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The map label for this gene is hisB

Identifier: 50842634

GI number: 50842634

Start: 1256120

End: 1256740

Strand: Direct

Name: hisB

Synonym: PPA1154

Alternate gene names: 50842634

Gene position: 1256120-1256740 (Clockwise)

Preceding gene: 50842633

Following gene: 50842635

Centisome position: 49.06

GC content: 58.45

Gene sequence:

>621_bases
ATGACCCATCGTCGCGCTCACATTTACCGCGAGACCTCGGAATCCACTGTCGACGTCGCAATTGATCTCGATGGGGCGGG
GGAGTCCACTATCTCTACCGGGGTTGGATTTTACGACCATATGCTGACGACATTGTCGAAGCATTCAGGTATCGATATGA
CGATCACCACTACCGGTGACGTCGAGATCGATGGTCACCACAGTATTGAAGACACGGCTATTGCTTTGGGCCAGGCTCTT
GCTCAGGCCTTGGGGGATAAATGCGGTATCACGCGTTTTGGTGACGCCGTGGTTCCCCTCGACGAGGCCCTTGCCCAGTG
CGTTGTTGACGTTGCTGGACGACCGTGGGTGGCGTGCTCGGGTGAGCCCGAGGGGCAGGCGTACGTTCGTATTGGTGGTT
CTGGCGTGTCCTACCAGGGTTCGATGACCTACCACGTCATGCACTCCTTAGCTTTCAACGCCGGTCTGTGCGTTCACCTG
CGTCTGCTGGCAGGACGCGACCCCCACCACATCTGCGAGGCCGAGTTCAAAGCGCTGGCCCGGGCGCTGAGAATTGCGAT
AGCACCGGATCCCCGTAATGCCGGTCGTGTCCCCAGCACTAAAGGCGCTCTCAATGTCTGA

Upstream 100 bases:

>100_bases
TGCGCGTCTGCGCCGGAACCCCATGCCAGACCGACGCTTTCCGTACCGCTTTGCTTGACGTCCTTCCCACCGCTCCGCGT
CTCGTCCCGGAGGAGGATCA

Downstream 100 bases:

>100_bases
TCCGGTGCGGGTCGGCATTATCGACCATGGATCAGGAAACCTTCACTCCGCTAGACGTGCGTTGCGTCAGGTAGGTGCCG
AGGTGATCGTTTCCAACGAC

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MTHRRAHIYRETSESTVDVAIDLDGAGESTISTGVGFYDHMLTTLSKHSGIDMTITTTGDVEIDGHHSIEDTAIALGQAL
AQALGDKCGITRFGDAVVPLDEALAQCVVDVAGRPWVACSGEPEGQAYVRIGGSGVSYQGSMTYHVMHSLAFNAGLCVHL
RLLAGRDPHHICEAEFKALARALRIAIAPDPRNAGRVPSTKGALNV

Sequences:

>Translated_206_residues
MTHRRAHIYRETSESTVDVAIDLDGAGESTISTGVGFYDHMLTTLSKHSGIDMTITTTGDVEIDGHHSIEDTAIALGQAL
AQALGDKCGITRFGDAVVPLDEALAQCVVDVAGRPWVACSGEPEGQAYVRIGGSGVSYQGSMTYHVMHSLAFNAGLCVHL
RLLAGRDPHHICEAEFKALARALRIAIAPDPRNAGRVPSTKGALNV
>Mature_205_residues
THRRAHIYRETSESTVDVAIDLDGAGESTISTGVGFYDHMLTTLSKHSGIDMTITTTGDVEIDGHHSIEDTAIALGQALA
QALGDKCGITRFGDAVVPLDEALAQCVVDVAGRPWVACSGEPEGQAYVRIGGSGVSYQGSMTYHVMHSLAFNAGLCVHLR
LLAGRDPHHICEAEFKALARALRIAIAPDPRNAGRVPSTKGALNV

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=201, Percent_Identity=44.2786069651741, Blast_Score=163, Evalue=9e-42,
Organism=Saccharomyces cerevisiae, GI6324776, Length=228, Percent_Identity=37.719298245614, Blast_Score=138, Evalue=8e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_PROAC (Q6A8L3)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_055861.1
- ProteinModelPortal:   Q6A8L3
- SMR:   Q6A8L3
- GeneID:   2932029
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA1154
- NMPDR:   fig|267747.1.peg.1138
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- ProtClustDB:   CLSK2763771
- BioCyc:   PACN267747:PPA1154-MONOMER
- BRENDA:   4.2.1.19
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21790; Mature: 21659

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHRRAHIYRETSESTVDVAIDLDGAGESTISTGVGFYDHMLTTLSKHSGIDMTITTTGD
CCCCCCCEEECCCCCEEEEEEEECCCCCCHHHHCCHHHHHHHHHHHHCCCCEEEEEECCC
VEIDGHHSIEDTAIALGQALAQALGDKCGITRFGDAVVPLDEALAQCVVDVAGRPWVACS
EEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHHHHCCCCEEEEC
GEPEGQAYVRIGGSGVSYQGSMTYHVMHSLAFNAGLCVHLRLLAGRDPHHICEAEFKALA
CCCCCEEEEEECCCCCEECCCHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHH
RALRIAIAPDPRNAGRVPSTKGALNV
HHHEEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
THRRAHIYRETSESTVDVAIDLDGAGESTISTGVGFYDHMLTTLSKHSGIDMTITTTGD
CCCCCCEEECCCCCEEEEEEEECCCCCCHHHHCCHHHHHHHHHHHHCCCCEEEEEECCC
VEIDGHHSIEDTAIALGQALAQALGDKCGITRFGDAVVPLDEALAQCVVDVAGRPWVACS
EEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHHHHCCCCEEEEC
GEPEGQAYVRIGGSGVSYQGSMTYHVMHSLAFNAGLCVHLRLLAGRDPHHICEAEFKALA
CCCCCEEEEEECCCCCEECCCHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHH
RALRIAIAPDPRNAGRVPSTKGALNV
HHHEEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA