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The map label for this gene is ldh [H]

Identifier: 50842374

GI number: 50842374

Start: 964375

End: 965343

Strand: Direct

Name: ldh [H]

Synonym: PPA0887

Alternate gene names: 50842374

Gene position: 964375-965343 (Clockwise)

Preceding gene: 50842373

Following gene: 50842375

Centisome position: 37.67

GC content: 60.06

Gene sequence:

>969_bases
ATGACCGTCATGAGCACTTTTGACGCCACTCGTCGCGCCTCCAAAATTTCCGTTGTCGGTGCTGGTTCAGTCGGTTCTTC
ACTGGCCTACGCCTGCCTCATCCGTGGATCGGCCGGCCTGGTATCCCTCTACGACATCGCCAAGGACAAGGTCGAGGCCG
AGGTGGCGGATCTCGCCCACGGCACTCAGTTCACCCCTGCTTCGGTCATGGGCGGTGCTGACGTCCACGACACTGCTGAC
TCTGACGTCGTCTTCATTACTGCTGGAGCCAGACAAAAGCCGGGCCAGACTCGCCTAGACCTCGCCGGCGTCAACGCCAA
TATTTTGCGCTCCCTCATGCCACAGCTCGTTGAGCAATCCCCGAACGCCCTGTTCGTGCTAGTGACCAACCCGTGTGACG
TCCTCACCGTCGTTGCCCAGGAGGCCACCGGACTGCCCGCCAACCGTGTTTTTTCCACCGGTACGATGCTCGACACCTCG
CGGCTGCGTTGGCTCATCCGTCAGTGGGCCAACGTCGAGCAGCGTCATGTCCATGCCACCATTGTGGGCGAGCACGGCGA
CTCGGAGTTTCCGCTGTGGTCGACAGCCAATATCTCCGGCGTACCGATCCGCGACTGGGCAGTTGACGGTAACCGGGTGT
TCACCGAGGATGTACTGGCTGACCTAGCCCACGAGGCGGCTTACGCGGCTTACAAGATTATTGAGGGCAAGGGTGCTACG
AACTACGCCATTGGTTTGACGGGTGCTCGTCTAGCCGAGGCTTTGCTCCGTCCAGGCCGCTCCGTTCTGCCATTGTCGAG
CGTCATGACGGACATGCACGGAATATCGGGGGTGGCCCTATCGATGCCCTGCATTGTCTCCCGCGACGGCATTGAGGGGG
TCGTCCCTGTTGCTATGGATACCGAAGAAATCGCTTCTCTCAAGGCTTCAGCGGAACGGCTGCATGACACTTTGTCATCG
ATCGCTTGA

Upstream 100 bases:

>100_bases
GGCGTGGAGACGTGCACAAATGGCCATAGATGCTGGCATCTTGTTCAGATGAGCGGACCTGGTGCGCAGCGTTCTGAATC
AGGCGCGAAGGCACCTTAAG

Downstream 100 bases:

>100_bases
CCCGATGAACATCTGTGCTGCTGACCGCATAAGCTAAGGGATATGTCAGTTCCCTTTCAGTATGCGCATGATGACGACGG
AGGCCTTCTAAGGATTGCGG

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: L-LDH [H]

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MTVMSTFDATRRASKISVVGAGSVGSSLAYACLIRGSAGLVSLYDIAKDKVEAEVADLAHGTQFTPASVMGGADVHDTAD
SDVVFITAGARQKPGQTRLDLAGVNANILRSLMPQLVEQSPNALFVLVTNPCDVLTVVAQEATGLPANRVFSTGTMLDTS
RLRWLIRQWANVEQRHVHATIVGEHGDSEFPLWSTANISGVPIRDWAVDGNRVFTEDVLADLAHEAAYAAYKIIEGKGAT
NYAIGLTGARLAEALLRPGRSVLPLSSVMTDMHGISGVALSMPCIVSRDGIEGVVPVAMDTEEIASLKASAERLHDTLSS
IA

Sequences:

>Translated_322_residues
MTVMSTFDATRRASKISVVGAGSVGSSLAYACLIRGSAGLVSLYDIAKDKVEAEVADLAHGTQFTPASVMGGADVHDTAD
SDVVFITAGARQKPGQTRLDLAGVNANILRSLMPQLVEQSPNALFVLVTNPCDVLTVVAQEATGLPANRVFSTGTMLDTS
RLRWLIRQWANVEQRHVHATIVGEHGDSEFPLWSTANISGVPIRDWAVDGNRVFTEDVLADLAHEAAYAAYKIIEGKGAT
NYAIGLTGARLAEALLRPGRSVLPLSSVMTDMHGISGVALSMPCIVSRDGIEGVVPVAMDTEEIASLKASAERLHDTLSS
IA
>Mature_321_residues
TVMSTFDATRRASKISVVGAGSVGSSLAYACLIRGSAGLVSLYDIAKDKVEAEVADLAHGTQFTPASVMGGADVHDTADS
DVVFITAGARQKPGQTRLDLAGVNANILRSLMPQLVEQSPNALFVLVTNPCDVLTVVAQEATGLPANRVFSTGTMLDTSR
LRWLIRQWANVEQRHVHATIVGEHGDSEFPLWSTANISGVPIRDWAVDGNRVFTEDVLADLAHEAAYAAYKIIEGKGATN
YAIGLTGARLAEALLRPGRSVLPLSSVMTDMHGISGVALSMPCIVSRDGIEGVVPVAMDTEEIASLKASAERLHDTLSSI
A

Specific function: Catalyzes The Reversible Oxidation Of Malate To Oxaloacetate. [C]

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. LDH family [H]

Homologues:

Organism=Homo sapiens, GI15082234, Length=305, Percent_Identity=39.0163934426229, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI5031857, Length=304, Percent_Identity=39.4736842105263, Blast_Score=229, Evalue=2e-60,
Organism=Homo sapiens, GI260099723, Length=304, Percent_Identity=39.4736842105263, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI47059044, Length=303, Percent_Identity=38.2838283828383, Blast_Score=224, Evalue=9e-59,
Organism=Homo sapiens, GI221136809, Length=303, Percent_Identity=38.2838283828383, Blast_Score=224, Evalue=9e-59,
Organism=Homo sapiens, GI9257228, Length=309, Percent_Identity=36.8932038834951, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI4504973, Length=309, Percent_Identity=36.8932038834951, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI291575128, Length=312, Percent_Identity=36.2179487179487, Blast_Score=214, Evalue=8e-56,
Organism=Homo sapiens, GI4557032, Length=312, Percent_Identity=36.2179487179487, Blast_Score=214, Evalue=8e-56,
Organism=Homo sapiens, GI260099727, Length=193, Percent_Identity=41.9689119170984, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI260099725, Length=193, Percent_Identity=41.9689119170984, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI207028494, Length=209, Percent_Identity=34.9282296650718, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI103472011, Length=309, Percent_Identity=23.9482200647249, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI103472015, Length=185, Percent_Identity=27.027027027027, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI21735621, Length=330, Percent_Identity=26.969696969697, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1789632, Length=293, Percent_Identity=29.6928327645051, Blast_Score=86, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17535107, Length=296, Percent_Identity=37.5, Blast_Score=200, Evalue=8e-52,
Organism=Caenorhabditis elegans, GI17554310, Length=302, Percent_Identity=27.4834437086093, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322765, Length=301, Percent_Identity=26.9102990033223, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6320125, Length=343, Percent_Identity=25.0728862973761, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17136226, Length=304, Percent_Identity=38.1578947368421, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI45550422, Length=320, Percent_Identity=37.5, Blast_Score=183, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24647881, Length=299, Percent_Identity=28.0936454849498, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24663599, Length=196, Percent_Identity=30.6122448979592, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: 2640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2380 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). 260 Molecules/Cell In: Stationary Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001557
- InterPro:   IPR011304
- InterPro:   IPR018177
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N [H]

EC number: =1.1.1.27 [H]

Molecular weight: Translated: 33995; Mature: 33864

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00064 L_LDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVMSTFDATRRASKISVVGAGSVGSSLAYACLIRGSAGLVSLYDIAKDKVEAEVADLAH
CCEECCHHHHHCCCEEEEEECCCCHHHHHHHHEECCCCCEEHHHHHHHHHHHHHHHHHHC
GTQFTPASVMGGADVHDTADSDVVFITAGARQKPGQTRLDLAGVNANILRSLMPQLVEQS
CCCCCCHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHCC
PNALFVLVTNPCDVLTVVAQEATGLPANRVFSTGTMLDTSRLRWLIRQWANVEQRHVHAT
CCEEEEEEECCCHHHHHHHHHHCCCCHHHEEECCCEECHHHHHHHHHHHCCHHHHEEEEE
IVGEHGDSEFPLWSTANISGVPIRDWAVDGNRVFTEDVLADLAHEAAYAAYKIIEGKGAT
EEECCCCCCCCEEECCCCCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHHEEEECCCCC
NYAIGLTGARLAEALLRPGRSVLPLSSVMTDMHGISGVALSMPCIVSRDGIEGVVPVAMD
EEEEECCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEECCEEEECCCCCCEEEEEEC
TEEIASLKASAERLHDTLSSIA
HHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TVMSTFDATRRASKISVVGAGSVGSSLAYACLIRGSAGLVSLYDIAKDKVEAEVADLAH
CEECCHHHHHCCCEEEEEECCCCHHHHHHHHEECCCCCEEHHHHHHHHHHHHHHHHHHC
GTQFTPASVMGGADVHDTADSDVVFITAGARQKPGQTRLDLAGVNANILRSLMPQLVEQS
CCCCCCHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHCC
PNALFVLVTNPCDVLTVVAQEATGLPANRVFSTGTMLDTSRLRWLIRQWANVEQRHVHAT
CCEEEEEEECCCHHHHHHHHHHCCCCHHHEEECCCEECHHHHHHHHHHHCCHHHHEEEEE
IVGEHGDSEFPLWSTANISGVPIRDWAVDGNRVFTEDVLADLAHEAAYAAYKIIEGKGAT
EEECCCCCCCCEEECCCCCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHHEEEECCCCC
NYAIGLTGARLAEALLRPGRSVLPLSSVMTDMHGISGVALSMPCIVSRDGIEGVVPVAMD
EEEEECCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEECCEEEECCCCCCEEEEEEC
TEEIASLKASAERLHDTLSSIA
HHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA