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Identifier: 50843110

GI number: 50843110

Start: 1789012

End: 1789620

Strand: Direct

Name: orn

Synonym: PPA1642

Alternate gene names: 50843110

Gene position: 1789012-1789620 (Clockwise)

Preceding gene: 50843109

Following gene: 50843111

Centisome position: 69.88

GC content: 60.92

Gene sequence:

>609_bases
ATGCTGGTGTGGATCGATTGCGAGATGACCGGGCTCGACCTGGCCCACGACGGGCTCATCGAGGTGGCCGCACTGGTCAC
CGATGGACAGCTCAACGTTCAAGGTGAGGGGGTGGACGTCATCATCAAGCCCGAGCCCCAGTGGCTCGATCACATGAATG
ATTTCGTGCGCAACATGCACACCACATCCGGCCTTCTTGCGGAGCTCGACAAGGGACTGACGATGGCGCAGGCCCAGGAT
CAGGTGCTCGACTACATCCGTACCTACGTCCCACAGGCTGGTAAGGCGCCGTTAGCTGGCAACACCATAGGCACCGACCG
CTCCTTCCTGGCCAAGGACATGCCTAAACTCGAGTCCTACGTGCACTACCGCAACGTCGACGTCTCCTCCATCAAGGAAC
TGGCACGACGCTGGTACCCGCGCGCATTCGGACACTCCCCGGAGAAGCAGGGCAACCACCGAGCGCTCGCTGACATCCAG
GAGTCCATTGAGGAGCTCATGTACTGGCGCGAGGTCCTTATGGTTCCTTCCCCTGGGCCGGAAACCACGCGTTGTGATGA
GATCGCGGCCAAGTATCAGGGCTTCCTCACCGGGGCTGGGAGAGACTGA

Upstream 100 bases:

>100_bases
CTGGATGGGGCGCTGGGTGCCGCACGGCAAACGCTAATTGACGCCGTCCTCGCCCACCCGCTGTCCTAACTACCGACTAG
GCTGTGATGCCGTGAAAGAC

Downstream 100 bases:

>100_bases
CGCCGGCGGGCGAGAAAGTCAAAGTTGCATTTCTGTTTCAGAAACAGATACCCTTCACGGGTTGCCTGAGAGAGGCACGT
GGTGGCTATAGCTCAGTCGG

Product: oligoribonuclease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MLVWIDCEMTGLDLAHDGLIEVAALVTDGQLNVQGEGVDVIIKPEPQWLDHMNDFVRNMHTTSGLLAELDKGLTMAQAQD
QVLDYIRTYVPQAGKAPLAGNTIGTDRSFLAKDMPKLESYVHYRNVDVSSIKELARRWYPRAFGHSPEKQGNHRALADIQ
ESIEELMYWREVLMVPSPGPETTRCDEIAAKYQGFLTGAGRD

Sequences:

>Translated_202_residues
MLVWIDCEMTGLDLAHDGLIEVAALVTDGQLNVQGEGVDVIIKPEPQWLDHMNDFVRNMHTTSGLLAELDKGLTMAQAQD
QVLDYIRTYVPQAGKAPLAGNTIGTDRSFLAKDMPKLESYVHYRNVDVSSIKELARRWYPRAFGHSPEKQGNHRALADIQ
ESIEELMYWREVLMVPSPGPETTRCDEIAAKYQGFLTGAGRD
>Mature_202_residues
MLVWIDCEMTGLDLAHDGLIEVAALVTDGQLNVQGEGVDVIIKPEPQWLDHMNDFVRNMHTTSGLLAELDKGLTMAQAQD
QVLDYIRTYVPQAGKAPLAGNTIGTDRSFLAKDMPKLESYVHYRNVDVSSIKELARRWYPRAFGHSPEKQGNHRALADIQ
ESIEELMYWREVLMVPSPGPETTRCDEIAAKYQGFLTGAGRD

Specific function: 3'-to-5' exoribonuclease specific for small oligoribonucleotides

COG id: COG1949

COG function: function code A; Oligoribonuclease (3'->5' exoribonuclease)

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain

Homologues:

Organism=Homo sapiens, GI224496106, Length=170, Percent_Identity=45.2941176470588, Blast_Score=163, Evalue=1e-40,
Organism=Escherichia coli, GI87082382, Length=172, Percent_Identity=48.2558139534884, Blast_Score=156, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17557752, Length=179, Percent_Identity=44.1340782122905, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6323088, Length=190, Percent_Identity=38.9473684210526, Blast_Score=138, Evalue=7e-34,
Organism=Drosophila melanogaster, GI21355135, Length=174, Percent_Identity=42.5287356321839, Blast_Score=150, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ORN_PROAC (Q6A786)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_056337.1
- ProteinModelPortal:   Q6A786
- SMR:   Q6A786
- GeneID:   2931064
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA1642
- NMPDR:   fig|267747.1.peg.1614
- HOGENOM:   HBG448545
- OMA:   ARRWYPR
- ProtClustDB:   PRK05359
- BioCyc:   PACN267747:PPA1642-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00045
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR022894
- InterPro:   IPR012337
- SMART:   SM00479

Pfam domain/function: PF00929 Exonuc_X-T; SSF53098 RNaseH_fold

EC number: 3.1.-.- [C]

Molecular weight: Translated: 22615; Mature: 22615

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: ACT_SITE 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVWIDCEMTGLDLAHDGLIEVAALVTDGQLNVQGEGVDVIIKPEPQWLDHMNDFVRNMH
CEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEECCCEEEEECCCCHHHHHHHHHHHHHH
TTSGLLAELDKGLTMAQAQDQVLDYIRTYVPQAGKAPLAGNTIGTDRSFLAKDMPKLESY
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
VHYRNVDVSSIKELARRWYPRAFGHSPEKQGNHRALADIQESIEELMYWREVLMVPSPGP
HHHCCCCHHHHHHHHHHHCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
ETTRCDEIAAKYQGFLTGAGRD
CCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLVWIDCEMTGLDLAHDGLIEVAALVTDGQLNVQGEGVDVIIKPEPQWLDHMNDFVRNMH
CEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEECCCEEEEECCCCHHHHHHHHHHHHHH
TTSGLLAELDKGLTMAQAQDQVLDYIRTYVPQAGKAPLAGNTIGTDRSFLAKDMPKLESY
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
VHYRNVDVSSIKELARRWYPRAFGHSPEKQGNHRALADIQESIEELMYWREVLMVPSPGP
HHHCCCCHHHHHHHHHHHCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
ETTRCDEIAAKYQGFLTGAGRD
CCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA