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The map label for this gene is comEA [H]

Identifier: 50842380

GI number: 50842380

Start: 972470

End: 973321

Strand: Direct

Name: comEA [H]

Synonym: PPA0894

Alternate gene names: 50842380

Gene position: 972470-973321 (Clockwise)

Preceding gene: 50842379

Following gene: 50842381

Centisome position: 37.98

GC content: 61.85

Gene sequence:

>852_bases
ATGAATGACGACTACCGAGACCGTCTTGAAGACCTCATCGCGCGGCTGCCTGCCCGAAACCTGGGGCCCCGACGCTCGGC
GACCCCAGCGGAGGAGGAACCGGCCCAGGAGGAGACTCCACCTCCTCGACGAACAGTGAGCCGAGTCCATGCCTCAGCAG
TGGGGGTATTGCTCGTTGTGGCGTTGTCCGTCATCGCTGTCTGGCTGATGCGCTCGAAACCTACCGAAGTGCCAGCGGGT
GCTGTCATGGTGTCAACGGTGCCCGAGGGCACGACTATGCCCGGCAGGGAGACAACCGAGTCAGAAGCGTCGTCTGAAAG
CACCACGCCCGCCGCGCTCCCGGTCGCAACGACGACGCCCGCAGTGGGTGCACCCATCCAGGTTCACGTGGCCGGACGAG
TGAAGCATCCCGGTGTGTACACGGTTAATCCCAACGCCCGCGTCGCTGATGCCATTGAAGTCGCGGGCGGGATGACGGCG
GGCGCCCACCCCGGTCGTCTCAATCTTGCTGCCCCGGTCTGTGATGGGTGCCAGGTATGGATCCCCGTAGGTGGAGACGG
AGCAGTGACACCACCCAACCAAAGCGCTGGCGGTTCGTCGGGGGCTGTTGAAGGGTCGGGACGTAGTTCTGGAGTAGCAG
CGGCTTCGGGTAGCGGTAAAGCTCCAGTTGATCTCAACACTGCAAATCAAAGCGAACTTGAGACGATTGACGGGGTCGGT
CCAGTAATGGCGGGCAAGATCATGGCTTGGCGCCAGGAACACGGACAGTTCGCCTCGGTTGACCAATTACGGGAGATTTC
TGGGATCGGGGCAAAGACGTTCGAGAAGATCAAGCCGTATGTCACCGTCTAA

Upstream 100 bases:

>100_bases
GGCGGCGGGCCTGTGGATAGCAGGCTGGCCGTCGCGTCGTGTTATCCACAGGTTTGAAATTGCCTGGCGAAATTCGGTTG
TCCCGACGACAACTGAAGGT

Downstream 100 bases:

>100_bases
ATCTCACCGTGATGACTATCAACGCCAGGTTGTTTCGACCCCCGATGTGCGCATGGTTCCGGTGGCCATCACGGCATGTG
GGATGGCTGCTGTCGGTACC

Product: ComE operon protein 1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MNDDYRDRLEDLIARLPARNLGPRRSATPAEEEPAQEETPPPRRTVSRVHASAVGVLLVVALSVIAVWLMRSKPTEVPAG
AVMVSTVPEGTTMPGRETTESEASSESTTPAALPVATTTPAVGAPIQVHVAGRVKHPGVYTVNPNARVADAIEVAGGMTA
GAHPGRLNLAAPVCDGCQVWIPVGGDGAVTPPNQSAGGSSGAVEGSGRSSGVAAASGSGKAPVDLNTANQSELETIDGVG
PVMAGKIMAWRQEHGQFASVDQLREISGIGAKTFEKIKPYVTV

Sequences:

>Translated_283_residues
MNDDYRDRLEDLIARLPARNLGPRRSATPAEEEPAQEETPPPRRTVSRVHASAVGVLLVVALSVIAVWLMRSKPTEVPAG
AVMVSTVPEGTTMPGRETTESEASSESTTPAALPVATTTPAVGAPIQVHVAGRVKHPGVYTVNPNARVADAIEVAGGMTA
GAHPGRLNLAAPVCDGCQVWIPVGGDGAVTPPNQSAGGSSGAVEGSGRSSGVAAASGSGKAPVDLNTANQSELETIDGVG
PVMAGKIMAWRQEHGQFASVDQLREISGIGAKTFEKIKPYVTV
>Mature_283_residues
MNDDYRDRLEDLIARLPARNLGPRRSATPAEEEPAQEETPPPRRTVSRVHASAVGVLLVVALSVIAVWLMRSKPTEVPAG
AVMVSTVPEGTTMPGRETTESEASSESTTPAALPVATTTPAVGAPIQVHVAGRVKHPGVYTVNPNARVADAIEVAGGMTA
GAHPGRLNLAAPVCDGCQVWIPVGGDGAVTPPNQSAGGSSGAVEGSGRSSGVAAASGSGKAPVDLNTANQSELETIDGVG
PVMAGKIMAWRQEHGQFASVDQLREISGIGAKTFEKIKPYVTV

Specific function: Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect [H]

COG id: COG1555

COG function: function code L; DNA uptake protein and related DNA-binding proteins

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HhH domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004787
- InterPro:   IPR004509
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR019554 [H]

Pfam domain/function: PF00633 HHH; PF10531 SLBB [H]

EC number: NA

Molecular weight: Translated: 29045; Mature: 29045

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDDYRDRLEDLIARLPARNLGPRRSATPAEEEPAQEETPPPRRTVSRVHASAVGVLLVV
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
ALSVIAVWLMRSKPTEVPAGAVMVSTVPEGTTMPGRETTESEASSESTTPAALPVATTTP
HHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHCCCCCCCCCEEEEECCCC
AVGAPIQVHVAGRVKHPGVYTVNPNARVADAIEVAGGMTAGAHPGRLNLAAPVCDGCQVW
CCCCCEEEEEECEECCCCEEEECCCCCHHHHHHHHCCCCCCCCCCCEEECCCCCCCCEEE
IPVGGDGAVTPPNQSAGGSSGAVEGSGRSSGVAAASGSGKAPVDLNTANQSELETIDGVG
EEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCEEECCCCHHHHHHHCCCC
PVMAGKIMAWRQEHGQFASVDQLREISGIGAKTFEKIKPYVTV
HHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHCCCCCCC
>Mature Secondary Structure
MNDDYRDRLEDLIARLPARNLGPRRSATPAEEEPAQEETPPPRRTVSRVHASAVGVLLVV
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
ALSVIAVWLMRSKPTEVPAGAVMVSTVPEGTTMPGRETTESEASSESTTPAALPVATTTP
HHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHCCCCCCCCCEEEEECCCC
AVGAPIQVHVAGRVKHPGVYTVNPNARVADAIEVAGGMTAGAHPGRLNLAAPVCDGCQVW
CCCCCEEEEEECEECCCCEEEECCCCCHHHHHHHHCCCCCCCCCCCEEECCCCCCCCEEE
IPVGGDGAVTPPNQSAGGSSGAVEGSGRSSGVAAASGSGKAPVDLNTANQSELETIDGVG
EEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCEEECCCCHHHHHHHCCCC
PVMAGKIMAWRQEHGQFASVDQLREISGIGAKTFEKIKPYVTV
HHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377; 7768800 [H]