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The map label for this gene is purK [H]

Identifier: 50843164

GI number: 50843164

Start: 1856631

End: 1857803

Strand: Reverse

Name: purK [H]

Synonym: PPA1702

Alternate gene names: 50843164

Gene position: 1857803-1856631 (Counterclockwise)

Preceding gene: 50843166

Following gene: 50843163

Centisome position: 72.56

GC content: 61.47

Gene sequence:

>1173_bases
ATGAACGTCGTGACGTCTTACACCATCGGAATCATTGGCGGCGGGCAGTTAGCCCGCATGATGCATCAGGCTGCGATCGG
ATTGGGGGTGCGCACCCGCCTGCTGGCCTCTGATCCTGAAGAGTCTGCGGCCCAGGTGATGTCTGACGTCGTCGTTGGCT
CCCACCTCGACCACGACGCTGTTATGAATTTCGCCGCCGGGTGCGATGCCGTCACCTTCGACCACGAACACGTACCGACG
GTCCTCGTTGAGGAGATGGAAGAGGCCGGGTACGCGGTCCGCCCAGGGGCGGCCGCCATGGTTCACGCGCAAGACAAGGT
CGTCATGCGTGAGTTTATGGAGCGCGAGGGTTTCCCGAATCCTGCGTGGCAGGTTTGCGACACTCCCGAAGACCTCGTCT
CTTTTGGTCATGACCGTGGCTGGCCTGTCATTGCGAAAACCTCCCGTGGCGGTTATGACGGCAAAGGAGTGTTCAAGATC
GACGGCCCCGATGGTGCTGGTGAGCCCTTTGACGCGGCCGGGGATCTGGCCGACGGCAAGCAGCCGATTCGTATTCTCGC
GGAAGAGTTCGTCGATTTCCGACGCGAACTCTCCGCGGTCGTTGTGCGCTCCCCGTCGGGTCAGGGAGCCGCGTACCCGG
TTACCGAAACTATTCAGCGTCACGGGGTATGTGCGGAGACTATCAGCCCGGCCCCTGACCTCTCGTCGGACCGTCAAGTT
GAGCTGCAAACCATGGCGCTCGACATTGCTGGACGCCTCGACGTCATCGGGGTGCTGGCAGTCGAGCTGATGGAGCGTGA
GGACGGATCCGTCGTCGTCAATGAGCTGGCGACCCGTCCTCACAACACTGCCCATTGGACGATCGACGGAGCTGAGACGA
GTCAGTTTGGAAACCACATGCGAGCCGTGCTTAACCTACCCCTCGGTTCACCGGCCCTGATCGCTCCCGTTGTTGTCATG
GCCAACGTCCTCGGTGGGTCCGAAGAGGATTTGACCGGGGCTTTGCAACATTGCTTCGCTCGTGACCCAGAACTTCGCGT
CGAGCTGTACGGCAAGTCCGTGCGGCCCGGTCGCAAGGTCGGTCACGTCACCTGCCTTGGTAACGACATTGAGACGACTC
ATCGTCGGGCCCGCCATGCCGCCGCCTACCTTATGGGAGAACACGATGCCTGA

Upstream 100 bases:

>100_bases
AGTATGGACGATTCGCGCTGCGAGGTGATTGCGGCTGCCGGAGGTGAGTCTGAGTCCTACGCCCGTCACGGTGGGCGTTT
TATGTCCGGTGGTCGTTACG

Downstream 100 bases:

>100_bases
GACCACCACTGCTAGCCGTAAGCCGCGCCGAGGTGAGAAGGTCAAAACAACCACCGGGGGAGCACGCCGGCTGGCGTGCG
ACGCCAATGGCCCTCAAGTG

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MNVVTSYTIGIIGGGQLARMMHQAAIGLGVRTRLLASDPEESAAQVMSDVVVGSHLDHDAVMNFAAGCDAVTFDHEHVPT
VLVEEMEEAGYAVRPGAAAMVHAQDKVVMREFMEREGFPNPAWQVCDTPEDLVSFGHDRGWPVIAKTSRGGYDGKGVFKI
DGPDGAGEPFDAAGDLADGKQPIRILAEEFVDFRRELSAVVVRSPSGQGAAYPVTETIQRHGVCAETISPAPDLSSDRQV
ELQTMALDIAGRLDVIGVLAVELMEREDGSVVVNELATRPHNTAHWTIDGAETSQFGNHMRAVLNLPLGSPALIAPVVVM
ANVLGGSEEDLTGALQHCFARDPELRVELYGKSVRPGRKVGHVTCLGNDIETTHRRARHAAAYLMGEHDA

Sequences:

>Translated_390_residues
MNVVTSYTIGIIGGGQLARMMHQAAIGLGVRTRLLASDPEESAAQVMSDVVVGSHLDHDAVMNFAAGCDAVTFDHEHVPT
VLVEEMEEAGYAVRPGAAAMVHAQDKVVMREFMEREGFPNPAWQVCDTPEDLVSFGHDRGWPVIAKTSRGGYDGKGVFKI
DGPDGAGEPFDAAGDLADGKQPIRILAEEFVDFRRELSAVVVRSPSGQGAAYPVTETIQRHGVCAETISPAPDLSSDRQV
ELQTMALDIAGRLDVIGVLAVELMEREDGSVVVNELATRPHNTAHWTIDGAETSQFGNHMRAVLNLPLGSPALIAPVVVM
ANVLGGSEEDLTGALQHCFARDPELRVELYGKSVRPGRKVGHVTCLGNDIETTHRRARHAAAYLMGEHDA
>Mature_390_residues
MNVVTSYTIGIIGGGQLARMMHQAAIGLGVRTRLLASDPEESAAQVMSDVVVGSHLDHDAVMNFAAGCDAVTFDHEHVPT
VLVEEMEEAGYAVRPGAAAMVHAQDKVVMREFMEREGFPNPAWQVCDTPEDLVSFGHDRGWPVIAKTSRGGYDGKGVFKI
DGPDGAGEPFDAAGDLADGKQPIRILAEEFVDFRRELSAVVVRSPSGQGAAYPVTETIQRHGVCAETISPAPDLSSDRQV
ELQTMALDIAGRLDVIGVLAVELMEREDGSVVVNELATRPHNTAHWTIDGAETSQFGNHMRAVLNLPLGSPALIAPVVVM
ANVLGGSEEDLTGALQHCFARDPELRVELYGKSVRPGRKVGHVTCLGNDIETTHRRARHAAAYLMGEHDA

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=362, Percent_Identity=26.5193370165746, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788155, Length=319, Percent_Identity=25.3918495297806, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324702, Length=401, Percent_Identity=32.1695760598504, Blast_Score=190, Evalue=4e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 41824; Mature: 41824

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVVTSYTIGIIGGGQLARMMHQAAIGLGVRTRLLASDPEESAAQVMSDVVVGSHLDHDA
CCCEEEEEEEEECCHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHH
VMNFAAGCDAVTFDHEHVPTVLVEEMEEAGYAVRPGAAAMVHAQDKVVMREFMEREGFPN
HHHHHCCCCEEEECCCCCHHHHHHHHHHCCCEECCCCEEEEECHHHHHHHHHHHHCCCCC
PAWQVCDTPEDLVSFGHDRGWPVIAKTSRGGYDGKGVFKIDGPDGAGEPFDAAGDLADGK
CCCCCCCCHHHHHHCCCCCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCC
QPIRILAEEFVDFRRELSAVVVRSPSGQGAAYPVTETIQRHGVCAETISPAPDLSSDRQV
HHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCHHHHHHHCCCCHHHCCCCCCCCCCCCE
ELQTMALDIAGRLDVIGVLAVELMEREDGSVVVNELATRPHNTAHWTIDGAETSQFGNHM
EEEEEEEHHHCCHHHHHHHHHHHHHCCCCCEEHHHHHCCCCCCEEEEECCCHHHHHHHHH
RAVLNLPLGSPALIAPVVVMANVLGGSEEDLTGALQHCFARDPELRVELYGKSVRPGRKV
HHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCC
GHVTCLGNDIETTHRRARHAAAYLMGEHDA
CEEEEECCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNVVTSYTIGIIGGGQLARMMHQAAIGLGVRTRLLASDPEESAAQVMSDVVVGSHLDHDA
CCCEEEEEEEEECCHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHH
VMNFAAGCDAVTFDHEHVPTVLVEEMEEAGYAVRPGAAAMVHAQDKVVMREFMEREGFPN
HHHHHCCCCEEEECCCCCHHHHHHHHHHCCCEECCCCEEEEECHHHHHHHHHHHHCCCCC
PAWQVCDTPEDLVSFGHDRGWPVIAKTSRGGYDGKGVFKIDGPDGAGEPFDAAGDLADGK
CCCCCCCCHHHHHHCCCCCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCC
QPIRILAEEFVDFRRELSAVVVRSPSGQGAAYPVTETIQRHGVCAETISPAPDLSSDRQV
HHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCHHHHHHHCCCCHHHCCCCCCCCCCCCE
ELQTMALDIAGRLDVIGVLAVELMEREDGSVVVNELATRPHNTAHWTIDGAETSQFGNHM
EEEEEEEHHHCCHHHHHHHHHHHHHCCCCCEEHHHHHCCCCCCEEEEECCCHHHHHHHHH
RAVLNLPLGSPALIAPVVVMANVLGGSEEDLTGALQHCFARDPELRVELYGKSVRPGRKV
HHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCC
GHVTCLGNDIETTHRRARHAAAYLMGEHDA
CEEEEECCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]