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The map label for this gene is aroC

Identifier: 50842662

GI number: 50842662

Start: 1289196

End: 1290392

Strand: Direct

Name: aroC

Synonym: PPA1182

Alternate gene names: 50842662

Gene position: 1289196-1290392 (Clockwise)

Preceding gene: 50842661

Following gene: 50842663

Centisome position: 50.35

GC content: 63.07

Gene sequence:

>1197_bases
ATGCTGCGTTATCTCACTGCCGGGGAGTCTCATGGCCCTGCTCTCGTCGCGACGATGGAGGGCATTCCGGCTCACGTCCA
GGTCGGGGCTGTAGAGATTTCCGAGGAGTTGCGACGTCGCCGTCTCGGGGCGGGACGAGGAGCCCGCATGTCTTTCGAAG
CTGACGAGTTGGAGTTGCTTGCCGGATTCCGACACGGGGAGACGTTAGGCGATCCCCTTGCGATCCGGATCGGCAATTCG
GAATGGGAGAAGTGGCGCACCGTCATGGCTCCTGGTCCGGTAGCTCCCGAGGATCTGGCCGGGCATGCCCGTGCAGCTGC
GCTCACGCGACCCCGCCCAGGCCATGCTGACCTTGCTGGCATGCAGAAATACGACTTTGATGAGGCCCGGCCAATCCTAG
AGCGCGCCTCTGCCCGCGAGACAGCCGCCCGCGTCGCATTGGGAGCGATTGCGAAGGCTTTCCTTAAGCAGTCTCTCGGC
ATCGAGGTGCTTTCCCACGTGGTGTCCTTGGGCCCTGTCTCAGCTCCAAATGGTCCACGTCCGGATCCAAGCGATCTGAC
CCGTATCGATGCGGATCCAGTGCGGTGCGCCGATTCAGTCACGAGCAAGCGCATGGTTGCGGAAATCGAGGCCTGCCGCA
AGGAAGGCGACACCCTGGGAGGTGTCGTGGAAGTACTGGCCTACGGTCTACCGGCCGGGTTGGGATCGCATAGTCAGGGG
GACCGACGGCTCGACGCCCGTCTTGCCGGAGCCTTGATGGGCATTCAAGCTATTAAGGGGGTCGAGTTTGGCGACGGTTT
CGACCTGACCCGTCGCCGAGGGTCGCAGGCTCACGACTGGATGGAGCCGACTGAGGGCGGTATCCATCGAGTGAGTGATC
GTGCCGGTGGCACTGAGGGTGGCATGTCGACTGGTCAGATACTACGGGTGCGTGCGGCGATGAAACCGATTGCCACCGTA
CCGCGAGCATTGCCGACCGTAGACGTGACCACCGGTGAAGCTGCCAATGCCCACCACCAGCGTTCCGACGTGTGTGCGGT
TCCTGCCGCCGGTGTGGTTGCTGAGGCCATGGCCGCATTGGTGTTGGCTGAGTGCGCGTTGGAGAAATTTGGCGGGGATT
CAGTAACTGAGACCCGTCGCAATGCGCAGGCCTACCTGGATCGTCTTGCCGCGCGCGGTCTGGCGGTGGCCCCATGA

Upstream 100 bases:

>100_bases
GTGCAACTCATGACTGGCTACCCGGTGCCGATGGACGTTTTGAGGTCCACAGCGCAGAACGGCCTGGCTGAGCACGCCCG
CCTTTGAAAGACTGAATGTT

Downstream 100 bases:

>100_bases
TAGCTCTCATCGGTGCTCCTGGATCAGGCAAGTCGACCGTCGGGCCGTTGCTGGCCCAGCGCCTTGGAGAAGAGTTCGTC
GACGTCGATGCCGTGATTGA

Product: chorismate synthase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate phospholyase

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MLRYLTAGESHGPALVATMEGIPAHVQVGAVEISEELRRRRLGAGRGARMSFEADELELLAGFRHGETLGDPLAIRIGNS
EWEKWRTVMAPGPVAPEDLAGHARAAALTRPRPGHADLAGMQKYDFDEARPILERASARETAARVALGAIAKAFLKQSLG
IEVLSHVVSLGPVSAPNGPRPDPSDLTRIDADPVRCADSVTSKRMVAEIEACRKEGDTLGGVVEVLAYGLPAGLGSHSQG
DRRLDARLAGALMGIQAIKGVEFGDGFDLTRRRGSQAHDWMEPTEGGIHRVSDRAGGTEGGMSTGQILRVRAAMKPIATV
PRALPTVDVTTGEAANAHHQRSDVCAVPAAGVVAEAMAALVLAECALEKFGGDSVTETRRNAQAYLDRLAARGLAVAP

Sequences:

>Translated_398_residues
MLRYLTAGESHGPALVATMEGIPAHVQVGAVEISEELRRRRLGAGRGARMSFEADELELLAGFRHGETLGDPLAIRIGNS
EWEKWRTVMAPGPVAPEDLAGHARAAALTRPRPGHADLAGMQKYDFDEARPILERASARETAARVALGAIAKAFLKQSLG
IEVLSHVVSLGPVSAPNGPRPDPSDLTRIDADPVRCADSVTSKRMVAEIEACRKEGDTLGGVVEVLAYGLPAGLGSHSQG
DRRLDARLAGALMGIQAIKGVEFGDGFDLTRRRGSQAHDWMEPTEGGIHRVSDRAGGTEGGMSTGQILRVRAAMKPIATV
PRALPTVDVTTGEAANAHHQRSDVCAVPAAGVVAEAMAALVLAECALEKFGGDSVTETRRNAQAYLDRLAARGLAVAP
>Mature_398_residues
MLRYLTAGESHGPALVATMEGIPAHVQVGAVEISEELRRRRLGAGRGARMSFEADELELLAGFRHGETLGDPLAIRIGNS
EWEKWRTVMAPGPVAPEDLAGHARAAALTRPRPGHADLAGMQKYDFDEARPILERASARETAARVALGAIAKAFLKQSLG
IEVLSHVVSLGPVSAPNGPRPDPSDLTRIDADPVRCADSVTSKRMVAEIEACRKEGDTLGGVVEVLAYGLPAGLGSHSQG
DRRLDARLAGALMGIQAIKGVEFGDGFDLTRRRGSQAHDWMEPTEGGIHRVSDRAGGTEGGMSTGQILRVRAAMKPIATV
PRALPTVDVTTGEAANAHHQRSDVCAVPAAGVVAEAMAALVLAECALEKFGGDSVTETRRNAQAYLDRLAARGLAVAP

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; seventh step. [C]

COG id: COG0082

COG function: function code E; Chorismate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chorismate synthase family

Homologues:

Organism=Escherichia coli, GI1788669, Length=369, Percent_Identity=35.5013550135501, Blast_Score=167, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6321290, Length=378, Percent_Identity=33.3333333333333, Blast_Score=174, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROC_PROAC (Q6A8I4)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_055889.1
- ProteinModelPortal:   Q6A8I4
- SMR:   Q6A8I4
- GeneID:   2931316
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA1182
- NMPDR:   fig|267747.1.peg.1166
- HOGENOM:   HBG292336
- OMA:   GSEAHDE
- ProtClustDB:   PRK05382
- BioCyc:   PACN267747:PPA1182-MONOMER
- BRENDA:   4.2.3.5
- HAMAP:   MF_00300_B
- InterPro:   IPR000453
- InterPro:   IPR020541
- PANTHER:   PTHR21085
- PIRSF:   PIRSF001456
- TIGRFAMs:   TIGR00033

Pfam domain/function: PF01264 Chorismate_synt; SSF103263 Chorismate_synth

EC number: =4.2.3.5

Molecular weight: Translated: 41931; Mature: 41931

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00787 CHORISMATE_SYNTHASE_1; PS00788 CHORISMATE_SYNTHASE_2; PS00789 CHORISMATE_SYNTHASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRYLTAGESHGPALVATMEGIPAHVQVGAVEISEELRRRRLGAGRGARMSFEADELELL
CCEEEECCCCCCCEEEEEECCCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
AGFRHGETLGDPLAIRIGNSEWEKWRTVMAPGPVAPEDLAGHARAAALTRPRPGHADLAG
HHCCCCCCCCCCEEEEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHC
MQKYDFDEARPILERASARETAARVALGAIAKAFLKQSLGIEVLSHVVSLGPVSAPNGPR
CHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCC
PDPSDLTRIDADPVRCADSVTSKRMVAEIEACRKEGDTLGGVVEVLAYGLPAGLGSHSQG
CCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCC
DRRLDARLAGALMGIQAIKGVEFGDGFDLTRRRGSQAHDWMEPTEGGIHRVSDRAGGTEG
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCHHCCCCCCCCHHHHHHHCCCCCC
GMSTGQILRVRAAMKPIATVPRALPTVDVTTGEAANAHHQRSDVCAVPAAGVVAEAMAAL
CCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHCCCCCCCCCHHHHHHHHHHH
VLAECALEKFGGDSVTETRRNAQAYLDRLAARGLAVAP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLRYLTAGESHGPALVATMEGIPAHVQVGAVEISEELRRRRLGAGRGARMSFEADELELL
CCEEEECCCCCCCEEEEEECCCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
AGFRHGETLGDPLAIRIGNSEWEKWRTVMAPGPVAPEDLAGHARAAALTRPRPGHADLAG
HHCCCCCCCCCCEEEEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHC
MQKYDFDEARPILERASARETAARVALGAIAKAFLKQSLGIEVLSHVVSLGPVSAPNGPR
CHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCC
PDPSDLTRIDADPVRCADSVTSKRMVAEIEACRKEGDTLGGVVEVLAYGLPAGLGSHSQG
CCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCC
DRRLDARLAGALMGIQAIKGVEFGDGFDLTRRRGSQAHDWMEPTEGGIHRVSDRAGGTEG
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCHHCCCCCCCCHHHHHHHCCCCCC
GMSTGQILRVRAAMKPIATVPRALPTVDVTTGEAANAHHQRSDVCAVPAAGVVAEAMAAL
CCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHCCCCCCCCCHHHHHHHHHHH
VLAECALEKFGGDSVTETRRNAQAYLDRLAARGLAVAP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA