLADSPIPTPVTAFAIKHYGAVAGVMVTASHNPPADNGYKVYLGDGSQI
HHHHHCCCCCEECCCCCCCCCHHHHHHHHHCCEEEEEEEECCCCCCCCCEEEEECCCCEE
VPPTDAEIAHEIEVASEEPVGAIVRGDDIEFIGDELIDAYVCRAAKLTTANPDVTWVYTA
CCCCCHHHHHHEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHEEECCCCCEEEEEHH
MHGVGTRVVRRLVEKAGLSEFIGVTEQLNPDPDFPTVAFPNPEEPGAIDLAIAQARKHDA
HHHHHHHHHHHHHHHCCHHHHHCHHHHCCCCCCCCEEECCCCCCCCEEEHEEHHHCCCCC
DVVIASDPDADRCAVAAVIDGDWRMLTGDELGTLLGDDALRRGLDGVYANSVVSSTCLGR
CEEEECCCCCCCEEEEEEECCCEEEECCCHHHHHHCHHHHHHCCCHHHHHHHHHHHHHHH
MAKAAGREHHMTLTGFKWIGRVPGLVFGYEEAIGYCCDPSHVPDKDGITALATILRLVGE
HHHHCCCCCEEEEEHHHHHHCCCCCEEEHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
LKASGTTIAERLDEIWATHGLHRTSQLAVRVTTMSIISQAMDRLRNQPPATLLGDRVDVC
HHCCCHHHHHHHHHHHHHCCCCCCHHHEEEHHHHHHHHHHHHHHHCCCCCHHHCCCCCEE
DLDDPSNGSGLPQQNAIELTGPRVHVVTRPSGTEPKLKCYLEVRAAPAESAADLSATKAR
CCCCCCCCCCCCCCCCEEECCCEEEEEECCCCCCCCEEEEEEEECCCCCCHHHHHHHHHH
LDADMTTLRDEMSQALGI
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]