| Definition | Propionibacterium acnes KPA171202, complete genome. |
|---|---|
| Accession | NC_006085 |
| Length | 2,560,265 |
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The map label for this gene is lysA [H]
Identifier: 50842737
GI number: 50842737
Start: 1363060
End: 1364490
Strand: Reverse
Name: lysA [H]
Synonym: PPA1259
Alternate gene names: 50842737
Gene position: 1364490-1363060 (Counterclockwise)
Preceding gene: 50842741
Following gene: 50842736
Centisome position: 53.29
GC content: 59.75
Gene sequence:
>1431_bases ATGACGCACATGCACGTTGCCGGCTCGGTCCACGCCGACGTCGCAGCTGCCGGTCCGCAGTGGCTGACCTTGCCTGATGA CGTTAACGCATTGGACCCTGCGCTCTGGTCAGCATCGACTGATCGTGATGACGATGGAATCGTTGAGGTGGCCGGGGTGA CCGTCACCGAGCTGTTGTCGCAATACGGATCGCCTCTTTACGTGCTTGACGAGTCCGACCTCCGGCAGCGGGCACGGGCC TTCCGTGACGCTTTTTCCGAGTGGGACGTCTACTACGCCGGGAAAGCTTTTTTGACCCGCACGATCGCCTCATGGATTGA CCAGGAGGGTCTGTTCCTAGATACCTGCACCGGCGGCGAGCTCATAACAGCCCTGCAAGGTGGGATGGATCCTGCCCGGA TCGGGTTGCACGGGAATAACAAGTCAATTGACGAGCTTAAATTGGCTCTTAGCGTCGGAGTGGGGCGGATCATCGTCGAC TCCCTAGATGAAATCATGCGCATCGAGCAATTGTGTCGGGAAAACGGCTGGCATGCCCGCGTCATGGTACGAGTAACTGC AGGTGTCGAAGCGCATACTCATGAATACATTGCCACCGCCCACGAGGATCAAAAATTTGGTTTCTCAATTACCAATGGCG CCGCGATGGTTGCCATGGTGAGGTGCCACACCAGTGACGCCATCGACCTGTTAGGCGTCCACTCCCACATCGGTTCTCAG ATCTTCGATACCGCTGGTTTCGAGGTGGCGGCTCGTCGCACTATGAAGCTTCTCGAGCAGTTCCATCAGGCCACCGGGAG CGCCCTCCCCGAACTCGACCTTGGCGGTGGGTTCGGTATTGCCTACACCAGTCAAGATTCTCCGGCCACCGTCGAAAGCT TAGCTGGGGCCCTTCGCGAGATCGTCACCCTTGAAGCCCGGGGAAGGGGTATGGAGGTTCCCCATATTTCTCTGGAGCCC GGCCGTGCCATTGTAGGGCCGACGACGATGGCCCTATACACCGTCGGCACCGTGAAACCAGTCGACCTGGATACTGGTGC CCAGCGAATGTACGTCTCCGTCGATGGCGGGATGAGCGACAATATTCGCCCTGCCCTGTACGCTGCAGAGTACTCGGCTG TTATTGCCAACCGGACTTCGGAAGTGGCGCCGGTGCTGTGCCGCATTGTGGGCAAGCACTGTGAGGCCGGAGACATCTTG GTGCGCGACGTCTACCTGCCCGGTGACGTTTCCCCAGGGGATGTCATAGCGGTGCCCGGAGCCGGGGCCTACTCAAGGTC GATGGCTTCCAACTACAACCATGTACCGCGTCCGGCGGTCGTGAGCGTGAACGAGGACCGGGGTGTGTTGGTGCTGTTGC GCCGGGAGAACATCGACGACCTCCTTGCTCTCGATCCAGGGCCGATCCGTGCCGAGGTGCCATGCCCGTAA
Upstream 100 bases:
>100_bases CCACCTGTGGAGTTTAGCGCACCGGTGGGCTGCTCGCCATTCAAGATCGCGAGCATGGACACTCTGCGATCGTGTCGGTG GCCTCTGGCAAGGTGTAACC
Downstream 100 bases:
>100_bases CGCATCGAAAAGTCCTATTACGCACTATCTGTGAACTTTCATCAGCTGACAACAACGAGGTGAGGAAGAGATGACGAATA CCACCGATTCCGCGTCAGCC
Product: diaminopimelate decarboxylase
Products: NA
Alternate protein names: DAP decarboxylase [H]
Number of amino acids: Translated: 476; Mature: 475
Protein sequence:
>476_residues MTHMHVAGSVHADVAAAGPQWLTLPDDVNALDPALWSASTDRDDDGIVEVAGVTVTELLSQYGSPLYVLDESDLRQRARA FRDAFSEWDVYYAGKAFLTRTIASWIDQEGLFLDTCTGGELITALQGGMDPARIGLHGNNKSIDELKLALSVGVGRIIVD SLDEIMRIEQLCRENGWHARVMVRVTAGVEAHTHEYIATAHEDQKFGFSITNGAAMVAMVRCHTSDAIDLLGVHSHIGSQ IFDTAGFEVAARRTMKLLEQFHQATGSALPELDLGGGFGIAYTSQDSPATVESLAGALREIVTLEARGRGMEVPHISLEP GRAIVGPTTMALYTVGTVKPVDLDTGAQRMYVSVDGGMSDNIRPALYAAEYSAVIANRTSEVAPVLCRIVGKHCEAGDIL VRDVYLPGDVSPGDVIAVPGAGAYSRSMASNYNHVPRPAVVSVNEDRGVLVLLRRENIDDLLALDPGPIRAEVPCP
Sequences:
>Translated_476_residues MTHMHVAGSVHADVAAAGPQWLTLPDDVNALDPALWSASTDRDDDGIVEVAGVTVTELLSQYGSPLYVLDESDLRQRARA FRDAFSEWDVYYAGKAFLTRTIASWIDQEGLFLDTCTGGELITALQGGMDPARIGLHGNNKSIDELKLALSVGVGRIIVD SLDEIMRIEQLCRENGWHARVMVRVTAGVEAHTHEYIATAHEDQKFGFSITNGAAMVAMVRCHTSDAIDLLGVHSHIGSQ IFDTAGFEVAARRTMKLLEQFHQATGSALPELDLGGGFGIAYTSQDSPATVESLAGALREIVTLEARGRGMEVPHISLEP GRAIVGPTTMALYTVGTVKPVDLDTGAQRMYVSVDGGMSDNIRPALYAAEYSAVIANRTSEVAPVLCRIVGKHCEAGDIL VRDVYLPGDVSPGDVIAVPGAGAYSRSMASNYNHVPRPAVVSVNEDRGVLVLLRRENIDDLLALDPGPIRAEVPCP >Mature_475_residues THMHVAGSVHADVAAAGPQWLTLPDDVNALDPALWSASTDRDDDGIVEVAGVTVTELLSQYGSPLYVLDESDLRQRARAF RDAFSEWDVYYAGKAFLTRTIASWIDQEGLFLDTCTGGELITALQGGMDPARIGLHGNNKSIDELKLALSVGVGRIIVDS LDEIMRIEQLCRENGWHARVMVRVTAGVEAHTHEYIATAHEDQKFGFSITNGAAMVAMVRCHTSDAIDLLGVHSHIGSQI FDTAGFEVAARRTMKLLEQFHQATGSALPELDLGGGFGIAYTSQDSPATVESLAGALREIVTLEARGRGMEVPHISLEPG RAIVGPTTMALYTVGTVKPVDLDTGAQRMYVSVDGGMSDNIRPALYAAEYSAVIANRTSEVAPVLCRIVGKHCEAGDILV RDVYLPGDVSPGDVIAVPGAGAYSRSMASNYNHVPRPAVVSVNEDRGVLVLLRRENIDDLLALDPGPIRAEVPCP
Specific function: Lysine biosynthesis; last step. [C]
COG id: COG0019
COG function: function code E; Diaminopimelate decarboxylase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]
Homologues:
Organism=Escherichia coli, GI1789203, Length=446, Percent_Identity=28.0269058295964, Blast_Score=116, Evalue=3e-27,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR009006 - InterPro: IPR002986 - InterPro: IPR022643 - InterPro: IPR022657 - InterPro: IPR022644 - InterPro: IPR022653 - InterPro: IPR000183 [H]
Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]
EC number: =4.1.1.20 [H]
Molecular weight: Translated: 51037; Mature: 50906
Theoretical pI: Translated: 4.66; Mature: 4.66
Prosite motif: PS00141 ASP_PROTEASE ; PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.3 %Cys (Translated Protein) 2.7 %Met (Translated Protein) 4.0 %Cys+Met (Translated Protein) 1.3 %Cys (Mature Protein) 2.5 %Met (Mature Protein) 3.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTHMHVAGSVHADVAAAGPQWLTLPDDVNALDPALWSASTDRDDDGIVEVAGVTVTELLS CCEEEECCCCCCCCCCCCCCEEECCCCCCCCCHHHHCCCCCCCCCCEEEECCCCHHHHHH QYGSPLYVLDESDLRQRARAFRDAFSEWDVYYAGKAFLTRTIASWIDQEGLFLDTCTGGE HHCCCEEEECCHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHCCCCCEEEECCCCH LITALQGGMDPARIGLHGNNKSIDELKLALSVGVGRIIVDSLDEIMRIEQLCRENGWHAR HHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEE VMVRVTAGVEAHTHEYIATAHEDQKFGFSITNGAAMVAMVRCHTSDAIDLLGVHSHIGSQ EEEEEECCCCHHHHHHHHCCCCCCCCCEEEECCCEEEEEEEECCCCCHHHHHHHHHHHHH IFDTAGFEVAARRTMKLLEQFHQATGSALPELDLGGGFGIAYTSQDSPATVESLAGALRE HHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCEEEEEECCCCCHHHHHHHHHHHH IVTLEARGRGMEVPHISLEPGRAIVGPTTMALYTVGTVKPVDLDTGAQRMYVSVDGGMSD HHHHCCCCCCCCCCEEECCCCCEEECCCEEEEEEECCCEEEECCCCCCEEEEEECCCCCC NIRPALYAAEYSAVIANRTSEVAPVLCRIVGKHCEAGDILVRDVYLPGDVSPGDVIAVPG CCCCEEEHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCEEEECC AGAYSRSMASNYNHVPRPAVVSVNEDRGVLVLLRRENIDDLLALDPGPIRAEVPCP CCHHHHHHHCCCCCCCCCEEEEECCCCCEEEEEECCCCCHHEEECCCCCEECCCCC >Mature Secondary Structure THMHVAGSVHADVAAAGPQWLTLPDDVNALDPALWSASTDRDDDGIVEVAGVTVTELLS CEEEECCCCCCCCCCCCCCEEECCCCCCCCCHHHHCCCCCCCCCCEEEECCCCHHHHHH QYGSPLYVLDESDLRQRARAFRDAFSEWDVYYAGKAFLTRTIASWIDQEGLFLDTCTGGE HHCCCEEEECCHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHCCCCCEEEECCCCH LITALQGGMDPARIGLHGNNKSIDELKLALSVGVGRIIVDSLDEIMRIEQLCRENGWHAR HHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEE VMVRVTAGVEAHTHEYIATAHEDQKFGFSITNGAAMVAMVRCHTSDAIDLLGVHSHIGSQ EEEEEECCCCHHHHHHHHCCCCCCCCCEEEECCCEEEEEEEECCCCCHHHHHHHHHHHHH IFDTAGFEVAARRTMKLLEQFHQATGSALPELDLGGGFGIAYTSQDSPATVESLAGALRE HHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCEEEEEECCCCCHHHHHHHHHHHH IVTLEARGRGMEVPHISLEPGRAIVGPTTMALYTVGTVKPVDLDTGAQRMYVSVDGGMSD HHHHCCCCCCCCCCEEECCCCCEEECCCEEEEEEECCCEEEECCCCCCEEEEEECCCCCC NIRPALYAAEYSAVIANRTSEVAPVLCRIVGKHCEAGDILVRDVYLPGDVSPGDVIAVPG CCCCEEEHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCEEEECC AGAYSRSMASNYNHVPRPAVVSVNEDRGVLVLLRRENIDDLLALDPGPIRAEVPCP CCHHHHHHHCCCCCCCCCEEEEECCCCCEEEEEECCCCCHHEEECCCCCEECCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 12788972 [H]