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The map label for this gene is czcD [H]

Identifier: 50842708

GI number: 50842708

Start: 1336629

End: 1337540

Strand: Reverse

Name: czcD [H]

Synonym: PPA1228

Alternate gene names: 50842708

Gene position: 1337540-1336629 (Counterclockwise)

Preceding gene: 50842709

Following gene: 50842706

Centisome position: 52.24

GC content: 60.53

Gene sequence:

>912_bases
TTGAGCAATCACAGGCATGATCATTCTCTACCCTCGGACGCGGACTCCCGATACCTCGTTGCTGCGCTTACACTCCTGGC
GGCGTTCATGATCACGGAGATCATCACAGCTGTCATCTCCGGGTCGCTGGCGCTGCTCTCCGACGCTGGCCACATGCTGT
CGGACATTGGTGCCATCGCCATTGCCCTGTGGGCTGCGAGACTCACTCGGCGCCGTCCGCAGGGATCGTGGACGTGGGGT
TGGAAACGAGCCGAGATCATGTCGGCTGCGGTCAATGGCGTCACGCTGCTCGTGGTCGCCATCCTCGTCGGAATCGAGGC
TGTTCGACGCCTCGTCACTCCCCCTGCCGTTGGCGGAGGGCTGGTTATGGTCATCGCCGCTGTAGGCGTTGTCGTCAACG
TCGCGGTTGCTTGGCTGGTGGCACGAGCCAATCGCCGTAGTCTCAACGTCGAAGGTGCCTACCAACATATTCTCACTGAC
CTATTCGGGTTCATCGGCACCTTGGTGGCGGGCCTGGTCATTGTGACGACCGGATGGACCCGTGCGGATGCCATTGCCTC
CCTTATTATCTGTGGTCTTATGCTCCGCGCTGCGTGGTCCCTCCTTAGCCAGACGGGGCGGATACTGATGGAGGTTGCGC
CCGCCTCCCTCGACCTTGATGAGGTGCGACACCATCTTATGGACCTTGACCATGTGAGATCGGTTCATGATCTCCACGCG
TGGACGGTGTCGAGCGATCTACCAGCGCTCAGCGCCCATATCGTCGTCGAGGACTCCTGCTTCGCCGATGGTCATGCCCC
CATCCTCTTGGCACAGATCCAGCAGTGCTTGTCGGGCCACTTCGACCTCGACCATTCGACGCTACAGCTAGAACCACCCC
GGCACGCCGGCACCGAAAATCAAACGATGTGA

Upstream 100 bases:

>100_bases
GGGAGTGCGCTGAGCTATGCGGCATGCTCGATGTTGAGTACCGTGGAGAACCCAGCGATGACCACATCGGCGGCAATGAC
GACGCAGTGAGGGAAGAATA

Downstream 100 bases:

>100_bases
CGCGAAGGGGTCCCAGCTCGGAGGCTAGGACCCCATGATCTTGCATGATTACTGAGCTTCAACACATGTCACAGAAATCA
TGTCACGGAAAGATCAGAAG

Product: cation-efflux transport protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MSNHRHDHSLPSDADSRYLVAALTLLAAFMITEIITAVISGSLALLSDAGHMLSDIGAIAIALWAARLTRRRPQGSWTWG
WKRAEIMSAAVNGVTLLVVAILVGIEAVRRLVTPPAVGGGLVMVIAAVGVVVNVAVAWLVARANRRSLNVEGAYQHILTD
LFGFIGTLVAGLVIVTTGWTRADAIASLIICGLMLRAAWSLLSQTGRILMEVAPASLDLDEVRHHLMDLDHVRSVHDLHA
WTVSSDLPALSAHIVVEDSCFADGHAPILLAQIQQCLSGHFDLDHSTLQLEPPRHAGTENQTM

Sequences:

>Translated_303_residues
MSNHRHDHSLPSDADSRYLVAALTLLAAFMITEIITAVISGSLALLSDAGHMLSDIGAIAIALWAARLTRRRPQGSWTWG
WKRAEIMSAAVNGVTLLVVAILVGIEAVRRLVTPPAVGGGLVMVIAAVGVVVNVAVAWLVARANRRSLNVEGAYQHILTD
LFGFIGTLVAGLVIVTTGWTRADAIASLIICGLMLRAAWSLLSQTGRILMEVAPASLDLDEVRHHLMDLDHVRSVHDLHA
WTVSSDLPALSAHIVVEDSCFADGHAPILLAQIQQCLSGHFDLDHSTLQLEPPRHAGTENQTM
>Mature_302_residues
SNHRHDHSLPSDADSRYLVAALTLLAAFMITEIITAVISGSLALLSDAGHMLSDIGAIAIALWAARLTRRRPQGSWTWGW
KRAEIMSAAVNGVTLLVVAILVGIEAVRRLVTPPAVGGGLVMVIAAVGVVVNVAVAWLVARANRRSLNVEGAYQHILTDL
FGFIGTLVAGLVIVTTGWTRADAIASLIICGLMLRAAWSLLSQTGRILMEVAPASLDLDEVRHHLMDLDHVRSVHDLHAW
TVSSDLPALSAHIVVEDSCFADGHAPILLAQIQQCLSGHFDLDHSTLQLEPPRHAGTENQTM

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI64762489, Length=307, Percent_Identity=29.9674267100977, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI289803013, Length=307, Percent_Identity=29.9674267100977, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI289803009, Length=307, Percent_Identity=29.9674267100977, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI289803007, Length=307, Percent_Identity=29.9674267100977, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI289803003, Length=307, Percent_Identity=29.9674267100977, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI52352805, Length=300, Percent_Identity=27.3333333333333, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI21359890, Length=266, Percent_Identity=30.4511278195489, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI21361112, Length=322, Percent_Identity=27.3291925465839, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI20070323, Length=286, Percent_Identity=25.8741258741259, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI222080086, Length=126, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI40255009, Length=126, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI52351208, Length=118, Percent_Identity=36.4406779661017, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI52352803, Length=118, Percent_Identity=38.135593220339, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI14210520, Length=220, Percent_Identity=25.9090909090909, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1786966, Length=284, Percent_Identity=40.4929577464789, Blast_Score=180, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI193210990, Length=315, Percent_Identity=29.2063492063492, Blast_Score=134, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17555794, Length=313, Percent_Identity=28.7539936102236, Blast_Score=130, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17555796, Length=292, Percent_Identity=29.4520547945205, Blast_Score=127, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI32564488, Length=309, Percent_Identity=25.2427184466019, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17550440, Length=120, Percent_Identity=32.5, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17550442, Length=120, Percent_Identity=32.5, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324892, Length=130, Percent_Identity=34.6153846153846, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6323899, Length=123, Percent_Identity=38.2113821138211, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320411, Length=180, Percent_Identity=26.6666666666667, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583858, Length=324, Percent_Identity=24.6913580246914, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24645863, Length=123, Percent_Identity=32.520325203252, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24656728, Length=117, Percent_Identity=34.1880341880342, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24656724, Length=117, Percent_Identity=34.1880341880342, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24656720, Length=117, Percent_Identity=34.1880341880342, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24656715, Length=117, Percent_Identity=34.1880341880342, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21357035, Length=117, Percent_Identity=34.1880341880342, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24585900, Length=138, Percent_Identity=26.8115942028986, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24585898, Length=138, Percent_Identity=26.8115942028986, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24585896, Length=138, Percent_Identity=26.8115942028986, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19921672, Length=138, Percent_Identity=26.8115942028986, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 32496; Mature: 32365

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCC
>Mature Secondary Structure 
SNHRHDHSLPSDADSRYLVAALTLLAAFMITEIITAVISGSLALLSDAGHMLSDIGAIA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
IALWAARLTRRRPQGSWTWGWKRAEIMSAAVNGVTLLVVAILVGIEAVRRLVTPPAVGGG
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
LVMVIAAVGVVVNVAVAWLVARANRRSLNVEGAYQHILTDLFGFIGTLVAGLVIVTTGWT
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
RADAIASLIICGLMLRAAWSLLSQTGRILMEVAPASLDLDEVRHHLMDLDHVRSVHDLHA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCHHHHHHHHHHHH
WTVSSDLPALSAHIVVEDSCFADGHAPILLAQIQQCLSGHFDLDHSTLQLEPPRHAGTEN
HHCCCCCCCHHEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCC
QTM
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA