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The map label for this gene is clpP1 [H]

Identifier: 50843046

GI number: 50843046

Start: 1699463

End: 1700224

Strand: Reverse

Name: clpP1 [H]

Synonym: PPA1572

Alternate gene names: 50843046

Gene position: 1700224-1699463 (Counterclockwise)

Preceding gene: 50843047

Following gene: 50843045

Centisome position: 66.41

GC content: 59.19

Gene sequence:

>762_bases
ATGGGCTCATTGACCACGTCTACAGCAATGCGTCGCAGCTTCGCGGCGACGCCCCCAATCAGTGAGGTGACCATGGGATT
CAACGCCTTTGACAAGAATCGGTTGGCCGCCTTGAACGCTGAGCAGGCCGAACAGGCTGCTCCCGGCGGGCTAGCCCCGG
CAGGTCCGCGCAACGACTACTACATCCCGCAGTGGGAGGAGCGCACCTCTTACGGTGTGCGTCGCGTCGATCCGTACACC
AAGTTGTTCGAGGATCGCATCATCTTCCTTGGCACTCCGGTGACTGACGACATCGCCAACGCCGTGATGGCCCAGCTGCT
GTGTCTGCAGTCGATGGATGCCGATCGTCAGATCAGCATGTACATCAACTCGCCTGGTGGCTCGTTCACAGCTATGACGG
CGATCTACGACACCATGAATTATGTGCGCCCCGACATCCAGACGATTTGTCTGGGTATGGCGGCATCGGCTGCGGCCGTG
TTGCTGGCCGCCGGCGCGAAGGGGCAGCGTTTGTCCTTGCCGAACTCGACCGTCCTCATCCATCAGCCGGCTATGGGCCA
GGCCACGTATGGTCAGGCCACCGATATTGAGATCTTGGACGACGAGATTCAGCGCATCCGCAAGCTCATGGAGAACATGC
TCGCTACTGCGACTGGTCAGAGCGTCGAGCAGATTTCCAAGGACATCGATCGCGACAAGTATCTAACTGCCCAGGGGGCG
AAGGAGTATGGCCTTATCGACGACATTTTGACCTCGCTGTGA

Upstream 100 bases:

>100_bases
TTGTCTCAGCTCAACGCCGACCACTCTGGCCACACCCTTGAGCAGATCCTTGAGGACTCCGACCGGGACCACTGGTTTAC
CGCTCAGGAGGCTCTCGAAT

Downstream 100 bases:

>100_bases
GGTTCGACGCGGTCGTCTGGTGACCCTCGAGGGTTACTGCAGGGTTGGTCGTCGTCACTCGACACGGGTGACGACGACAT
CCGAAATGGATACTGTCCAT

Product: ATP-dependent Clp protease proteolytic subunit 2

Products: NA

Alternate protein names: Endopeptidase Clp 1 [H]

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MGSLTTSTAMRRSFAATPPISEVTMGFNAFDKNRLAALNAEQAEQAAPGGLAPAGPRNDYYIPQWEERTSYGVRRVDPYT
KLFEDRIIFLGTPVTDDIANAVMAQLLCLQSMDADRQISMYINSPGGSFTAMTAIYDTMNYVRPDIQTICLGMAASAAAV
LLAAGAKGQRLSLPNSTVLIHQPAMGQATYGQATDIEILDDEIQRIRKLMENMLATATGQSVEQISKDIDRDKYLTAQGA
KEYGLIDDILTSL

Sequences:

>Translated_253_residues
MGSLTTSTAMRRSFAATPPISEVTMGFNAFDKNRLAALNAEQAEQAAPGGLAPAGPRNDYYIPQWEERTSYGVRRVDPYT
KLFEDRIIFLGTPVTDDIANAVMAQLLCLQSMDADRQISMYINSPGGSFTAMTAIYDTMNYVRPDIQTICLGMAASAAAV
LLAAGAKGQRLSLPNSTVLIHQPAMGQATYGQATDIEILDDEIQRIRKLMENMLATATGQSVEQISKDIDRDKYLTAQGA
KEYGLIDDILTSL
>Mature_252_residues
GSLTTSTAMRRSFAATPPISEVTMGFNAFDKNRLAALNAEQAEQAAPGGLAPAGPRNDYYIPQWEERTSYGVRRVDPYTK
LFEDRIIFLGTPVTDDIANAVMAQLLCLQSMDADRQISMYINSPGGSFTAMTAIYDTMNYVRPDIQTICLGMAASAAAVL
LAAGAKGQRLSLPNSTVLIHQPAMGQATYGQATDIEILDDEIQRIRKLMENMLATATGQSVEQISKDIDRDKYLTAQGAK
EYGLIDDILTSL

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=190, Percent_Identity=46.3157894736842, Blast_Score=170, Evalue=1e-42,
Organism=Escherichia coli, GI1786641, Length=207, Percent_Identity=47.8260869565217, Blast_Score=201, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17538017, Length=190, Percent_Identity=43.6842105263158, Blast_Score=160, Evalue=9e-40,
Organism=Drosophila melanogaster, GI20129427, Length=194, Percent_Identity=46.3917525773196, Blast_Score=175, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 27503; Mature: 27371

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSLTTSTAMRRSFAATPPISEVTMGFNAFDKNRLAALNAEQAEQAAPGGLAPAGPRNDY
CCCCHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCEEECCHHHHHHCCCCCCCCCCCCCCC
YIPQWEERTSYGVRRVDPYTKLFEDRIIFLGTPVTDDIANAVMAQLLCLQSMDADRQISM
CCCCCHHHHHCCCCCCCHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEE
YINSPGGSFTAMTAIYDTMNYVRPDIQTICLGMAASAAAVLLAAGAKGQRLSLPNSTVLI
EEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEE
HQPAMGQATYGQATDIEILDDEIQRIRKLMENMLATATGQSVEQISKDIDRDKYLTAQGA
ECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHEEECCCC
KEYGLIDDILTSL
CCCCHHHHHHHCC
>Mature Secondary Structure 
GSLTTSTAMRRSFAATPPISEVTMGFNAFDKNRLAALNAEQAEQAAPGGLAPAGPRNDY
CCCHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCEEECCHHHHHHCCCCCCCCCCCCCCC
YIPQWEERTSYGVRRVDPYTKLFEDRIIFLGTPVTDDIANAVMAQLLCLQSMDADRQISM
CCCCCHHHHHCCCCCCCHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEE
YINSPGGSFTAMTAIYDTMNYVRPDIQTICLGMAASAAAVLLAAGAKGQRLSLPNSTVLI
EEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEE
HQPAMGQATYGQATDIEILDDEIQRIRKLMENMLATATGQSVEQISKDIDRDKYLTAQGA
ECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHEEECCCC
KEYGLIDDILTSL
CCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA