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The map label for this gene is purE [H]

Identifier: 50843163

GI number: 50843163

Start: 1856048

End: 1856638

Strand: Reverse

Name: purE [H]

Synonym: PPA1701

Alternate gene names: 50843163

Gene position: 1856638-1856048 (Counterclockwise)

Preceding gene: 50843164

Following gene: 50843160

Centisome position: 72.52

GC content: 63.62

Gene sequence:

>591_bases
ATGCCTGAGACCACCACTGCTAGCCGTAAGCCGCGCCGAGGTGAGAAGGTCAAAACAACCACCGGGGGAGCACGCCGGCT
GGCGTGCGACGCCAATGGCCCTCAAGTGTCGATCATCATGGGCTCGGACTCTGACTGGCCGACGATGGAGCCTGCGGCTC
AGGTGCTTACCGACTTCAATGTGGGATTTGAGGCTGACGTCGTGTCGGCCCACCGCATGCCTGAGGACATGATCGAGTTC
GGTCGAGGCGCGCACAAGCGCGGTATCAAGGTGATCATCGCCGGTGCTGGCGGTGCCGCCCATCTGCCGGGCATGGTCGC
CGCGCTGACCCCGCTGCCGGTTATCGGGGTTCCCGTGCCGCTAGCCCACCTCGACGGTATGGATTCCTTGCTATCGATCG
TTCAGATGCCAGGTGGTGTGCCGGTGGCGACGGTCGGCGTCGGTAATGCCAAGAACGCCGGCCTGCTAGCGGTACGGATT
CTTGCCGCGTCGACCCCTGAGCTGTGCGAGGCCATGGTCAAGTACCAGTCCGATTTGCACGATGTGGCTGCGGGCAAGGG
CGAGAAAGTGCGTCGTCACTCCTGTCCCTGA

Upstream 100 bases:

>100_bases
CCCGGTCGCAAGGTCGGTCACGTCACCTGCCTTGGTAACGACATTGAGACGACTCATCGTCGGGCCCGCCATGCCGCCGC
CTACCTTATGGGAGAACACG

Downstream 100 bases:

>100_bases
GCGACTACCGAGAGTTCATTGCTGAGCTGGCCCGGGATTGGGCCAGCTACGACCCGGCCATTAGATCAGCGACAGGGTTA
GTGACAGGTCAACCGGTTGG

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MPETTTASRKPRRGEKVKTTTGGARRLACDANGPQVSIIMGSDSDWPTMEPAAQVLTDFNVGFEADVVSAHRMPEDMIEF
GRGAHKRGIKVIIAGAGGAAHLPGMVAALTPLPVIGVPVPLAHLDGMDSLLSIVQMPGGVPVATVGVGNAKNAGLLAVRI
LAASTPELCEAMVKYQSDLHDVAAGKGEKVRRHSCP

Sequences:

>Translated_196_residues
MPETTTASRKPRRGEKVKTTTGGARRLACDANGPQVSIIMGSDSDWPTMEPAAQVLTDFNVGFEADVVSAHRMPEDMIEF
GRGAHKRGIKVIIAGAGGAAHLPGMVAALTPLPVIGVPVPLAHLDGMDSLLSIVQMPGGVPVATVGVGNAKNAGLLAVRI
LAASTPELCEAMVKYQSDLHDVAAGKGEKVRRHSCP
>Mature_195_residues
PETTTASRKPRRGEKVKTTTGGARRLACDANGPQVSIIMGSDSDWPTMEPAAQVLTDFNVGFEADVVSAHRMPEDMIEFG
RGAHKRGIKVIIAGAGGAAHLPGMVAALTPLPVIGVPVPLAHLDGMDSLLSIVQMPGGVPVATVGVGNAKNAGLLAVRIL
AASTPELCEAMVKYQSDLHDVAAGKGEKVRRHSCP

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=119, Percent_Identity=54.6218487394958, Blast_Score=130, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6324702, Length=158, Percent_Identity=58.2278481012658, Blast_Score=171, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 20333; Mature: 20202

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPETTTASRKPRRGEKVKTTTGGARRLACDANGPQVSIIMGSDSDWPTMEPAAQVLTDFN
CCCCCCCCCCCCCCCEEEECCCCCEEEEECCCCCEEEEEEECCCCCCCCCHHHHHHHHCC
VGFEADVVSAHRMPEDMIEFGRGAHKRGIKVIIAGAGGAAHLPGMVAALTPLPVIGVPVP
CCCCCHHHHHHCCCHHHHHHCCCCCCCCCEEEEECCCCCHHHCHHHHHHCCCCEECCCCC
LAHLDGMDSLLSIVQMPGGVPVATVGVGNAKNAGLLAVRILAASTPELCEAMVKYQSDLH
HHHHCCHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHH
DVAAGKGEKVRRHSCP
HHHCCCCCCCCCCCCC
>Mature Secondary Structure 
PETTTASRKPRRGEKVKTTTGGARRLACDANGPQVSIIMGSDSDWPTMEPAAQVLTDFN
CCCCCCCCCCCCCCEEEECCCCCEEEEECCCCCEEEEEEECCCCCCCCCHHHHHHHHCC
VGFEADVVSAHRMPEDMIEFGRGAHKRGIKVIIAGAGGAAHLPGMVAALTPLPVIGVPVP
CCCCCHHHHHHCCCHHHHHHCCCCCCCCCEEEEECCCCCHHHCHHHHHHCCCCEECCCCC
LAHLDGMDSLLSIVQMPGGVPVATVGVGNAKNAGLLAVRILAASTPELCEAMVKYQSDLH
HHHHCCHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHH
DVAAGKGEKVRRHSCP
HHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8998996 [H]