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The map label for this gene is hisN [H]

Identifier: 50842750

GI number: 50842750

Start: 1378433

End: 1379326

Strand: Direct

Name: hisN [H]

Synonym: PPA1271

Alternate gene names: 50842750

Gene position: 1378433-1379326 (Clockwise)

Preceding gene: 50842748

Following gene: 50842757

Centisome position: 53.84

GC content: 61.63

Gene sequence:

>894_bases
GTGGGAGTTTCGTGTGCCGTCATAACTTCAGCCTACGGCCGCCAGTCGCAAGGCACCGTGAGGCTTCATCTCCTCGATCT
GCCGGTATCCCAGTATGGTGTGGATATGGCCGACCACACCGATGACCTCCGCCTGGCACATATCCTCGCTGACGACGCTG
ATTCTTTGACGATGTCTCGTTTTGGCGCCCGAGATCTGACGGTCTCGACTAAGCCTGACCATTCCGAAGTCACCGACGCG
GACCTTGCCGTCGAAGATTCGGTGCGCAGAACCCTGTCTCGGATGCGCTCCCGGGACGCCGTCCACGGCGAGGAACGTGC
CGATACCGGGGATGGACCCCGCCGGTGGATCATTGATCCGATCGACGGCACTGCGAATTTTCTGCGTGGGGTCCCAGTGT
GGGCCACCCTCATTGCCCTCAGCGTCGAGGACCAGATTGTCGCATCTGTGGTCTCTGCTCCTGCCCTCAAGCGACGCTGG
TGGGCAGCCCGTGGCTCAGGAGCATGGTCGGGCAAATCCCTGGCCTCAGCGACACCGATCCACGTCTCGAATGTGCGCAA
TCTTGCCGACGCGTTCTTGTCCTATTCTTCGCTGCACGGATGGGTCGAGAGCGGACGAGGGCACGGGTTCGGTGAACTCA
TGCGGTCGGTGTGGCGGACCCGAGCCTTCGGCGATTTCTGGTCTTACATGATGGTGGCAGAAGGTGTCGTCGATGTGGCA
TGCGAGCCGGAACTCAGCCTGCACGACATGGCCGCCCTCGACGCTATCGTCACCGAGGCGGGCGGTAAGTTCACCGGTCT
CGATGGCAAAGACGGCCCGTGGTCTGGGAATGCTCTGGCGTCGAATGGTTTCCTTCATGACCAGGCCCTAGCCATGGTCC
AGCCCCAGGAGTGA

Upstream 100 bases:

>100_bases
CTGACGAGGACCCAGGCACGCCATTATAGACAAACGTCAACGGCCTCGCAAGTGGGTTATCACCAGATCGTCGGTTGGGA
CTGGTTCCGCTGGAGCCTTG

Downstream 100 bases:

>100_bases
GCACCGGTCGCCGGACGCCCCTGTCCCCGCTGCGCATCGCCAGTTAGAGGATACGAGCCCGAATTGTCCCCTCAAGAACG
GTGACATTGGCGAGCAGCCC

Product: putative inositol monophosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MGVSCAVITSAYGRQSQGTVRLHLLDLPVSQYGVDMADHTDDLRLAHILADDADSLTMSRFGARDLTVSTKPDHSEVTDA
DLAVEDSVRRTLSRMRSRDAVHGEERADTGDGPRRWIIDPIDGTANFLRGVPVWATLIALSVEDQIVASVVSAPALKRRW
WAARGSGAWSGKSLASATPIHVSNVRNLADAFLSYSSLHGWVESGRGHGFGELMRSVWRTRAFGDFWSYMMVAEGVVDVA
CEPELSLHDMAALDAIVTEAGGKFTGLDGKDGPWSGNALASNGFLHDQALAMVQPQE

Sequences:

>Translated_297_residues
MGVSCAVITSAYGRQSQGTVRLHLLDLPVSQYGVDMADHTDDLRLAHILADDADSLTMSRFGARDLTVSTKPDHSEVTDA
DLAVEDSVRRTLSRMRSRDAVHGEERADTGDGPRRWIIDPIDGTANFLRGVPVWATLIALSVEDQIVASVVSAPALKRRW
WAARGSGAWSGKSLASATPIHVSNVRNLADAFLSYSSLHGWVESGRGHGFGELMRSVWRTRAFGDFWSYMMVAEGVVDVA
CEPELSLHDMAALDAIVTEAGGKFTGLDGKDGPWSGNALASNGFLHDQALAMVQPQE
>Mature_296_residues
GVSCAVITSAYGRQSQGTVRLHLLDLPVSQYGVDMADHTDDLRLAHILADDADSLTMSRFGARDLTVSTKPDHSEVTDAD
LAVEDSVRRTLSRMRSRDAVHGEERADTGDGPRRWIIDPIDGTANFLRGVPVWATLIALSVEDQIVASVVSAPALKRRWW
AARGSGAWSGKSLASATPIHVSNVRNLADAFLSYSSLHGWVESGRGHGFGELMRSVWRTRAFGDFWSYMMVAEGVVDVAC
EPELSLHDMAALDAIVTEAGGKFTGLDGKDGPWSGNALASNGFLHDQALAMVQPQE

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine (Probable) [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI193202570, Length=233, Percent_Identity=31.7596566523605, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI193202572, Length=233, Percent_Identity=30.9012875536481, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI21357957, Length=256, Percent_Identity=30.46875, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24664918, Length=209, Percent_Identity=32.0574162679426, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24664922, Length=204, Percent_Identity=29.4117647058824, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24664926, Length=197, Percent_Identity=28.4263959390863, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357329, Length=231, Percent_Identity=29.004329004329, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21357303, Length=198, Percent_Identity=31.8181818181818, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 32089; Mature: 31958

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00629 IMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVSCAVITSAYGRQSQGTVRLHLLDLPVSQYGVDMADHTDDLRLAHILADDADSLTMSR
CCCEEEEHHHHCCCCCCCEEEEEEEECCHHHHCCCHHCCCCCCEEEHHHHCCCCHHHHHH
FGARDLTVSTKPDHSEVTDADLAVEDSVRRTLSRMRSRDAVHGEERADTGDGPRRWIIDP
CCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEC
IDGTANFLRGVPVWATLIALSVEDQIVASVVSAPALKRRWWAARGSGAWSGKSLASATPI
CCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
HVSNVRNLADAFLSYSSLHGWVESGRGHGFGELMRSVWRTRAFGDFWSYMMVAEGVVDVA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
CEPELSLHDMAALDAIVTEAGGKFTGLDGKDGPWSGNALASNGFLHDQALAMVQPQE
CCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCCCCHHHHEECCCCC
>Mature Secondary Structure 
GVSCAVITSAYGRQSQGTVRLHLLDLPVSQYGVDMADHTDDLRLAHILADDADSLTMSR
CCEEEEHHHHCCCCCCCEEEEEEEECCHHHHCCCHHCCCCCCEEEHHHHCCCCHHHHHH
FGARDLTVSTKPDHSEVTDADLAVEDSVRRTLSRMRSRDAVHGEERADTGDGPRRWIIDP
CCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEC
IDGTANFLRGVPVWATLIALSVEDQIVASVVSAPALKRRWWAARGSGAWSGKSLASATPI
CCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
HVSNVRNLADAFLSYSSLHGWVESGRGHGFGELMRSVWRTRAFGDFWSYMMVAEGVVDVA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
CEPELSLHDMAALDAIVTEAGGKFTGLDGKDGPWSGNALASNGFLHDQALAMVQPQE
CCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCCCCHHHHEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]