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The map label for this gene is leuS

Identifier: 50842379

GI number: 50842379

Start: 969866

End: 972346

Strand: Direct

Name: leuS

Synonym: PPA0893

Alternate gene names: 50842379

Gene position: 969866-972346 (Clockwise)

Preceding gene: 50842377

Following gene: 50842380

Centisome position: 37.88

GC content: 59.77

Gene sequence:

>2481_bases
GTGAGCGACCAGGTGCGCGAGACAACGGGCTACGACGCAGTCGCAGCCCAGGAGAAGTGGTCCAAGTATTGGGAGGAGCA
CCGCACCTTCGCCTCCCTTGATGACGGCTCCAGGGAGCGTCGCTACGTGCTTGACATGTTCGCCTACCCCTCCGGCGACC
TTCACATGGGGCATGCTGAGGCGTTCGCCATTGGCGATGTGCTGGCCCGTTACTGGCGTCTGCGTGGATTCGACGTGTTG
CACCCGGTGGGCTGGGACTCCTTCGGTCTGCCGGCTGAGAACGCCGCGATCAAGCACGGGACCCATCCCGCGGAATGGAC
CTACCGCAATATCGACACTCAGGCGGCCTCTTTTAAGCGGTACGCGGTTTCCTTCGACTGGTCGATGAGGCTGCATACCT
CAGACGAGGAGTACTACCGCTGGACCCAGTGGCTGTTTAACCGTTTCTTCGAAAAGGGACTGGCCTACCGTAAGGACTCC
TGGGCTAACTGGTGCCCCATCGACCAGACGGTGCTCGCCAATGAGCAGGTCAAGGATGGGTGTTGCGAGCGTTGTGGTGC
TGTCGTCACCAAGCGTCAGCTCAACCAGTGGTATTTCCGCATCACTGACTACGCTCAGCGCCTGCTCGACGACATGGACC
AGATCGAGGGGAAATGGCCTGAGCGTGTGCTGTCGATGCAGCGCAACTGGATCGGTCGTTCCGAAGGTGCCTACGTTGAT
TTCACGATTGATGGTCACAAGGAGCCAGTGAGGGTTTTCACCACCCGTCCGGACACCCTGTACGGAGCTACCTTCATGGT
GGTGGCTCCTGACTCGGCCCTGGCCCAGGAGATCGTCTCCGATGAGGCCCGGCCAGCCTTTGAAACCTACCTCGATGAGG
TCAAGAAGAAGTCCGAAATTGAGCGGCAAGCCACCGATCACGAGAAGACTGGAGTGCCCCTCGGGGTCGAGGCGACTAAT
CCTGTCAATGGTGCCAAGGTTCCGGTGTGGGCTGGTGACTATGTGCTGGCGGACTACGGGACGGGTGCCGTCATGGCTGT
GCCCGCCCATGACCAGCGCGACCTCGACTTCGCTCGCACATATGGCATTGACGTCATCCCGGTCATCGACACTGGCGAGG
CTGATCCTCGCGAGTCTGGGGTCGCTACGACGGGTGATGGCGTTTACCAAAACTCCGGATTCCTCAATGGCATTGCCACT
AAGGCTGAGGCCATCGCGAAAATGTGCGAATTCCTTGATGAAAAGGGGATCGGTGAGCCGACAATCACCTATCGGCTGCG
CGACTGGCTGCTAAGCCGTCAGCGTTTCTGGGGATGCCCCATCCCGATCATCCATTGTGAGTCCTGCGGCGACGTCCCGG
TCCCTGATGAACAGCTGCCAGTCAAGCTGCCTGATCTCCGCGGCGCCGAGCTTGCCCCTAAGGGAACGTCACCGCTGGCT
GGCGAAGAGGCCAGCGAATGGCGTTCGGTGGCCTGCCCGTCGTGTGGGGGAGCTGCCCAGCGTGACACCGACACCATGGA
CACCTTCGTGGACTCGTCGTGGTATTTCATGCGCTATTGCTGTCCGCACTATGACAAGGGCCCGTTTGATGTGGAGGCAG
TTCGTCGTTGGATGCCGGTAGCCCAGTACATCGGTGGCGTCGAGCATGCCACTATGCACTTGCTGTACTCCCGGTTCTTC
ACCAAAGTGCTGTATGACCTCGGCATGGTCGACTTCACCGAACCGTTCCAGCGGCTCATGAACCAGGGTCAGGTCATCAA
TGAAGGCCGGGCAATGTCGAAGTCGCTGGGCAATGGCGTGGACCTCGGCAAGCAGATCGACGAGTTCGGTGTCGACGCAG
TACGTACCACCGTTATCTTCGCCGGTCCACCAGATGAAGACATTGATTGGGCCGACGTCTCACCGGCCTCGACTCTAAAG
TTTTTGCAGCGTGCCTGGCGCGTGGCTGCTGAGGTCACGAGCGATCCTGACGCTGACCTGACACAAGGCGACTCCACCCT
GCGTCGGGTTACCCATCGCAGCATCGCCGACATCACCGAGTTGCTGGAGGGCGGGCGTTACAACGTCGTTGTGGCGCGGA
TCATGGAACTGGTCAATGCCACCCGTAAGGCCATTGATTCGGGGTGCGGCCCAGCTGATCCTGCAGTGCGCGAGGCCGTC
ACCTTTACTGCCCAGGCGCTATCTTTAGTGGCCCCGTACTTGGCTGAGGAGATGTGGGAGATGCTCGGCTTGGAGCCCTC
GGTTGCCAACTCTCATTGGCCCACTGCTGACGAGAAACTGCTGGTAGCCGACAAGGTGACCATGGTCGTCCAGGTGACGG
GCAAGGTACGCGCTAAGCTCACAGTGAGCCCCGATATCACCGAGGCCGAGGCCCGCGAGGTGGCTTTAGCCGACGTTAAT
GTGCAGCGGTTTACTGAAGGTAAGGAGATCGTCAAGATCATTGCCAAGCTGCCGAAGATGATATCGATCGTCGCGAAATA
A

Upstream 100 bases:

>100_bases
ACAGGGAACCCTGACGCCTGGTGTGGGGAGGTTTCGCTAGACTCAAGCCCATATGTGTCGCGGGTCTGGTTAGACCCGTA
GTGGATCCGAGAGGTGTGAC

Downstream 100 bases:

>100_bases
CGACTTAACCCGTTCCGGCACGAGGCGGCGGGCCTGTGGATAGCAGGCTGGCCGTCGCGTCGTGTTATCCACAGGTTTGA
AATTGCCTGGCGAAATTCGG

Product: leucyl-tRNA synthetase

Products: NA

Alternate protein names: Leucine--tRNA ligase; LeuRS [H]

Number of amino acids: Translated: 826; Mature: 825

Protein sequence:

>826_residues
MSDQVRETTGYDAVAAQEKWSKYWEEHRTFASLDDGSRERRYVLDMFAYPSGDLHMGHAEAFAIGDVLARYWRLRGFDVL
HPVGWDSFGLPAENAAIKHGTHPAEWTYRNIDTQAASFKRYAVSFDWSMRLHTSDEEYYRWTQWLFNRFFEKGLAYRKDS
WANWCPIDQTVLANEQVKDGCCERCGAVVTKRQLNQWYFRITDYAQRLLDDMDQIEGKWPERVLSMQRNWIGRSEGAYVD
FTIDGHKEPVRVFTTRPDTLYGATFMVVAPDSALAQEIVSDEARPAFETYLDEVKKKSEIERQATDHEKTGVPLGVEATN
PVNGAKVPVWAGDYVLADYGTGAVMAVPAHDQRDLDFARTYGIDVIPVIDTGEADPRESGVATTGDGVYQNSGFLNGIAT
KAEAIAKMCEFLDEKGIGEPTITYRLRDWLLSRQRFWGCPIPIIHCESCGDVPVPDEQLPVKLPDLRGAELAPKGTSPLA
GEEASEWRSVACPSCGGAAQRDTDTMDTFVDSSWYFMRYCCPHYDKGPFDVEAVRRWMPVAQYIGGVEHATMHLLYSRFF
TKVLYDLGMVDFTEPFQRLMNQGQVINEGRAMSKSLGNGVDLGKQIDEFGVDAVRTTVIFAGPPDEDIDWADVSPASTLK
FLQRAWRVAAEVTSDPDADLTQGDSTLRRVTHRSIADITELLEGGRYNVVVARIMELVNATRKAIDSGCGPADPAVREAV
TFTAQALSLVAPYLAEEMWEMLGLEPSVANSHWPTADEKLLVADKVTMVVQVTGKVRAKLTVSPDITEAEAREVALADVN
VQRFTEGKEIVKIIAKLPKMISIVAK

Sequences:

>Translated_826_residues
MSDQVRETTGYDAVAAQEKWSKYWEEHRTFASLDDGSRERRYVLDMFAYPSGDLHMGHAEAFAIGDVLARYWRLRGFDVL
HPVGWDSFGLPAENAAIKHGTHPAEWTYRNIDTQAASFKRYAVSFDWSMRLHTSDEEYYRWTQWLFNRFFEKGLAYRKDS
WANWCPIDQTVLANEQVKDGCCERCGAVVTKRQLNQWYFRITDYAQRLLDDMDQIEGKWPERVLSMQRNWIGRSEGAYVD
FTIDGHKEPVRVFTTRPDTLYGATFMVVAPDSALAQEIVSDEARPAFETYLDEVKKKSEIERQATDHEKTGVPLGVEATN
PVNGAKVPVWAGDYVLADYGTGAVMAVPAHDQRDLDFARTYGIDVIPVIDTGEADPRESGVATTGDGVYQNSGFLNGIAT
KAEAIAKMCEFLDEKGIGEPTITYRLRDWLLSRQRFWGCPIPIIHCESCGDVPVPDEQLPVKLPDLRGAELAPKGTSPLA
GEEASEWRSVACPSCGGAAQRDTDTMDTFVDSSWYFMRYCCPHYDKGPFDVEAVRRWMPVAQYIGGVEHATMHLLYSRFF
TKVLYDLGMVDFTEPFQRLMNQGQVINEGRAMSKSLGNGVDLGKQIDEFGVDAVRTTVIFAGPPDEDIDWADVSPASTLK
FLQRAWRVAAEVTSDPDADLTQGDSTLRRVTHRSIADITELLEGGRYNVVVARIMELVNATRKAIDSGCGPADPAVREAV
TFTAQALSLVAPYLAEEMWEMLGLEPSVANSHWPTADEKLLVADKVTMVVQVTGKVRAKLTVSPDITEAEAREVALADVN
VQRFTEGKEIVKIIAKLPKMISIVAK
>Mature_825_residues
SDQVRETTGYDAVAAQEKWSKYWEEHRTFASLDDGSRERRYVLDMFAYPSGDLHMGHAEAFAIGDVLARYWRLRGFDVLH
PVGWDSFGLPAENAAIKHGTHPAEWTYRNIDTQAASFKRYAVSFDWSMRLHTSDEEYYRWTQWLFNRFFEKGLAYRKDSW
ANWCPIDQTVLANEQVKDGCCERCGAVVTKRQLNQWYFRITDYAQRLLDDMDQIEGKWPERVLSMQRNWIGRSEGAYVDF
TIDGHKEPVRVFTTRPDTLYGATFMVVAPDSALAQEIVSDEARPAFETYLDEVKKKSEIERQATDHEKTGVPLGVEATNP
VNGAKVPVWAGDYVLADYGTGAVMAVPAHDQRDLDFARTYGIDVIPVIDTGEADPRESGVATTGDGVYQNSGFLNGIATK
AEAIAKMCEFLDEKGIGEPTITYRLRDWLLSRQRFWGCPIPIIHCESCGDVPVPDEQLPVKLPDLRGAELAPKGTSPLAG
EEASEWRSVACPSCGGAAQRDTDTMDTFVDSSWYFMRYCCPHYDKGPFDVEAVRRWMPVAQYIGGVEHATMHLLYSRFFT
KVLYDLGMVDFTEPFQRLMNQGQVINEGRAMSKSLGNGVDLGKQIDEFGVDAVRTTVIFAGPPDEDIDWADVSPASTLKF
LQRAWRVAAEVTSDPDADLTQGDSTLRRVTHRSIADITELLEGGRYNVVVARIMELVNATRKAIDSGCGPADPAVREAVT
FTAQALSLVAPYLAEEMWEMLGLEPSVANSHWPTADEKLLVADKVTMVVQVTGKVRAKLTVSPDITEAEAREVALADVNV
QRFTEGKEIVKIIAKLPKMISIVAK

Specific function: Unknown

COG id: COG0495

COG function: function code J; Leucyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7661872, Length=863, Percent_Identity=33.0243337195828, Blast_Score=456, Evalue=1e-128,
Organism=Escherichia coli, GI1786861, Length=864, Percent_Identity=41.6666666666667, Blast_Score=666, Evalue=0.0,
Organism=Escherichia coli, GI1790708, Length=387, Percent_Identity=22.7390180878553, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71997510, Length=781, Percent_Identity=30.2176696542894, Blast_Score=328, Evalue=6e-90,
Organism=Caenorhabditis elegans, GI71997517, Length=781, Percent_Identity=30.2176696542894, Blast_Score=328, Evalue=6e-90,
Organism=Caenorhabditis elegans, GI212645227, Length=314, Percent_Identity=27.7070063694268, Blast_Score=117, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6323414, Length=891, Percent_Identity=34.5679012345679, Blast_Score=488, Evalue=1e-138,
Organism=Saccharomyces cerevisiae, GI6325217, Length=178, Percent_Identity=25.2808988764045, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21355409, Length=864, Percent_Identity=30.2083333333333, Blast_Score=379, Evalue=1e-105,

Paralogues:

None

Copy number: 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002300
- InterPro:   IPR002302
- InterPro:   IPR014729
- InterPro:   IPR009080
- InterPro:   IPR013155
- InterPro:   IPR009008 [H]

Pfam domain/function: PF08264 Anticodon_1; PF00133 tRNA-synt_1 [H]

EC number: =6.1.1.4 [H]

Molecular weight: Translated: 92523; Mature: 92392

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQVRETTGYDAVAAQEKWSKYWEEHRTFASLDDGSRERRYVLDMFAYPSGDLHMGHAE
CCCCCCHHCCCCHHHHHHHHHHHHHHHCCEECCCCCCCCHHEEEHHHCCCCCCEECCCHH
AFAIGDVLARYWRLRGFDVLHPVGWDSFGLPAENAAIKHGTHPAEWTYRNIDTQAASFKR
HHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCHHHHHHHH
YAVSFDWSMRLHTSDEEYYRWTQWLFNRFFEKGLAYRKDSWANWCPIDQTVLANEQVKDG
EEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCHHHHH
CCERCGAVVTKRQLNQWYFRITDYAQRLLDDMDQIEGKWPERVLSMQRNWIGRSEGAYVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEE
FTIDGHKEPVRVFTTRPDTLYGATFMVVAPDSALAQEIVSDEARPAFETYLDEVKKKSEI
EEECCCCCCEEEEECCCCCEECCEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
ERQATDHEKTGVPLGVEATNPVNGAKVPVWAGDYVLADYGTGAVMAVPAHDQRDLDFART
HHHHCCHHHCCCCCCCCCCCCCCCCCCEEEECCEEEEECCCCEEEEECCCCCCCCHHHHH
YGIDVIPVIDTGEADPRESGVATTGDGVYQNSGFLNGIATKAEAIAKMCEFLDEKGIGEP
CCCEEEEEEECCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
TITYRLRDWLLSRQRFWGCPIPIIHCESCGDVPVPDEQLPVKLPDLRGAELAPKGTSPLA
HHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCC
GEEASEWRSVACPSCGGAAQRDTDTMDTFVDSSWYFMRYCCPHYDKGPFDVEAVRRWMPV
CCCHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHHHHH
AQYIGGVEHATMHLLYSRFFTKVLYDLGMVDFTEPFQRLMNQGQVINEGRAMSKSLGNGV
HHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEECCCHHHHHHCCCCH
DLGKQIDEFGVDAVRTTVIFAGPPDEDIDWADVSPASTLKFLQRAWRVAAEVTSDPDADL
HHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
TQGDSTLRRVTHRSIADITELLEGGRYNVVVARIMELVNATRKAIDSGCGPADPAVREAV
CCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
TFTAQALSLVAPYLAEEMWEMLGLEPSVANSHWPTADEKLLVADKVTMVVQVTGKVRAKL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEEEEEEEECCEEEEE
TVSPDITEAEAREVALADVNVQRFTEGKEIVKIIAKLPKMISIVAK
EECCCCCHHHHHHEEEECCCHHHHHCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SDQVRETTGYDAVAAQEKWSKYWEEHRTFASLDDGSRERRYVLDMFAYPSGDLHMGHAE
CCCCCHHCCCCHHHHHHHHHHHHHHHCCEECCCCCCCCHHEEEHHHCCCCCCEECCCHH
AFAIGDVLARYWRLRGFDVLHPVGWDSFGLPAENAAIKHGTHPAEWTYRNIDTQAASFKR
HHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCHHHHHHHH
YAVSFDWSMRLHTSDEEYYRWTQWLFNRFFEKGLAYRKDSWANWCPIDQTVLANEQVKDG
EEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCHHHHH
CCERCGAVVTKRQLNQWYFRITDYAQRLLDDMDQIEGKWPERVLSMQRNWIGRSEGAYVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEE
FTIDGHKEPVRVFTTRPDTLYGATFMVVAPDSALAQEIVSDEARPAFETYLDEVKKKSEI
EEECCCCCCEEEEECCCCCEECCEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
ERQATDHEKTGVPLGVEATNPVNGAKVPVWAGDYVLADYGTGAVMAVPAHDQRDLDFART
HHHHCCHHHCCCCCCCCCCCCCCCCCCEEEECCEEEEECCCCEEEEECCCCCCCCHHHHH
YGIDVIPVIDTGEADPRESGVATTGDGVYQNSGFLNGIATKAEAIAKMCEFLDEKGIGEP
CCCEEEEEEECCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
TITYRLRDWLLSRQRFWGCPIPIIHCESCGDVPVPDEQLPVKLPDLRGAELAPKGTSPLA
HHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCC
GEEASEWRSVACPSCGGAAQRDTDTMDTFVDSSWYFMRYCCPHYDKGPFDVEAVRRWMPV
CCCHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHHHHH
AQYIGGVEHATMHLLYSRFFTKVLYDLGMVDFTEPFQRLMNQGQVINEGRAMSKSLGNGV
HHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEECCCHHHHHHCCCCH
DLGKQIDEFGVDAVRTTVIFAGPPDEDIDWADVSPASTLKFLQRAWRVAAEVTSDPDADL
HHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
TQGDSTLRRVTHRSIADITELLEGGRYNVVVARIMELVNATRKAIDSGCGPADPAVREAV
CCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
TFTAQALSLVAPYLAEEMWEMLGLEPSVANSHWPTADEKLLVADKVTMVVQVTGKVRAKL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEEEEEEEECCEEEEE
TVSPDITEAEAREVALADVNVQRFTEGKEIVKIIAKLPKMISIVAK
EECCCCCHHHHHHEEEECCCHHHHHCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA