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The map label for this gene is macB2 [H]

Identifier: 50842284

GI number: 50842284

Start: 878164

End: 878439

Strand: Reverse

Name: macB2 [H]

Synonym: PPA0796

Alternate gene names: 50842284

Gene position: 878439-878164 (Counterclockwise)

Preceding gene: 50842285

Following gene: 50842281

Centisome position: 34.31

GC content: 58.33

Gene sequence:

>276_bases
TTGGAACGCGTTGGACTGCCCGGGCAGGAACAAACTCCCGTACACACCCTTAGCGGAGGCGAACAGCAGCGTGTCGCCTT
GGCTCGATTGCTCCTCAAGCCGAGCCGGATCATCCTGGCCGACGAACCCACGGCGTCACTTGACCGGGACAACGAGGACC
TGGTCCTAAATCTTTTACAAGATCTCGCCAATGAAGGCAAAGTGATACTTCTCGCCACTCACAGCGGCCGAGTCGCGAGT
CGTTGTTCGCGGGTGCTGTCACTGCACCACCATTAA

Upstream 100 bases:

>100_bases
TCAGGATTAGGCTCTGCTCGAGAGCGCTACGGTACGCGAAAACCTAGACATCGCGGCGCGCCCAAGACCCTTACTACCCA
AGCCCTCCTTCGCATCCGCC

Downstream 100 bases:

>100_bases
CTGCCCAACCGCCTCACGCCAAGGGACAGGAAGACTCGCTCTCAGTATCCTCGACCACGTGCGACCGACTCCGGTGGGCA
GGTTCCTAGCCACTGTTAAC

Product: ABC transporter ATP-binding protein

Products: 3-phospho-serine [Cytoplasm]; phosphite [Cytoplasm]; ADP; phosphate [Cytoplasm]; alkylphosphonate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 91; Mature: 91

Protein sequence:

>91_residues
MERVGLPGQEQTPVHTLSGGEQQRVALARLLLKPSRIILADEPTASLDRDNEDLVLNLLQDLANEGKVILLATHSGRVAS
RCSRVLSLHHH

Sequences:

>Translated_91_residues
MERVGLPGQEQTPVHTLSGGEQQRVALARLLLKPSRIILADEPTASLDRDNEDLVLNLLQDLANEGKVILLATHSGRVAS
RCSRVLSLHHH
>Mature_91_residues
MERVGLPGQEQTPVHTLSGGEQQRVALARLLLKPSRIILADEPTASLDRDNEDLVLNLLQDLANEGKVILLATHSGRVAS
RCSRVLSLHHH

Specific function: Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation [H]

COG id: COG1136

COG function: function code V; ABC-type antimicrobial peptide transport system, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Escherichia coli, GI1790544, Length=90, Percent_Identity=42.2222222222222, Blast_Score=70, Evalue=2e-14,
Organism=Escherichia coli, GI1787105, Length=88, Percent_Identity=37.5, Blast_Score=68, Evalue=1e-13,
Organism=Escherichia coli, GI87081834, Length=73, Percent_Identity=47.945205479452, Blast_Score=64, Evalue=1e-12,
Organism=Escherichia coli, GI1786703, Length=73, Percent_Identity=47.945205479452, Blast_Score=64, Evalue=2e-12,
Organism=Escherichia coli, GI1788644, Length=84, Percent_Identity=44.047619047619, Blast_Score=63, Evalue=3e-12,
Organism=Escherichia coli, GI1788225, Length=74, Percent_Identity=44.5945945945946, Blast_Score=63, Evalue=4e-12,
Organism=Escherichia coli, GI1788897, Length=81, Percent_Identity=37.037037037037, Blast_Score=63, Evalue=5e-12,
Organism=Escherichia coli, GI1786872, Length=89, Percent_Identity=40.4494382022472, Blast_Score=63, Evalue=5e-12,
Organism=Escherichia coli, GI1787029, Length=85, Percent_Identity=42.3529411764706, Blast_Score=62, Evalue=8e-12,
Organism=Escherichia coli, GI1789873, Length=89, Percent_Identity=39.3258426966292, Blast_Score=60, Evalue=2e-11,
Organism=Escherichia coli, GI1787089, Length=92, Percent_Identity=38.0434782608696, Blast_Score=59, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR017911
- InterPro:   IPR003593
- InterPro:   IPR003838 [H]

Pfam domain/function: PF00005 ABC_tran; PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 9977; Mature: 9977

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERVGLPGQEQTPVHTLSGGEQQRVALARLLLKPSRIILADEPTASLDRDNEDLVLNLLQ
CCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHH
DLANEGKVILLATHSGRVASRCSRVLSLHHH
HHHCCCCEEEEEECCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MERVGLPGQEQTPVHTLSGGEQQRVALARLLLKPSRIILADEPTASLDRDNEDLVLNLLQ
CCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHH
DLANEGKVILLATHSGRVASRCSRVLSLHHH
HHHCCCCEEEEEECCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 3-phospho-serine [Periplasm]; phosphite [Periplasm]; H2O; phosphate [Periplasm]; alkylphosphonate [Periplasm] [C]

Specific reaction: H2O + ATP + 3-phospho-serine [Periplasm] = ADP + phosphate + 3-phospho-serine [Cytoplasm] ATP + phosphite [Periplasm] + H2O = phosphite [Cytoplasm] + ADP + phosphate phosphate [Periplasm] + ATP + H2O = ADP + phosphate [Cytoplasm] + phosphate [Cytoplasm] A

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA