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The map label for this gene is pyrH

Identifier: 50842997

GI number: 50842997

Start: 1641358

End: 1642071

Strand: Reverse

Name: pyrH

Synonym: PPA1519

Alternate gene names: 50842997

Gene position: 1642071-1641358 (Counterclockwise)

Preceding gene: 50842998

Following gene: 50842996

Centisome position: 64.14

GC content: 58.68

Gene sequence:

>714_bases
ATGCCAGAGCGCTACAACCGAGTCCTTCTCAAGCTGTCCGGAGAGGTTTTCGGAGGAGGAGGAATCGGCGTCGACGCCGA
TGTCGTGTCCGCCAAGGCCCGCGAGATCGCTGAGATCGCTAATAGCGGCGTTCAGGTGGCCGTCGTCGTCGGTGGGGGGA
ACTTCTTCCGCGGGGCTGAACTTCAGCAGCACGGCATGCAACGTGATCGCGCGGACTATATGGGAATGCTCGGCACCGTC
ATGAATTGCCTTGCCTTGCAGGATTTCTGTGAGAAGGCTGGTGTCGATACCCGCGTTCAGACAGCCATCACGATGGGCCA
GGTTGCTGAGCCTTACATCCCGCGCAAGGCCGAGCGCCATATGGAGAAGGGACGAGTCGTCATTTTTGGTGCCGGGTCCG
GAATGCCGTATTTCTCGACCGACACCGTCGCTGCTCAGCGAGCCTTAGAGATCGGAGCCGATGCGCTCCTCATGGGTAAG
CAGGGGGTTGACGGCGTCTACGACAGTGATCCCAAGACGAACCCGAACGCCCACAAGTTTGACGAACTGACCTACGATGA
GTTTCTGTCGCGTGATCTTAAGGTCGCCGACGCAACTGCCGTCGCCATGGCCAGGGATAATGACCTGACGATGGTCTTCT
TCAACCTCGAGATGCCAGGCAATATTAGCCGCGTCATCAATGGTGAGGACATCGGCACCACCGTCCATCGCTGA

Upstream 100 bases:

>100_bases
CGAATGACGGTCGCGGCTAGGGCGAACTGCGATGGTAGCCGTCATCGGGCTAAGCTGGGGTGACGCATCCCGCGTCAATG
TCCGCTGACCAGGAGAGATG

Downstream 100 bases:

>100_bases
ACCATCGAGACATACCAAGGAAGGACAACACAGTGAGCGACATCATTAAGGACGCCGAGAAAAAGATGGGGTCAGCGGTC
GACCATGCCCGCGAGGAGTT

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MPERYNRVLLKLSGEVFGGGGIGVDADVVSAKAREIAEIANSGVQVAVVVGGGNFFRGAELQQHGMQRDRADYMGMLGTV
MNCLALQDFCEKAGVDTRVQTAITMGQVAEPYIPRKAERHMEKGRVVIFGAGSGMPYFSTDTVAAQRALEIGADALLMGK
QGVDGVYDSDPKTNPNAHKFDELTYDEFLSRDLKVADATAVAMARDNDLTMVFFNLEMPGNISRVINGEDIGTTVHR

Sequences:

>Translated_237_residues
MPERYNRVLLKLSGEVFGGGGIGVDADVVSAKAREIAEIANSGVQVAVVVGGGNFFRGAELQQHGMQRDRADYMGMLGTV
MNCLALQDFCEKAGVDTRVQTAITMGQVAEPYIPRKAERHMEKGRVVIFGAGSGMPYFSTDTVAAQRALEIGADALLMGK
QGVDGVYDSDPKTNPNAHKFDELTYDEFLSRDLKVADATAVAMARDNDLTMVFFNLEMPGNISRVINGEDIGTTVHR
>Mature_236_residues
PERYNRVLLKLSGEVFGGGGIGVDADVVSAKAREIAEIANSGVQVAVVVGGGNFFRGAELQQHGMQRDRADYMGMLGTVM
NCLALQDFCEKAGVDTRVQTAITMGQVAEPYIPRKAERHMEKGRVVIFGAGSGMPYFSTDTVAAQRALEIGADALLMGKQ
GVDGVYDSDPKTNPNAHKFDELTYDEFLSRDLKVADATAVAMARDNDLTMVFFNLEMPGNISRVINGEDIGTTVHR

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=232, Percent_Identity=45.2586206896552, Blast_Score=202, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_PROAC (Q6A7J9)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_056224.1
- HSSP:   P65938
- ProteinModelPortal:   Q6A7J9
- SMR:   Q6A7J9
- GeneID:   2931577
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA1519
- NMPDR:   fig|267747.1.peg.1501
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   PACN267747:PPA1519-MONOMER
- BRENDA:   2.7.4.22
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 25583; Mature: 25452

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: BINDING 52-52 BINDING 53-53 BINDING 57-57 BINDING 72-72 BINDING 161-161 BINDING 167-167 BINDING 170-170

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPERYNRVLLKLSGEVFGGGGIGVDADVVSAKAREIAEIANSGVQVAVVVGGGNFFRGAE
CCCHHHEEEEEECCCEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCH
LQQHGMQRDRADYMGMLGTVMNCLALQDFCEKAGVDTRVQTAITMGQVAEPYIPRKAERH
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHH
MEKGRVVIFGAGSGMPYFSTDTVAAQRALEIGADALLMGKQGVDGVYDSDPKTNPNAHKF
HHCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCHH
DELTYDEFLSRDLKVADATAVAMARDNDLTMVFFNLEMPGNISRVINGEDIGTTVHR
HCCCHHHHHCCCCCHHHHEEEEEEECCCEEEEEEEEECCCCHHEEECCCCCCCCCCC
>Mature Secondary Structure 
PERYNRVLLKLSGEVFGGGGIGVDADVVSAKAREIAEIANSGVQVAVVVGGGNFFRGAE
CCHHHEEEEEECCCEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCH
LQQHGMQRDRADYMGMLGTVMNCLALQDFCEKAGVDTRVQTAITMGQVAEPYIPRKAERH
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHH
MEKGRVVIFGAGSGMPYFSTDTVAAQRALEIGADALLMGKQGVDGVYDSDPKTNPNAHKF
HHCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCHH
DELTYDEFLSRDLKVADATAVAMARDNDLTMVFFNLEMPGNISRVINGEDIGTTVHR
HCCCHHHHHCCCCCHHHHEEEEEEECCCEEEEEEEEECCCCHHEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA