Click here to switch to the map view.

The map label for this gene is comEC [H]

Identifier: 50842381

GI number: 50842381

Start: 973308

End: 975662

Strand: Direct

Name: comEC [H]

Synonym: PPA0895

Alternate gene names: 50842381

Gene position: 973308-975662 (Clockwise)

Preceding gene: 50842380

Following gene: 50842382

Centisome position: 38.02

GC content: 61.91

Gene sequence:

>2355_bases
ATGTCACCGTCTAAATCTCACCGTGATGACTATCAACGCCAGGTTGTTTCGACCCCCGATGTGCGCATGGTTCCGGTGGC
CATCACGGCATGTGGGATGGCTGCTGTCGGTACCGGCGGTCATCGCTGGATGATTCTTAGTGCCGGAATTGGATGCCTTG
CCGCAGGCATGATCGCGGTAAAGCGTAAGGCGTGGTTGGTTGTGGTATCCGCCGCGGTGGGGTTGACCGTCCTCATGAGC
GCCGGAATGCGCGACCTCGTTGTCCACCACACCGGTGTTGCTGAGCTTGCCCAGGAAGGAGCCGCAGTGACGGTGACAGG
TCGCGTCGCCGCCGACCCACGGATCTTCGAGGTAAGTGGTTCGGGTGGGAGCACCGTCATGATCACTCTGGTAGCCCATC
GCATCGTCGCAGAAGCCCAGGCTATTGATCAATCGGTAAGGGTAGTCGCCATGGCGTCGGGATCCACATCGGGCCCAGCG
ACGACGGTGGTCGTCGGGCAACAGGTTCAGGTGCGGGGACTGCTGACTCCGCCACGGGAAGGCCGGGCTGAAGCAGCGGT
ACTGAAGCTACGGGCCCCGCCGAGGGTCGTCGCACCTCCCGGGCCTCTTGACCGTGGGGTCAATCGTTTTCGCGCCGGTC
TGGTCAGTGCTGTCGCCGGATGTCCAGAAGGTCAACGGGCTATCGTTCCATCGCTTGTTGTGGGGGACACCGCTGCGGTC
TCGGAAGAGATGTCCGAGGATTTCCGAGTGACGGCGTTAACTCATCTCATGGCCGTGTCTGGAGCCAACCTTGCCTCCAC
GACGGCCCTGTTGTGGTGGATAGGTGCGTGGTGCGGCCTGAAGCGGCGAGGGTTAAGGGCGACGTCGATAGCTGGCGTCG
TCGTGTTTGTGGTGGTGTGTCGGGCCGAAGCCTCGGTGGTGAGGGCGGCCGCGATGGGAGTGGTCGCCATGGCTGCGACG
GGGGTCGCATTCGACCGACGCGGTGGAATCCGAACCTTAGCTGTCGCGGTGACTGGGCTGATGCTTATCGATCCATGGTT
AGTGAGATCGGTGGGTTTCTGGCTGTCAGCCTGCGCCACGGCTGGCATCTTGTGGTGGGCTCAACCGTGGTCGGTCGCGA
TGGAATGGGCACCAGCCTGGCTAGCGGTAGGCGTCACAGTGCCATGGGCAGCCCAGGTGACGACTCAGCCCGTCATCACC
TGGATGGCTGGCACCGTATCGACTACCGGCCTCGTCGCTAACCTCGCGGCCGCCCCCTTTGTACCACCAGCCTCGGCACT
AGGGATGGTGACCGGGCTTCTCGCCTTCATCTGGCCGCCTCTGGGGACGCCGTTCGGGCGGCTTGCCGGGTGGTGCGTCC
AACCGATTATCTGGATAGCTCACTTTGGTGCCAAGGCGCCATCTGGTCTGATCAGGTGGCCAGCAGGCGGATGGGCTCTT
GGGGTGCTGGCCGGGCTATGTGTGGGATTGGCCTTGATCACTCCAACGGTCTTGGCGAGGCCTTGGTTGACTGCGCTTGC
AGGACTAGCAGTCATAGCAGCGATGGTCGTGCGTCCTCCCCTCCCAGGCTGGCCGGGACAGTGGCAGGTGGCGATCTGTG
ACGTCGGTCAGGGCAGCGCGGCTCTGGTGCGTGCTGGCCCACATGAGGCTGTCGTCGTCGATACTGGGCCAGATCCGCAC
AGACTGAGTCGTTGTCTGGATGACCTCGATGTTGCCCAAGTGCCGATGGTCATCCTCAGCCACTTCCACGCCGATCATGT
CGACGGCCTCAACGCCGTTCATGACCATGGCCTGACGAGGGCCATCGTCGTGTCCCAACTGTCCTCTCCTCCTTGGTCAG
CGAAGCGGGTGGCGCAAACGGCTGCGCAGCTGGGCGCCAGGGTTGTCGAGGCTAACCCGGGCCGTGTGATGACGGCTGGA
ACGGCAAAACTTGAACTGTGGGGAGGAACCCAGCTTTCCGATACCGGTAAAGATGAATCAGGAGAGGAGCATGCTGTCGA
GAACAACTCGTCGGTTGTGATCAAAGCGACGGTTGACGAGTTGAGAGTTGTGCTTCCCGGAGACGCCGAACCTGAAGAAC
AGCACCATATTCTGACCGGAGGCACGGACCTGTCGAGTGATGTCCTTGTGCTGCCTCATCACGGATCGGCCCGTCAAGAT
GAGGGCTTCTGGGCGGCGACCGGGGCAAGTGTGGCGGTGGCATCTGCTGGCCAGGGAAATCCCTTCGGACATCCCTCATA
CAAGGCATTATCTTTGGCTAAACGGATGGGGATGCAGCTGCATCGCACTGATCTTGAGGGGACGGTGCTATTGGCTCGCA
ATGGTGGGTCCGTATTGGTCCAAACACGGTCGTGA

Upstream 100 bases:

>100_bases
ATCATGGCTTGGCGCCAGGAACACGGACAGTTCGCCTCGGTTGACCAATTACGGGAGATTTCTGGGATCGGGGCAAAGAC
GTTCGAGAAGATCAAGCCGT

Downstream 100 bases:

>100_bases
CGTTCCGTGTCGTCGGGAACGTCGTCGATAGCTGTCGGCCGGCCGCGCTAACCTGATCGGTCGGTTCACAGTGAGCTGTT
GCGGGAAGGAGAACAGGTGG

Product: putative ComE operon protein 3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 784; Mature: 783

Protein sequence:

>784_residues
MSPSKSHRDDYQRQVVSTPDVRMVPVAITACGMAAVGTGGHRWMILSAGIGCLAAGMIAVKRKAWLVVVSAAVGLTVLMS
AGMRDLVVHHTGVAELAQEGAAVTVTGRVAADPRIFEVSGSGGSTVMITLVAHRIVAEAQAIDQSVRVVAMASGSTSGPA
TTVVVGQQVQVRGLLTPPREGRAEAAVLKLRAPPRVVAPPGPLDRGVNRFRAGLVSAVAGCPEGQRAIVPSLVVGDTAAV
SEEMSEDFRVTALTHLMAVSGANLASTTALLWWIGAWCGLKRRGLRATSIAGVVVFVVVCRAEASVVRAAAMGVVAMAAT
GVAFDRRGGIRTLAVAVTGLMLIDPWLVRSVGFWLSACATAGILWWAQPWSVAMEWAPAWLAVGVTVPWAAQVTTQPVIT
WMAGTVSTTGLVANLAAAPFVPPASALGMVTGLLAFIWPPLGTPFGRLAGWCVQPIIWIAHFGAKAPSGLIRWPAGGWAL
GVLAGLCVGLALITPTVLARPWLTALAGLAVIAAMVVRPPLPGWPGQWQVAICDVGQGSAALVRAGPHEAVVVDTGPDPH
RLSRCLDDLDVAQVPMVILSHFHADHVDGLNAVHDHGLTRAIVVSQLSSPPWSAKRVAQTAAQLGARVVEANPGRVMTAG
TAKLELWGGTQLSDTGKDESGEEHAVENNSSVVIKATVDELRVVLPGDAEPEEQHHILTGGTDLSSDVLVLPHHGSARQD
EGFWAATGASVAVASAGQGNPFGHPSYKALSLAKRMGMQLHRTDLEGTVLLARNGGSVLVQTRS

Sequences:

>Translated_784_residues
MSPSKSHRDDYQRQVVSTPDVRMVPVAITACGMAAVGTGGHRWMILSAGIGCLAAGMIAVKRKAWLVVVSAAVGLTVLMS
AGMRDLVVHHTGVAELAQEGAAVTVTGRVAADPRIFEVSGSGGSTVMITLVAHRIVAEAQAIDQSVRVVAMASGSTSGPA
TTVVVGQQVQVRGLLTPPREGRAEAAVLKLRAPPRVVAPPGPLDRGVNRFRAGLVSAVAGCPEGQRAIVPSLVVGDTAAV
SEEMSEDFRVTALTHLMAVSGANLASTTALLWWIGAWCGLKRRGLRATSIAGVVVFVVVCRAEASVVRAAAMGVVAMAAT
GVAFDRRGGIRTLAVAVTGLMLIDPWLVRSVGFWLSACATAGILWWAQPWSVAMEWAPAWLAVGVTVPWAAQVTTQPVIT
WMAGTVSTTGLVANLAAAPFVPPASALGMVTGLLAFIWPPLGTPFGRLAGWCVQPIIWIAHFGAKAPSGLIRWPAGGWAL
GVLAGLCVGLALITPTVLARPWLTALAGLAVIAAMVVRPPLPGWPGQWQVAICDVGQGSAALVRAGPHEAVVVDTGPDPH
RLSRCLDDLDVAQVPMVILSHFHADHVDGLNAVHDHGLTRAIVVSQLSSPPWSAKRVAQTAAQLGARVVEANPGRVMTAG
TAKLELWGGTQLSDTGKDESGEEHAVENNSSVVIKATVDELRVVLPGDAEPEEQHHILTGGTDLSSDVLVLPHHGSARQD
EGFWAATGASVAVASAGQGNPFGHPSYKALSLAKRMGMQLHRTDLEGTVLLARNGGSVLVQTRS
>Mature_783_residues
SPSKSHRDDYQRQVVSTPDVRMVPVAITACGMAAVGTGGHRWMILSAGIGCLAAGMIAVKRKAWLVVVSAAVGLTVLMSA
GMRDLVVHHTGVAELAQEGAAVTVTGRVAADPRIFEVSGSGGSTVMITLVAHRIVAEAQAIDQSVRVVAMASGSTSGPAT
TVVVGQQVQVRGLLTPPREGRAEAAVLKLRAPPRVVAPPGPLDRGVNRFRAGLVSAVAGCPEGQRAIVPSLVVGDTAAVS
EEMSEDFRVTALTHLMAVSGANLASTTALLWWIGAWCGLKRRGLRATSIAGVVVFVVVCRAEASVVRAAAMGVVAMAATG
VAFDRRGGIRTLAVAVTGLMLIDPWLVRSVGFWLSACATAGILWWAQPWSVAMEWAPAWLAVGVTVPWAAQVTTQPVITW
MAGTVSTTGLVANLAAAPFVPPASALGMVTGLLAFIWPPLGTPFGRLAGWCVQPIIWIAHFGAKAPSGLIRWPAGGWALG
VLAGLCVGLALITPTVLARPWLTALAGLAVIAAMVVRPPLPGWPGQWQVAICDVGQGSAALVRAGPHEAVVVDTGPDPHR
LSRCLDDLDVAQVPMVILSHFHADHVDGLNAVHDHGLTRAIVVSQLSSPPWSAKRVAQTAAQLGARVVEANPGRVMTAGT
AKLELWGGTQLSDTGKDESGEEHAVENNSSVVIKATVDELRVVLPGDAEPEEQHHILTGGTDLSSDVLVLPHHGSARQDE
GFWAATGASVAVASAGQGNPFGHPSYKALSLAKRMGMQLHRTDLEGTVLLARNGGSVLVQTRS

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 81351; Mature: 81220

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPSKSHRDDYQRQVVSTPDVRMVPVAITACGMAAVGTGGHRWMILSAGIGCLAAGMIAV
CCCCCCCHHHHHHHHCCCCCCEEEEEHHHHCCHHHCCCCCCEEEEEECCHHHHHHHHHHH
KRKAWLVVVSAAVGLTVLMSAGMRDLVVHHTGVAELAQEGAAVTVTGRVAADPRIFEVSG
HCCCEEEEHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHCCCEEEEEEEEECCCEEEEEEC
SGGSTVMITLVAHRIVAEAQAIDQSVRVVAMASGSTSGPATTVVVGQQVQVRGLLTPPRE
CCCCEEEHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEEEECCEEEEEEECCCCCC
GRAEAAVLKLRAPPRVVAPPGPLDRGVNRFRAGLVSAVAGCPEGQRAIVPSLVVGDTAAV
CCCCEEEEEECCCCCEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHH
SEEMSEDFRVTALTHLMAVSGANLASTTALLWWIGAWCGLKRRGLRATSIAGVVVFVVVC
HHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
RAEASVVRAAAMGVVAMAATGVAFDRRGGIRTLAVAVTGLMLIDPWLVRSVGFWLSACAT
HHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGILWWAQPWSVAMEWAPAWLAVGVTVPWAAQVTTQPVITWMAGTVSTTGLVANLAAAPF
HCEEEECCCHHHHHHHCCEEEEEEECCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHCCCC
VPPASALGMVTGLLAFIWPPLGTPFGRLAGWCVQPIIWIAHFGAKAPSGLIRWPAGGWAL
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHH
GVLAGLCVGLALITPTVLARPWLTALAGLAVIAAMVVRPPLPGWPGQWQVAICDVGQGSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCE
ALVRAGPHEAVVVDTGPDPHRLSRCLDDLDVAQVPMVILSHFHADHVDGLNAVHDHGLTR
EEEECCCCCEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHCHHHCCCCHHHHHCCCHH
AIVVSQLSSPPWSAKRVAQTAAQLGARVVEANPGRVMTAGTAKLELWGGTQLSDTGKDES
HHHHHHCCCCCCHHHHHHHHHHHHCCEEEECCCCEEEEECCEEEEEECCCCCCCCCCCCC
GEEHAVENNSSVVIKATVDELRVVLPGDAEPEEQHHILTGGTDLSSDVLVLPHHGSARQD
CCCCCCCCCCCEEEEEEHHHEEEEECCCCCCCCCCEEEECCCCCCCCEEEECCCCCCCCC
EGFWAATGASVAVASAGQGNPFGHPSYKALSLAKRMGMQLHRTDLEGTVLLARNGGSVLV
CCEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCEEEECCCCEEEEEEECCCEEEE
QTRS
EECC
>Mature Secondary Structure 
SPSKSHRDDYQRQVVSTPDVRMVPVAITACGMAAVGTGGHRWMILSAGIGCLAAGMIAV
CCCCCCHHHHHHHHCCCCCCEEEEEHHHHCCHHHCCCCCCEEEEEECCHHHHHHHHHHH
KRKAWLVVVSAAVGLTVLMSAGMRDLVVHHTGVAELAQEGAAVTVTGRVAADPRIFEVSG
HCCCEEEEHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHCCCEEEEEEEEECCCEEEEEEC
SGGSTVMITLVAHRIVAEAQAIDQSVRVVAMASGSTSGPATTVVVGQQVQVRGLLTPPRE
CCCCEEEHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEEEECCEEEEEEECCCCCC
GRAEAAVLKLRAPPRVVAPPGPLDRGVNRFRAGLVSAVAGCPEGQRAIVPSLVVGDTAAV
CCCCEEEEEECCCCCEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHH
SEEMSEDFRVTALTHLMAVSGANLASTTALLWWIGAWCGLKRRGLRATSIAGVVVFVVVC
HHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
RAEASVVRAAAMGVVAMAATGVAFDRRGGIRTLAVAVTGLMLIDPWLVRSVGFWLSACAT
HHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGILWWAQPWSVAMEWAPAWLAVGVTVPWAAQVTTQPVITWMAGTVSTTGLVANLAAAPF
HCEEEECCCHHHHHHHCCEEEEEEECCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHCCCC
VPPASALGMVTGLLAFIWPPLGTPFGRLAGWCVQPIIWIAHFGAKAPSGLIRWPAGGWAL
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHH
GVLAGLCVGLALITPTVLARPWLTALAGLAVIAAMVVRPPLPGWPGQWQVAICDVGQGSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCE
ALVRAGPHEAVVVDTGPDPHRLSRCLDDLDVAQVPMVILSHFHADHVDGLNAVHDHGLTR
EEEECCCCCEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHCHHHCCCCHHHHHCCCHH
AIVVSQLSSPPWSAKRVAQTAAQLGARVVEANPGRVMTAGTAKLELWGGTQLSDTGKDES
HHHHHHCCCCCCHHHHHHHHHHHHCCEEEECCCCEEEEECCEEEEEECCCCCCCCCCCCC
GEEHAVENNSSVVIKATVDELRVVLPGDAEPEEQHHILTGGTDLSSDVLVLPHHGSARQD
CCCCCCCCCCCEEEEEEHHHEEEEECCCCCCCCCCEEEECCCCCCCCEEEECCCCCCCCC
EGFWAATGASVAVASAGQGNPFGHPSYKALSLAKRMGMQLHRTDLEGTVLLARNGGSVLV
CCEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCEEEECCCCEEEEEEECCCEEEE
QTRS
EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]