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The map label for this gene is lpd [H]

Identifier: 50842707

GI number: 50842707

Start: 1335132

End: 1336535

Strand: Direct

Name: lpd [H]

Synonym: PPA1227

Alternate gene names: 50842707

Gene position: 1335132-1336535 (Clockwise)

Preceding gene: 50842705

Following gene: 50842714

Centisome position: 52.15

GC content: 58.9

Gene sequence:

>1404_bases
ATGAGCTCACATTTTGACGTCGTTGTCCTTGGAGCCGGCCCCGGTGGCTATGTTGCCGCCATTCGTGCCGCCCAGCTCGG
TAAGAAGACCGCCATCATCGAGAAGGAGTATTGGGGTGGTGTTTGCCTCAATGTTGGTTGCATCCCCACCAAGTCACTTT
TGCGCAACGCAGAACTAGCCCACATCGTCACCAAGGAGGCCAAGACCTTCGGTATTGGCGGGGACATCACCGTCGACTTC
GGCAAAGCCTTCAGTCGTTCCCGCGAAGTGTCTGCCCGCATGGTCAAGGGCATCCACTTCCTCATGAAGAAGAACAAAAT
CACCGAGTTCAACGGCTGGGGGGAGTTCACCGGCCCCAAGGCCATCTCTGTTAAAGACTCTGACGGCAAGGTGACCGACG
AGATCACTTTCGACAACGCGATCATCGCAGTCGGTTCGGTCGTCAAGACTCTGCCAGGCACCCAGCTCTCCGGTCGGGTC
GTCACCTACAAGGAACAGATCCTTTCCGACACCGTCCCTGGATCCATCGTCATCGCCGGTTCTGGAGCCATCGGTACTGA
GTTCGCCTATGTGCTGGCTAATTACGGCTGTGACGTGACCATCGTTGAATTTCTCGATCGTATGGTCCCGAACGAGGACA
AGGAGGTCTCGGCCGAGCTGGCTAAGGCCTACAAGAAACTCGGCATTAAGGTGCTGACTTCCACTAAGGTCGATTCCATC
GACGACTCCGGTGACAAGGTCAAGGTCACCATCTCGCCGTCGAAGGGTGGGGAGTCCAAGGTCATTGAAGCCGACCGCGT
TTTGCAAGCCGTCGGATTCGCTCCGCGGGTTGAGGGCTACGGCCTGGAGAAGACCGGCGTGAAGCTCACCGAGCGTGGCG
CCATCGAGATCGACGACTTTATGCGCACCAACGTTGACGGCATCTACGCCATTGGCGACTGTACCGCCAAGCTCATGCTG
GCCCATACCGCCGAGGCTCAAGGCGTCGTCGCCGCCGAGACAATTGCTGGGGCACAGACCATGCCCATCAACTACGACAT
GATTCCGCGCGCTACCTACTGTCAGCCGCAGGTTGGTTCTTTCGGTTACTCGGAGGACCAGGCCCGGGAAAAGGGCTACG
ACGTCAAGGTGTCCAAATTCCCGTTCGCCGCCAATGGCAAGGCGTGGGGTCTGGGCGATGGCACCGGCTTCGTGAAGATC
GTCGCCGACGCCCGTCACGGCGAGCTTCTCGGTGCCTCGCTAGTCGGCCATGACGTCTCCGAGTTGCTCCCCGAACTAAC
CTTGGCACAGCTGTGGGACATCACCGCTGAGGAGATCGGCCGCAACATCCACGCGCACCCGTCGCTGTCGGAAGCTCTCA
AGGATGCTGCGGAAGGCGTCGAGGGACACATGATCAACTTCTGA

Upstream 100 bases:

>100_bases
CTGAGTTCCTCCCCTCGGGAAGAACGGGTCGAGCAAGCCAGTCGAGATCTCTTCAGTGAGATCTTCGTCACAGACCGATG
TTCCCACTAGAGTGTTACCT

Downstream 100 bases:

>100_bases
TCTTTCCGTGACATGATTTCTGTGACATGTGTTGAAGCTCAGTAATCATGCAAGATCATGGGGTCCTAGCCTCCGAGCTG
GGACCCCTTCGCGTCACATC

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of alpha keto acid dehydrogenase complexes [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MSSHFDVVVLGAGPGGYVAAIRAAQLGKKTAIIEKEYWGGVCLNVGCIPTKSLLRNAELAHIVTKEAKTFGIGGDITVDF
GKAFSRSREVSARMVKGIHFLMKKNKITEFNGWGEFTGPKAISVKDSDGKVTDEITFDNAIIAVGSVVKTLPGTQLSGRV
VTYKEQILSDTVPGSIVIAGSGAIGTEFAYVLANYGCDVTIVEFLDRMVPNEDKEVSAELAKAYKKLGIKVLTSTKVDSI
DDSGDKVKVTISPSKGGESKVIEADRVLQAVGFAPRVEGYGLEKTGVKLTERGAIEIDDFMRTNVDGIYAIGDCTAKLML
AHTAEAQGVVAAETIAGAQTMPINYDMIPRATYCQPQVGSFGYSEDQAREKGYDVKVSKFPFAANGKAWGLGDGTGFVKI
VADARHGELLGASLVGHDVSELLPELTLAQLWDITAEEIGRNIHAHPSLSEALKDAAEGVEGHMINF

Sequences:

>Translated_467_residues
MSSHFDVVVLGAGPGGYVAAIRAAQLGKKTAIIEKEYWGGVCLNVGCIPTKSLLRNAELAHIVTKEAKTFGIGGDITVDF
GKAFSRSREVSARMVKGIHFLMKKNKITEFNGWGEFTGPKAISVKDSDGKVTDEITFDNAIIAVGSVVKTLPGTQLSGRV
VTYKEQILSDTVPGSIVIAGSGAIGTEFAYVLANYGCDVTIVEFLDRMVPNEDKEVSAELAKAYKKLGIKVLTSTKVDSI
DDSGDKVKVTISPSKGGESKVIEADRVLQAVGFAPRVEGYGLEKTGVKLTERGAIEIDDFMRTNVDGIYAIGDCTAKLML
AHTAEAQGVVAAETIAGAQTMPINYDMIPRATYCQPQVGSFGYSEDQAREKGYDVKVSKFPFAANGKAWGLGDGTGFVKI
VADARHGELLGASLVGHDVSELLPELTLAQLWDITAEEIGRNIHAHPSLSEALKDAAEGVEGHMINF
>Mature_466_residues
SSHFDVVVLGAGPGGYVAAIRAAQLGKKTAIIEKEYWGGVCLNVGCIPTKSLLRNAELAHIVTKEAKTFGIGGDITVDFG
KAFSRSREVSARMVKGIHFLMKKNKITEFNGWGEFTGPKAISVKDSDGKVTDEITFDNAIIAVGSVVKTLPGTQLSGRVV
TYKEQILSDTVPGSIVIAGSGAIGTEFAYVLANYGCDVTIVEFLDRMVPNEDKEVSAELAKAYKKLGIKVLTSTKVDSID
DSGDKVKVTISPSKGGESKVIEADRVLQAVGFAPRVEGYGLEKTGVKLTERGAIEIDDFMRTNVDGIYAIGDCTAKLMLA
HTAEAQGVVAAETIAGAQTMPINYDMIPRATYCQPQVGSFGYSEDQAREKGYDVKVSKFPFAANGKAWGLGDGTGFVKIV
ADARHGELLGASLVGHDVSELLPELTLAQLWDITAEEIGRNIHAHPSLSEALKDAAEGVEGHMINF

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=469, Percent_Identity=39.0191897654584, Blast_Score=297, Evalue=2e-80,
Organism=Homo sapiens, GI50301238, Length=464, Percent_Identity=26.0775862068966, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI148277065, Length=455, Percent_Identity=24.3956043956044, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI33519430, Length=455, Percent_Identity=24.3956043956044, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI33519428, Length=455, Percent_Identity=24.3956043956044, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI33519426, Length=455, Percent_Identity=24.3956043956044, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI148277071, Length=456, Percent_Identity=24.5614035087719, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI291045266, Length=463, Percent_Identity=25.0539956803456, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI22035672, Length=462, Percent_Identity=24.4588744588745, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI291045268, Length=460, Percent_Identity=23.695652173913, Blast_Score=89, Evalue=7e-18,
Organism=Escherichia coli, GI1786307, Length=467, Percent_Identity=36.1884368308351, Blast_Score=254, Evalue=8e-69,
Organism=Escherichia coli, GI87081717, Length=457, Percent_Identity=28.4463894967177, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1789915, Length=470, Percent_Identity=26.5957446808511, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI87082354, Length=430, Percent_Identity=25.5813953488372, Blast_Score=122, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI32565766, Length=454, Percent_Identity=37.4449339207048, Blast_Score=300, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI17557007, Length=481, Percent_Identity=27.6507276507277, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71983429, Length=467, Percent_Identity=26.7665952890792, Blast_Score=105, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI71983419, Length=467, Percent_Identity=26.7665952890792, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71982272, Length=395, Percent_Identity=26.8354430379747, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17559934, Length=296, Percent_Identity=28.3783783783784, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321091, Length=471, Percent_Identity=39.2781316348195, Blast_Score=287, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6325240, Length=474, Percent_Identity=27.6371308016878, Blast_Score=163, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6325166, Length=472, Percent_Identity=26.9067796610169, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI21358499, Length=468, Percent_Identity=40.1709401709402, Blast_Score=320, Evalue=1e-87,
Organism=Drosophila melanogaster, GI24640549, Length=481, Percent_Identity=25.5717255717256, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24640553, Length=481, Percent_Identity=25.5717255717256, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24640551, Length=487, Percent_Identity=25.4620123203285, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI17737741, Length=385, Percent_Identity=26.7532467532467, Blast_Score=83, Evalue=4e-16,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 49726; Mature: 49595

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSHFDVVVLGAGPGGYVAAIRAAQLGKKTAIIEKEYWGGVCLNVGCIPTKSLLRNAELA
CCCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCCEEEEECCCCCHHHHCCCHHH
HIVTKEAKTFGIGGDITVDFGKAFSRSREVSARMVKGIHFLMKKNKITEFNGWGEFTGPK
HHHHHCCCEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCE
AISVKDSDGKVTDEITFDNAIIAVGSVVKTLPGTQLSGRVVTYKEQILSDTVPGSIVIAG
EEEEECCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHCCCCCEEEEEE
SGAIGTEFAYVLANYGCDVTIVEFLDRMVPNEDKEVSAELAKAYKKLGIKVLTSTKVDSI
CCCCHHHHHHHHHHCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCC
DDSGDKVKVTISPSKGGESKVIEADRVLQAVGFAPRVEGYGLEKTGVKLTERGAIEIDDF
CCCCCEEEEEECCCCCCCCCEEHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCEEEHHH
MRTNVDGIYAIGDCTAKLMLAHTAEAQGVVAAETIAGAQTMPINYDMIPRATYCQPQVGS
HHCCCCCEEEECHHHEEEHEEECCCCCCEEEEHHHCCCEECCCCCCCCCCCCCCCCCCCC
FGYSEDQAREKGYDVKVSKFPFAANGKAWGLGDGTGFVKIVADARHGELLGASLVGHDVS
CCCCHHHHHHCCCCEEEECCCEECCCCEEECCCCCCEEEEEEECCCCCEEEHHHHHCCHH
ELLPELTLAQLWDITAEEIGRNIHAHPSLSEALKDAAEGVEGHMINF
HHHHHHHHHHHHCCCHHHHCCCCCCCCCHHHHHHHHHCCCCCCEECC
>Mature Secondary Structure 
SSHFDVVVLGAGPGGYVAAIRAAQLGKKTAIIEKEYWGGVCLNVGCIPTKSLLRNAELA
CCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCCEEEEECCCCCHHHHCCCHHH
HIVTKEAKTFGIGGDITVDFGKAFSRSREVSARMVKGIHFLMKKNKITEFNGWGEFTGPK
HHHHHCCCEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCE
AISVKDSDGKVTDEITFDNAIIAVGSVVKTLPGTQLSGRVVTYKEQILSDTVPGSIVIAG
EEEEECCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHCCCCCEEEEEE
SGAIGTEFAYVLANYGCDVTIVEFLDRMVPNEDKEVSAELAKAYKKLGIKVLTSTKVDSI
CCCCHHHHHHHHHHCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCC
DDSGDKVKVTISPSKGGESKVIEADRVLQAVGFAPRVEGYGLEKTGVKLTERGAIEIDDF
CCCCCEEEEEECCCCCCCCCEEHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCEEEHHH
MRTNVDGIYAIGDCTAKLMLAHTAEAQGVVAAETIAGAQTMPINYDMIPRATYCQPQVGS
HHCCCCCEEEECHHHEEEHEEECCCCCCEEEEHHHCCCEECCCCCCCCCCCCCCCCCCCC
FGYSEDQAREKGYDVKVSKFPFAANGKAWGLGDGTGFVKIVADARHGELLGASLVGHDVS
CCCCHHHHHHCCCCEEEECCCEECCCCEEECCCCCCEEEEEEECCCCCEEEHHHHHCCHH
ELLPELTLAQLWDITAEEIGRNIHAHPSLSEALKDAAEGVEGHMINF
HHHHHHHHHHHHCCCHHHHCCCCCCCCCHHHHHHHHHCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]