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The map label for this gene is uvrC [C]

Identifier: 50842208

GI number: 50842208

Start: 790983

End: 792884

Strand: Reverse

Name: uvrC [C]

Synonym: PPA0720

Alternate gene names: 50842208

Gene position: 792884-790983 (Counterclockwise)

Preceding gene: 50842211

Following gene: 50842205

Centisome position: 30.97

GC content: 59.83

Gene sequence:

>1902_bases
TTGTTACCAAAAACCGCTCACCATGACGCTCGCTCGCCACCTCCATCCACATGGAATACTGCGCTGACTAGGTTGTTCTC
CCTACTCTGCTTGTATTCGCGGTGTTTTTTGTCGCCACGCCTACCTACCGTGCCGATTATGAGCGCCGCGCCCCTTCAGC
CGTCTTTCGACGACCTGGGAACTTCCCTGTCCGAGGTCACTTTCTGCGTCGTCGACCTTGAAACTACCGGTACTAGCGAG
GGCTCCCAGATCACCGAGATCGGAGCCGTGAAAGTGTGTGGAGGCCGCGTCGAAGGCGAGTTTCAAACCCTCGTCTGCCC
AACCGGATCTATCCCAGCTTCGGTACAGGTCCTCACCGGCATCACGGACGTCATGGTGCGCTCGGCTCCATCACTGAACG
CTGTACTACCTAGCTGGTCAGAATTTAGTCGCAGCACGGCACTTGTAGCACACAATGCTCGTTTTGATATTGGTTTCCTT
CAACGCGCCTATGCTCAACATGATTATCCTTGGGACGACCCAGCCGTCGTCGACACCCTCGCATTAGCTCGGTCAGTGCT
TGCCCGCGGAGAGGTCCGAAACTACAAGCTCAGCACCCTATCTCGGCTATTCCACACCACGACGACGCCCTCACACCGCG
CCCTTGCCGATGCGAGGGCCACCGTCGACGTCCTTCACGGACTCATCGACAGAGTCGGCAATCTCGGCGTGACGACCCTT
GAAGACCTTTTAGAAATGACCCATCGGGTACCGCAGGCTCGGCGTCGCCGACGGGTGTGGGCTAAGGACCTTCCCGAAAG
GTCCGGAGTCTATTGGTTTTGCCTGGATAAACCTGCACCAGCACATCCGGAGGTCCTCTATGTCGGTAAGTCGGTCAACA
TCCGACGCCGAGTATCCCAATACTTCACAGCATCGGAAACACGACGCCGCATGGACGAGATGGTGCGAATAGCTACGGGC
GTCAAAGCTCGCGAGTGCTCTACTCAGCTAGAAGCGGGGGTACGCGAACTACGCCTCATTGACGCTCACCAACCGCGCTA
CAACCGTCGCTCTCGTCGGCAAGGATCGGTGTGGTGGGTTACCCTCACTCATGAGGCTCACCCGAGACTCGCCGTCGTGC
AGCGAGCTCACCGCGATTCCCAACCGCCGTGGGGCCCTTTCACTAGCCGTCAAGCAGCGACTCGCGCGGCGATCATACTG
GCTGAAGCCTTTGGCCTGCGACAGTGCAGTGGAGCTATGTCACGGCACCCTGATGGCTGTCCTCTCGCAGAGATGGGCCG
TTGCTCAGCCCCATGTTTGGACCCCCACATCGACTACTCCACCATCGTCGGCTTTGCTCGTCTCGCCATGACTGACGACG
TTCGCGACCTCACTGATCGGCTTGCTCAACGCATCGCACGGCTGTCCGCGGCAGAACGTTTCGAAGAGGCCGCAGAGTTC
ACCGAGGACGCCCAAGAAGTGCTGCGCGCCACCCGACGTCGTTCCCGACTGGTCTCCCTGGCGTCCTGCCCTGAAATTGT
CGCGGCGCGGCGCGATGGCGCCTCCTGGGAGATCCACGTCATTCGACATGGCCGCCTAGCGGGAGCTGGACGATGCCGTC
TGGGTACTGATCCAATGCCCGTTATTGACGCAGTGTGTGCCACCGCAGAAACCGTTTCTGCTTCGCCAGCCGGGCTACCA
GCCTGCACTATTGAGGAGGCCGAGCTTGTGGCGTCCTGGTTTGAAGAACCTGGGGTACGACTGGTTGACGTCATCGGAGA
ATGGTCCTGGCCCGCCCACTGCTGGATGGACACCAATGATCTCGCTGCCCGGGTAGCCGCTTTACATCACCCAGGTCACA
ACGAGAGCGACGAGGCAGACAGCCAAGACCGCCAAGCCCGCCCCCAACTGGCGCAGGTATGA

Upstream 100 bases:

>100_bases
TGCGAGCCAAGTCATCCGTCCACCTGTGATTTGGTCGATCGGACCAGGACCATCCCTGCCGACTGAGAGAATCTTATGCG
ATCCTCAGGAGCGGGGCAAC

Downstream 100 bases:

>100_bases
CGACCACCGGGTCTGCAACCATGCCCAGCCAGAAACGGCTCCCACAACGACCGCACCGATGTCAGCGACCCATGTATTGG
AACCGACGACAATTGCCCAG

Product: hypothetical protein

Products: diphosphate; DNAn+1

Alternate protein names: NA

Number of amino acids: Translated: 633; Mature: 633

Protein sequence:

>633_residues
MLPKTAHHDARSPPPSTWNTALTRLFSLLCLYSRCFLSPRLPTVPIMSAAPLQPSFDDLGTSLSEVTFCVVDLETTGTSE
GSQITEIGAVKVCGGRVEGEFQTLVCPTGSIPASVQVLTGITDVMVRSAPSLNAVLPSWSEFSRSTALVAHNARFDIGFL
QRAYAQHDYPWDDPAVVDTLALARSVLARGEVRNYKLSTLSRLFHTTTTPSHRALADARATVDVLHGLIDRVGNLGVTTL
EDLLEMTHRVPQARRRRRVWAKDLPERSGVYWFCLDKPAPAHPEVLYVGKSVNIRRRVSQYFTASETRRRMDEMVRIATG
VKARECSTQLEAGVRELRLIDAHQPRYNRRSRRQGSVWWVTLTHEAHPRLAVVQRAHRDSQPPWGPFTSRQAATRAAIIL
AEAFGLRQCSGAMSRHPDGCPLAEMGRCSAPCLDPHIDYSTIVGFARLAMTDDVRDLTDRLAQRIARLSAAERFEEAAEF
TEDAQEVLRATRRRSRLVSLASCPEIVAARRDGASWEIHVIRHGRLAGAGRCRLGTDPMPVIDAVCATAETVSASPAGLP
ACTIEEAELVASWFEEPGVRLVDVIGEWSWPAHCWMDTNDLAARVAALHHPGHNESDEADSQDRQARPQLAQV

Sequences:

>Translated_633_residues
MLPKTAHHDARSPPPSTWNTALTRLFSLLCLYSRCFLSPRLPTVPIMSAAPLQPSFDDLGTSLSEVTFCVVDLETTGTSE
GSQITEIGAVKVCGGRVEGEFQTLVCPTGSIPASVQVLTGITDVMVRSAPSLNAVLPSWSEFSRSTALVAHNARFDIGFL
QRAYAQHDYPWDDPAVVDTLALARSVLARGEVRNYKLSTLSRLFHTTTTPSHRALADARATVDVLHGLIDRVGNLGVTTL
EDLLEMTHRVPQARRRRRVWAKDLPERSGVYWFCLDKPAPAHPEVLYVGKSVNIRRRVSQYFTASETRRRMDEMVRIATG
VKARECSTQLEAGVRELRLIDAHQPRYNRRSRRQGSVWWVTLTHEAHPRLAVVQRAHRDSQPPWGPFTSRQAATRAAIIL
AEAFGLRQCSGAMSRHPDGCPLAEMGRCSAPCLDPHIDYSTIVGFARLAMTDDVRDLTDRLAQRIARLSAAERFEEAAEF
TEDAQEVLRATRRRSRLVSLASCPEIVAARRDGASWEIHVIRHGRLAGAGRCRLGTDPMPVIDAVCATAETVSASPAGLP
ACTIEEAELVASWFEEPGVRLVDVIGEWSWPAHCWMDTNDLAARVAALHHPGHNESDEADSQDRQARPQLAQV
>Mature_633_residues
MLPKTAHHDARSPPPSTWNTALTRLFSLLCLYSRCFLSPRLPTVPIMSAAPLQPSFDDLGTSLSEVTFCVVDLETTGTSE
GSQITEIGAVKVCGGRVEGEFQTLVCPTGSIPASVQVLTGITDVMVRSAPSLNAVLPSWSEFSRSTALVAHNARFDIGFL
QRAYAQHDYPWDDPAVVDTLALARSVLARGEVRNYKLSTLSRLFHTTTTPSHRALADARATVDVLHGLIDRVGNLGVTTL
EDLLEMTHRVPQARRRRRVWAKDLPERSGVYWFCLDKPAPAHPEVLYVGKSVNIRRRVSQYFTASETRRRMDEMVRIATG
VKARECSTQLEAGVRELRLIDAHQPRYNRRSRRQGSVWWVTLTHEAHPRLAVVQRAHRDSQPPWGPFTSRQAATRAAIIL
AEAFGLRQCSGAMSRHPDGCPLAEMGRCSAPCLDPHIDYSTIVGFARLAMTDDVRDLTDRLAQRIARLSAAERFEEAAEF
TEDAQEVLRATRRRSRLVSLASCPEIVAARRDGASWEIHVIRHGRLAGAGRCRLGTDPMPVIDAVCATAETVSASPAGLP
ACTIEEAELVASWFEEPGVRLVDVIGEWSWPAHCWMDTNDLAARVAALHHPGHNESDEADSQDRQARPQLAQV

Specific function: The Uvrabc Repair System Catalyzes The Recognition And Processing Of DNA Lesions. Uvrc Both Incises The 5' And 3' Sides Of The Lesion. The N-Terminal Half Is Responsible For The 3' Incision And The C-Terminal Half Is Responsible For The 5' Incision. [C]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI87081999, Length=278, Percent_Identity=26.6187050359712, Blast_Score=105, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR012337
- InterPro:   IPR000305 [H]

Pfam domain/function: PF00929 Exonuc_X-T; PF01541 GIY-YIG [H]

EC number: 2.7.7.7

Molecular weight: Translated: 69978; Mature: 69978

Theoretical pI: Translated: 7.69; Mature: 7.69

Prosite motif: PS50164 UVRC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPKTAHHDARSPPPSTWNTALTRLFSLLCLYSRCFLSPRLPTVPIMSAAPLQPSFDDLG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHC
TSLSEVTFCVVDLETTGTSEGSQITEIGAVKVCGGRVEGEFQTLVCPTGSIPASVQVLTG
CCHHHEEEEEEEEECCCCCCCCEEHHHCEEEEECCCCCCCEEEEEECCCCCCCHHHHHHH
ITDVMVRSAPSLNAVLPSWSEFSRSTALVAHNARFDIGFLQRAYAQHDYPWDDPAVVDTL
HHHHHHHCCCCCCCCCCCHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCHHHHHHH
ALARSVLARGEVRNYKLSTLSRLFHTTTTPSHRALADARATVDVLHGLIDRVGNLGVTTL
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
EDLLEMTHRVPQARRRRRVWAKDLPERSGVYWFCLDKPAPAHPEVLYVGKSVNIRRRVSQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEECCCCCHHHHHHH
YFTASETRRRMDEMVRIATGVKARECSTQLEAGVRELRLIDAHQPRYNRRSRRQGSVWWV
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEE
TLTHEAHPRLAVVQRAHRDSQPPWGPFTSRQAATRAAIILAEAFGLRQCSGAMSRHPDGC
EEECCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCC
PLAEMGRCSAPCLDPHIDYSTIVGFARLAMTDDVRDLTDRLAQRIARLSAAERFEEAAEF
CHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEDAQEVLRATRRRSRLVSLASCPEIVAARRDGASWEIHVIRHGRLAGAGRCRLGTDPMP
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCHH
VIDAVCATAETVSASPAGLPACTIEEAELVASWFEEPGVRLVDVIGEWSWPAHCWMDTND
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEHHHCCCCCCCEEEECCHH
LAARVAALHHPGHNESDEADSQDRQARPQLAQV
HHHHHHHHHCCCCCCCCCCCCHHHHCCCHHCCC
>Mature Secondary Structure
MLPKTAHHDARSPPPSTWNTALTRLFSLLCLYSRCFLSPRLPTVPIMSAAPLQPSFDDLG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHC
TSLSEVTFCVVDLETTGTSEGSQITEIGAVKVCGGRVEGEFQTLVCPTGSIPASVQVLTG
CCHHHEEEEEEEEECCCCCCCCEEHHHCEEEEECCCCCCCEEEEEECCCCCCCHHHHHHH
ITDVMVRSAPSLNAVLPSWSEFSRSTALVAHNARFDIGFLQRAYAQHDYPWDDPAVVDTL
HHHHHHHCCCCCCCCCCCHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCHHHHHHH
ALARSVLARGEVRNYKLSTLSRLFHTTTTPSHRALADARATVDVLHGLIDRVGNLGVTTL
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
EDLLEMTHRVPQARRRRRVWAKDLPERSGVYWFCLDKPAPAHPEVLYVGKSVNIRRRVSQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEECCCCCHHHHHHH
YFTASETRRRMDEMVRIATGVKARECSTQLEAGVRELRLIDAHQPRYNRRSRRQGSVWWV
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEE
TLTHEAHPRLAVVQRAHRDSQPPWGPFTSRQAATRAAIILAEAFGLRQCSGAMSRHPDGC
EEECCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCC
PLAEMGRCSAPCLDPHIDYSTIVGFARLAMTDDVRDLTDRLAQRIARLSAAERFEEAAEF
CHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEDAQEVLRATRRRSRLVSLASCPEIVAARRDGASWEIHVIRHGRLAGAGRCRLGTDPMP
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCHH
VIDAVCATAETVSASPAGLPACTIEEAELVASWFEEPGVRLVDVIGEWSWPAHCWMDTND
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEHHHCCCCCCCEEEECCHH
LAARVAALHHPGHNESDEADSQDRQARPQLAQV
HHHHHHHHHCCCCCCCCCCCCHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: deoxynucleoside triphosphate; DNAn

Specific reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]