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The map label for this gene is tetR [H]

Identifier: 50842888

GI number: 50842888

Start: 1527969

End: 1528580

Strand: Reverse

Name: tetR [H]

Synonym: PPA1406

Alternate gene names: 50842888

Gene position: 1528580-1527969 (Counterclockwise)

Preceding gene: 50842890

Following gene: 50842887

Centisome position: 59.7

GC content: 57.84

Gene sequence:

>612_bases
ATGTGGACTACCCCCGGAAATGGTGTCGTCGTCAAGGGAGTCATCGTGAGCCTGACGAAGCCGGACGTTGTTCGGGCAGG
AGTAGAGATTCTCGACGCGTACGGGCTCGGAGACCTGTCCATGCGACGTCTGGCTGAGCGTCTTGGAGTGAAGGCGGGAG
CGCTGTACTGGCACGTTGCTAATAAGCAGAGCTTGCTTGCTGCGGTAAGCGACGAAATTCTTGCGGTTGACGGAGGCCCA
ACGACGGTGCCATCTCAGGACGCCGAACTTTCCGACGGAGTTGACGAATGGGCGCGATGTTTTAGGGCTACTCTCCTTGC
TCACCGTGACGGTGCTGAACTCGTTGCGTCAACGATCTCGGTGGGACTAGGGAAAACCGACCCAACCGTTAAGTTGCGCC
AATTTATGGAGTGTCAGGGGGTCTGCCGCGAGCGTGCGGATTCGGTCTGTCGGGCCTTGGTGCACTTGGTGCTTGGCCAC
ACGATGGAGGAGCAGACCCGTACCCAGTTGCATGACCTCGGGGTGGTGGGCAAGATTGATCCGGCTAGACAAGATGACGA
TTTTGACCTGGCCCTGGCCATTTTTGTCGCCGGTCTTGTCTCTTTGCTTTGA

Upstream 100 bases:

>100_bases
CGGCTAGATTCAGCAATACTCTGGTCCTTCCGAGACTGGAGACGTCCTGAACGCCGTTCAGGATTGAACGGGATTCAATG
TAGTCCATGAGGCAGCACCA

Downstream 100 bases:

>100_bases
ACTAGCAACTGGATTCCATGGCTCACCATGGTACATATATGTAGCTAGGTGAATGTTTAGTAGGCGCTCCTGATGGGCGT
AACCGAGGGGGTTCGATGAG

Product: tetracycline repressor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MWTTPGNGVVVKGVIVSLTKPDVVRAGVEILDAYGLGDLSMRRLAERLGVKAGALYWHVANKQSLLAAVSDEILAVDGGP
TTVPSQDAELSDGVDEWARCFRATLLAHRDGAELVASTISVGLGKTDPTVKLRQFMECQGVCRERADSVCRALVHLVLGH
TMEEQTRTQLHDLGVVGKIDPARQDDDFDLALAIFVAGLVSLL

Sequences:

>Translated_203_residues
MWTTPGNGVVVKGVIVSLTKPDVVRAGVEILDAYGLGDLSMRRLAERLGVKAGALYWHVANKQSLLAAVSDEILAVDGGP
TTVPSQDAELSDGVDEWARCFRATLLAHRDGAELVASTISVGLGKTDPTVKLRQFMECQGVCRERADSVCRALVHLVLGH
TMEEQTRTQLHDLGVVGKIDPARQDDDFDLALAIFVAGLVSLL
>Mature_203_residues
MWTTPGNGVVVKGVIVSLTKPDVVRAGVEILDAYGLGDLSMRRLAERLGVKAGALYWHVANKQSLLAAVSDEILAVDGGP
TTVPSQDAELSDGVDEWARCFRATLLAHRDGAELVASTISVGLGKTDPTVKLRQFMECQGVCRERADSVCRALVHLVLGH
TMEEQTRTQLHDLGVVGKIDPARQDDDFDLALAIFVAGLVSLL

Specific function: TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to tetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter opera

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR003012
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR004111
- InterPro:   IPR001647 [H]

Pfam domain/function: PF02909 TetR_C; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 21758; Mature: 21758

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWTTPGNGVVVKGVIVSLTKPDVVRAGVEILDAYGLGDLSMRRLAERLGVKAGALYWHVA
CCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEEC
NKQSLLAAVSDEILAVDGGPTTVPSQDAELSDGVDEWARCFRATLLAHRDGAELVASTIS
CHHHHHHHHCCCEEEECCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
VGLGKTDPTVKLRQFMECQGVCRERADSVCRALVHLVLGHTMEEQTRTQLHDLGVVGKID
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCC
PARQDDDFDLALAIFVAGLVSLL
CCCCCCCHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MWTTPGNGVVVKGVIVSLTKPDVVRAGVEILDAYGLGDLSMRRLAERLGVKAGALYWHVA
CCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEEC
NKQSLLAAVSDEILAVDGGPTTVPSQDAELSDGVDEWARCFRATLLAHRDGAELVASTIS
CHHHHHHHHCCCEEEECCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
VGLGKTDPTVKLRQFMECQGVCRERADSVCRALVHLVLGHTMEEQTRTQLHDLGVVGKID
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCC
PARQDDDFDLALAIFVAGLVSLL
CCCCCCCHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1479961 [H]