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The map label for this gene is malS [H]

Identifier: 50842375

GI number: 50842375

Start: 965386

End: 967092

Strand: Direct

Name: malS [H]

Synonym: PPA0888

Alternate gene names: 50842375

Gene position: 965386-967092 (Clockwise)

Preceding gene: 50842374

Following gene: 50842377

Centisome position: 37.71

GC content: 59.7

Gene sequence:

>1707_bases
ATGTCAGTTCCCTTTCAGTATGCGCATGATGACGACGGAGGCCTTCTAAGGATTGCGGCCCGTGGCCAGGAGGTGTTGAC
GAACCCTCTGGCCAATCGGGGCACTGCCTTCACTATCGAGCAGCGAAAGGCGCTTGGTCTCACCGGCCTGCTGCCGTCGG
GTGTCATGACGATCACTGATCAGCTCAAGCGGGTCTACGCACAGTATTCGGCGCAGCCTGATGACCTGGCCAAGTACCTG
TACCTCAACCACATGCATGACCGCAATGAGGTGCTGTATTTCCGCCTCCTTGCCGAGCATATTGAGGAGATGCTTCCAAT
CGTTTACACGCCGACCATCGGCAAAGCGATTGAGGAGTACAGCCACTGGTACGACCGTCCGCGCGGCATTTACCTGTCCA
TCGATGATCCGGAAGACATGGAGCAGGCTCTCGCACAGTTGGGTCATGGCCCTGACGACGTCGACCTCATCGTGGCCACC
GATGCGGAGGGCATCCTGGGCATCGGCGACCAAGGTGTCGGTGGCGTCGCGATCACGGTAGGAAAGCTAGCCGTATACAC
CGCAGCTGCAGGGATTCACCCTCACCGCGTGCTCCCGGTCATTCTCGACGTCGGTACCGACAATATGGAACGTCTTAACG
ACGATGGCTACCTTGGGGTGCGTCACCCCCGCGTGCGCGGCGAGCGTTACGATGAATTCGTCCAGCAATATGTCGAGACC
GCTCATCGGATGTTCCCCCACGCCCTACTGCACTGGGAGGATTTTGCGGCCGGCAACGCCACCCGGATTCTCAACAAATA
CCGCGACGACTACTGCACGTTTAATGACGACATCCAGGGCACCGCGGCTGTCGTCGTCGCGGCAGTGCTGAGTGCCGTTA
AGTCGTCGGGGATCCCGCTGAATGATCATCGCATTGTCATCCATGGGGCGGGCTCGGCTGGTACCGGGATTGCCAACCTG
CTGGTGCAGCTTATGGTGAGCCAGGGCGCTGACGAAAAGACGGCTCGCTCTCATTTCTGGGGGCTTGGATCCCATGGCTT
GTTGCGCGAAGGTTTACGTCTGCGCGACTTTCAGCAACCCTTCGCGCGCAATAAAGAGGAGTTGGAAGGCTGGACCCTCG
ATAGCCCAGACCAGTACACGCTCGGTGACGTGGTACGAAACGTCCACCCGACGATCCTTATCGGCTGCTCCGCCCAGCCC
GGTGCCTTCACCGAGGACATCGTCAAGACGATGGCTGCCCAGTGTGAGCGTCCGGTCATCATGCCACTGTCGAACCCGAC
CCGTAAGGCTGAAGCCCTGCCGTCCGACGTACTCACGTGGACTGACGGGCGTGCTTTGGTCGCTACCGGTTCGCCGTTCA
AGCCAGTCATGATCAATGGCGTGACCTATCAGATCGCGCAGGCAAATAACGCTCTAGTGTTCCCAGGAATTGGTTTGGGA
ACTATCGCTGTTCGGGCGTCCCGGGTCACTAGCGGCATGATCGCGGCCGCTGCCGAGGCGGTGGCGATGCATATCGATAA
CCGCGTTGTGGGAGCTTCGCTGTTGCCGTCAATCAAGAGCCTAAGGCCACTGTCGGCATCTGTGGCCATTGCTGTCGCCC
AGCAGGCGATGGAGGAGGGCGTGGCAACCGAGGTCACAGACAATCCAGTTGAGAAGGTGTTCTCGGCGATGTGGCAGCCG
CGTTACCCGCGCATCGCGGTTGTCTGA

Upstream 100 bases:

>100_bases
CGCTTCTCTCAAGGCTTCAGCGGAACGGCTGCATGACACTTTGTCATCGATCGCTTGACCCGATGAACATCTGTGCTGCT
GACCGCATAAGCTAAGGGAT

Downstream 100 bases:

>100_bases
TGCGCTGACGTGAGAGGTCGGCTGATGCCAGGCTCGCGCTTCATGCGCATGCTTTGTATGAGGCGCGAGCTACGCCCTGA
TCATTAATGCCGAAATGGGG

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME 3 [H]

Number of amino acids: Translated: 568; Mature: 567

Protein sequence:

>568_residues
MSVPFQYAHDDDGGLLRIAARGQEVLTNPLANRGTAFTIEQRKALGLTGLLPSGVMTITDQLKRVYAQYSAQPDDLAKYL
YLNHMHDRNEVLYFRLLAEHIEEMLPIVYTPTIGKAIEEYSHWYDRPRGIYLSIDDPEDMEQALAQLGHGPDDVDLIVAT
DAEGILGIGDQGVGGVAITVGKLAVYTAAAGIHPHRVLPVILDVGTDNMERLNDDGYLGVRHPRVRGERYDEFVQQYVET
AHRMFPHALLHWEDFAAGNATRILNKYRDDYCTFNDDIQGTAAVVVAAVLSAVKSSGIPLNDHRIVIHGAGSAGTGIANL
LVQLMVSQGADEKTARSHFWGLGSHGLLREGLRLRDFQQPFARNKEELEGWTLDSPDQYTLGDVVRNVHPTILIGCSAQP
GAFTEDIVKTMAAQCERPVIMPLSNPTRKAEALPSDVLTWTDGRALVATGSPFKPVMINGVTYQIAQANNALVFPGIGLG
TIAVRASRVTSGMIAAAAEAVAMHIDNRVVGASLLPSIKSLRPLSASVAIAVAQQAMEEGVATEVTDNPVEKVFSAMWQP
RYPRIAVV

Sequences:

>Translated_568_residues
MSVPFQYAHDDDGGLLRIAARGQEVLTNPLANRGTAFTIEQRKALGLTGLLPSGVMTITDQLKRVYAQYSAQPDDLAKYL
YLNHMHDRNEVLYFRLLAEHIEEMLPIVYTPTIGKAIEEYSHWYDRPRGIYLSIDDPEDMEQALAQLGHGPDDVDLIVAT
DAEGILGIGDQGVGGVAITVGKLAVYTAAAGIHPHRVLPVILDVGTDNMERLNDDGYLGVRHPRVRGERYDEFVQQYVET
AHRMFPHALLHWEDFAAGNATRILNKYRDDYCTFNDDIQGTAAVVVAAVLSAVKSSGIPLNDHRIVIHGAGSAGTGIANL
LVQLMVSQGADEKTARSHFWGLGSHGLLREGLRLRDFQQPFARNKEELEGWTLDSPDQYTLGDVVRNVHPTILIGCSAQP
GAFTEDIVKTMAAQCERPVIMPLSNPTRKAEALPSDVLTWTDGRALVATGSPFKPVMINGVTYQIAQANNALVFPGIGLG
TIAVRASRVTSGMIAAAAEAVAMHIDNRVVGASLLPSIKSLRPLSASVAIAVAQQAMEEGVATEVTDNPVEKVFSAMWQP
RYPRIAVV
>Mature_567_residues
SVPFQYAHDDDGGLLRIAARGQEVLTNPLANRGTAFTIEQRKALGLTGLLPSGVMTITDQLKRVYAQYSAQPDDLAKYLY
LNHMHDRNEVLYFRLLAEHIEEMLPIVYTPTIGKAIEEYSHWYDRPRGIYLSIDDPEDMEQALAQLGHGPDDVDLIVATD
AEGILGIGDQGVGGVAITVGKLAVYTAAAGIHPHRVLPVILDVGTDNMERLNDDGYLGVRHPRVRGERYDEFVQQYVETA
HRMFPHALLHWEDFAAGNATRILNKYRDDYCTFNDDIQGTAAVVVAAVLSAVKSSGIPLNDHRIVIHGAGSAGTGIANLL
VQLMVSQGADEKTARSHFWGLGSHGLLREGLRLRDFQQPFARNKEELEGWTLDSPDQYTLGDVVRNVHPTILIGCSAQPG
AFTEDIVKTMAAQCERPVIMPLSNPTRKAEALPSDVLTWTDGRALVATGSPFKPVMINGVTYQIAQANNALVFPGIGLGT
IAVRASRVTSGMIAAAAEAVAMHIDNRVVGASLLPSIKSLRPLSASVAIAVAQQAMEEGVATEVTDNPVEKVFSAMWQPR
YPRIAVV

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=553, Percent_Identity=41.0488245931284, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI62420882, Length=568, Percent_Identity=39.2605633802817, Blast_Score=401, Evalue=1e-112,
Organism=Homo sapiens, GI62420880, Length=568, Percent_Identity=39.2605633802817, Blast_Score=401, Evalue=1e-112,
Organism=Homo sapiens, GI239049447, Length=568, Percent_Identity=39.2605633802817, Blast_Score=401, Evalue=1e-112,
Organism=Homo sapiens, GI4505145, Length=525, Percent_Identity=39.4285714285714, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI270265879, Length=466, Percent_Identity=41.8454935622318, Blast_Score=359, Evalue=3e-99,
Organism=Escherichia coli, GI87081919, Length=550, Percent_Identity=43.6363636363636, Blast_Score=472, Evalue=1e-134,
Organism=Escherichia coli, GI1788806, Length=406, Percent_Identity=26.3546798029557, Blast_Score=85, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17537199, Length=530, Percent_Identity=41.5094339622642, Blast_Score=392, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6322823, Length=570, Percent_Identity=44.0350877192982, Blast_Score=464, Evalue=1e-131,
Organism=Drosophila melanogaster, GI281362672, Length=529, Percent_Identity=39.5085066162571, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI281362674, Length=529, Percent_Identity=39.5085066162571, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI21356279, Length=529, Percent_Identity=39.5085066162571, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24646386, Length=541, Percent_Identity=38.8170055452865, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24646388, Length=541, Percent_Identity=38.8170055452865, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI78707232, Length=521, Percent_Identity=36.852207293666, Blast_Score=355, Evalue=4e-98,
Organism=Drosophila melanogaster, GI281363505, Length=524, Percent_Identity=36.4503816793893, Blast_Score=353, Evalue=2e-97,
Organism=Drosophila melanogaster, GI78707236, Length=524, Percent_Identity=36.4503816793893, Blast_Score=353, Evalue=2e-97,
Organism=Drosophila melanogaster, GI281363503, Length=515, Percent_Identity=36.504854368932, Blast_Score=348, Evalue=4e-96,
Organism=Drosophila melanogaster, GI78707242, Length=522, Percent_Identity=36.3984674329502, Blast_Score=335, Evalue=5e-92,
Organism=Drosophila melanogaster, GI78707238, Length=522, Percent_Identity=36.3984674329502, Blast_Score=335, Evalue=5e-92,
Organism=Drosophila melanogaster, GI78707240, Length=520, Percent_Identity=36.3461538461538, Blast_Score=334, Evalue=1e-91,
Organism=Drosophila melanogaster, GI19922384, Length=542, Percent_Identity=26.7527675276753, Blast_Score=224, Evalue=9e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 61808; Mature: 61677

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVPFQYAHDDDGGLLRIAARGQEVLTNPLANRGTAFTIEQRKALGLTGLLPSGVMTITD
CCCCCCCCCCCCCCEEEEECCCHHHHHCCCCCCCCEEEEECHHHCCCCCCCCCCHHHHHH
QLKRVYAQYSAQPDDLAKYLYLNHMHDRNEVLYFRLLAEHIEEMLPIVYTPTIGKAIEEY
HHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCEEECCHHHHHHHHH
SHWYDRPRGIYLSIDDPEDMEQALAQLGHGPDDVDLIVATDAEGILGIGDQGVGGVAITV
HHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCCEEEEEECCCCEEECCCCCCCCEEEEH
GKLAVYTAAAGIHPHRVLPVILDVGTDNMERLNDDGYLGVRHPRVRGERYDEFVQQYVET
HHHHHHHHHCCCCCCCEEEEEEECCCCHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHHH
AHRMFPHALLHWEDFAAGNATRILNKYRDDYCTFNDDIQGTAAVVVAAVLSAVKSSGIPL
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
NDHRIVIHGAGSAGTGIANLLVQLMVSQGADEKTARSHFWGLGSHGLLREGLRLRDFQQP
CCCEEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHCCHHHHHHHH
FARNKEELEGWTLDSPDQYTLGDVVRNVHPTILIGCSAQPGAFTEDIVKTMAAQCERPVI
HHCCHHHCCCCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCEE
MPLSNPTRKAEALPSDVLTWTDGRALVATGSPFKPVMINGVTYQIAQANNALVFPGIGLG
EECCCCCHHHHCCCCCCEEECCCCEEEECCCCCCCEEECCEEEEEEECCCEEEECCCCHH
TIAVRASRVTSGMIAAAAEAVAMHIDNRVVGASLLPSIKSLRPLSASVAIAVAQQAMEEG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
VATEVTDNPVEKVFSAMWQPRYPRIAVV
CCCCCCCCHHHHHHHHHCCCCCCEEEEC
>Mature Secondary Structure 
SVPFQYAHDDDGGLLRIAARGQEVLTNPLANRGTAFTIEQRKALGLTGLLPSGVMTITD
CCCCCCCCCCCCCEEEEECCCHHHHHCCCCCCCCEEEEECHHHCCCCCCCCCCHHHHHH
QLKRVYAQYSAQPDDLAKYLYLNHMHDRNEVLYFRLLAEHIEEMLPIVYTPTIGKAIEEY
HHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCEEECCHHHHHHHHH
SHWYDRPRGIYLSIDDPEDMEQALAQLGHGPDDVDLIVATDAEGILGIGDQGVGGVAITV
HHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCCEEEEEECCCCEEECCCCCCCCEEEEH
GKLAVYTAAAGIHPHRVLPVILDVGTDNMERLNDDGYLGVRHPRVRGERYDEFVQQYVET
HHHHHHHHHCCCCCCCEEEEEEECCCCHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHHH
AHRMFPHALLHWEDFAAGNATRILNKYRDDYCTFNDDIQGTAAVVVAAVLSAVKSSGIPL
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
NDHRIVIHGAGSAGTGIANLLVQLMVSQGADEKTARSHFWGLGSHGLLREGLRLRDFQQP
CCCEEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHCCHHHHHHHH
FARNKEELEGWTLDSPDQYTLGDVVRNVHPTILIGCSAQPGAFTEDIVKTMAAQCERPVI
HHCCHHHCCCCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCEE
MPLSNPTRKAEALPSDVLTWTDGRALVATGSPFKPVMINGVTYQIAQANNALVFPGIGLG
EECCCCCHHHHCCCCCCEEECCCCEEEECCCCCCCEEECCEEEEEEECCCEEEECCCCHH
TIAVRASRVTSGMIAAAAEAVAMHIDNRVVGASLLPSIKSLRPLSASVAIAVAQQAMEEG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
VATEVTDNPVEKVFSAMWQPRYPRIAVV
CCCCCCCCHHHHHHHHHCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]