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The map label for this gene is hom [H]

Identifier: 50842736

GI number: 50842736

Start: 1361664

End: 1362989

Strand: Reverse

Name: hom [H]

Synonym: PPA1258

Alternate gene names: 50842736

Gene position: 1362989-1361664 (Counterclockwise)

Preceding gene: 50842737

Following gene: 50842735

Centisome position: 53.24

GC content: 60.48

Gene sequence:

>1326_bases
ATGACGAATACCACCGATTCCGCGTCAGCCCAGCCGATACGCGTGGCCTTGCTGGGGTGCGGGGTTGTGGGGTCCCAGGT
GGCCCGGATGATTGAATCGAGGACGGAGGATATCGCCGCTCGAGTGGGGCGGCAGGTCGAGCTCGCTGGTATTGCTGTCG
CCCATCCTGATCGCCCGCGCCAGGGCCTTGACTCGCGTCTTTTTACCGATGATCCCACAGTGCTCGTTAACCGGGACGAT
GTGGATATCGTCATCGAGCTCATCGGTGGCATCGACCCTGCCCGTCAGCTCCTGACAGCTGCCCTCGGCAAGGGGCACTC
CGTTGTGACGGCGAATAAGGCCCTGTTGGCAGCTCACGGGACTGAGTTACACGCTGTGGCCGAGAGCAACGGCGTCGATC
TGTACTACGAAGCTGCGGTAGCCGGGGCAATTCCGATCGTCCGCCCGCTGCGCGAGTCTCTTGTCGGAGATCAAATCACT
CGTGTTATGGGCATCGTCAATGGCACGACCAACTACATCCTTGACCAAATGACGACTACGGGTGCCCGGTTCGATGAAGC
CCTTGCCCAGGCGAAAGCTCAAGGGTATGCCGAGGCCGATCCGACGGCTGACGTGGAGGGTTATGACGCTGCGGCTAAGG
CTGCGCTGCTGTCGTCGCTTGCGTTCCATACTCAGTTGCGCGGCGACCAGGTGTATCGAGAAGGGATTACCGAGATCACC
CCAGATGACATCCTCGCTGCACATGATATGGATTGCGTCGTCAAGCTCTTAGCTGTGTGCCAGGCCGGCCCCGACGGTAT
TTCGGCTCGCGTCCATCCGGCCCTCGTTCCTGCAACCCATCCTTTGGGGAGTGTCTCAGGAGCCTTCAACGCGGTGTTCA
TCGAAGCTCGTGAAGCCGGACGCCTCATGTTCCTTGGCCCTGGAGCCGGAGGCTCTCCCACGGCATCAGCCGTTATGGGA
GACCTCGTCACTGTGGCACGTAACCTCGTGCGAGGGGTTGCTGGTCCGCCTCAGGACGTCTACGGGGAGTTCCCGATCTT
GCCCATGTCCGAGGTCCACACCCGGTTTCACCTACGGTTGCAAGTTCGTGACGAGCCCGGTGTGCTCGCCGAAGTCGCAA
AGATCTTCGCCAGCCACAGGGTGTCCTTGCAGACTGTGCAACAGTCTGCAGTGGAGGGTACTGACCGCGCTGATGGATGG
TCAGCTACCCTCAAGGTCCTCACTCACGAAGCCCGAGAATGTGACGTCGACGAGTGCGTCAACGAACTCACCGGCCATCA
CTACGTCAACTCCGATCCTCGTGTTATCCGAGTGGAGGGAATGTGA

Upstream 100 bases:

>100_bases
CCGATCCGTGCCGAGGTGCCATGCCCGTAACGCATCGAAAAGTCCTATTACGCACTATCTGTGAACTTTCATCAGCTGAC
AACAACGAGGTGAGGAAGAG

Downstream 100 bases:

>100_bases
TCATGAGCCAGCAGAATCGTCTCTTCGGCGTGATTGAGACCTATCGAGACCGTCTCCCTATGGACGGAATTGACCAGATC
GTGACGTTGGGGGAGGGGGC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MTNTTDSASAQPIRVALLGCGVVGSQVARMIESRTEDIAARVGRQVELAGIAVAHPDRPRQGLDSRLFTDDPTVLVNRDD
VDIVIELIGGIDPARQLLTAALGKGHSVVTANKALLAAHGTELHAVAESNGVDLYYEAAVAGAIPIVRPLRESLVGDQIT
RVMGIVNGTTNYILDQMTTTGARFDEALAQAKAQGYAEADPTADVEGYDAAAKAALLSSLAFHTQLRGDQVYREGITEIT
PDDILAAHDMDCVVKLLAVCQAGPDGISARVHPALVPATHPLGSVSGAFNAVFIEAREAGRLMFLGPGAGGSPTASAVMG
DLVTVARNLVRGVAGPPQDVYGEFPILPMSEVHTRFHLRLQVRDEPGVLAEVAKIFASHRVSLQTVQQSAVEGTDRADGW
SATLKVLTHEARECDVDECVNELTGHHYVNSDPRVIRVEGM

Sequences:

>Translated_441_residues
MTNTTDSASAQPIRVALLGCGVVGSQVARMIESRTEDIAARVGRQVELAGIAVAHPDRPRQGLDSRLFTDDPTVLVNRDD
VDIVIELIGGIDPARQLLTAALGKGHSVVTANKALLAAHGTELHAVAESNGVDLYYEAAVAGAIPIVRPLRESLVGDQIT
RVMGIVNGTTNYILDQMTTTGARFDEALAQAKAQGYAEADPTADVEGYDAAAKAALLSSLAFHTQLRGDQVYREGITEIT
PDDILAAHDMDCVVKLLAVCQAGPDGISARVHPALVPATHPLGSVSGAFNAVFIEAREAGRLMFLGPGAGGSPTASAVMG
DLVTVARNLVRGVAGPPQDVYGEFPILPMSEVHTRFHLRLQVRDEPGVLAEVAKIFASHRVSLQTVQQSAVEGTDRADGW
SATLKVLTHEARECDVDECVNELTGHHYVNSDPRVIRVEGM
>Mature_440_residues
TNTTDSASAQPIRVALLGCGVVGSQVARMIESRTEDIAARVGRQVELAGIAVAHPDRPRQGLDSRLFTDDPTVLVNRDDV
DIVIELIGGIDPARQLLTAALGKGHSVVTANKALLAAHGTELHAVAESNGVDLYYEAAVAGAIPIVRPLRESLVGDQITR
VMGIVNGTTNYILDQMTTTGARFDEALAQAKAQGYAEADPTADVEGYDAAAKAALLSSLAFHTQLRGDQVYREGITEITP
DDILAAHDMDCVVKLLAVCQAGPDGISARVHPALVPATHPLGSVSGAFNAVFIEAREAGRLMFLGPGAGGSPTASAVMGD
LVTVARNLVRGVAGPPQDVYGEFPILPMSEVHTRFHLRLQVRDEPGVLAEVAKIFASHRVSLQTVQQSAVEGTDRADGWS
ATLKVLTHEARECDVDECVNELTGHHYVNSDPRVIRVEGM

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=358, Percent_Identity=27.6536312849162, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786183, Length=250, Percent_Identity=27.6, Blast_Score=65, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6322599, Length=237, Percent_Identity=28.2700421940928, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46658; Mature: 46527

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNTTDSASAQPIRVALLGCGVVGSQVARMIESRTEDIAARVGRQVELAGIAVAHPDRPR
CCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCC
QGLDSRLFTDDPTVLVNRDDVDIVIELIGGIDPARQLLTAALGKGHSVVTANKALLAAHG
CCCCCCCCCCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCEEEEECC
TELHAVAESNGVDLYYEAAVAGAIPIVRPLRESLVGDQITRVMGIVNGTTNYILDQMTTT
CEEEEEECCCCCEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
GARFDEALAQAKAQGYAEADPTADVEGYDAAAKAALLSSLAFHTQLRGDQVYREGITEIT
CHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC
PDDILAAHDMDCVVKLLAVCQAGPDGISARVHPALVPATHPLGSVSGAFNAVFIEAREAG
CHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCCCCCCCEEEEEEECCCC
RLMFLGPGAGGSPTASAVMGDLVTVARNLVRGVAGPPQDVYGEFPILPMSEVHTRFHLRL
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCHHHHCCEEEEEE
QVRDEPGVLAEVAKIFASHRVSLQTVQQSAVEGTDRADGWSATLKVLTHEARECDVDECV
EEECCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHH
NELTGHHYVNSDPRVIRVEGM
HHHCCCCEECCCCCEEEEECC
>Mature Secondary Structure 
TNTTDSASAQPIRVALLGCGVVGSQVARMIESRTEDIAARVGRQVELAGIAVAHPDRPR
CCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCC
QGLDSRLFTDDPTVLVNRDDVDIVIELIGGIDPARQLLTAALGKGHSVVTANKALLAAHG
CCCCCCCCCCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCEEEEECC
TELHAVAESNGVDLYYEAAVAGAIPIVRPLRESLVGDQITRVMGIVNGTTNYILDQMTTT
CEEEEEECCCCCEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
GARFDEALAQAKAQGYAEADPTADVEGYDAAAKAALLSSLAFHTQLRGDQVYREGITEIT
CHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC
PDDILAAHDMDCVVKLLAVCQAGPDGISARVHPALVPATHPLGSVSGAFNAVFIEAREAG
CHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCCCCCCCEEEEEEECCCC
RLMFLGPGAGGSPTASAVMGDLVTVARNLVRGVAGPPQDVYGEFPILPMSEVHTRFHLRL
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCHHHHCCEEEEEE
QVRDEPGVLAEVAKIFASHRVSLQTVQQSAVEGTDRADGWSATLKVLTHEARECDVDECV
EEECCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHH
NELTGHHYVNSDPRVIRVEGM
HHHCCCCEECCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2835591; 3320973; 9362124; 12948626; 1902466 [H]