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The map label for this gene is clpP2

Identifier: 50843047

GI number: 50843047

Start: 1700160

End: 1700798

Strand: Reverse

Name: clpP2

Synonym: PPA1573

Alternate gene names: 50843047

Gene position: 1700798-1700160 (Counterclockwise)

Preceding gene: 50843048

Following gene: 50843046

Centisome position: 66.43

GC content: 58.69

Gene sequence:

>639_bases
GTGAGTCACAATACTTCGATCGCTTCCCAGGGCATGCCCGCCATGGCCGGCCCCGAGACCGGCGGTGCCGGGATGACCGA
CAACGTCTACCAGTCGCTGCTGCGCAACCGCATTGTCTTCCTTGGTTCCGAGGTTAAAGACGAGAATGCGAATGCGTTAT
GCGCCCAGATGTTGCTACTCAACGCCGAGGATCCCGAGGCCGATATTTACCTCTACATCAACTCTCCAGGTGGCTCGGTC
ACCGGGGGAATGGCGATCTATGACACTATGCAGTGGATCTCTAATGATGTTGCGACCGTGACGATGGGCATGGCAGCGTC
CATGGGCCAGTTCTTGCTGACCGCTGGCACACCCGGTAAGAGGTACGCCCTGCCGCACGCCAAGATCCTCATGCACCAGC
CGCTCGGCGGAGTTGGTGGTACTGCTACTGAGATCGCCATTAACGCCAAGATGCTCAAGGACACCAAACGTGAGTTGTCT
CAGCTCAACGCCGACCACTCTGGCCACACCCTTGAGCAGATCCTTGAGGACTCCGACCGGGACCACTGGTTTACCGCTCA
GGAGGCTCTCGAATATGGGCTCATTGACCACGTCTACAGCAATGCGTCGCAGCTTCGCGGCGACGCCCCCAATCAGTGA

Upstream 100 bases:

>100_bases
GCTTGAGGACAACCCCGATGAGTAGCATGCCGGTGGTGTTCGGACGCGCTGACCGCGAAAGGCTCTGGAACTGTCGTGCC
CACAGGGTAGATTCAGGACC

Downstream 100 bases:

>100_bases
GGTGACCATGGGATTCAACGCCTTTGACAAGAATCGGTTGGCCGCCTTGAACGCTGAGCAGGCCGAACAGGCTGCTCCCG
GCGGGCTAGCCCCGGCAGGT

Product: ATP-dependent Clp protease proteolytic subunit 1

Products: NA

Alternate protein names: Endopeptidase Clp 2

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MSHNTSIASQGMPAMAGPETGGAGMTDNVYQSLLRNRIVFLGSEVKDENANALCAQMLLLNAEDPEADIYLYINSPGGSV
TGGMAIYDTMQWISNDVATVTMGMAASMGQFLLTAGTPGKRYALPHAKILMHQPLGGVGGTATEIAINAKMLKDTKRELS
QLNADHSGHTLEQILEDSDRDHWFTAQEALEYGLIDHVYSNASQLRGDAPNQ

Sequences:

>Translated_212_residues
MSHNTSIASQGMPAMAGPETGGAGMTDNVYQSLLRNRIVFLGSEVKDENANALCAQMLLLNAEDPEADIYLYINSPGGSV
TGGMAIYDTMQWISNDVATVTMGMAASMGQFLLTAGTPGKRYALPHAKILMHQPLGGVGGTATEIAINAKMLKDTKRELS
QLNADHSGHTLEQILEDSDRDHWFTAQEALEYGLIDHVYSNASQLRGDAPNQ
>Mature_211_residues
SHNTSIASQGMPAMAGPETGGAGMTDNVYQSLLRNRIVFLGSEVKDENANALCAQMLLLNAEDPEADIYLYINSPGGSVT
GGMAIYDTMQWISNDVATVTMGMAASMGQFLLTAGTPGKRYALPHAKILMHQPLGGVGGTATEIAINAKMLKDTKRELSQ
LNADHSGHTLEQILEDSDRDHWFTAQEALEYGLIDHVYSNASQLRGDAPNQ

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=209, Percent_Identity=40.6698564593301, Blast_Score=168, Evalue=3e-42,
Organism=Escherichia coli, GI1786641, Length=174, Percent_Identity=53.448275862069, Blast_Score=209, Evalue=9e-56,
Organism=Caenorhabditis elegans, GI17538017, Length=198, Percent_Identity=43.9393939393939, Blast_Score=170, Evalue=4e-43,
Organism=Drosophila melanogaster, GI20129427, Length=193, Percent_Identity=41.9689119170984, Blast_Score=168, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP2_PROAC (Q6A7E9)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_056274.1
- ProteinModelPortal:   Q6A7E9
- SMR:   Q6A7E9
- MEROPS:   S14.008
- GeneID:   2931815
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA1573
- NMPDR:   fig|267747.1.peg.1551
- HOGENOM:   HBG558421
- OMA:   ADIYLYI
- ProtClustDB:   CLSK2764059
- BioCyc:   PACN267747:PPA1573-MONOMER
- BRENDA:   3.4.21.92
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 22743; Mature: 22612

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 107-107 ACT_SITE 132-132

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHNTSIASQGMPAMAGPETGGAGMTDNVYQSLLRNRIVFLGSEVKDENANALCAQMLLL
CCCCCCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHH
NAEDPEADIYLYINSPGGSVTGGMAIYDTMQWISNDVATVTMGMAASMGQFLLTAGTPGK
CCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCEEEECCCCCC
RYALPHAKILMHQPLGGVGGTATEIAINAKMLKDTKRELSQLNADHSGHTLEQILEDSDR
EEECCHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCC
DHWFTAQEALEYGLIDHVYSNASQLRGDAPNQ
CCEEHHHHHHHHHHHHHHHHCHHHHCCCCCCC
>Mature Secondary Structure 
SHNTSIASQGMPAMAGPETGGAGMTDNVYQSLLRNRIVFLGSEVKDENANALCAQMLLL
CCCCCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHH
NAEDPEADIYLYINSPGGSVTGGMAIYDTMQWISNDVATVTMGMAASMGQFLLTAGTPGK
CCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCEEEECCCCCC
RYALPHAKILMHQPLGGVGGTATEIAINAKMLKDTKRELSQLNADHSGHTLEQILEDSDR
EEECCHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCC
DHWFTAQEALEYGLIDHVYSNASQLRGDAPNQ
CCEEHHHHHHHHHHHHHHHHCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA