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The map label for this gene is tlyA [H]

Identifier: 50842878

GI number: 50842878

Start: 1514497

End: 1515273

Strand: Reverse

Name: tlyA [H]

Synonym: PPA1396

Alternate gene names: 50842878

Gene position: 1515273-1514497 (Counterclockwise)

Preceding gene: 50842879

Following gene: 50842877

Centisome position: 59.18

GC content: 58.56

Gene sequence:

>777_bases
ATGGATGCACCAAGGTCTCGGAGGTGGCAGTCTGTCCCTGTGAGACTTGACCAGGCCCTTGTTGAAGCCGGACTGGCACG
TTCCCGCACTCTTGCCACACGCCTAGTGCGGGAAGGCAGAGTGACGGTCAATAGAGTCGTCGTTACTAAACCGGCGATGA
AAGTGAGTACCGCCGACGTGCTGGTCGCCGACGAAGAGGTGTGGGTGTCTCGCGGAGCACACAAACTTCTAGGTGCCTTG
GATATCCTTGGCGTCCAAGTGCCGTCAAGAGTGCTTGATGCTGGTGCGTCCACCGGCGGGTTCACCCAAGTTGTGCTGTC
ACGGGGAGCCAAACTTGTGCATGCCGTCGATGTTGGTCACGACCAGATGTCTCCGGTGCTGCGGAATGATCCCCGTGTCA
TTGTTCATGAAGGCTTGAACTTGCGTGATCTTCAGCCTGCAGACCTGGCGGTTGACGGCGTTGTTGAGCCGGTGGACCTC
GTGGTCGGAGATGTCTCTTTTATCTCCTTGACGATGATCCTTGAACCCATGTCAGCTGTTGTCAGCCCAGACGGCCTCAT
GCTGCTGCTGGTGAAGCCTCAATTTGAGGTTGGTCGCAAGGCTTTGGGAGCCCATGGCGTTGTCACGGACCCGGCCCTGC
GCTTGCAGGCCATCGCGGGTGTCATGGCAGCAGCGGTAGATCTGGGTTGGCGTATGCGTGACGAGTGCGATAGCCCGTTG
CCCGGGCAGGATGGAAACGTTGAGCACTTCGTCTTGCTGGAACGTACGGGTCGGTGA

Upstream 100 bases:

>100_bases
AACACCAGATGCAGGCAGGACGTGAGTGCAATGCGACGATTAACGCTGTGGACACTGCGTGGCAGAAGACCTGCTACGCC
GACGGATGAGGCTGCCGCCG

Downstream 100 bases:

>100_bases
CAGACGTCCGGGCATATCATGGGCCGCTACTGTGGTCTTGTGAACGACACGAGCCCTTCGAGATACGTTGTCGTCGTCAC
CCATGCCACGCGGGACGACG

Product: putative cytotoxin/hemolysin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MDAPRSRRWQSVPVRLDQALVEAGLARSRTLATRLVREGRVTVNRVVVTKPAMKVSTADVLVADEEVWVSRGAHKLLGAL
DILGVQVPSRVLDAGASTGGFTQVVLSRGAKLVHAVDVGHDQMSPVLRNDPRVIVHEGLNLRDLQPADLAVDGVVEPVDL
VVGDVSFISLTMILEPMSAVVSPDGLMLLLVKPQFEVGRKALGAHGVVTDPALRLQAIAGVMAAAVDLGWRMRDECDSPL
PGQDGNVEHFVLLERTGR

Sequences:

>Translated_258_residues
MDAPRSRRWQSVPVRLDQALVEAGLARSRTLATRLVREGRVTVNRVVVTKPAMKVSTADVLVADEEVWVSRGAHKLLGAL
DILGVQVPSRVLDAGASTGGFTQVVLSRGAKLVHAVDVGHDQMSPVLRNDPRVIVHEGLNLRDLQPADLAVDGVVEPVDL
VVGDVSFISLTMILEPMSAVVSPDGLMLLLVKPQFEVGRKALGAHGVVTDPALRLQAIAGVMAAAVDLGWRMRDECDSPL
PGQDGNVEHFVLLERTGR
>Mature_258_residues
MDAPRSRRWQSVPVRLDQALVEAGLARSRTLATRLVREGRVTVNRVVVTKPAMKVSTADVLVADEEVWVSRGAHKLLGAL
DILGVQVPSRVLDAGASTGGFTQVVLSRGAKLVHAVDVGHDQMSPVLRNDPRVIVHEGLNLRDLQPADLAVDGVVEPVDL
VVGDVSFISLTMILEPMSAVVSPDGLMLLLVKPQFEVGRKALGAHGVVTDPALRLQAIAGVMAAAVDLGWRMRDECDSPL
PGQDGNVEHFVLLERTGR

Specific function: Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined [H]

COG id: COG1189

COG function: function code J; Predicted rRNA methylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004538
- InterPro:   IPR002877
- InterPro:   IPR002942 [H]

Pfam domain/function: PF01728 FtsJ; PF01479 S4 [H]

EC number: NA

Molecular weight: Translated: 27650; Mature: 27650

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50889 S4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAPRSRRWQSVPVRLDQALVEAGLARSRTLATRLVREGRVTVNRVVVTKPAMKVSTADV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCEECCCEE
LVADEEVWVSRGAHKLLGALDILGVQVPSRVLDAGASTGGFTQVVLSRGAKLVHAVDVGH
EEECHHHHHHCCHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHCCCEEEEEEECCC
DQMSPVLRNDPRVIVHEGLNLRDLQPADLAVDGVVEPVDLVVGDVSFISLTMILEPMSAV
HHCCHHHHCCCEEEEECCCCCCCCCCCCEECCCCCCCHHHHHCCHHHHHHHHHHHHHHHH
VSPDGLMLLLVKPQFEVGRKALGAHGVVTDPALRLQAIAGVMAAAVDLGWRMRDECDSPL
CCCCCEEEEEECCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCC
PGQDGNVEHFVLLERTGR
CCCCCCEEEEEEEEECCC
>Mature Secondary Structure
MDAPRSRRWQSVPVRLDQALVEAGLARSRTLATRLVREGRVTVNRVVVTKPAMKVSTADV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCEECCCEE
LVADEEVWVSRGAHKLLGALDILGVQVPSRVLDAGASTGGFTQVVLSRGAKLVHAVDVGH
EEECHHHHHHCCHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHCCCEEEEEEECCC
DQMSPVLRNDPRVIVHEGLNLRDLQPADLAVDGVVEPVDLVVGDVSFISLTMILEPMSAV
HHCCHHHHCCCEEEEECCCCCCCCCCCCEECCCCCCCHHHHHCCHHHHHHHHHHHHHHHH
VSPDGLMLLLVKPQFEVGRKALGAHGVVTDPALRLQAIAGVMAAAVDLGWRMRDECDSPL
CCCCCEEEEEECCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCC
PGQDGNVEHFVLLERTGR
CCCCCCEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1730486 [H]