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The map label for this gene is glkA [H]

Identifier: 50842210

GI number: 50842210

Start: 794199

End: 795269

Strand: Direct

Name: glkA [H]

Synonym: PPA0722

Alternate gene names: 50842210

Gene position: 794199-795269 (Clockwise)

Preceding gene: 50842209

Following gene: 50842212

Centisome position: 31.02

GC content: 59.85

Gene sequence:

>1071_bases
TTGCTTAGCGTTGGCATAGATATTGGCGGCACGAAGGTCGCCGCTGGTGTCGTAGATGAAAGTGGCCAGATTGTTCGGCG
TATTCAGCGCCTGACACCCTCGCGCAGCCCCGAGGCTGTTGAGGACGCTATCGTTGAGTCGGTCCGTGAACTGGCTCGTA
ACCTTCCTATCTGTGCTGTAGGCATCGGGGCAGCCGGCTGGATAGACACTGAGCAGGCGCTCGTGCGGTTTTCCCCGCAT
TTGGCATGGCGTAATGAGCCGCTGCGCGATCGTCTGTCTGAGCGCATCACTGTGCCTGTTCTCGTCGATAATGACGCCAA
TGCGGCTGCGTGGGCTGAGTTCCGGTTTGGAGCCGGACAAGGATCACGGGTCATGGTGTGCCTGACGTTGGGAACGGGTA
TCGGGGGTGCACTCGTTATCAATGGGCGGATGTTCCGCGGCCGATACGGCATGGCCGGAGAATTCGGACATATGACGGTG
GTTCCCGATGGCCACTGGTGCCCATGTGGCAACCGTGGTTGCTGGGAGCAATACGCCTCTGGAAATTCCCTCGTGAGGGA
CGCTCGAGCGTTGCTTGCCGAGGGAGCTCCCGGTGCTCAGGACCTGTTGGGTTATGTAGCTGACCGCAATCCCGATAACC
TCATTGGTCCTGATGTCACACGCGCAGCGGTCGATGGCGATCGTCTTGCTATTGAGCTCATTGCAGACATTGGCATCTGG
CTGGGCCGTGGAATGGCGAACTTGGCAGCTGCCTTAGATCCAGATCTCTTTGTCATTGGTGGGGGAGTGAGCGCCGCCGG
AGACCTCTTGCTTGAACCTGCGCGCACTGTATATGCCCGCACGCTGACGGGTCGGGGGTTCCGCCCGATGGCCGATATTC
AGAAGGCACATTTCGGTAACGATGCTGGGCTTATCGGCGCCGCAGACTTGGCTCGCCACTCCATCAACGAACCGCCGGGC
ATGGCTCGCGGGTTCTGGCCACGTCGTCGTACTGCTGTTCGCAAGCCACGCCGTACTTTGCGTCAGAGCCTGAGTGAAAC
TCTCGCCGGCCCGGTTGTTCGGGACAAGTGA

Upstream 100 bases:

>100_bases
CAAGTTTATTCACGCCTCCAGTCCGCGAACTGGCATCAAAGTCTCCGTTCTAGCGCAACAGCCCTCATACCAGGGCGCGC
GTCGTTTCGGCTGATTTTCA

Downstream 100 bases:

>100_bases
CTCGCTACAAACGTGAGTGGTTTCCCCAGGGACCTTCATCATCGCGGTCTTTCCGAGTGATGGCCCGCCAGATGAGCAGG
CTAATCCCTGCTCCTCCGGA

Product: glucokinase

Products: NA

Alternate protein names: Glucose kinase [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MLSVGIDIGGTKVAAGVVDESGQIVRRIQRLTPSRSPEAVEDAIVESVRELARNLPICAVGIGAAGWIDTEQALVRFSPH
LAWRNEPLRDRLSERITVPVLVDNDANAAAWAEFRFGAGQGSRVMVCLTLGTGIGGALVINGRMFRGRYGMAGEFGHMTV
VPDGHWCPCGNRGCWEQYASGNSLVRDARALLAEGAPGAQDLLGYVADRNPDNLIGPDVTRAAVDGDRLAIELIADIGIW
LGRGMANLAAALDPDLFVIGGGVSAAGDLLLEPARTVYARTLTGRGFRPMADIQKAHFGNDAGLIGAADLARHSINEPPG
MARGFWPRRRTAVRKPRRTLRQSLSETLAGPVVRDK

Sequences:

>Translated_356_residues
MLSVGIDIGGTKVAAGVVDESGQIVRRIQRLTPSRSPEAVEDAIVESVRELARNLPICAVGIGAAGWIDTEQALVRFSPH
LAWRNEPLRDRLSERITVPVLVDNDANAAAWAEFRFGAGQGSRVMVCLTLGTGIGGALVINGRMFRGRYGMAGEFGHMTV
VPDGHWCPCGNRGCWEQYASGNSLVRDARALLAEGAPGAQDLLGYVADRNPDNLIGPDVTRAAVDGDRLAIELIADIGIW
LGRGMANLAAALDPDLFVIGGGVSAAGDLLLEPARTVYARTLTGRGFRPMADIQKAHFGNDAGLIGAADLARHSINEPPG
MARGFWPRRRTAVRKPRRTLRQSLSETLAGPVVRDK
>Mature_356_residues
MLSVGIDIGGTKVAAGVVDESGQIVRRIQRLTPSRSPEAVEDAIVESVRELARNLPICAVGIGAAGWIDTEQALVRFSPH
LAWRNEPLRDRLSERITVPVLVDNDANAAAWAEFRFGAGQGSRVMVCLTLGTGIGGALVINGRMFRGRYGMAGEFGHMTV
VPDGHWCPCGNRGCWEQYASGNSLVRDARALLAEGAPGAQDLLGYVADRNPDNLIGPDVTRAAVDGDRLAIELIADIGIW
LGRGMANLAAALDPDLFVIGGGVSAAGDLLLEPARTVYARTLTGRGFRPMADIQKAHFGNDAGLIGAADLARHSINEPPG
MARGFWPRRRTAVRKPRRTLRQSLSETLAGPVVRDK

Specific function: Required for glucose repression of many different genes [H]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Homo sapiens, GI298566315, Length=271, Percent_Identity=33.5793357933579, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI4885285, Length=271, Percent_Identity=33.5793357933579, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI190014632, Length=271, Percent_Identity=33.5793357933579, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI298566325, Length=271, Percent_Identity=33.5793357933579, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1786891, Length=318, Percent_Identity=27.3584905660377, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1787363, Length=323, Percent_Identity=31.2693498452012, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1787878, Length=293, Percent_Identity=26.6211604095563, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI87081733, Length=322, Percent_Identity=27.0186335403727, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI87082230, Length=272, Percent_Identity=33.8235294117647, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI87082127, Length=232, Percent_Identity=25.8620689655172, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600
- InterPro:   IPR004654 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: =2.7.1.2 [H]

Molecular weight: Translated: 37982; Mature: 37982

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSVGIDIGGTKVAAGVVDESGQIVRRIQRLTPSRSPEAVEDAIVESVRELARNLPICAV
CEEEEEECCCCEEEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEE
GIGAAGWIDTEQALVRFSPHLAWRNEPLRDRLSERITVPVLVDNDANAAAWAEFRFGAGQ
ECCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHCEEEEEEECCCCCCEEEEEEEECCCC
GSRVMVCLTLGTGIGGALVINGRMFRGRYGMAGEFGHMTVVPDGHWCPCGNRGCWEQYAS
CCEEEEEEEECCCCCCEEEECCEEEECCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHCC
GNSLVRDARALLAEGAPGAQDLLGYVADRNPDNLIGPDVTRAAVDGDRLAIELIADIGIW
CCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHH
LGRGMANLAAALDPDLFVIGGGVSAAGDLLLEPARTVYARTLTGRGFRPMADIQKAHFGN
HHCCHHHHHHHCCCCEEEEECCCCHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHCCC
DAGLIGAADLARHSINEPPGMARGFWPRRRTAVRKPRRTLRQSLSETLAGPVVRDK
CCCCEEHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLSVGIDIGGTKVAAGVVDESGQIVRRIQRLTPSRSPEAVEDAIVESVRELARNLPICAV
CEEEEEECCCCEEEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEE
GIGAAGWIDTEQALVRFSPHLAWRNEPLRDRLSERITVPVLVDNDANAAAWAEFRFGAGQ
ECCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHCEEEEEEECCCCCCEEEEEEEECCCC
GSRVMVCLTLGTGIGGALVINGRMFRGRYGMAGEFGHMTVVPDGHWCPCGNRGCWEQYAS
CCEEEEEEEECCCCCCEEEECCEEEECCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHCC
GNSLVRDARALLAEGAPGAQDLLGYVADRNPDNLIGPDVTRAAVDGDRLAIELIADIGIW
CCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHH
LGRGMANLAAALDPDLFVIGGGVSAAGDLLLEPARTVYARTLTGRGFRPMADIQKAHFGN
HHCCHHHHHHHCCCCEEEEECCCCHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHCCC
DAGLIGAADLARHSINEPPGMARGFWPRRRTAVRKPRRTLRQSLSETLAGPVVRDK
CCCCEEHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1435260; 12000953 [H]