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The map label for this gene is murC

Identifier: 50842246

GI number: 50842246

Start: 835102

End: 836517

Strand: Direct

Name: murC

Synonym: PPA0759

Alternate gene names: 50842246

Gene position: 835102-836517 (Clockwise)

Preceding gene: 50842245

Following gene: 50842247

Centisome position: 32.62

GC content: 61.23

Gene sequence:

>1416_bases
ATGTCACTGCGGGAACCTGTCGAGCTACTTGATCCCAGCGCCGTAGGGCCGGTCTACTTCATCGCCATCGGCGGAGCCGG
AATGAGCGGTGTGGCACGGATTTACCACGACTTGGGAGTTGAGGTGCGCGGCTCCGACCAGGTCGACTCGGCTAATTTGC
GTGACCTTGCAAGTCTCGGCGTTCAGACCTGGGTAGGTCATGATCCGTCCCACCTGGCGGGGGCTCGTACCGTGGTCGTC
TCCTCGGCTATTCGTCCTGACAACCCCGAGCTGGTCGAGGCACACCGGCTGGGTTTGCGGATCTGGCATCGCTCGGCTGC
TTTGGCGGCACTCATGCTCGGCCGGGAAGGCGTCTCAATCGCTGGTACGCACGGCAAGACAACGACAACCGGCATGGTTG
CCACCATGCTCGATTGTGCCGGAGCTGACCCGTCCTATGTCATTGGCTCTCCACTGGCTGCCACGGGCATGTCCTCCCAT
CTTGGTGGGGGAGAAGCATTCGTGGTGGAGGCTGATGAATCCGATGGGTCTTTCCTGCAGTACCCAAGCCAGATCGTCGT
CGTCACCAATGTGGAAGCCGATCACCTAGACAATTGGGGTACCCCGCAGGCGTACTTCGACGGCTTCGTGTCGATGGCAA
CCCGTCCCGAGGTGCGCTACGTCGTGACTAATGCCGACGATCCGGGGGCAGCCGAATTGGCCTGCCGACTGGAAAGCACC
GGCACAGTGCGAGTCGTTACTTACGGAGAATCTGAGCAAGCTGAGGTCAGGCTCGTTGACCTTGACTTAAATGGGACGAC
GGCTTCGGCGACTCTCGTTTATGGCCCTACCCAGGGACGCCTGGAGCTCCAGGTGCCTGGTCGCTACAATCTCTCTAATG
CGGCAGCCGCCTACTGCGTCGGTTCCCTGCTGGGAATTAGTCACCAGGATCTGTTGACCGGGATCGCATCCTTCACGGGG
ACGTTGCGACGCTTCCAACTGGTGGGTCGGGTTGCTGACGTCTCAGTCTTTGACGATTACGCCCATCACCCGACCGAATT
GCGCGCCACCCTTGGCGCGGCACGTCGTGTCGTGACGGGGCAGGGGAGGGTCATCGCCTGCTTCCAGCCTCATCTGTTTT
CCCGTACCAGAGATTTCGCCGGGGAGTTCGGATCGGCGCTTACCCTTGCAGACCGGGTCATCGTTTCCGACATATATCCG
GCCCGTGAGGATCCGATTCCCGGTGTGACCGGCGAGTTGGTGCACGACGCCGTTATCGCCGCAGGCGGGGACTCCCGGTA
TGTGCCCGATAAGCAGGACCTTCCGGAGGCCCTCGCTGAAGAGGTACGTCCTGGGGACCTCGTCATCACCCTTGGCGCAG
GAGATGTCACTTTAGTTGGCCCGGTTCTGGTGGGCCTACTGGAGGGCAAGGCTTGA

Upstream 100 bases:

>100_bases
GACGGGGACTCATGCCCGCTCACGCTGCTGAGGAGATGGCGGTCCGGGTGATCTCGGCGGCGACGTCGATAGACCCTACG
ATTGGTTGAGGAGATATCTC

Downstream 100 bases:

>100_bases
TGCCGGTTTCCGACATCAGCGTCGCGATGGAGCTACGACGTCGACGCCGTAGGAAGCGTAACCGGATCATTGCGGGTGTT
GTCGCCGCTGTGGTGGTGCT

Product: UDP-N-acetylmuramate--alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MSLREPVELLDPSAVGPVYFIAIGGAGMSGVARIYHDLGVEVRGSDQVDSANLRDLASLGVQTWVGHDPSHLAGARTVVV
SSAIRPDNPELVEAHRLGLRIWHRSAALAALMLGREGVSIAGTHGKTTTTGMVATMLDCAGADPSYVIGSPLAATGMSSH
LGGGEAFVVEADESDGSFLQYPSQIVVVTNVEADHLDNWGTPQAYFDGFVSMATRPEVRYVVTNADDPGAAELACRLEST
GTVRVVTYGESEQAEVRLVDLDLNGTTASATLVYGPTQGRLELQVPGRYNLSNAAAAYCVGSLLGISHQDLLTGIASFTG
TLRRFQLVGRVADVSVFDDYAHHPTELRATLGAARRVVTGQGRVIACFQPHLFSRTRDFAGEFGSALTLADRVIVSDIYP
AREDPIPGVTGELVHDAVIAAGGDSRYVPDKQDLPEALAEEVRPGDLVITLGAGDVTLVGPVLVGLLEGKA

Sequences:

>Translated_471_residues
MSLREPVELLDPSAVGPVYFIAIGGAGMSGVARIYHDLGVEVRGSDQVDSANLRDLASLGVQTWVGHDPSHLAGARTVVV
SSAIRPDNPELVEAHRLGLRIWHRSAALAALMLGREGVSIAGTHGKTTTTGMVATMLDCAGADPSYVIGSPLAATGMSSH
LGGGEAFVVEADESDGSFLQYPSQIVVVTNVEADHLDNWGTPQAYFDGFVSMATRPEVRYVVTNADDPGAAELACRLEST
GTVRVVTYGESEQAEVRLVDLDLNGTTASATLVYGPTQGRLELQVPGRYNLSNAAAAYCVGSLLGISHQDLLTGIASFTG
TLRRFQLVGRVADVSVFDDYAHHPTELRATLGAARRVVTGQGRVIACFQPHLFSRTRDFAGEFGSALTLADRVIVSDIYP
AREDPIPGVTGELVHDAVIAAGGDSRYVPDKQDLPEALAEEVRPGDLVITLGAGDVTLVGPVLVGLLEGKA
>Mature_470_residues
SLREPVELLDPSAVGPVYFIAIGGAGMSGVARIYHDLGVEVRGSDQVDSANLRDLASLGVQTWVGHDPSHLAGARTVVVS
SAIRPDNPELVEAHRLGLRIWHRSAALAALMLGREGVSIAGTHGKTTTTGMVATMLDCAGADPSYVIGSPLAATGMSSHL
GGGEAFVVEADESDGSFLQYPSQIVVVTNVEADHLDNWGTPQAYFDGFVSMATRPEVRYVVTNADDPGAAELACRLESTG
TVRVVTYGESEQAEVRLVDLDLNGTTASATLVYGPTQGRLELQVPGRYNLSNAAAAYCVGSLLGISHQDLLTGIASFTGT
LRRFQLVGRVADVSVFDDYAHHPTELRATLGAARRVVTGQGRVIACFQPHLFSRTRDFAGEFGSALTLADRVIVSDIYPA
REDPIPGVTGELVHDAVIAAGGDSRYVPDKQDLPEALAEEVRPGDLVITLGAGDVTLVGPVLVGLLEGKA

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=452, Percent_Identity=38.4955752212389, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1790680, Length=454, Percent_Identity=27.0925110132159, Blast_Score=136, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_PROAC (Q6A9Q1)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_055473.1
- ProteinModelPortal:   Q6A9Q1
- SMR:   Q6A9Q1
- GeneID:   2932663
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA0759
- NMPDR:   fig|267747.1.peg.750
- HOGENOM:   HBG476594
- OMA:   EPNFSAV
- ProtClustDB:   CLSK2763507
- BioCyc:   PACN267747:PPA0759-MONOMER
- BRENDA:   6.3.2.8
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 49506; Mature: 49375

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLREPVELLDPSAVGPVYFIAIGGAGMSGVARIYHDLGVEVRGSDQVDSANLRDLASLG
CCCCCCHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHCC
VQTWVGHDPSHLAGARTVVVSSAIRPDNPELVEAHRLGLRIWHRSAALAALMLGREGVSI
HHHHCCCCHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
AGTHGKTTTTGMVATMLDCAGADPSYVIGSPLAATGMSSHLGGGEAFVVEADESDGSFLQ
EECCCCCCHHHHHHHHHHHCCCCCCEEECCCHHHCCCCCCCCCCEEEEEEECCCCCCEEE
YPSQIVVVTNVEADHLDNWGTPQAYFDGFVSMATRPEVRYVVTNADDPGAAELACRLEST
CCCEEEEEEECCHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCHHHEEEEECCC
GTVRVVTYGESEQAEVRLVDLDLNGTTASATLVYGPTQGRLELQVPGRYNLSNAAAAYCV
CEEEEEEECCCCCCEEEEEEEECCCCCEEEEEEECCCCCEEEEECCCCCCCCHHHHHHHH
GSLLGISHQDLLTGIASFTGTLRRFQLVGRVADVSVFDDYAHHPTELRATLGAARRVVTG
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEHHHHHCCCCHHHHHHHHHHHEEEEC
QGRVIACFQPHLFSRTRDFAGEFGSALTLADRVIVSDIYPAREDPIPGVTGELVHDAVIA
CCCEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHEEEE
AGGDSRYVPDKQDLPEALAEEVRPGDLVITLGAGDVTLVGPVLVGLLEGKA
ECCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCEEEHHHHHHHHHCCCC
>Mature Secondary Structure 
SLREPVELLDPSAVGPVYFIAIGGAGMSGVARIYHDLGVEVRGSDQVDSANLRDLASLG
CCCCCHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHCC
VQTWVGHDPSHLAGARTVVVSSAIRPDNPELVEAHRLGLRIWHRSAALAALMLGREGVSI
HHHHCCCCHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
AGTHGKTTTTGMVATMLDCAGADPSYVIGSPLAATGMSSHLGGGEAFVVEADESDGSFLQ
EECCCCCCHHHHHHHHHHHCCCCCCEEECCCHHHCCCCCCCCCCEEEEEEECCCCCCEEE
YPSQIVVVTNVEADHLDNWGTPQAYFDGFVSMATRPEVRYVVTNADDPGAAELACRLEST
CCCEEEEEEECCHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCHHHEEEEECCC
GTVRVVTYGESEQAEVRLVDLDLNGTTASATLVYGPTQGRLELQVPGRYNLSNAAAAYCV
CEEEEEEECCCCCCEEEEEEEECCCCCEEEEEEECCCCCEEEEECCCCCCCCHHHHHHHH
GSLLGISHQDLLTGIASFTGTLRRFQLVGRVADVSVFDDYAHHPTELRATLGAARRVVTG
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEHHHHHCCCCHHHHHHHHHHHEEEEC
QGRVIACFQPHLFSRTRDFAGEFGSALTLADRVIVSDIYPAREDPIPGVTGELVHDAVIA
CCCEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHEEEE
AGGDSRYVPDKQDLPEALAEEVRPGDLVITLGAGDVTLVGPVLVGLLEGKA
ECCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCEEEHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA