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The map label for this gene is yfmO [H]

Identifier: 50842713

GI number: 50842713

Start: 1340864

End: 1342060

Strand: Reverse

Name: yfmO [H]

Synonym: PPA1233

Alternate gene names: 50842713

Gene position: 1342060-1340864 (Counterclockwise)

Preceding gene: 50842717

Following gene: 50842712

Centisome position: 52.42

GC content: 59.57

Gene sequence:

>1197_bases
ATGAGTAAAGAGCCTGTCAGACCGGCTGTGTGGGCGGTCACCATTGCGGTGGCGTTCTCCTACATGGGGGTTGGGGTGGT
CGACCCGATTCTTCCCGAGATCTCTTCGGCCCTGAAGGCCAGCCCAGGTCAGACCGAGCTACTGTTCAGTACCTATCTCT
TCGTGTCTGCAGCGTTGATGTTTTTTGCTTCCTGGGTCGCCACTCGCATTGGGCGCAAGAAGACCCTGCTCGTCGGCTTG
GCTATCATCGTGACCTTCGCGGCGGCGTGCGCATTATCTGGGCATGTCGATCTCATCATTGGATTCCGCGGCGGTTGGGG
GGTGGGCAACGCCCTGTTCGTCTCAACCGCTTTGGCCACGGTGTTAGGAGCATCCGCCGAACCCAGGCGAGCGATCATGC
TCTACGAGGGTGCCTTGGGAGCTGGTATGGCTCTCGGTCCGCTCGTCGGCGGAGCCCTCGGATCGATCTCGTGGCGTGGC
CCTTTCCTCGGCACAGCCGTTCTCATGGCTGTCGGACTGATCGCCATTGTTCTGTTCGTCCCGCCTACACCGATCGAACG
ATCTGCACGCCGCTCGGCAATCGAACCATTCCGTGCCCTCGTCGATTCGCGGGTGTCGATCCTCATGTTGGCGGCATTGG
TCTACAACTATGGCTACTTCACCCTGCTGGCGTACGCGCCCTTTCCAGTAGCTGAAGCCTCCATTCGGGCCGGTGGTCAG
TTCACGCCCTTGGATCTCGGCCTAGTGTTCTTTGGTTGGGGCTTGATGGTGGCGCTCGGATCGGTATGGCTTGGTCCCCG
CGGTTGTGAGCATGTGGGGATTCGTCGAACGGTTGCGGTGACCTTGATCCTGTTCACGATCGACGAGATTGTCCTTGCCA
CCTGGATCTCCCCGATCCCACAAGTGATCGGGGTCGTTCTTGGTGGCCTGTTAATCGGGATCATTAACACTGCCATGACC
GAGATCGTGATGTCGGCCAGTGACATCCAGCGCGAGGTGGCCTCTTCGGCCTATTCTGGTGTTCGGTTCCTCGGTGGCGC
GTGTGCTCCAACCTTGGCTGGTGCCTTGAGCTCGATGTGGGGGATCGGAGGCCCGTATTACATTGGAGCCGTCGCCCTCG
TCTTGACGATCATCCTGCTGTGGATTGACCGTCAACGTCGCATGCAAATGACCGCACACAGCGTTGCTTTGGGGTGA

Upstream 100 bases:

>100_bases
GCGATAGGGACCGAGATCTGCTGATGAGAGTTTTGCCCGCCTTGCGCCGGGCTGTCGAAGTGCTGTCCGAGAATGATGAG
AGGACGACGAGGAATTGACG

Downstream 100 bases:

>100_bases
TCTCCTCAACGACCTGGATCGGGTCTGGTAGACGAACACAGCCCAGGCGCGATGCGCAAAAGGTGCCCCGGAACTTTCGT
ACTATTCGATGGTGACTGAT

Product: putative multidrug-efflux transporter protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MSKEPVRPAVWAVTIAVAFSYMGVGVVDPILPEISSALKASPGQTELLFSTYLFVSAALMFFASWVATRIGRKKTLLVGL
AIIVTFAAACALSGHVDLIIGFRGGWGVGNALFVSTALATVLGASAEPRRAIMLYEGALGAGMALGPLVGGALGSISWRG
PFLGTAVLMAVGLIAIVLFVPPTPIERSARRSAIEPFRALVDSRVSILMLAALVYNYGYFTLLAYAPFPVAEASIRAGGQ
FTPLDLGLVFFGWGLMVALGSVWLGPRGCEHVGIRRTVAVTLILFTIDEIVLATWISPIPQVIGVVLGGLLIGIINTAMT
EIVMSASDIQREVASSAYSGVRFLGGACAPTLAGALSSMWGIGGPYYIGAVALVLTIILLWIDRQRRMQMTAHSVALG

Sequences:

>Translated_398_residues
MSKEPVRPAVWAVTIAVAFSYMGVGVVDPILPEISSALKASPGQTELLFSTYLFVSAALMFFASWVATRIGRKKTLLVGL
AIIVTFAAACALSGHVDLIIGFRGGWGVGNALFVSTALATVLGASAEPRRAIMLYEGALGAGMALGPLVGGALGSISWRG
PFLGTAVLMAVGLIAIVLFVPPTPIERSARRSAIEPFRALVDSRVSILMLAALVYNYGYFTLLAYAPFPVAEASIRAGGQ
FTPLDLGLVFFGWGLMVALGSVWLGPRGCEHVGIRRTVAVTLILFTIDEIVLATWISPIPQVIGVVLGGLLIGIINTAMT
EIVMSASDIQREVASSAYSGVRFLGGACAPTLAGALSSMWGIGGPYYIGAVALVLTIILLWIDRQRRMQMTAHSVALG
>Mature_397_residues
SKEPVRPAVWAVTIAVAFSYMGVGVVDPILPEISSALKASPGQTELLFSTYLFVSAALMFFASWVATRIGRKKTLLVGLA
IIVTFAAACALSGHVDLIIGFRGGWGVGNALFVSTALATVLGASAEPRRAIMLYEGALGAGMALGPLVGGALGSISWRGP
FLGTAVLMAVGLIAIVLFVPPTPIERSARRSAIEPFRALVDSRVSILMLAALVYNYGYFTLLAYAPFPVAEASIRAGGQF
TPLDLGLVFFGWGLMVALGSVWLGPRGCEHVGIRRTVAVTLILFTIDEIVLATWISPIPQVIGVVLGGLLIGIINTAMTE
IVMSASDIQREVASSAYSGVRFLGGACAPTLAGALSSMWGIGGPYYIGAVALVLTIILLWIDRQRRMQMTAHSVALG

Specific function: Acts to efflux copper or a copper complex. It is possible that yfmO could contribute to copper resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41743; Mature: 41612

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKEPVRPAVWAVTIAVAFSYMGVGVVDPILPEISSALKASPGQTELLFSTYLFVSAALM
CCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
FFASWVATRIGRKKTLLVGLAIIVTFAAACALSGHVDLIIGFRGGWGVGNALFVSTALAT
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHH
VLGASAEPRRAIMLYEGALGAGMALGPLVGGALGSISWRGPFLGTAVLMAVGLIAIVLFV
HHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHC
PPTPIERSARRSAIEPFRALVDSRVSILMLAALVYNYGYFTLLAYAPFPVAEASIRAGGQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCHHHHHCCCCC
FTPLDLGLVFFGWGLMVALGSVWLGPRGCEHVGIRRTVAVTLILFTIDEIVLATWISPIP
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QVIGVVLGGLLIGIINTAMTEIVMSASDIQREVASSAYSGVRFLGGACAPTLAGALSSMW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
GIGGPYYIGAVALVLTIILLWIDRQRRMQMTAHSVALG
CCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKEPVRPAVWAVTIAVAFSYMGVGVVDPILPEISSALKASPGQTELLFSTYLFVSAALM
CCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
FFASWVATRIGRKKTLLVGLAIIVTFAAACALSGHVDLIIGFRGGWGVGNALFVSTALAT
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHH
VLGASAEPRRAIMLYEGALGAGMALGPLVGGALGSISWRGPFLGTAVLMAVGLIAIVLFV
HHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHC
PPTPIERSARRSAIEPFRALVDSRVSILMLAALVYNYGYFTLLAYAPFPVAEASIRAGGQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCHHHHHCCCCC
FTPLDLGLVFFGWGLMVALGSVWLGPRGCEHVGIRRTVAVTLILFTIDEIVLATWISPIP
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QVIGVVLGGLLIGIINTAMTEIVMSASDIQREVASSAYSGVRFLGGACAPTLAGALSSMW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
GIGGPYYIGAVALVLTIILLWIDRQRRMQMTAHSVALG
CCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9141694; 9384377 [H]