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The map label for this gene is uvrC

Identifier: 50842299

GI number: 50842299

Start: 892433

End: 894493

Strand: Direct

Name: uvrC

Synonym: PPA0812

Alternate gene names: 50842299

Gene position: 892433-894493 (Clockwise)

Preceding gene: 50842298

Following gene: 50842300

Centisome position: 34.86

GC content: 59.1

Gene sequence:

>2061_bases
GTGGGAAGTGATATTTCGCTACTTGCGCATAGAGTTCACCCCATGGCCGATCCGTCCAGCTACCGTCCCGCTCCGGGCAC
GATTCCTACCCAGCCAGGTGTCTATCGATTCAGTGATGCGCATGGCCAGGTCATCTATGTCGGCAAGGCTAAGAACCTGC
GCAACCGATTGAATTCCTATTTCCAGGACATCTCGGCTCTCCACCCGCGCACCCAGCGGATGGTGACGACGGCAGCGCAC
GTGCAGTGGACGGTAGTTCAGAACGAAGTCGAGTCCCTACAGCTCGAATACACCTGGATCAAAGAATTCGACCCGCGGTT
CAATGTTATGTACCGCGACGACAAGTCTTATCCGTGGCTGTGTTTTACCTGGACCGATGAGTATCCACGCGTCTTCGTCG
GGCGCGGTGCGCACCACAAGGGGTGGCGTTATTACGGACCTTTTGGCCAGGCCTGGGCGATTCGCGACACCGTCGAGACC
CTGTTGCGTGTATTCCCGATGCGCTCTTGCTCGACGGGAGTTTTCAACCGCGCGAAGAACCAGGGACGTCCCTGCCTACT
CGGATATATCGGTAAGTGTTCGGCTCCCTGCGTTGAACGGATCACATCCGAGGCTCATCGCGAGATCGCTGACGAGTTCT
GTGATTTCATGGCCGGGCGGACGACGAAAATTGTCAAGCGGCTTGAATCCCAGATGGCGGAGGCCTCTGAGAACCTTGAA
TTTGAACGCGCTGCGGTGATCCGGGATTCCTTGGGCGCTTTATCCAAAACTTTGGAGCGCAACGCTGTCGTACTTGGTGA
TGGTACTGACGCGGACGTCATCTCCATGGCGCTCGATCCGCTCGAGGTCGGCGTCAAGATTTTCCATGTCCGAGGTGGCC
GCATCCGTGGTGAACGCGGTTGGGTCGCTGATCGTGCTGACGATGCCGACGAGGCCGAGCTCATGGAAACCTTCCTAACT
CAGTTGTACGGCGTCAATGCCAGTGACGGTCAGGTCCGCGACGATGGGCACGGCAATGCTGTTCCGCCACTGGTGCTCGT
CTCCGCCGAGCCTACGAACCCCGACGTCATGTCGACGATTCTCAGCTCCGAACGCGGCTCCCACGTCGAGATTCGTGTCC
CGCGCCGTGGTGACAAAGCGACTCTCATGGACACCGTCACTCGCAATGCCCAGGAAACTCTTGCCCAGCACAAGCTCAAG
CGGGCCTCTGACCTTGCTACCCGTACTCGCGCTCTGGAAGAAATTCAGGAGTCACTCGGCTTGGACCGCGCCCCGCTACG
GATGGAGTCCTACGACATTTCCCATATCCAGGGCACCAATGTCGTTGGGTCGATGGTGGTCTTCGAAGACGGTATGCCCC
GCAAGTCTGAGTACCGTCGTTTCAGCATCAAGGGATTTGAGGGGTCCGACGACTTCGCCGCTATGCACGAGGTGCTTTCT
CGTCGACTGCGTCGCCTCATCGAGGACCGTGATGCCATGGCCGCTGCTCAAACTCCTGACGGCGACGTTGGCTCCCTTAT
CGATCCGACTACCGGATCCCCTCGGAAATTCGCCTACGCCCCGCACCTCATCGTCGTCGATGGTGGTGCGCCTCAGGTGC
ATGCCGCCCAGCAGGTGCTTGAAGAGTTCGGCCTGGAGGACGAAATCGCGTTGTGTGGCCTGGCCAAGCGCCTGGAGGAG
GTGTGGCTTCCTGACGAGGAATGGCCGGTCATTTTGCCGCGAACTTCCGAAGGACTCTACCTGCTTCAGCGTCTGCGTGA
TGAGGCTCACCGTTTCGCTATTACCTTTCACCGGTCTAAGCGTTCCAAGGCCATGGTGGAGTCCGTTCTCGACGGTGTGT
CGGGGCTGGGAGAGACCCGGCGCAAAGCGCTCGTCTCCCACTTTGGATCGGTACGGTCGCTACGCAAGGCCACCGTTGAC
GACATTGTCGAGGTGCCAGGCTTTGGCCCGAAACTCGCTGGCGAAGTTGTCGCAGCTTTGTCCCAGGACAAACCAGCCGA
GGCCATCAACACCGCTACTGGCGAGGTTGTTGACGCCAACGGCCCAGACGCAGGGAGATAA

Upstream 100 bases:

>100_bases
CTCCGCCCCGCTCGGTCGGCTTTGTGCCTGTGATCGTCGGCGGGACGGTTGAGCGGCATCAACGGCAGTGCCGCTCCCTA
AAGTCACGTCCGTGGTGTGA

Downstream 100 bases:

>100_bases
CGGCACTACCCTTGAGCTGTGAGCACCGAGCAGACGACGAAGACCCCACGAGTTGTCATTATCACCGGCATTTCTGGTGC
TGGGCGTCGTACCGCAGCTC

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 686; Mature: 685

Protein sequence:

>686_residues
MGSDISLLAHRVHPMADPSSYRPAPGTIPTQPGVYRFSDAHGQVIYVGKAKNLRNRLNSYFQDISALHPRTQRMVTTAAH
VQWTVVQNEVESLQLEYTWIKEFDPRFNVMYRDDKSYPWLCFTWTDEYPRVFVGRGAHHKGWRYYGPFGQAWAIRDTVET
LLRVFPMRSCSTGVFNRAKNQGRPCLLGYIGKCSAPCVERITSEAHREIADEFCDFMAGRTTKIVKRLESQMAEASENLE
FERAAVIRDSLGALSKTLERNAVVLGDGTDADVISMALDPLEVGVKIFHVRGGRIRGERGWVADRADDADEAELMETFLT
QLYGVNASDGQVRDDGHGNAVPPLVLVSAEPTNPDVMSTILSSERGSHVEIRVPRRGDKATLMDTVTRNAQETLAQHKLK
RASDLATRTRALEEIQESLGLDRAPLRMESYDISHIQGTNVVGSMVVFEDGMPRKSEYRRFSIKGFEGSDDFAAMHEVLS
RRLRRLIEDRDAMAAAQTPDGDVGSLIDPTTGSPRKFAYAPHLIVVDGGAPQVHAAQQVLEEFGLEDEIALCGLAKRLEE
VWLPDEEWPVILPRTSEGLYLLQRLRDEAHRFAITFHRSKRSKAMVESVLDGVSGLGETRRKALVSHFGSVRSLRKATVD
DIVEVPGFGPKLAGEVVAALSQDKPAEAINTATGEVVDANGPDAGR

Sequences:

>Translated_686_residues
MGSDISLLAHRVHPMADPSSYRPAPGTIPTQPGVYRFSDAHGQVIYVGKAKNLRNRLNSYFQDISALHPRTQRMVTTAAH
VQWTVVQNEVESLQLEYTWIKEFDPRFNVMYRDDKSYPWLCFTWTDEYPRVFVGRGAHHKGWRYYGPFGQAWAIRDTVET
LLRVFPMRSCSTGVFNRAKNQGRPCLLGYIGKCSAPCVERITSEAHREIADEFCDFMAGRTTKIVKRLESQMAEASENLE
FERAAVIRDSLGALSKTLERNAVVLGDGTDADVISMALDPLEVGVKIFHVRGGRIRGERGWVADRADDADEAELMETFLT
QLYGVNASDGQVRDDGHGNAVPPLVLVSAEPTNPDVMSTILSSERGSHVEIRVPRRGDKATLMDTVTRNAQETLAQHKLK
RASDLATRTRALEEIQESLGLDRAPLRMESYDISHIQGTNVVGSMVVFEDGMPRKSEYRRFSIKGFEGSDDFAAMHEVLS
RRLRRLIEDRDAMAAAQTPDGDVGSLIDPTTGSPRKFAYAPHLIVVDGGAPQVHAAQQVLEEFGLEDEIALCGLAKRLEE
VWLPDEEWPVILPRTSEGLYLLQRLRDEAHRFAITFHRSKRSKAMVESVLDGVSGLGETRRKALVSHFGSVRSLRKATVD
DIVEVPGFGPKLAGEVVAALSQDKPAEAINTATGEVVDANGPDAGR
>Mature_685_residues
GSDISLLAHRVHPMADPSSYRPAPGTIPTQPGVYRFSDAHGQVIYVGKAKNLRNRLNSYFQDISALHPRTQRMVTTAAHV
QWTVVQNEVESLQLEYTWIKEFDPRFNVMYRDDKSYPWLCFTWTDEYPRVFVGRGAHHKGWRYYGPFGQAWAIRDTVETL
LRVFPMRSCSTGVFNRAKNQGRPCLLGYIGKCSAPCVERITSEAHREIADEFCDFMAGRTTKIVKRLESQMAEASENLEF
ERAAVIRDSLGALSKTLERNAVVLGDGTDADVISMALDPLEVGVKIFHVRGGRIRGERGWVADRADDADEAELMETFLTQ
LYGVNASDGQVRDDGHGNAVPPLVLVSAEPTNPDVMSTILSSERGSHVEIRVPRRGDKATLMDTVTRNAQETLAQHKLKR
ASDLATRTRALEEIQESLGLDRAPLRMESYDISHIQGTNVVGSMVVFEDGMPRKSEYRRFSIKGFEGSDDFAAMHEVLSR
RLRRLIEDRDAMAAAQTPDGDVGSLIDPTTGSPRKFAYAPHLIVVDGGAPQVHAAQQVLEEFGLEDEIALCGLAKRLEEV
WLPDEEWPVILPRTSEGLYLLQRLRDEAHRFAITFHRSKRSKAMVESVLDGVSGLGETRRKALVSHFGSVRSLRKATVDD
IVEVPGFGPKLAGEVVAALSQDKPAEAINTATGEVVDANGPDAGR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=656, Percent_Identity=34.7560975609756, Blast_Score=369, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 76211; Mature: 76080

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSDISLLAHRVHPMADPSSYRPAPGTIPTQPGVYRFSDAHGQVIYVGKAKNLRNRLNSY
CCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEECCHHHHHHHHHH
FQDISALHPRTQRMVTTAAHVQWTVVQNEVESLQLEYTWIKEFDPRFNVMYRDDKSYPWL
HHHHHHHCCHHHHHHHHHHHEEEEEEHHHHHHEEEEEEEEECCCCCEEEEEECCCCCCEE
CFTWTDEYPRVFVGRGAHHKGWRYYGPFGQAWAIRDTVETLLRVFPMRSCSTGVFNRAKN
EEEECCCCCEEEEECCCCCCCCEEECCCCCCEEHHHHHHHHHHHHCCCCCCHHHHHHHHC
QGRPCLLGYIGKCSAPCVERITSEAHREIADEFCDFMAGRTTKIVKRLESQMAEASENLE
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
FERAAVIRDSLGALSKTLERNAVVLGDGTDADVISMALDPLEVGVKIFHVRGGRIRGERG
HHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHCHHHHCEEEEEEECCEEECCCC
WVADRADDADEAELMETFLTQLYGVNASDGQVRDDGHGNAVPPLVLVSAEPTNPDVMSTI
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHH
LSSERGSHVEIRVPRRGDKATLMDTVTRNAQETLAQHKLKRASDLATRTRALEEIQESLG
HHCCCCCEEEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LDRAPLRMESYDISHIQGTNVVGSMVVFEDGMPRKSEYRRFSIKGFEGSDDFAAMHEVLS
CCCCCCEECCCCCCCCCCCCCCEEEEEEECCCCCHHHCCEEEEECCCCCCHHHHHHHHHH
RRLRRLIEDRDAMAAAQTPDGDVGSLIDPTTGSPRKFAYAPHLIVVDGGAPQVHAAQQVL
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCEEEEECCCCCCHHHHHHHH
EEFGLEDEIALCGLAKRLEEVWLPDEEWPVILPRTSEGLYLLQRLRDEAHRFAITFHRSK
HHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHEEEEEECCH
RSKAMVESVLDGVSGLGETRRKALVSHFGSVRSLRKATVDDIVEVPGFGPKLAGEVVAAL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
SQDKPAEAINTATGEVVDANGPDAGR
CCCCCHHHHHCCCCCEEECCCCCCCC
>Mature Secondary Structure 
GSDISLLAHRVHPMADPSSYRPAPGTIPTQPGVYRFSDAHGQVIYVGKAKNLRNRLNSY
CCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEECCHHHHHHHHHH
FQDISALHPRTQRMVTTAAHVQWTVVQNEVESLQLEYTWIKEFDPRFNVMYRDDKSYPWL
HHHHHHHCCHHHHHHHHHHHEEEEEEHHHHHHEEEEEEEEECCCCCEEEEEECCCCCCEE
CFTWTDEYPRVFVGRGAHHKGWRYYGPFGQAWAIRDTVETLLRVFPMRSCSTGVFNRAKN
EEEECCCCCEEEEECCCCCCCCEEECCCCCCEEHHHHHHHHHHHHCCCCCCHHHHHHHHC
QGRPCLLGYIGKCSAPCVERITSEAHREIADEFCDFMAGRTTKIVKRLESQMAEASENLE
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
FERAAVIRDSLGALSKTLERNAVVLGDGTDADVISMALDPLEVGVKIFHVRGGRIRGERG
HHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHCHHHHCEEEEEEECCEEECCCC
WVADRADDADEAELMETFLTQLYGVNASDGQVRDDGHGNAVPPLVLVSAEPTNPDVMSTI
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHH
LSSERGSHVEIRVPRRGDKATLMDTVTRNAQETLAQHKLKRASDLATRTRALEEIQESLG
HHCCCCCEEEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LDRAPLRMESYDISHIQGTNVVGSMVVFEDGMPRKSEYRRFSIKGFEGSDDFAAMHEVLS
CCCCCCEECCCCCCCCCCCCCCEEEEEEECCCCCHHHCCEEEEECCCCCCHHHHHHHHHH
RRLRRLIEDRDAMAAAQTPDGDVGSLIDPTTGSPRKFAYAPHLIVVDGGAPQVHAAQQVL
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCEEEEECCCCCCHHHHHHHH
EEFGLEDEIALCGLAKRLEEVWLPDEEWPVILPRTSEGLYLLQRLRDEAHRFAITFHRSK
HHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHEEEEEECCH
RSKAMVESVLDGVSGLGETRRKALVSHFGSVRSLRKATVDDIVEVPGFGPKLAGEVVAAL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
SQDKPAEAINTATGEVVDANGPDAGR
CCCCCHHHHHCCCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA