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The map label for this gene is cycA [H]

Identifier: 50843111

GI number: 50843111

Start: 1790038

End: 1791465

Strand: Direct

Name: cycA [H]

Synonym: PPA1643

Alternate gene names: 50843111

Gene position: 1790038-1791465 (Clockwise)

Preceding gene: 50843110

Following gene: 50843112

Centisome position: 69.92

GC content: 57.91

Gene sequence:

>1428_bases
ATGCTCCCCATGACCGTGAAGAATCAGCATTCCGCCGCTGAAGAGCAACACCTCCGGCGAAGCCTCAGCAATAGGCACAT
CCAACTTATTGCCATTAGCGGCGCCATAGGTACCGGCCTGTTTATGGGCTCCGGCAAATCCATCAGCACTGCCGGTCCGA
GCATCGTGGTGGCCTACCTCGTTATCGGCGCAATGCTCTTCTTCGTCATGCGTGCCATGGGCGAGTTGTTGCTGCACAAC
CTGCAATGGAAGTCTTTTCAGGATTTTGCCGCTGACCTCCTCGGCCCGTGGGCAGGATTCTTTCTGGGATGGACGTATTG
GTTGTGCTGGGTCGTCACAGGCATGGCCGACGTCATCGCCATCACCTCGTATTGGAGTTTCTGGACTCACGACCGCGCTT
GGGCCTTCATCCTCACCGCGACGACGCTTCTCCTGCTCCTCGCCCTCAACCTCTTAACGGTAAAACTTTTCGGCGAGCTG
GAGTTCTGGTTTGCCCTTATCAAGATCGTCGCGATCCTCACCCTCATTGCGGTGGCAATTGTGCTCATCGTCATGGGATT
TACCTCAGCCAGCGGATATAAGGCGTCGGTGTCGAATCTGTGGTCCTACGGTGGCTTCGCTCCACGTGGCTGGAGCGGAT
TCTTCGGCGGCTTCCAGATCGCAGTCTTTGCCTACGTCGGTATTGAGCTGGTCGGCACCACCTCTGCTGAGACCGCCAAT
CCCCCAAAGACGATGCCTAAGGCCATCAACGCTGTGCCGGTCCGTGTTCTCGTGTTCTATGTGGCAGCTCTACTCGCCAT
GATGTGCGTTACCCCATGGAATCTCATCCAGACCGATTCCTCCCCCTTCGTGCAAATGTTCGGGCTCATTGGATTTACCG
CAGCCGCTGGCATCATGAACTTCGTCGTCCTCACCTCAGCGGCCTCGAGCGCCAACTCAGGCGTCTACTCAACGTCTCGC
ATGCTCTACGGCCTAGCCCACAAGGGCATGGCGCCCCGCGCGTTCGGCAAGCTATCCCGCCACGGTGTCCCCGGCTGGGG
ACTGTTCTGCACCATCATCCTCATCGGATCGGCCCTCATCCTCGCCGCGAAAGACTCGGTCATGGGAGCATTCACACTCG
TTACGACGGTGTCGGCGGTGCTGTTCGTCTTCGTATGGAGCATGATCCTCATCAGCCATATCGTCCACGTACGACGCAAC
CCTCAAGCTCATGCCAAGTCGATCTATCCGATGCCCGGCGCCAGTTTCATGCCGTGGGTCGTACTCGCTTTCTTCGTCTT
TGTCATTGTCCTTCTCACTGGAGCTGACGACACACTTCAAGCCTTGCTTGCTGCTCCTATCTGGTTCGTCGTGTTGGGGA
TCGTGTGGGCAATCGTTCGGCGCCGCTCCCACCATGACGACCTCGAGACCGACCTGCCAGCCGACTAG

Upstream 100 bases:

>100_bases
GCACGACGCTTTACCCAACATCGTCCAAAAATGGCCAGAGGGCGTCCACGATGTGGAACATGAGATTGTTGACCATTCTC
AACCCCTTCGGCGGGACACA

Downstream 100 bases:

>100_bases
ACCCCCAACTCCAGCCGCTACAGTAAGTACGGTCGAATCCGGTCATTGCGGGGGTAAATCATGTCCGACGAGGGCGTCAT
GGGCAAATCGACGACGAAGC

Product: D-serine/D-alanine/glycine transporter

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MLPMTVKNQHSAAEEQHLRRSLSNRHIQLIAISGAIGTGLFMGSGKSISTAGPSIVVAYLVIGAMLFFVMRAMGELLLHN
LQWKSFQDFAADLLGPWAGFFLGWTYWLCWVVTGMADVIAITSYWSFWTHDRAWAFILTATTLLLLLALNLLTVKLFGEL
EFWFALIKIVAILTLIAVAIVLIVMGFTSASGYKASVSNLWSYGGFAPRGWSGFFGGFQIAVFAYVGIELVGTTSAETAN
PPKTMPKAINAVPVRVLVFYVAALLAMMCVTPWNLIQTDSSPFVQMFGLIGFTAAAGIMNFVVLTSAASSANSGVYSTSR
MLYGLAHKGMAPRAFGKLSRHGVPGWGLFCTIILIGSALILAAKDSVMGAFTLVTTVSAVLFVFVWSMILISHIVHVRRN
PQAHAKSIYPMPGASFMPWVVLAFFVFVIVLLTGADDTLQALLAAPIWFVVLGIVWAIVRRRSHHDDLETDLPAD

Sequences:

>Translated_475_residues
MLPMTVKNQHSAAEEQHLRRSLSNRHIQLIAISGAIGTGLFMGSGKSISTAGPSIVVAYLVIGAMLFFVMRAMGELLLHN
LQWKSFQDFAADLLGPWAGFFLGWTYWLCWVVTGMADVIAITSYWSFWTHDRAWAFILTATTLLLLLALNLLTVKLFGEL
EFWFALIKIVAILTLIAVAIVLIVMGFTSASGYKASVSNLWSYGGFAPRGWSGFFGGFQIAVFAYVGIELVGTTSAETAN
PPKTMPKAINAVPVRVLVFYVAALLAMMCVTPWNLIQTDSSPFVQMFGLIGFTAAAGIMNFVVLTSAASSANSGVYSTSR
MLYGLAHKGMAPRAFGKLSRHGVPGWGLFCTIILIGSALILAAKDSVMGAFTLVTTVSAVLFVFVWSMILISHIVHVRRN
PQAHAKSIYPMPGASFMPWVVLAFFVFVIVLLTGADDTLQALLAAPIWFVVLGIVWAIVRRRSHHDDLETDLPAD
>Mature_475_residues
MLPMTVKNQHSAAEEQHLRRSLSNRHIQLIAISGAIGTGLFMGSGKSISTAGPSIVVAYLVIGAMLFFVMRAMGELLLHN
LQWKSFQDFAADLLGPWAGFFLGWTYWLCWVVTGMADVIAITSYWSFWTHDRAWAFILTATTLLLLLALNLLTVKLFGEL
EFWFALIKIVAILTLIAVAIVLIVMGFTSASGYKASVSNLWSYGGFAPRGWSGFFGGFQIAVFAYVGIELVGTTSAETAN
PPKTMPKAINAVPVRVLVFYVAALLAMMCVTPWNLIQTDSSPFVQMFGLIGFTAAAGIMNFVVLTSAASSANSGVYSTSR
MLYGLAHKGMAPRAFGKLSRHGVPGWGLFCTIILIGSALILAAKDSVMGAFTLVTTVSAVLFVFVWSMILISHIVHVRRN
PQAHAKSIYPMPGASFMPWVVLAFFVFVIVLLTGADDTLQALLAAPIWFVVLGIVWAIVRRRSHHDDLETDLPAD

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=348, Percent_Identity=22.9885057471264, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI110347453, Length=366, Percent_Identity=24.8633879781421, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI114326544, Length=375, Percent_Identity=22.6666666666667, Blast_Score=65, Evalue=1e-10,
Organism=Homo sapiens, GI114326550, Length=375, Percent_Identity=22.6666666666667, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI1790653, Length=464, Percent_Identity=60.3448275862069, Blast_Score=575, Evalue=1e-165,
Organism=Escherichia coli, GI1786789, Length=466, Percent_Identity=37.3390557939914, Blast_Score=311, Evalue=7e-86,
Organism=Escherichia coli, GI1786602, Length=457, Percent_Identity=40.0437636761488, Blast_Score=306, Evalue=1e-84,
Organism=Escherichia coli, GI1786302, Length=451, Percent_Identity=37.4722838137472, Blast_Score=301, Evalue=6e-83,
Organism=Escherichia coli, GI48994972, Length=469, Percent_Identity=38.592750533049, Blast_Score=292, Evalue=3e-80,
Organism=Escherichia coli, GI87081915, Length=469, Percent_Identity=35.6076759061834, Blast_Score=259, Evalue=4e-70,
Organism=Escherichia coli, GI1788480, Length=452, Percent_Identity=35.3982300884956, Blast_Score=231, Evalue=7e-62,
Organism=Escherichia coli, GI1789017, Length=433, Percent_Identity=31.4087759815243, Blast_Score=201, Evalue=8e-53,
Organism=Escherichia coli, GI87081708, Length=445, Percent_Identity=31.2359550561798, Blast_Score=198, Evalue=5e-52,
Organism=Escherichia coli, GI87081869, Length=386, Percent_Identity=23.3160621761658, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=349, Percent_Identity=22.9226361031519, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6324061, Length=448, Percent_Identity=32.8125, Blast_Score=209, Evalue=7e-55,
Organism=Saccharomyces cerevisiae, GI6320772, Length=405, Percent_Identity=31.358024691358, Blast_Score=183, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6324990, Length=448, Percent_Identity=29.9107142857143, Blast_Score=173, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6324059, Length=449, Percent_Identity=31.8485523385301, Blast_Score=169, Evalue=9e-43,
Organism=Saccharomyces cerevisiae, GI6321629, Length=427, Percent_Identity=29.5081967213115, Blast_Score=165, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6324924, Length=363, Percent_Identity=32.5068870523416, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6324553, Length=405, Percent_Identity=30.3703703703704, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6322892, Length=413, Percent_Identity=29.2978208232446, Blast_Score=157, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6320717, Length=413, Percent_Identity=26.1501210653753, Blast_Score=150, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6319543, Length=405, Percent_Identity=27.4074074074074, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6319608, Length=347, Percent_Identity=28.5302593659942, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6322967, Length=410, Percent_Identity=29.0243902439024, Blast_Score=139, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6320251, Length=415, Percent_Identity=27.2289156626506, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6319824, Length=424, Percent_Identity=25.4716981132075, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6319542, Length=415, Percent_Identity=25.3012048192771, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6321053, Length=418, Percent_Identity=26.0765550239234, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6324981, Length=440, Percent_Identity=27.9545454545455, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320364, Length=502, Percent_Identity=25.0996015936255, Blast_Score=103, Evalue=5e-23,
Organism=Drosophila melanogaster, GI161077963, Length=429, Percent_Identity=23.3100233100233, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24666159, Length=425, Percent_Identity=21.1764705882353, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI221512776, Length=425, Percent_Identity=21.1764705882353, Blast_Score=76, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51658; Mature: 51658

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPMTVKNQHSAAEEQHLRRSLSNRHIQLIAISGAIGTGLFMGSGKSISTAGPSIVVAYL
CCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCHHHCEEECCCCCCCCCCHHHHHHHH
VIGAMLFFVMRAMGELLLHNLQWKSFQDFAADLLGPWAGFFLGWTYWLCWVVTGMADVIA
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITSYWSFWTHDRAWAFILTATTLLLLLALNLLTVKLFGELEFWFALIKIVAILTLIAVAI
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLIVMGFTSASGYKASVSNLWSYGGFAPRGWSGFFGGFQIAVFAYVGIELVGTTSAETAN
HHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCCCCC
PPKTMPKAINAVPVRVLVFYVAALLAMMCVTPWNLIQTDSSPFVQMFGLIGFTAAAGIMN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHHHHHHH
FVVLTSAASSANSGVYSTSRMLYGLAHKGMAPRAFGKLSRHGVPGWGLFCTIILIGSALI
HHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LAAKDSVMGAFTLVTTVSAVLFVFVWSMILISHIVHVRRNPQAHAKSIYPMPGASFMPWV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCHHHHH
VLAFFVFVIVLLTGADDTLQALLAAPIWFVVLGIVWAIVRRRSHHDDLETDLPAD
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MLPMTVKNQHSAAEEQHLRRSLSNRHIQLIAISGAIGTGLFMGSGKSISTAGPSIVVAYL
CCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCHHHCEEECCCCCCCCCCHHHHHHHH
VIGAMLFFVMRAMGELLLHNLQWKSFQDFAADLLGPWAGFFLGWTYWLCWVVTGMADVIA
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITSYWSFWTHDRAWAFILTATTLLLLLALNLLTVKLFGELEFWFALIKIVAILTLIAVAI
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLIVMGFTSASGYKASVSNLWSYGGFAPRGWSGFFGGFQIAVFAYVGIELVGTTSAETAN
HHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCCCCC
PPKTMPKAINAVPVRVLVFYVAALLAMMCVTPWNLIQTDSSPFVQMFGLIGFTAAAGIMN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHHHHHHH
FVVLTSAASSANSGVYSTSRMLYGLAHKGMAPRAFGKLSRHGVPGWGLFCTIILIGSALI
HHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LAAKDSVMGAFTLVTTVSAVLFVFVWSMILISHIVHVRRNPQAHAKSIYPMPGASFMPWV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCHHHHH
VLAFFVFVIVLLTGADDTLQALLAAPIWFVVLGIVWAIVRRRSHHDDLETDLPAD
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]