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The map label for this gene is hisC

Identifier: 50842633

GI number: 50842633

Start: 1254957

End: 1256123

Strand: Direct

Name: hisC

Synonym: PPA1153

Alternate gene names: 50842633

Gene position: 1254957-1256123 (Clockwise)

Preceding gene: 50842632

Following gene: 50842634

Centisome position: 49.02

GC content: 60.33

Gene sequence:

>1167_bases
TTGACTCAACATCGACAGACCAGCCAGCCCCGTCCGGTGGCTAAGCCGGAGCCTAACTCTATCCAGTTGGCGGATCTTCC
GCTGCGCTCCGAACTTGTCGGGGCACAACCATACGGGGCTCCGCAGCTTGACGTCCCGGTACGCCTGAACGTCAACGAAA
ATCCGTATCCGCCATCGGAGGCGGTGCGCAAGGACATGGCCAAGGCTGTTGCCAAGGCTGCCAAGAGTCTTAACCGCTAC
CCCGACCGGGAAGCCACCGGCCTTCGCGAGGATCTGGCCCGATATATCGGCTTCGGTATTAGCAGCTCCCAGATATGGCC
TGCTAATGGCTCCAACGAGGTTATGACCCATATTTTGCAGGCGTTTGGTGGTCCAGGACGCTCTATGCTGACCTTCACAC
CGACCTACTCGATGTATCCCGAGTATGCCCGCAATACTCACACGAATTACGTCACTCGTCCTCGCAACGCCTCCTGGGGA
CTGACAACTGACGAAATACTGTCGGCAATCGAGGAGGTCAAGCCGGATGTCGTCTTACTGACGACGCCAAATAACCCCAC
CGGAACCACTATCCCGGTCGCCGTCATTGACGAGGTGTGTGCTGGCACCGACACCATCGTCGTCGTTGACGAGGCATATC
AGGAGTTCACAGACGCTCCGGAGGACTCCTCGATTGCTTTGCTTCCGAAGTACGGTCGGCTCATTGTGGTGCGCACCCTA
TCCAAGGCCTTCGCCCTGGCGGGTGGCCGACTGGGGTATGCGGTGGCCGCACCGGCCGTCGTTGACGCGCTGCAGATGGT
GCGGCTGCCCTATCATCTCTCGGACGTGTCACAGGTGGTGGCGAGAGTTGCCCTCGCTCATGCCCCCGAGATGCTTGCGC
GGGTCGACGAGTTGCGTGAGACCCGCGCAAACCTGGAGGACTGGCTGCAACTGCACGGGTTGGACGTCGTTTCCTCACAG
TCGAACTTCGTCCTCTTCGGCAGGTTCGCTGATCGTCACGCGGTATTCCAGGCGCTGCTTGATCGCGGTGTGCTCATCCG
AGAGGTCGGACCAACTGGCTACTTGCGCGTCTGCGCCGGAACCCCATGCCAGACCGACGCTTTCCGTACCGCTTTGCTTG
ACGTCCTTCCCACCGCTCCGCGTCTCGTCCCGGAGGAGGATCAATGA

Upstream 100 bases:

>100_bases
CCGAGGATGCCCTACTCGAACTGGCCGATTCCGTTGAGGCTTTTGCCTTGGCGGAGAATTTGCCCGGCCATGCCAATGCC
ATCACTGTGAGGAGGTCACG

Downstream 100 bases:

>100_bases
CCCATCGTCGCGCTCACATTTACCGCGAGACCTCGGAATCCACTGTCGACGTCGCAATTGATCTCGATGGGGCGGGGGAG
TCCACTATCTCTACCGGGGT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MTQHRQTSQPRPVAKPEPNSIQLADLPLRSELVGAQPYGAPQLDVPVRLNVNENPYPPSEAVRKDMAKAVAKAAKSLNRY
PDREATGLREDLARYIGFGISSSQIWPANGSNEVMTHILQAFGGPGRSMLTFTPTYSMYPEYARNTHTNYVTRPRNASWG
LTTDEILSAIEEVKPDVVLLTTPNNPTGTTIPVAVIDEVCAGTDTIVVVDEAYQEFTDAPEDSSIALLPKYGRLIVVRTL
SKAFALAGGRLGYAVAAPAVVDALQMVRLPYHLSDVSQVVARVALAHAPEMLARVDELRETRANLEDWLQLHGLDVVSSQ
SNFVLFGRFADRHAVFQALLDRGVLIREVGPTGYLRVCAGTPCQTDAFRTALLDVLPTAPRLVPEEDQ

Sequences:

>Translated_388_residues
MTQHRQTSQPRPVAKPEPNSIQLADLPLRSELVGAQPYGAPQLDVPVRLNVNENPYPPSEAVRKDMAKAVAKAAKSLNRY
PDREATGLREDLARYIGFGISSSQIWPANGSNEVMTHILQAFGGPGRSMLTFTPTYSMYPEYARNTHTNYVTRPRNASWG
LTTDEILSAIEEVKPDVVLLTTPNNPTGTTIPVAVIDEVCAGTDTIVVVDEAYQEFTDAPEDSSIALLPKYGRLIVVRTL
SKAFALAGGRLGYAVAAPAVVDALQMVRLPYHLSDVSQVVARVALAHAPEMLARVDELRETRANLEDWLQLHGLDVVSSQ
SNFVLFGRFADRHAVFQALLDRGVLIREVGPTGYLRVCAGTPCQTDAFRTALLDVLPTAPRLVPEEDQ
>Mature_387_residues
TQHRQTSQPRPVAKPEPNSIQLADLPLRSELVGAQPYGAPQLDVPVRLNVNENPYPPSEAVRKDMAKAVAKAAKSLNRYP
DREATGLREDLARYIGFGISSSQIWPANGSNEVMTHILQAFGGPGRSMLTFTPTYSMYPEYARNTHTNYVTRPRNASWGL
TTDEILSAIEEVKPDVVLLTTPNNPTGTTIPVAVIDEVCAGTDTIVVVDEAYQEFTDAPEDSSIALLPKYGRLIVVRTLS
KAFALAGGRLGYAVAAPAVVDALQMVRLPYHLSDVSQVVARVALAHAPEMLARVDELRETRANLEDWLQLHGLDVVSSQS
NFVLFGRFADRHAVFQALLDRGVLIREVGPTGYLRVCAGTPCQTDAFRTALLDVLPTAPRLVPEEDQ

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=329, Percent_Identity=33.7386018237082, Blast_Score=131, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6322075, Length=370, Percent_Identity=27.027027027027, Blast_Score=109, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_PROAC (Q6A8L4)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_055860.1
- ProteinModelPortal:   Q6A8L4
- SMR:   Q6A8L4
- GeneID:   2931028
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA1153
- NMPDR:   fig|267747.1.peg.1137
- HOGENOM:   HBG646350
- OMA:   CELYANQ
- ProtClustDB:   PRK03317
- BioCyc:   PACN267747:PPA1153-MONOMER
- BRENDA:   2.6.1.9
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 42422; Mature: 42290

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQHRQTSQPRPVAKPEPNSIQLADLPLRSELVGAQPYGAPQLDVPVRLNVNENPYPPSE
CCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCHH
AVRKDMAKAVAKAAKSLNRYPDREATGLREDLARYIGFGISSSQIWPANGSNEVMTHILQ
HHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHH
AFGGPGRSMLTFTPTYSMYPEYARNTHTNYVTRPRNASWGLTTDEILSAIEEVKPDVVLL
HHCCCCCCEEEECCCHHHCHHHHHCCCCCCEECCCCCCCCCCHHHHHHHHHHCCCCEEEE
TTPNNPTGTTIPVAVIDEVCAGTDTIVVVDEAYQEFTDAPEDSSIALLPKYGRLIVVRTL
ECCCCCCCCEEHHHHHHHHHCCCCEEEEEHHHHHHHHCCCCCCCEEEEECCCCEEEEHHH
SKAFALAGGRLGYAVAAPAVVDALQMVRLPYHLSDVSQVVARVALAHAPEMLARVDELRE
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRANLEDWLQLHGLDVVSSQSNFVLFGRFADRHAVFQALLDRGVLIREVGPTGYLRVCAG
HHHCHHHHHHHHCCCEEECCCCEEEEECCHHHHHHHHHHHHCCEEEEECCCCCEEEEECC
TPCQTDAFRTALLDVLPTAPRLVPEEDQ
CCCCHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TQHRQTSQPRPVAKPEPNSIQLADLPLRSELVGAQPYGAPQLDVPVRLNVNENPYPPSE
CCCCCCCCCCCCCCCCCCCEEEECCCHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCHH
AVRKDMAKAVAKAAKSLNRYPDREATGLREDLARYIGFGISSSQIWPANGSNEVMTHILQ
HHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHH
AFGGPGRSMLTFTPTYSMYPEYARNTHTNYVTRPRNASWGLTTDEILSAIEEVKPDVVLL
HHCCCCCCEEEECCCHHHCHHHHHCCCCCCEECCCCCCCCCCHHHHHHHHHHCCCCEEEE
TTPNNPTGTTIPVAVIDEVCAGTDTIVVVDEAYQEFTDAPEDSSIALLPKYGRLIVVRTL
ECCCCCCCCEEHHHHHHHHHCCCCEEEEEHHHHHHHHCCCCCCCEEEEECCCCEEEEHHH
SKAFALAGGRLGYAVAAPAVVDALQMVRLPYHLSDVSQVVARVALAHAPEMLARVDELRE
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRANLEDWLQLHGLDVVSSQSNFVLFGRFADRHAVFQALLDRGVLIREVGPTGYLRVCAG
HHHCHHHHHHHHCCCEEECCCCEEEEECCHHHHHHHHHHHHCCEEEEECCCCCEEEEECC
TPCQTDAFRTALLDVLPTAPRLVPEEDQ
CCCCHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA