Click here to switch to the map view.

The map label for this gene is lexA [H]

Identifier: 50842506

GI number: 50842506

Start: 1108732

End: 1109406

Strand: Reverse

Name: lexA [H]

Synonym: PPA1023

Alternate gene names: 50842506

Gene position: 1109406-1108732 (Counterclockwise)

Preceding gene: 50842514

Following gene: 50842501

Centisome position: 43.33

GC content: 58.22

Gene sequence:

>675_bases
ATGATCACCGATACGCCCGGAACCGATACCTCGGACCCGGCCGCCGTCTCGTCGGCTGTTCCGTTCACGAATACCCGTGA
GCCCTCTGCCAAGGAACGCGAAGTCTTGGCAGCCGTCAAGGAAGGGCTGCGTCGCGACGGCAAAGCCCCAACAGTTCGCG
CCCTTGCTGAGATGACAGGAGCTGCGAGCACATCAACAGTCCAGCGGCGTATTTCGTCCCTCATCGATCTAGGGCTGCTA
CGTCGAACCAATGGCACCCTCGAGGTGGTCGAAGAAACCGTCGAGTCCAGCGATCCGCACGGACCGCAAGCCTTTCAAGT
CAAACTCCTCAATCCGAGTAACGAAGAACACGATGAAACCGTCATCGCGGTGCCACCTCAGCTTCTAAGTCACGGCGAGC
ACGCAGTGATCATCGTCCGCGACGACGGAATGTCTCCCGATATCCACTCCGGAGATCTTGTAGTGGTGCGACGTATATCG
GTAAGCGATCTGCCCGACGATCCACCTGAGACATACCTCGTAGCAGCCACAGCGGGCGGAACGACCGTCGTTCGCACTTT
ATCCAACGTCTCGGGACGGCGATGGCTGTTGGCATCCAACCCTACCCACTCACCAATCAATCTCGATGATGCTTCTCTGC
TGGGTCAGGCTGTGTCCTTGCTGAGACGACTCTAA

Upstream 100 bases:

>100_bases
GAGCGGATTAGGTGCCCAGTTTTTGCCCCCACACTCCTCGCACGGAGCCAAAACGCCACTGATGGGGAAACTGTCGTAGC
TGCCCTATACCGTGACTGCC

Downstream 100 bases:

>100_bases
AGCGGCCCAATAAACCACCTAGCCGCAGGGCTCTCTCCCCTATCCTTGGTGTGCCTCGGCCGAAATCGATCACGACGAAA
ATACCGGGTCCGGGTCAAGA

Product: LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MITDTPGTDTSDPAAVSSAVPFTNTREPSAKEREVLAAVKEGLRRDGKAPTVRALAEMTGAASTSTVQRRISSLIDLGLL
RRTNGTLEVVEETVESSDPHGPQAFQVKLLNPSNEEHDETVIAVPPQLLSHGEHAVIIVRDDGMSPDIHSGDLVVVRRIS
VSDLPDDPPETYLVAATAGGTTVVRTLSNVSGRRWLLASNPTHSPINLDDASLLGQAVSLLRRL

Sequences:

>Translated_224_residues
MITDTPGTDTSDPAAVSSAVPFTNTREPSAKEREVLAAVKEGLRRDGKAPTVRALAEMTGAASTSTVQRRISSLIDLGLL
RRTNGTLEVVEETVESSDPHGPQAFQVKLLNPSNEEHDETVIAVPPQLLSHGEHAVIIVRDDGMSPDIHSGDLVVVRRIS
VSDLPDDPPETYLVAATAGGTTVVRTLSNVSGRRWLLASNPTHSPINLDDASLLGQAVSLLRRL
>Mature_224_residues
MITDTPGTDTSDPAAVSSAVPFTNTREPSAKEREVLAAVKEGLRRDGKAPTVRALAEMTGAASTSTVQRRISSLIDLGLL
RRTNGTLEVVEETVESSDPHGPQAFQVKLLNPSNEEHDETVIAVPPQLLSHGEHAVIIVRDDGMSPDIHSGDLVVVRRIS
VSDLPDDPPETYLVAATAGGTTVVRTLSNVSGRRWLLASNPTHSPINLDDASLLGQAVSLLRRL

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 23861; Mature: 23861

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITDTPGTDTSDPAAVSSAVPFTNTREPSAKEREVLAAVKEGLRRDGKAPTVRALAEMTG
CCCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
AASTSTVQRRISSLIDLGLLRRTNGTLEVVEETVESSDPHGPQAFQVKLLNPSNEEHDET
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCE
VIAVPPQLLSHGEHAVIIVRDDGMSPDIHSGDLVVVRRISVSDLPDDPPETYLVAATAGG
EEEECHHHHCCCCEEEEEEECCCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEECCC
TTVVRTLSNVSGRRWLLASNPTHSPINLDDASLLGQAVSLLRRL
HHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MITDTPGTDTSDPAAVSSAVPFTNTREPSAKEREVLAAVKEGLRRDGKAPTVRALAEMTG
CCCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
AASTSTVQRRISSLIDLGLLRRTNGTLEVVEETVESSDPHGPQAFQVKLLNPSNEEHDET
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCE
VIAVPPQLLSHGEHAVIIVRDDGMSPDIHSGDLVVVRRISVSDLPDDPPETYLVAATAGG
EEEECHHHHCCCCEEEEEEECCCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEECCC
TTVVRTLSNVSGRRWLLASNPTHSPINLDDASLLGQAVSLLRRL
HHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA