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The map label for this gene is lpdA [H]

Identifier: 50843181

GI number: 50843181

Start: 1874015

End: 1875394

Strand: Reverse

Name: lpdA [H]

Synonym: PPA1721

Alternate gene names: 50843181

Gene position: 1875394-1874015 (Counterclockwise)

Preceding gene: 50843184

Following gene: 50843177

Centisome position: 73.25

GC content: 61.38

Gene sequence:

>1380_bases
ATGACGTCTATGGTGATCATTGGGGCAGGGCCTGGAGGATACGAGGCCGCCAGCGTTGCGGCAGCTGGTGGCGTTGATGT
CACTGTCGTTGAGGAAACTGGTATCGGAGGAGCTGCTGTCCTCACCGACTGCGTCCCGTCGAAAACCCTCATCGCCACCG
CGGAGGTCACATCGACCTTGCGCCGCGCAGCTGAGCTCGGATTACGTCACACCGAGACGTTCGAGGTTGACCTCGACGCC
GTTAACTCTCGGGTGCGTCAGCTTGCCCAAGCCCAGTCTGACGACATTAGCCGCGGACTGGAGCGCAAAGGAGTGCGGCT
GATCAGCGGACGGGCGCGATTGGCGACAGGTGCTCCTGGTCACCTGCATCGGGTTGTTATCAACGACGATGAGACAATCG
ACGCCGACATTGTGCTGCTAGCCACCGGGACCACTCCGCGCGAGCTGCCCGCGGCCCGCTGTGACGGGGAGCGCATCCTT
ACCTGGAAACAGGTGTACTCGATGCGGGAGGTACCTGAACACCTCATCGTGGTGGGATCTGGCGTCACTGGTGCGGAGTT
CGCGTCGGCCTACGATTCGTTGGGATGCCCAGTAACGCTGGTGTCGTCACGCGATCAGGTTCTCCCCGGCGAAGACCCCG
ACGCGGCCCAGGTGTTGCAGCAGGTTTTCGAGTCTCGCGGCATGGAGATCTTGTCGCGCTCCCGCGCAGTGTCCGCGATC
CGTGACGGGGATGGAGTCGTGGTCGGGCTGGAGGACGGCCGGACTGTTCGTGGATCCCACGTCTTTATGGCAGTCGGGTC
GACCCCTAACAGTGCCGATCTCGGTTTGGAAGAGGTCGGTGTAGCTGTTGGTCCGCGCGGCCACATCACCGTCGACAAAG
TTTCGCGTACCAACGTTCCGGGTATCTATGCTGCCGGAGACTGCACCGGCGTCTTCGCCCTGGCGTCTGTGGCAGCGATG
CAGGGACGCATTGCGGTGTGGCATGCGCTGGGCCAGGCACTCCAACCGCTGGACTTGTCCTTGGTGTGTTCCAACGTTTT
TACCTCTCCCGAGATTGCCACAGTGGGTGTGACGCAAACTGACGTCGACTCTGGGAAGGTGCAGGCAAGGTCCACTCGGT
TGGACTTGTCGACGAATCCGCGTGCCAAAATGCAGGGGCTTCACGACGGTTTCGTCAAGCTTTTCTGCCGTCCCGCGACC
GGCAACATCATTGGCGGAGTGGTCGTTTCACCGCGGGCTAGCGAGCTCATCCATCCCATTTCGGTAGCAGTAGCCGAACG
CATACCCGTTGACGCTTTTCAGCATGACTTCACTGTCTATCCATCCCTATCGGGATCGGTTTCGGAGGCGGCACGCCGGT
TGCAGACCTTCGTCGCGTGA

Upstream 100 bases:

>100_bases
GTGTTCAGTGTCGAAATGCGTGATGAATCGAGGGTTTCCTCACGCCGGAGATTTCTCTCGATGTCGACAGATGAGCCGTC
GTGACTGAAAGAATGCCGCC

Downstream 100 bases:

>100_bases
ATTCGCCCATAGCCCCGGGGTGCGAGTATCCGGGCAGATCAGAAATCGTCGAAGAGGGCAGAGAATAAACCCAGCCCGAC
TAGGCCGAGACCGCCAACAG

Product: flavoprotein disulfide reductase

Products: NA

Alternate protein names: NAD(P)H quinone reductase; NAD(P)H: menadione oxidoreductase; NADH-menadione reductase [H]

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MTSMVIIGAGPGGYEAASVAAAGGVDVTVVEETGIGGAAVLTDCVPSKTLIATAEVTSTLRRAAELGLRHTETFEVDLDA
VNSRVRQLAQAQSDDISRGLERKGVRLISGRARLATGAPGHLHRVVINDDETIDADIVLLATGTTPRELPAARCDGERIL
TWKQVYSMREVPEHLIVVGSGVTGAEFASAYDSLGCPVTLVSSRDQVLPGEDPDAAQVLQQVFESRGMEILSRSRAVSAI
RDGDGVVVGLEDGRTVRGSHVFMAVGSTPNSADLGLEEVGVAVGPRGHITVDKVSRTNVPGIYAAGDCTGVFALASVAAM
QGRIAVWHALGQALQPLDLSLVCSNVFTSPEIATVGVTQTDVDSGKVQARSTRLDLSTNPRAKMQGLHDGFVKLFCRPAT
GNIIGGVVVSPRASELIHPISVAVAERIPVDAFQHDFTVYPSLSGSVSEAARRLQTFVA

Sequences:

>Translated_459_residues
MTSMVIIGAGPGGYEAASVAAAGGVDVTVVEETGIGGAAVLTDCVPSKTLIATAEVTSTLRRAAELGLRHTETFEVDLDA
VNSRVRQLAQAQSDDISRGLERKGVRLISGRARLATGAPGHLHRVVINDDETIDADIVLLATGTTPRELPAARCDGERIL
TWKQVYSMREVPEHLIVVGSGVTGAEFASAYDSLGCPVTLVSSRDQVLPGEDPDAAQVLQQVFESRGMEILSRSRAVSAI
RDGDGVVVGLEDGRTVRGSHVFMAVGSTPNSADLGLEEVGVAVGPRGHITVDKVSRTNVPGIYAAGDCTGVFALASVAAM
QGRIAVWHALGQALQPLDLSLVCSNVFTSPEIATVGVTQTDVDSGKVQARSTRLDLSTNPRAKMQGLHDGFVKLFCRPAT
GNIIGGVVVSPRASELIHPISVAVAERIPVDAFQHDFTVYPSLSGSVSEAARRLQTFVA
>Mature_458_residues
TSMVIIGAGPGGYEAASVAAAGGVDVTVVEETGIGGAAVLTDCVPSKTLIATAEVTSTLRRAAELGLRHTETFEVDLDAV
NSRVRQLAQAQSDDISRGLERKGVRLISGRARLATGAPGHLHRVVINDDETIDADIVLLATGTTPRELPAARCDGERILT
WKQVYSMREVPEHLIVVGSGVTGAEFASAYDSLGCPVTLVSSRDQVLPGEDPDAAQVLQQVFESRGMEILSRSRAVSAIR
DGDGVVVGLEDGRTVRGSHVFMAVGSTPNSADLGLEEVGVAVGPRGHITVDKVSRTNVPGIYAAGDCTGVFALASVAAMQ
GRIAVWHALGQALQPLDLSLVCSNVFTSPEIATVGVTQTDVDSGKVQARSTRLDLSTNPRAKMQGLHDGFVKLFCRPATG
NIIGGVVVSPRASELIHPISVAVAERIPVDAFQHDFTVYPSLSGSVSEAARRLQTFVA

Specific function: May contribute to virulence by increasing resistance to reactive oxygen intermediates. It can reduce 2,6-dimethyl-1,4- benzoquinone (DMBQ), 5-hydroxy-1,4-naphthaquinone (5-HNQ) and menadione. NAD(P)H is the physiological reductant rather than NADH [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=457, Percent_Identity=26.9146608315098, Blast_Score=169, Evalue=7e-42,
Organism=Homo sapiens, GI50301238, Length=449, Percent_Identity=25.3897550111359, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI291045266, Length=410, Percent_Identity=22.4390243902439, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI22035672, Length=417, Percent_Identity=25.4196642685851, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI33519430, Length=350, Percent_Identity=25.7142857142857, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI33519428, Length=350, Percent_Identity=25.7142857142857, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI33519426, Length=350, Percent_Identity=25.7142857142857, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI148277071, Length=350, Percent_Identity=25.7142857142857, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI148277065, Length=350, Percent_Identity=25.7142857142857, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI291045268, Length=324, Percent_Identity=23.1481481481481, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI65787454, Length=288, Percent_Identity=26.0416666666667, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI21389617, Length=288, Percent_Identity=26.0416666666667, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI226437568, Length=288, Percent_Identity=26.0416666666667, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1786307, Length=464, Percent_Identity=28.6637931034483, Blast_Score=182, Evalue=5e-47,
Organism=Escherichia coli, GI87082354, Length=458, Percent_Identity=26.8558951965066, Blast_Score=148, Evalue=7e-37,
Organism=Escherichia coli, GI1789915, Length=435, Percent_Identity=25.7471264367816, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI87081717, Length=456, Percent_Identity=25.4385964912281, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1788892, Length=190, Percent_Identity=28.9473684210526, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI32565766, Length=459, Percent_Identity=27.8867102396514, Blast_Score=151, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI71983429, Length=433, Percent_Identity=25.4041570438799, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI71983419, Length=433, Percent_Identity=25.4041570438799, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17557007, Length=479, Percent_Identity=24.8434237995825, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17559934, Length=215, Percent_Identity=27.906976744186, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6321091, Length=470, Percent_Identity=26.8085106382979, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6325166, Length=430, Percent_Identity=22.5581395348837, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6325240, Length=483, Percent_Identity=23.3954451345756, Blast_Score=100, Evalue=8e-22,
Organism=Drosophila melanogaster, GI21358499, Length=457, Percent_Identity=28.8840262582057, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24640549, Length=378, Percent_Identity=28.042328042328, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24640553, Length=378, Percent_Identity=28.042328042328, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24640551, Length=378, Percent_Identity=28.042328042328, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17737741, Length=388, Percent_Identity=26.5463917525773, Blast_Score=85, Evalue=9e-17,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.5.2 [H]

Molecular weight: Translated: 48015; Mature: 47884

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSMVIIGAGPGGYEAASVAAAGGVDVTVVEETGIGGAAVLTDCVPSKTLIATAEVTSTL
CCEEEEEECCCCCCCHHHEEECCCCEEEEEEECCCCCHHHHHHCCCCCEEEEHHHHHHHH
RRAAELGLRHTETFEVDLDAVNSRVRQLAQAQSDDISRGLERKGVRLISGRARLATGAPG
HHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCEEEECCCCC
HLHRVVINDDETIDADIVLLATGTTPRELPAARCDGERILTWKQVYSMREVPEHLIVVGS
CEEEEEECCCCCCCCEEEEEEECCCCHHCCCCCCCCCEEEHHHHHHHHHHCCCEEEEEEC
GVTGAEFASAYDSLGCPVTLVSSRDQVLPGEDPDAAQVLQQVFESRGMEILSRSRAVSAI
CCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHE
RDGDGVVVGLEDGRTVRGSHVFMAVGSTPNSADLGLEEVGVAVGPRGHITVDKVSRTNVP
ECCCEEEEEECCCCEEECCEEEEEECCCCCCCCCCHHHHCEEECCCCCEEEECCCCCCCC
GIYAAGDCTGVFALASVAAMQGRIAVWHALGQALQPLDLSLVCSNVFTSPEIATVGVTQT
CEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEECEEC
DVDSGKVQARSTRLDLSTNPRAKMQGLHDGFVKLFCRPATGNIIGGVVVSPRASELIHPI
CCCCCCEEEEEEEEECCCCCHHHHCCHHCCEEEEEEECCCCCEEECEEECCCHHHHHHHH
SVAVAERIPVDAFQHDFTVYPSLSGSVSEAARRLQTFVA
HHHHHHCCCHHHHCCCEEEECCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TSMVIIGAGPGGYEAASVAAAGGVDVTVVEETGIGGAAVLTDCVPSKTLIATAEVTSTL
CEEEEEECCCCCCCHHHEEECCCCEEEEEEECCCCCHHHHHHCCCCCEEEEHHHHHHHH
RRAAELGLRHTETFEVDLDAVNSRVRQLAQAQSDDISRGLERKGVRLISGRARLATGAPG
HHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCEEEECCCCC
HLHRVVINDDETIDADIVLLATGTTPRELPAARCDGERILTWKQVYSMREVPEHLIVVGS
CEEEEEECCCCCCCCEEEEEEECCCCHHCCCCCCCCCEEEHHHHHHHHHHCCCEEEEEEC
GVTGAEFASAYDSLGCPVTLVSSRDQVLPGEDPDAAQVLQQVFESRGMEILSRSRAVSAI
CCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHE
RDGDGVVVGLEDGRTVRGSHVFMAVGSTPNSADLGLEEVGVAVGPRGHITVDKVSRTNVP
ECCCEEEEEECCCCEEECCEEEEEECCCCCCCCCCHHHHCEEECCCCCEEEECCCCCCCC
GIYAAGDCTGVFALASVAAMQGRIAVWHALGQALQPLDLSLVCSNVFTSPEIATVGVTQT
CEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEECEEC
DVDSGKVQARSTRLDLSTNPRAKMQGLHDGFVKLFCRPATGNIIGGVVVSPRASELIHPI
CCCCCCEEEEEEEEECCCCCHHHHCCHHCCEEEEEEECCCCCEEECEEECCCHHHHHHHH
SVAVAERIPVDAFQHDFTVYPSLSGSVSEAARRLQTFVA
HHHHHHCCCHHHHCCCEEEECCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]