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The map label for this gene is hisD

Identifier: 50842632

GI number: 50842632

Start: 1253641

End: 1254960

Strand: Direct

Name: hisD

Synonym: PPA1152

Alternate gene names: 50842632

Gene position: 1253641-1254960 (Clockwise)

Preceding gene: 50842631

Following gene: 50842633

Centisome position: 48.97

GC content: 61.97

Gene sequence:

>1320_bases
GTGCTGAGAATCGTCGATGTGACCAGTGAGACCACTGACGACCTGCGTTGCGCCGTGCCTCGCGCGGACTTCGATGTCGA
TGCCGCCATGGCGGCCGTCATCCCTGTCTGCTCCGCGGTGAGGGATCGTGGCGTTGAGGCGCTACGTGAGTACAGCGAGA
AATTCGACCATGTGGTTCCCGAGCATCTGCGCGTTCCGGTCGAGGCTCTCGCCACGGCAGCTGCGAACCTCGACGGCACC
TTGCGTCGGGCTTTCAGCGAATCTATTCGACGTCGTCGTCAGGTATGTCAGGAAGCTGAGGTGGAGACCTCGTCCCAACC
GGTTGAGGTGGCAGGTGGCGCGCGGGTGAGCCAGCGCATCGTCCCGGTCGGGCGTGTAGGCCTTTACGTTCCGGGTGGGT
TCGCTCCGCTGGCATCGTCGGTCATCATGAACGTCGTTCCTGCGCAGGAGGCCGGTGTCTCGTCTATCGCTGTAGCATCT
CCGCCCCAGGCGGAGTTTGGTGGGTTGCCGCACCCGAGCATCTTGGCGCTGTGTCATCTACTGGGTGTCAATGAGGTCTA
CGCCGTTGGTGGCGCCCAGGCGATCGCCATGTTCGCTTACGGTGTTGAGGGCTCCGACGAGGCAGATTCCTGTCCGCGCG
TCGACATGGTTACGGGTCCAGGCAACATCTACGTAGTCGCGGCAAAGCGCTGCCTGCGTGGCACCGTCGGCATCGATTCG
GAGGCTGGGCCCACCGAAATCGCCATCCTGGCCGATGAGACTGCTGACCCGCGTCACATTGCTGCTGATCTTATGAGCCA
GGCTGAGCACGACACGCTGGCTGCCGCAGTGCTTGTCACAGACTCGACCACACTGGCCGAAGCTGTGCAACGAGAACTTG
CCCCGATGGTCAGTGCCACCTTACATTCCGAGCGCATTCGCACCTCGCTGACATCCAAGCAGTCGGCCATCGTCATGGTA
CGTGATATTGATCAGGGCCTCGAAGTGGTCAATGCGTATGCCGCCGAGCATCTCGAGATCCAGACGGCCGATGCTGCCGC
AGTCGCTGCTCGGGTCTGGAACGCTGGCGCCATTTTCGTCGGCCCATGGGCGCCTGTCTCTCTTGGGGATTACTCAGCCG
GATCCACTCACGTCCTTCCCACGGCAGGAGCAGCCTGCCACTCGTCTGGTCTGTCGGTGCGTTCCTTCATGCGCGCCGTC
CACGTGATCGACTACACCGAGGATGCCCTACTCGAACTGGCCGATTCCGTTGAGGCTTTTGCCTTGGCGGAGAATTTGCC
CGGCCATGCCAATGCCATCACTGTGAGGAGGTCACGTTGA

Upstream 100 bases:

>100_bases
ATGGTGCCCATGCTCATCGCCTCCCTGCTGGCGGCCAGACGTGGCGCTTCGCGGACCGGACGCGCAAAGACGTCGACCGG
GGCTTCATTAGACTAGCAAT

Downstream 100 bases:

>100_bases
CTCAACATCGACAGACCAGCCAGCCCCGTCCGGTGGCTAAGCCGGAGCCTAACTCTATCCAGTTGGCGGATCTTCCGCTG
CGCTCCGAACTTGTCGGGGC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MLRIVDVTSETTDDLRCAVPRADFDVDAAMAAVIPVCSAVRDRGVEALREYSEKFDHVVPEHLRVPVEALATAAANLDGT
LRRAFSESIRRRRQVCQEAEVETSSQPVEVAGGARVSQRIVPVGRVGLYVPGGFAPLASSVIMNVVPAQEAGVSSIAVAS
PPQAEFGGLPHPSILALCHLLGVNEVYAVGGAQAIAMFAYGVEGSDEADSCPRVDMVTGPGNIYVVAAKRCLRGTVGIDS
EAGPTEIAILADETADPRHIAADLMSQAEHDTLAAAVLVTDSTTLAEAVQRELAPMVSATLHSERIRTSLTSKQSAIVMV
RDIDQGLEVVNAYAAEHLEIQTADAAAVAARVWNAGAIFVGPWAPVSLGDYSAGSTHVLPTAGAACHSSGLSVRSFMRAV
HVIDYTEDALLELADSVEAFALAENLPGHANAITVRRSR

Sequences:

>Translated_439_residues
MLRIVDVTSETTDDLRCAVPRADFDVDAAMAAVIPVCSAVRDRGVEALREYSEKFDHVVPEHLRVPVEALATAAANLDGT
LRRAFSESIRRRRQVCQEAEVETSSQPVEVAGGARVSQRIVPVGRVGLYVPGGFAPLASSVIMNVVPAQEAGVSSIAVAS
PPQAEFGGLPHPSILALCHLLGVNEVYAVGGAQAIAMFAYGVEGSDEADSCPRVDMVTGPGNIYVVAAKRCLRGTVGIDS
EAGPTEIAILADETADPRHIAADLMSQAEHDTLAAAVLVTDSTTLAEAVQRELAPMVSATLHSERIRTSLTSKQSAIVMV
RDIDQGLEVVNAYAAEHLEIQTADAAAVAARVWNAGAIFVGPWAPVSLGDYSAGSTHVLPTAGAACHSSGLSVRSFMRAV
HVIDYTEDALLELADSVEAFALAENLPGHANAITVRRSR
>Mature_439_residues
MLRIVDVTSETTDDLRCAVPRADFDVDAAMAAVIPVCSAVRDRGVEALREYSEKFDHVVPEHLRVPVEALATAAANLDGT
LRRAFSESIRRRRQVCQEAEVETSSQPVEVAGGARVSQRIVPVGRVGLYVPGGFAPLASSVIMNVVPAQEAGVSSIAVAS
PPQAEFGGLPHPSILALCHLLGVNEVYAVGGAQAIAMFAYGVEGSDEADSCPRVDMVTGPGNIYVVAAKRCLRGTVGIDS
EAGPTEIAILADETADPRHIAADLMSQAEHDTLAAAVLVTDSTTLAEAVQRELAPMVSATLHSERIRTSLTSKQSAIVMV
RDIDQGLEVVNAYAAEHLEIQTADAAAVAARVWNAGAIFVGPWAPVSLGDYSAGSTHVLPTAGAACHSSGLSVRSFMRAV
HVIDYTEDALLELADSVEAFALAENLPGHANAITVRRSR

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=444, Percent_Identity=36.4864864864865, Blast_Score=254, Evalue=6e-69,
Organism=Saccharomyces cerevisiae, GI6319819, Length=423, Percent_Identity=36.1702127659575, Blast_Score=230, Evalue=3e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_PROAC (Q6A8L5)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_055859.1
- ProteinModelPortal:   Q6A8L5
- SMR:   Q6A8L5
- GeneID:   2932004
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA1152
- NMPDR:   fig|267747.1.peg.1136
- HOGENOM:   HBG329596
- OMA:   LDAHKNA
- ProtClustDB:   PRK00877
- BioCyc:   PACN267747:PPA1152-MONOMER
- BRENDA:   1.1.1.23
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 46099; Mature: 46099

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 336-336 ACT_SITE 337-337 BINDING 129-129 BINDING 193-193 BINDING 222-222 BINDING 245-245 BINDING 267-267 BINDING 270-270 BINDING 337-337 BINDING 370-370 BINDING 424-424 BINDING 429-429

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIVDVTSETTDDLRCAVPRADFDVDAAMAAVIPVCSAVRDRGVEALREYSEKFDHVVP
CEEEEECCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCH
EHLRVPVEALATAAANLDGTLRRAFSESIRRRRQVCQEAEVETSSQPVEVAGGARVSQRI
HHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHC
VPVGRVGLYVPGGFAPLASSVIMNVVPAQEAGVSSIAVASPPQAEFGGLPHPSILALCHL
CCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHCCCCCCHHHHHHHHH
LGVNEVYAVGGAQAIAMFAYGVEGSDEADSCPRVDMVTGPGNIYVVAAKRCLRGTVGIDS
HCCCHHHHCCCHHEEEHEEECCCCCCCCCCCCCEEEEECCCCEEEEEEHHHHCCCCCCCC
EAGPTEIAILADETADPRHIAADLMSQAEHDTLAAAVLVTDSTTLAEAVQRELAPMVSAT
CCCCCEEEEEECCCCCHHHHHHHHHHHCCCHHEEEEEEEECCHHHHHHHHHHHHHHHHHH
LHSERIRTSLTSKQSAIVMVRDIDQGLEVVNAYAAEHLEIQTADAAAVAARVWNAGAIFV
HHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHCCCEEEE
GPWAPVSLGDYSAGSTHVLPTAGAACHSSGLSVRSFMRAVHVIDYTEDALLELADSVEAF
CCCCCCCCCCCCCCCCEECCCCCCHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHH
ALAENLPGHANAITVRRSR
HHHHCCCCCCCEEEEEECC
>Mature Secondary Structure
MLRIVDVTSETTDDLRCAVPRADFDVDAAMAAVIPVCSAVRDRGVEALREYSEKFDHVVP
CEEEEECCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCH
EHLRVPVEALATAAANLDGTLRRAFSESIRRRRQVCQEAEVETSSQPVEVAGGARVSQRI
HHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHC
VPVGRVGLYVPGGFAPLASSVIMNVVPAQEAGVSSIAVASPPQAEFGGLPHPSILALCHL
CCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHCCCCCCHHHHHHHHH
LGVNEVYAVGGAQAIAMFAYGVEGSDEADSCPRVDMVTGPGNIYVVAAKRCLRGTVGIDS
HCCCHHHHCCCHHEEEHEEECCCCCCCCCCCCCEEEEECCCCEEEEEEHHHHCCCCCCCC
EAGPTEIAILADETADPRHIAADLMSQAEHDTLAAAVLVTDSTTLAEAVQRELAPMVSAT
CCCCCEEEEEECCCCCHHHHHHHHHHHCCCHHEEEEEEEECCHHHHHHHHHHHHHHHHHH
LHSERIRTSLTSKQSAIVMVRDIDQGLEVVNAYAAEHLEIQTADAAAVAARVWNAGAIFV
HHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHCCCEEEE
GPWAPVSLGDYSAGSTHVLPTAGAACHSSGLSVRSFMRAVHVIDYTEDALLELADSVEAF
CCCCCCCCCCCCCCCCEECCCCCCHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHH
ALAENLPGHANAITVRRSR
HHHHCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA