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The map label for this gene is nedA [H]

Identifier: 50843035

GI number: 50843035

Start: 1679681

End: 1681189

Strand: Reverse

Name: nedA [H]

Synonym: PPA1560

Alternate gene names: 50843035

Gene position: 1681189-1679681 (Counterclockwise)

Preceding gene: 50843036

Following gene: 50843026

Centisome position: 65.66

GC content: 61.1

Gene sequence:

>1509_bases
ATGACTTTGACCACGAAACTGAGCGCGTTGGCCATTGCCGGAATCATGGCCGTCATCGGGGCTCCCATGGTGACGCAGTC
AGCTATGGCATCAGGCAGGGCTCCGGCCCCAGATGCGGCCACCACCCAGCCGAAGCTCGTCACGGGTGATATCACCAGCA
CCGATCAGTCGGGCACTCATCTCTTCTTCGGTAAGAATATCGTCCGGAACGCCAAGGGAGCCATTATGAAAGTCGACCGG
ACATGGCCCGCAGCAGTGCCGGCACCTCTGCCGGATGTTCGTGCTGATTCGAGCACACGGATGCTCCTTGGCCCCGTCGT
GGATTTGGCTGTCAATGAGCATCCGGCAGGTGTTTTTTACCGAATCCCAGCCCTTGCGACCGCTTCGAACGGCGATTTGC
TGGCCTCCTACGATCTGCGTCCGGGGAGCGCCGCCGATGCGCCTAACCCCAATTCCATCGTGCAGCGCCGCTCTCGCGAC
AACGGTAGGACGCGGGGTCCGCAAACCGTCATCCATGCCGGGACCCTGGGTCGCAGGAAGGTGGGATACTCCGATCCTTC
CTATCTCGTCGATCCAGCCACGGGCCACATCCTCAATTTTCACGTGAAGTCCTACGACAGAGGATTCGCCACATCGGAGG
TGGGCACGGACCCGGATGATCGTCATGTTCTGCACGCCGAGGTCTCTACATCGACCGACAATGGACACACTTGGACCTAT
CGAGACATCACGCGCGAGATCACCCCGGATCCCACCACTCGGACACGATTCGTGGCATCAGGGCAGGGCATAGCGTTGCT
CCACGGCCCCCACGCTGGAGGTCTCATTGCCCAGATGACGGTGCGCAACAGTGTCGGCCAACAGGCCCAGTCGATCTATT
CCGATGATCACGGCATCACCTGGCATGCTGGCAACCCGGTGGGCCGAATGATGGACGAGAACAAGGTGGTGGAACTGTCC
GACGGTACCCTCATGCTCAATTCCAGGGACGCAGCCCGTTCCGGTCGGCGCAAAGTGGCCTATTCCCATGACGGTGGCTT
GACCTGGGGGCCGGTGAAGCTGGTCGACGACCTCATCGACCCCACCAACAACGCCCAGATCATTCGGGCTTACCCCAATG
CCCGGGCCGGGTCGGCGAAAGCCAGGATCCTGTTATTCACGAATGCCCGCAATGCCACGGAACGGGTAAACGGTACCCTC
TCGGTCTCCTGCGATGACGGACGGACATGGGTCAGTCATCAGACCTACATGCCCGGGGAAGTCGGATACACCACGGCAGC
GGTGCAGTCTGACGGGGCGTTGGGCGTTCTGTGGGAGCGCGACGGTATTCGGTACTCCACCATTCCGATGGGGTGGTTGA
ATTCCGTGTGCCCGGTGGCTCCTTCCGGGAGGCCGACTTCTGGAGAGCCAACTTCTGGCACATCTCTCCCGCTTACTGCG
ACCCCCTCCGGTTCTCTTCACGGAGGTGCCTCGTCGCGTCCCACTAGTTTGCCGCACACAGGAGACTGA

Upstream 100 bases:

>100_bases
GTGTTATTGGCGGGTTTCCCCGCAGCCCCGTATCGTATCCATTTAGCCTTACCGCAACGGCTAGTAAGGCACGTCAACAC
CACATGCAAAGGAGCATGGC

Downstream 100 bases:

>100_bases
GCGCTGACCGGGGCCGGAGGGCGGCGGGTATCTGGCGGGTCATCTGCACCGGCTACGACCTACCTAGCCGGTCAGGGGGC
CGTCAGTCTTGCAGTTCACG

Product: sialidase precursor

Products: NA

Alternate protein names: Neuraminidase [H]

Number of amino acids: Translated: 502; Mature: 501

Protein sequence:

>502_residues
MTLTTKLSALAIAGIMAVIGAPMVTQSAMASGRAPAPDAATTQPKLVTGDITSTDQSGTHLFFGKNIVRNAKGAIMKVDR
TWPAAVPAPLPDVRADSSTRMLLGPVVDLAVNEHPAGVFYRIPALATASNGDLLASYDLRPGSAADAPNPNSIVQRRSRD
NGRTRGPQTVIHAGTLGRRKVGYSDPSYLVDPATGHILNFHVKSYDRGFATSEVGTDPDDRHVLHAEVSTSTDNGHTWTY
RDITREITPDPTTRTRFVASGQGIALLHGPHAGGLIAQMTVRNSVGQQAQSIYSDDHGITWHAGNPVGRMMDENKVVELS
DGTLMLNSRDAARSGRRKVAYSHDGGLTWGPVKLVDDLIDPTNNAQIIRAYPNARAGSAKARILLFTNARNATERVNGTL
SVSCDDGRTWVSHQTYMPGEVGYTTAAVQSDGALGVLWERDGIRYSTIPMGWLNSVCPVAPSGRPTSGEPTSGTSLPLTA
TPSGSLHGGASSRPTSLPHTGD

Sequences:

>Translated_502_residues
MTLTTKLSALAIAGIMAVIGAPMVTQSAMASGRAPAPDAATTQPKLVTGDITSTDQSGTHLFFGKNIVRNAKGAIMKVDR
TWPAAVPAPLPDVRADSSTRMLLGPVVDLAVNEHPAGVFYRIPALATASNGDLLASYDLRPGSAADAPNPNSIVQRRSRD
NGRTRGPQTVIHAGTLGRRKVGYSDPSYLVDPATGHILNFHVKSYDRGFATSEVGTDPDDRHVLHAEVSTSTDNGHTWTY
RDITREITPDPTTRTRFVASGQGIALLHGPHAGGLIAQMTVRNSVGQQAQSIYSDDHGITWHAGNPVGRMMDENKVVELS
DGTLMLNSRDAARSGRRKVAYSHDGGLTWGPVKLVDDLIDPTNNAQIIRAYPNARAGSAKARILLFTNARNATERVNGTL
SVSCDDGRTWVSHQTYMPGEVGYTTAAVQSDGALGVLWERDGIRYSTIPMGWLNSVCPVAPSGRPTSGEPTSGTSLPLTA
TPSGSLHGGASSRPTSLPHTGD
>Mature_501_residues
TLTTKLSALAIAGIMAVIGAPMVTQSAMASGRAPAPDAATTQPKLVTGDITSTDQSGTHLFFGKNIVRNAKGAIMKVDRT
WPAAVPAPLPDVRADSSTRMLLGPVVDLAVNEHPAGVFYRIPALATASNGDLLASYDLRPGSAADAPNPNSIVQRRSRDN
GRTRGPQTVIHAGTLGRRKVGYSDPSYLVDPATGHILNFHVKSYDRGFATSEVGTDPDDRHVLHAEVSTSTDNGHTWTYR
DITREITPDPTTRTRFVASGQGIALLHGPHAGGLIAQMTVRNSVGQQAQSIYSDDHGITWHAGNPVGRMMDENKVVELSD
GTLMLNSRDAARSGRRKVAYSHDGGLTWGPVKLVDDLIDPTNNAQIIRAYPNARAGSAKARILLFTNARNATERVNGTLS
VSCDDGRTWVSHQTYMPGEVGYTTAAVQSDGALGVLWERDGIRYSTIPMGWLNSVCPVAPSGRPTSGEPTSGTSLPLTAT
PSGSLHGGASSRPTSLPHTGD

Specific function: To release sialic acids for use as carbon and energy sources for this non-pathogenic bacterium while in pathogenic microorganisms, sialidases have been suggested to be pathogenic factors [H]

COG id: COG4409

COG function: function code G; Neuraminidase (sialidase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 F5/8 type C domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018905
- InterPro:   IPR002860
- InterPro:   IPR000421
- InterPro:   IPR008979
- InterPro:   IPR013783
- InterPro:   IPR014756
- InterPro:   IPR011040
- InterPro:   IPR006311 [H]

Pfam domain/function: PF02012 BNR; PF00754 F5_F8_type_C; PF10633 NPCBM_assoc [H]

EC number: =3.2.1.18 [H]

Molecular weight: Translated: 53131; Mature: 53000

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLTTKLSALAIAGIMAVIGAPMVTQSAMASGRAPAPDAATTQPKLVTGDITSTDQSGTH
CCEEHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCE
LFFGKNIVRNAKGAIMKVDRTWPAAVPAPLPDVRADSSTRMLLGPVVDLAVNEHPAGVFY
EEECCHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEECCCCCCEEE
RIPALATASNGDLLASYDLRPGSAADAPNPNSIVQRRSRDNGRTRGPQTVIHAGTLGRRK
ECCEEEECCCCCEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCCC
VGYSDPSYLVDPATGHILNFHVKSYDRGFATSEVGTDPDDRHVLHAEVSTSTDNGHTWTY
CCCCCCCEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCEEEE
RDITREITPDPTTRTRFVASGQGIALLHGPHAGGLIAQMTVRNSVGQQAQSIYSDDHGIT
HHHHHCCCCCCCCCEEEEECCCCEEEEECCCCCCEEEEEEHHHHHHHHHHHHHCCCCCEE
WHAGNPVGRMMDENKVVELSDGTLMLNSRDAARSGRRKVAYSHDGGLTWGPVKLVDDLID
EECCCCHHHHCCCCCEEEEECCEEEEECCHHHHCCCEEEEEECCCCCEECHHHHHHHHHC
PTNNAQIIRAYPNARAGSAKARILLFTNARNATERVNGTLSVSCDDGRTWVSHQTYMPGE
CCCCCEEEEECCCCCCCCCCEEEEEEECCCCCHHHCCCEEEEEECCCCEEECCCCCCCCC
VGYTTAAVQSDGALGVLWERDGIRYSTIPMGWLNSVCPVAPSGRPTSGEPTSGTSLPLTA
CCCEEEEEECCCCEEEEECCCCCEEEEECCHHHHCCCCCCCCCCCCCCCCCCCCCEEEEE
TPSGSLHGGASSRPTSLPHTGD
CCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TLTTKLSALAIAGIMAVIGAPMVTQSAMASGRAPAPDAATTQPKLVTGDITSTDQSGTH
CEEHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCE
LFFGKNIVRNAKGAIMKVDRTWPAAVPAPLPDVRADSSTRMLLGPVVDLAVNEHPAGVFY
EEECCHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEECCCCCCEEE
RIPALATASNGDLLASYDLRPGSAADAPNPNSIVQRRSRDNGRTRGPQTVIHAGTLGRRK
ECCEEEECCCCCEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCCC
VGYSDPSYLVDPATGHILNFHVKSYDRGFATSEVGTDPDDRHVLHAEVSTSTDNGHTWTY
CCCCCCCEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCEEEE
RDITREITPDPTTRTRFVASGQGIALLHGPHAGGLIAQMTVRNSVGQQAQSIYSDDHGIT
HHHHHCCCCCCCCCEEEEECCCCEEEEECCCCCCEEEEEEHHHHHHHHHHHHHCCCCCEE
WHAGNPVGRMMDENKVVELSDGTLMLNSRDAARSGRRKVAYSHDGGLTWGPVKLVDDLID
EECCCCHHHHCCCCCEEEEECCEEEEECCHHHHCCCEEEEEECCCCCEECHHHHHHHHHC
PTNNAQIIRAYPNARAGSAKARILLFTNARNATERVNGTLSVSCDDGRTWVSHQTYMPGE
CCCCCEEEEECCCCCCCCCCEEEEEEECCCCCHHHCCCEEEEEECCCCEEECCCCCCCCC
VGYTTAAVQSDGALGVLWERDGIRYSTIPMGWLNSVCPVAPSGRPTSGEPTSGTSLPLTA
CCCEEEEEECCCCEEEEECCCCCEEEEECCHHHHCCCCCCCCCCCCCCCCCCCCCEEEEE
TPSGSLHGGASSRPTSLPHTGD
CCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1400240; 8591030 [H]