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The map label for this gene is guaB [C]

Identifier: 50842196

GI number: 50842196

Start: 779894

End: 781354

Strand: Reverse

Name: guaB [C]

Synonym: PPA0708

Alternate gene names: 50842196

Gene position: 781354-779894 (Counterclockwise)

Preceding gene: 50842198

Following gene: 50842195

Centisome position: 30.52

GC content: 61.05

Gene sequence:

>1461_bases
GTGCGTTTTCTCAACGAGCAGCCGAACTACGACCTGACGTATAACGACGTCTTCATGGCACCAAACCGTTCCTCGGTGGG
GTCCCGCATGAACGTCGACCTCACGTCAACAGACGGGCTAGGTACTCCTCTGCCCCTCGTAGTGGCCAATATGACCGCAA
TTTCCGGACGTCGCATGGCAGAGACCATCGCCAGGCGCGGAGGCATTGCGGTTCTGCCCCAAGATATCCCAGCAGATTTC
GTCGCCCGGTCCATTCGGCGCGTCAAAGATGCGCATACTCGATTCGACACCCCGGTCACCGTCAACCCGACAACGACTGT
CGGTGAGGCCATGAACTTGCTCAACAAACGCGCTCACGGCGTCGTCCTTGTCGTTGAAGATCATCGTCCGGTTGGTTTAG
TCTCCCCCATCGAGGCTGAGGGCGTAGACCGATTCGCTCAATGCCATGAGGTCATGACAACCGACCTCACCTTGGTTGGT
CCACAAGCAAGCCCAGACGACGTTTTCCAGACCCTTGCAGAGCGGCATCAGAAGGTCGCGGTAGCTGTTGACGAGGACGG
GGTTCTCGTCGGCATCATGACGTCACGGGGTGCCCTACGCACCGAAATCTATCGTCCTGCTGTTGATCCTGACGGCCACC
TTATGATCGGCACTGCGATTGGCATTAACGGCAACGTCGCCGAACGTGCCCGCAATGCCCTGGAATCCGGTTCGGACGTG
CTCGTCATGGACACCGCCCATGGCCACCAGGACCAGATGATTCGCGCTATCGAGATCGCCGATGAGGCCCGCACAGCTTT
TGAAACGAAGACTGGCCGACGAGTTTCCATCGTCGCCGGCAATATCGTTACCCGCAGCGGCACCCTCGATCTGCTGGAGG
CGGGTGCGGACATCATTAAGGTCGGCGTCGGACCGGGCGCCATGTGCACCACTCGGATGCAGACCGGGGTGGGGCGTCCG
CAGTTTTCGGCAGTGTTGGAGTGCGCCGAGGCTGCTGCTGAGGTTGATGGTGCCGTCTGGGCTGACGGTGGGGTGCGTCA
CCCCCGCGATGTTGCTCTTGCCCTTGCTGCAGGCGCCGGATCGGTCATGATTGGCTCGTGGTTCGCGGGTACCCACGAAT
CGACCGGGGCCATGCTCATCGACCACGATGGCCGGATGTACAAGGAGTCCTTCGGCATGGCCTCGGCTCGCGCCGTGCGT
CACCGTACCCGTGAACGCAGTGCTTTCGAGCGAGCCCGCGCCGCCCTCTTCGAGGAAGGCATTTCCCAGTCCAAGATGTA
CCTGGATCCCCAGCGCCCTGGCGTCGAGGACCTCGTCGATTTCATCACCTCCGGGGTACGTTCCTCGTGTACCTACGCCG
GAGCTGCTAATCTCACGGAATTTCATGAGAAGGCCGTGATTGGTGTGCAGTCGCCCTCTGGGTACGAGGAGGGCCGCCCG
CTGCAACGCAGCTGGACGTGA

Upstream 100 bases:

>100_bases
GCTTCTACTGCCGCGAGCACGTCGTCCACCGTCGAGGTCATGGTTCTAGTTTGCCGCGTCGCGGCATGACCCGAGGATAG
TGACGTGGGACAATGGCTAC

Downstream 100 bases:

>100_bases
GCCCACGGCGAACGTGTCTATATGTGACCTCCAACCCGAACCATCCGGTCCTAGTGTGGCCCCCATGACAGCACATCGGA
TTCTCGTGATTGGAGGCCAC

Product: inosine 5-monophosphate dehydrogenase

Products: xanthosine 5'-phosphate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MRFLNEQPNYDLTYNDVFMAPNRSSVGSRMNVDLTSTDGLGTPLPLVVANMTAISGRRMAETIARRGGIAVLPQDIPADF
VARSIRRVKDAHTRFDTPVTVNPTTTVGEAMNLLNKRAHGVVLVVEDHRPVGLVSPIEAEGVDRFAQCHEVMTTDLTLVG
PQASPDDVFQTLAERHQKVAVAVDEDGVLVGIMTSRGALRTEIYRPAVDPDGHLMIGTAIGINGNVAERARNALESGSDV
LVMDTAHGHQDQMIRAIEIADEARTAFETKTGRRVSIVAGNIVTRSGTLDLLEAGADIIKVGVGPGAMCTTRMQTGVGRP
QFSAVLECAEAAAEVDGAVWADGGVRHPRDVALALAAGAGSVMIGSWFAGTHESTGAMLIDHDGRMYKESFGMASARAVR
HRTRERSAFERARAALFEEGISQSKMYLDPQRPGVEDLVDFITSGVRSSCTYAGAANLTEFHEKAVIGVQSPSGYEEGRP
LQRSWT

Sequences:

>Translated_486_residues
MRFLNEQPNYDLTYNDVFMAPNRSSVGSRMNVDLTSTDGLGTPLPLVVANMTAISGRRMAETIARRGGIAVLPQDIPADF
VARSIRRVKDAHTRFDTPVTVNPTTTVGEAMNLLNKRAHGVVLVVEDHRPVGLVSPIEAEGVDRFAQCHEVMTTDLTLVG
PQASPDDVFQTLAERHQKVAVAVDEDGVLVGIMTSRGALRTEIYRPAVDPDGHLMIGTAIGINGNVAERARNALESGSDV
LVMDTAHGHQDQMIRAIEIADEARTAFETKTGRRVSIVAGNIVTRSGTLDLLEAGADIIKVGVGPGAMCTTRMQTGVGRP
QFSAVLECAEAAAEVDGAVWADGGVRHPRDVALALAAGAGSVMIGSWFAGTHESTGAMLIDHDGRMYKESFGMASARAVR
HRTRERSAFERARAALFEEGISQSKMYLDPQRPGVEDLVDFITSGVRSSCTYAGAANLTEFHEKAVIGVQSPSGYEEGRP
LQRSWT
>Mature_486_residues
MRFLNEQPNYDLTYNDVFMAPNRSSVGSRMNVDLTSTDGLGTPLPLVVANMTAISGRRMAETIARRGGIAVLPQDIPADF
VARSIRRVKDAHTRFDTPVTVNPTTTVGEAMNLLNKRAHGVVLVVEDHRPVGLVSPIEAEGVDRFAQCHEVMTTDLTLVG
PQASPDDVFQTLAERHQKVAVAVDEDGVLVGIMTSRGALRTEIYRPAVDPDGHLMIGTAIGINGNVAERARNALESGSDV
LVMDTAHGHQDQMIRAIEIADEARTAFETKTGRRVSIVAGNIVTRSGTLDLLEAGADIIKVGVGPGAMCTTRMQTGVGRP
QFSAVLECAEAAAEVDGAVWADGGVRHPRDVALALAAGAGSVMIGSWFAGTHESTGAMLIDHDGRMYKESFGMASARAVR
HRTRERSAFERARAALFEEGISQSKMYLDPQRPGVEDLVDFITSGVRSSCTYAGAANLTEFHEKAVIGVQSPSGYEEGRP
LQRSWT

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI50541956, Length=255, Percent_Identity=38.0392156862745, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI50541954, Length=255, Percent_Identity=38.0392156862745, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI50541952, Length=255, Percent_Identity=38.0392156862745, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI50541948, Length=255, Percent_Identity=38.0392156862745, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI66933016, Length=468, Percent_Identity=28.8461538461538, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI156104880, Length=260, Percent_Identity=36.1538461538462, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI34328930, Length=462, Percent_Identity=26.6233766233766, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI34328928, Length=462, Percent_Identity=26.6233766233766, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI217035146, Length=462, Percent_Identity=26.6233766233766, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI156616279, Length=462, Percent_Identity=26.6233766233766, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI217035152, Length=443, Percent_Identity=26.410835214447, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI217035148, Length=461, Percent_Identity=26.0303687635575, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI217035150, Length=461, Percent_Identity=24.9457700650759, Blast_Score=115, Evalue=1e-25,
Organism=Escherichia coli, GI1788855, Length=477, Percent_Identity=32.2851153039832, Blast_Score=162, Evalue=6e-41,
Organism=Escherichia coli, GI1786293, Length=264, Percent_Identity=35.9848484848485, Blast_Score=150, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17560440, Length=292, Percent_Identity=34.2465753424658, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI71994385, Length=495, Percent_Identity=24.6464646464646, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71994389, Length=434, Percent_Identity=25.8064516129032, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322012, Length=465, Percent_Identity=27.3118279569892, Blast_Score=166, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6323464, Length=478, Percent_Identity=28.0334728033473, Blast_Score=162, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6323585, Length=471, Percent_Identity=28.2377919320594, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6319352, Length=389, Percent_Identity=26.2210796915167, Blast_Score=126, Evalue=8e-30,
Organism=Drosophila melanogaster, GI24641071, Length=471, Percent_Identity=26.7515923566879, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24641073, Length=471, Percent_Identity=26.7515923566879, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI28571163, Length=430, Percent_Identity=25.8139534883721, Blast_Score=126, Evalue=3e-29,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR018529
- InterPro:   IPR001093
- InterPro:   IPR005991 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: 1.1.1.205

Molecular weight: Translated: 52160; Mature: 52160

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFLNEQPNYDLTYNDVFMAPNRSSVGSRMNVDLTSTDGLGTPLPLVVANMTAISGRRMA
CCCCCCCCCCCEEECCEEECCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCHHHH
ETIARRGGIAVLPQDIPADFVARSIRRVKDAHTRFDTPVTVNPTTTVGEAMNLLNKRAHG
HHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHCCCE
VVLVVEDHRPVGLVSPIEAEGVDRFAQCHEVMTTDLTLVGPQASPDDVFQTLAERHQKVA
EEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHCCEEE
VAVDEDGVLVGIMTSRGALRTEIYRPAVDPDGHLMIGTAIGINGNVAERARNALESGSDV
EEECCCCEEEEEECCCCCHHHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCE
LVMDTAHGHQDQMIRAIEIADEARTAFETKTGRRVSIVAGNIVTRSGTLDLLEAGADIIK
EEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEECCCCHHHHHCCCCEEE
VGVGPGAMCTTRMQTGVGRPQFSAVLECAEAAAEVDGAVWADGGVRHPRDVALALAAGAG
ECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCHHEEEEEECCCC
SVMIGSWFAGTHESTGAMLIDHDGRMYKESFGMASARAVRHRTRERSAFERARAALFEEG
CEEEEEEECCCCCCCCEEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ISQSKMYLDPQRPGVEDLVDFITSGVRSSCTYAGAANLTEFHEKAVIGVQSPSGYEEGRP
CCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHEEEEECCCCCCCCCCC
LQRSWT
CCCCCC
>Mature Secondary Structure
MRFLNEQPNYDLTYNDVFMAPNRSSVGSRMNVDLTSTDGLGTPLPLVVANMTAISGRRMA
CCCCCCCCCCCEEECCEEECCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCHHHH
ETIARRGGIAVLPQDIPADFVARSIRRVKDAHTRFDTPVTVNPTTTVGEAMNLLNKRAHG
HHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHCCCE
VVLVVEDHRPVGLVSPIEAEGVDRFAQCHEVMTTDLTLVGPQASPDDVFQTLAERHQKVA
EEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHCCEEE
VAVDEDGVLVGIMTSRGALRTEIYRPAVDPDGHLMIGTAIGINGNVAERARNALESGSDV
EEECCCCEEEEEECCCCCHHHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCE
LVMDTAHGHQDQMIRAIEIADEARTAFETKTGRRVSIVAGNIVTRSGTLDLLEAGADIIK
EEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEECCCCHHHHHCCCCEEE
VGVGPGAMCTTRMQTGVGRPQFSAVLECAEAAAEVDGAVWADGGVRHPRDVALALAAGAG
ECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCHHEEEEEECCCC
SVMIGSWFAGTHESTGAMLIDHDGRMYKESFGMASARAVRHRTRERSAFERARAALFEEG
CEEEEEEECCCCCCCCEEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ISQSKMYLDPQRPGVEDLVDFITSGVRSSCTYAGAANLTEFHEKAVIGVQSPSGYEEGRP
CCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHEEEEECCCCCCCCCCC
LQRSWT
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: inosine 5'-phosphate; NAD+; H2O

Specific reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]