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The map label for this gene is menE [H]

Identifier: 50842390

GI number: 50842390

Start: 987629

End: 988879

Strand: Reverse

Name: menE [H]

Synonym: PPA0906

Alternate gene names: 50842390

Gene position: 988879-987629 (Counterclockwise)

Preceding gene: 50842391

Following gene: 50842389

Centisome position: 38.62

GC content: 70.34

Gene sequence:

>1251_bases
GTGACGCCTTCCTCGAGCACCGCTCCCCGGACTGGTCCGACTACCCCTATTACTTCTGAGGCCGTCGTGGGATCCGAGCT
GACATCGCGGGTGCGGGTGGTACGCGTCGAGCGCACGCGCGAAGACGTCGACTGGCTGGCTGGGCGTCTGACCGAAGTGT
TCGACGGGGCCCGGTCGGTGCTCGTGCCGGCCGGTGGCAACGAGTTGCCTCCGGCGGTGTTCCAAGATGTCGAGGACCGC
ACGGTGTGGCTGCCAGACGAGGTCGCCCTCGTCGTACGCACCTCGGGGTCAACCTCCGGGACCGGGCGTCTCGTCGGACT
GTCGGCGACGCAGTTGCGAGCCTCGGGTGCGGCCACCCGGGAGCGCTTGGGAGGGCCATGCACGTGGGTGCTGGCCCTGC
CTCCCCATCACATCGCTGGGCTGCAGGTCGTCGCCCGAGCCGTCGGCGACGGTCGCGAGGTCGTGGTGGTCGAGGGGCGC
CTCGATGCTCCGGCTGTGGCGGCAGCCGTCGACGAGGCGGCAAACCGTCATGACGATGGCCGGGTGGCGATATCGGTGGT
GCCTACCCAGTTGTCGCGGCTCCTCGACGACCCGGTTGGGACGGAGGCCCTGACCCGGTGTGCCGCGGTGCTCGTCGGCG
GGGCCGCCGCGTCGGCGTCGTTGCTGTCGCGGGCCCAGAAGGCTGGCGTCCCGGTACGGGTGACCTACGGCATGAGCGAG
ACCTGCGGCGGGTGCGTCTATGACGGGGTGCCACTCGAAGGGGTACGGGTCGACCTGGCCGACGACAGCCGGGTGCGCAT
CGCCGGGCCGATGATCATGAGCGGCTACCTCGACGAAGGTCCGGTCGGGCCGTGGCTGGCCACCCAGGATCTCGGGCATT
GGCAGAGTGGGCGCCTGGTCATCGACGGGCGCATCGACGACGTCATCAACTCGGGCGGGCTCAAGATCGCCGCCGGTCAG
GTACTCGACCAGATCCGGGCCACCGGCATGGTCCGCGACGGCCTCGTCCTTGGCTTGGCGGACGCCACCTGGGGCCAGGT
TGTCACCGCCGTCGTCGTCCCGGGGCGGGGGTGGCGAGGTCCCGAGGCGCTGCGCGACCTCGTCGGACGACGTCTGGGAC
GCGCCCATGCTCCGCGGGTCATCGTTGAGGTCGACGAGCTGCCGATGCTGTCGTCGGGCAAGATCGACCGAGTAGAGGTA
CGCCGAATAGCGACGGCGACGCTAGAGTCCGGAGCAGCCTGGCGGGTGTGA

Upstream 100 bases:

>100_bases
TATGCCTTTAATATGGTTGACGACGGCATCGCTGGTCAGCAGGCATTCGCTGGTGAGGCGACCCGGATGGCATATATGAC
CGAGGAGGCCCAGGAGGGGC

Downstream 100 bases:

>100_bases
CCGCTGGTTTTCGGGGACATCCCGCACAAGACGTCACCTGCGAAATCCTTGGTCCGCGCCGCGCCGATCATGCTGCGCTT
GAGAGCCTCCTGTCTGATTC

Product: O-succinylbenzoic acid-CoA ligase

Products: NA

Alternate protein names: OSB-CoA synthetase; o-succinylbenzoyl-CoA synthetase [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MTPSSSTAPRTGPTTPITSEAVVGSELTSRVRVVRVERTREDVDWLAGRLTEVFDGARSVLVPAGGNELPPAVFQDVEDR
TVWLPDEVALVVRTSGSTSGTGRLVGLSATQLRASGAATRERLGGPCTWVLALPPHHIAGLQVVARAVGDGREVVVVEGR
LDAPAVAAAVDEAANRHDDGRVAISVVPTQLSRLLDDPVGTEALTRCAAVLVGGAAASASLLSRAQKAGVPVRVTYGMSE
TCGGCVYDGVPLEGVRVDLADDSRVRIAGPMIMSGYLDEGPVGPWLATQDLGHWQSGRLVIDGRIDDVINSGGLKIAAGQ
VLDQIRATGMVRDGLVLGLADATWGQVVTAVVVPGRGWRGPEALRDLVGRRLGRAHAPRVIVEVDELPMLSSGKIDRVEV
RRIATATLESGAAWRV

Sequences:

>Translated_416_residues
MTPSSSTAPRTGPTTPITSEAVVGSELTSRVRVVRVERTREDVDWLAGRLTEVFDGARSVLVPAGGNELPPAVFQDVEDR
TVWLPDEVALVVRTSGSTSGTGRLVGLSATQLRASGAATRERLGGPCTWVLALPPHHIAGLQVVARAVGDGREVVVVEGR
LDAPAVAAAVDEAANRHDDGRVAISVVPTQLSRLLDDPVGTEALTRCAAVLVGGAAASASLLSRAQKAGVPVRVTYGMSE
TCGGCVYDGVPLEGVRVDLADDSRVRIAGPMIMSGYLDEGPVGPWLATQDLGHWQSGRLVIDGRIDDVINSGGLKIAAGQ
VLDQIRATGMVRDGLVLGLADATWGQVVTAVVVPGRGWRGPEALRDLVGRRLGRAHAPRVIVEVDELPMLSSGKIDRVEV
RRIATATLESGAAWRV
>Mature_415_residues
TPSSSTAPRTGPTTPITSEAVVGSELTSRVRVVRVERTREDVDWLAGRLTEVFDGARSVLVPAGGNELPPAVFQDVEDRT
VWLPDEVALVVRTSGSTSGTGRLVGLSATQLRASGAATRERLGGPCTWVLALPPHHIAGLQVVARAVGDGREVVVVEGRL
DAPAVAAAVDEAANRHDDGRVAISVVPTQLSRLLDDPVGTEALTRCAAVLVGGAAASASLLSRAQKAGVPVRVTYGMSET
CGGCVYDGVPLEGVRVDLADDSRVRIAGPMIMSGYLDEGPVGPWLATQDLGHWQSGRLVIDGRIDDVINSGGLKIAAGQV
LDQIRATGMVRDGLVLGLADATWGQVVTAVVVPGRGWRGPEALRDLVGRRLGRAHAPRVIVEVDELPMLSSGKIDRVEVR
RIATATLESGAAWRV

Specific function: Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl- CoA (OSB-CoA). May be involved in the biosynthesis of menaquinone [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788595, Length=312, Percent_Identity=28.2051282051282, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI145693145, Length=355, Percent_Identity=25.9154929577465, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17558820, Length=283, Percent_Identity=25.4416961130742, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.26 [H]

Molecular weight: Translated: 43547; Mature: 43416

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPSSSTAPRTGPTTPITSEAVVGSELTSRVRVVRVERTREDVDWLAGRLTEVFDGARSV
CCCCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCEE
LVPAGGNELPPAVFQDVEDRTVWLPDEVALVVRTSGSTSGTGRLVGLSATQLRASGAATR
EEECCCCCCCHHHHHCCCCCEEECCCCEEEEEEECCCCCCCCEEEECCHHHHHHCCCHHH
ERLGGPCTWVLALPPHHIAGLQVVARAVGDGREVVVVEGRLDAPAVAAAVDEAANRHDDG
HHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCC
RVAISVVPTQLSRLLDDPVGTEALTRCAAVLVGGAAASASLLSRAQKAGVPVRVTYGMSE
EEEEEEEHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCC
TCGGCVYDGVPLEGVRVDLADDSRVRIAGPMIMSGYLDEGPVGPWLATQDLGHWQSGRLV
CCCCCEECCCCCCCEEEEECCCCEEEEECCEEEECCCCCCCCCCCEECCCCCCCCCCCEE
IDGRIDDVINSGGLKIAAGQVLDQIRATGMVRDGLVLGLADATWGQVVTAVVVPGRGWRG
ECCCHHHHHCCCCCEEEHHHHHHHHHHHCEECCCEEEEECCCCHHHEEEEEEECCCCCCC
PEALRDLVGRRLGRAHAPRVIVEVDELPMLSSGKIDRVEVRRIATATLESGAAWRV
HHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TPSSSTAPRTGPTTPITSEAVVGSELTSRVRVVRVERTREDVDWLAGRLTEVFDGARSV
CCCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCEE
LVPAGGNELPPAVFQDVEDRTVWLPDEVALVVRTSGSTSGTGRLVGLSATQLRASGAATR
EEECCCCCCCHHHHHCCCCCEEECCCCEEEEEEECCCCCCCCEEEECCHHHHHHCCCHHH
ERLGGPCTWVLALPPHHIAGLQVVARAVGDGREVVVVEGRLDAPAVAAAVDEAANRHDDG
HHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCC
RVAISVVPTQLSRLLDDPVGTEALTRCAAVLVGGAAASASLLSRAQKAGVPVRVTYGMSE
EEEEEEEHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCC
TCGGCVYDGVPLEGVRVDLADDSRVRIAGPMIMSGYLDEGPVGPWLATQDLGHWQSGRLV
CCCCCEECCCCCCCEEEEECCCCEEEEECCEEEECCCCCCCCCCCEECCCCCCCCCCCEE
IDGRIDDVINSGGLKIAAGQVLDQIRATGMVRDGLVLGLADATWGQVVTAVVVPGRGWRG
ECCCHHHHHCCCCCEEEHHHHHHHHHHHCEECCCEEEEECCCCHHHEEEEEEECCCCCCC
PEALRDLVGRRLGRAHAPRVIVEVDELPMLSSGKIDRVEVRRIATATLESGAAWRV
HHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]