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The map label for this gene is lysP [H]

Identifier: 50842077

GI number: 50842077

Start: 651675

End: 653099

Strand: Direct

Name: lysP [H]

Synonym: PPA0591

Alternate gene names: 50842077

Gene position: 651675-653099 (Clockwise)

Preceding gene: 50842076

Following gene: 50842078

Centisome position: 25.45

GC content: 57.89

Gene sequence:

>1425_bases
ATGGACGGCGAATTGAAGCGCGGGCTCTCCTCGCGGCACATGAACATGATCGCAATCGGCGGGGCCATTGGTACTGGCCT
GTTCGTGGCATCTGGTGCCACCATCTCCCAAGCTGGGCCGGGTGGAGCTCTGGTTGCCTACTTCGCTATGGGGCTTATGG
TCTTCTTGCTTATGCAGTCTCTCGGCGAGATGAGCTCCTATCTCCCGGTGCCAGGCGCATTCGAAACCTATGCCACCAGA
TTCGTCTCGCCTTCCTTTGGCTTCGCATTGGGGTGGAATTACTGGTTCAACTGGGCCATCACGGTCGCTGCTGAATTAGC
TGCTGCCTCCATCGTTATGGCCTACTGGTGGCCCGGTGTACCGGCCTGGATGTGGTCGGTCGGATTCCTGGCGTTGCTCT
TCCTCCTGAACGTCTTGTCTGCCCGCGCGTATGGTGAGAGCGAGTTCTGGTTCGCCATCATCAAGGTGACGGCAGTTATC
GTCTTCCTGGTGCTTGGGATCCTCATGATCGCCGGCGTGATGGGGACATCTCCTGGTCTATCTCATTGGCGTCGCGGTGA
CGCGCCCTTCGTTCACGGGTTCGGTGGCATCCTGACTGTCTTTCTTATTGCTGGATTCTCCTTCCAGGGCACCGAGCTCA
TCGGCATTGCTGCAGGAGAATCGAAAGACCCCCGAATGACGATCCCCAAGGCCACTCGTCAGATTTTCTGGCGGATCATG
ATCTTCTACATCGGTGCCATCGCCGTTATCGGTTTGTTGCTGCCTTATACTGACCCGCACCTGCTTGCGGGCGAGGTCAC
CGATGTTGCTGTCAGCCCGTTTACGTTGGTCCTAAAGCGGGCCGGTGTTGCTGCTGCGGCGGCTGTCATGAATGCGGTCA
TCCTTACCTCGGTGCTTTCGGCTGGTAACTCTGGTCTTTATGCGTCCACCCGAATGCTTTACGCCCTAGCGCGTGAGGGC
AAAGCTCCTCGCATCCTTGGCCGTACTAGTCGACGAGGTGTCCCGGTGCCGGCTCTTATCGTCACTACTCTTGTCGGCGC
GGCCTGTTTTGCTACATCTCTGGTGGGGTCAGGCCAGGCATACACCTGGTTGGTCAATATCTCTGGTCTGTGTGGATTCA
TCGCATGGATCGGTATTGCGATATGCCATATCCAGTTCCGGCGCGCCTTTCAGGCTCAGGGGCACGACCTGTCCGAGTTG
CCGTATCGGGCGCGCTGGTATCCTGCCGGTCCTATCGTCGCCGGGGTGTTGTGCGTCATCGTTACTCTCGGCCAGGGACG
TGACGCAGTTCTCAGCGGTGATGTCACCGACATGATCGTCGCTTACATCAGCATTCCGGTATTCCTGGCGTTGTGGGTCG
GTCACAAGATTGTCACCAAGGCGCCTCATGCCGACCTTTCAACGGCCGATCTTCATCACGACTGA

Upstream 100 bases:

>100_bases
CGTATCGACATACGGAGTATTGAATAGGGAGGTATGGGAGGGCGGTACAGTGGCCGACGCTTCGTTCAGCAGGGCGGGGC
GCTCCTATCTGAGGACCACC

Downstream 100 bases:

>100_bases
CATGATGGTGGTAATTGATCGGCCGTGACAAACGGGGAGGCATCATGGCTTATCGGCCCGGATGGGTTGACCACCTCATT
GGGTGGCACGTCTATCCCCT

Product: lysine-specific permease

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MDGELKRGLSSRHMNMIAIGGAIGTGLFVASGATISQAGPGGALVAYFAMGLMVFLLMQSLGEMSSYLPVPGAFETYATR
FVSPSFGFALGWNYWFNWAITVAAELAAASIVMAYWWPGVPAWMWSVGFLALLFLLNVLSARAYGESEFWFAIIKVTAVI
VFLVLGILMIAGVMGTSPGLSHWRRGDAPFVHGFGGILTVFLIAGFSFQGTELIGIAAGESKDPRMTIPKATRQIFWRIM
IFYIGAIAVIGLLLPYTDPHLLAGEVTDVAVSPFTLVLKRAGVAAAAAVMNAVILTSVLSAGNSGLYASTRMLYALAREG
KAPRILGRTSRRGVPVPALIVTTLVGAACFATSLVGSGQAYTWLVNISGLCGFIAWIGIAICHIQFRRAFQAQGHDLSEL
PYRARWYPAGPIVAGVLCVIVTLGQGRDAVLSGDVTDMIVAYISIPVFLALWVGHKIVTKAPHADLSTADLHHD

Sequences:

>Translated_474_residues
MDGELKRGLSSRHMNMIAIGGAIGTGLFVASGATISQAGPGGALVAYFAMGLMVFLLMQSLGEMSSYLPVPGAFETYATR
FVSPSFGFALGWNYWFNWAITVAAELAAASIVMAYWWPGVPAWMWSVGFLALLFLLNVLSARAYGESEFWFAIIKVTAVI
VFLVLGILMIAGVMGTSPGLSHWRRGDAPFVHGFGGILTVFLIAGFSFQGTELIGIAAGESKDPRMTIPKATRQIFWRIM
IFYIGAIAVIGLLLPYTDPHLLAGEVTDVAVSPFTLVLKRAGVAAAAAVMNAVILTSVLSAGNSGLYASTRMLYALAREG
KAPRILGRTSRRGVPVPALIVTTLVGAACFATSLVGSGQAYTWLVNISGLCGFIAWIGIAICHIQFRRAFQAQGHDLSEL
PYRARWYPAGPIVAGVLCVIVTLGQGRDAVLSGDVTDMIVAYISIPVFLALWVGHKIVTKAPHADLSTADLHHD
>Mature_474_residues
MDGELKRGLSSRHMNMIAIGGAIGTGLFVASGATISQAGPGGALVAYFAMGLMVFLLMQSLGEMSSYLPVPGAFETYATR
FVSPSFGFALGWNYWFNWAITVAAELAAASIVMAYWWPGVPAWMWSVGFLALLFLLNVLSARAYGESEFWFAIIKVTAVI
VFLVLGILMIAGVMGTSPGLSHWRRGDAPFVHGFGGILTVFLIAGFSFQGTELIGIAAGESKDPRMTIPKATRQIFWRIM
IFYIGAIAVIGLLLPYTDPHLLAGEVTDVAVSPFTLVLKRAGVAAAAAVMNAVILTSVLSAGNSGLYASTRMLYALAREG
KAPRILGRTSRRGVPVPALIVTTLVGAACFATSLVGSGQAYTWLVNISGLCGFIAWIGIAICHIQFRRAFQAQGHDLSEL
PYRARWYPAGPIVAGVLCVIVTLGQGRDAVLSGDVTDMIVAYISIPVFLALWVGHKIVTKAPHADLSTADLHHD

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788480, Length=464, Percent_Identity=58.6206896551724, Blast_Score=562, Evalue=1e-161,
Organism=Escherichia coli, GI87081708, Length=469, Percent_Identity=40.5117270788913, Blast_Score=336, Evalue=2e-93,
Organism=Escherichia coli, GI1786789, Length=449, Percent_Identity=36.7483296213808, Blast_Score=287, Evalue=9e-79,
Organism=Escherichia coli, GI1786302, Length=409, Percent_Identity=39.6088019559902, Blast_Score=287, Evalue=1e-78,
Organism=Escherichia coli, GI48994972, Length=436, Percent_Identity=38.5321100917431, Blast_Score=281, Evalue=8e-77,
Organism=Escherichia coli, GI1789017, Length=410, Percent_Identity=36.5853658536585, Blast_Score=252, Evalue=4e-68,
Organism=Escherichia coli, GI1790653, Length=398, Percent_Identity=35.1758793969849, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI87081915, Length=402, Percent_Identity=34.0796019900498, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI1786602, Length=392, Percent_Identity=35.969387755102, Blast_Score=226, Evalue=4e-60,
Organism=Escherichia coli, GI87081869, Length=341, Percent_Identity=24.0469208211144, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17533459, Length=430, Percent_Identity=26.5116279069767, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=464, Percent_Identity=39.8706896551724, Blast_Score=349, Evalue=5e-97,
Organism=Saccharomyces cerevisiae, GI6324061, Length=484, Percent_Identity=37.8099173553719, Blast_Score=340, Evalue=3e-94,
Organism=Saccharomyces cerevisiae, GI6322892, Length=492, Percent_Identity=38.0081300813008, Blast_Score=317, Evalue=3e-87,
Organism=Saccharomyces cerevisiae, GI6324059, Length=485, Percent_Identity=38.1443298969072, Blast_Score=310, Evalue=3e-85,
Organism=Saccharomyces cerevisiae, GI6321629, Length=480, Percent_Identity=35.625, Blast_Score=304, Evalue=2e-83,
Organism=Saccharomyces cerevisiae, GI6324990, Length=496, Percent_Identity=35.2822580645161, Blast_Score=300, Evalue=4e-82,
Organism=Saccharomyces cerevisiae, GI6324924, Length=478, Percent_Identity=35.5648535564854, Blast_Score=291, Evalue=1e-79,
Organism=Saccharomyces cerevisiae, GI6321053, Length=474, Percent_Identity=35.2320675105485, Blast_Score=286, Evalue=5e-78,
Organism=Saccharomyces cerevisiae, GI6320717, Length=476, Percent_Identity=32.7731092436975, Blast_Score=282, Evalue=7e-77,
Organism=Saccharomyces cerevisiae, GI6324553, Length=401, Percent_Identity=36.9077306733167, Blast_Score=267, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6319824, Length=468, Percent_Identity=32.2649572649573, Blast_Score=263, Evalue=3e-71,
Organism=Saccharomyces cerevisiae, GI6322967, Length=465, Percent_Identity=33.7634408602151, Blast_Score=263, Evalue=5e-71,
Organism=Saccharomyces cerevisiae, GI6320251, Length=473, Percent_Identity=32.1353065539112, Blast_Score=259, Evalue=7e-70,
Organism=Saccharomyces cerevisiae, GI6319542, Length=473, Percent_Identity=30.8668076109937, Blast_Score=251, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6319543, Length=470, Percent_Identity=31.063829787234, Blast_Score=240, Evalue=3e-64,
Organism=Saccharomyces cerevisiae, GI6324981, Length=480, Percent_Identity=32.7083333333333, Blast_Score=231, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6319608, Length=478, Percent_Identity=28.2426778242678, Blast_Score=218, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6320364, Length=496, Percent_Identity=25.8064516129032, Blast_Score=168, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50495; Mature: 50495

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGELKRGLSSRHMNMIAIGGAIGTGLFVASGATISQAGPGGALVAYFAMGLMVFLLMQS
CCCHHHCCHHHCCCEEEEECCHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHH
LGEMSSYLPVPGAFETYATRFVSPSFGFALGWNYWFNWAITVAAELAAASIVMAYWWPGV
HHHHHHCCCCCCCHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PAWMWSVGFLALLFLLNVLSARAYGESEFWFAIIKVTAVIVFLVLGILMIAGVMGTSPGL
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
SHWRRGDAPFVHGFGGILTVFLIAGFSFQGTELIGIAAGESKDPRMTIPKATRQIFWRIM
HHHCCCCCCEEHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHH
IFYIGAIAVIGLLLPYTDPHLLAGEVTDVAVSPFTLVLKRAGVAAAAAVMNAVILTSVLS
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
AGNSGLYASTRMLYALAREGKAPRILGRTSRRGVPVPALIVTTLVGAACFATSLVGSGQA
CCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCE
YTWLVNISGLCGFIAWIGIAICHIQFRRAFQAQGHDLSELPYRARWYPAGPIVAGVLCVI
EEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCEECCCCHHHHHHHHHH
VTLGQGRDAVLSGDVTDMIVAYISIPVFLALWVGHKIVTKAPHADLSTADLHHD
HHCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHCCHHEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MDGELKRGLSSRHMNMIAIGGAIGTGLFVASGATISQAGPGGALVAYFAMGLMVFLLMQS
CCCHHHCCHHHCCCEEEEECCHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHH
LGEMSSYLPVPGAFETYATRFVSPSFGFALGWNYWFNWAITVAAELAAASIVMAYWWPGV
HHHHHHCCCCCCCHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PAWMWSVGFLALLFLLNVLSARAYGESEFWFAIIKVTAVIVFLVLGILMIAGVMGTSPGL
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
SHWRRGDAPFVHGFGGILTVFLIAGFSFQGTELIGIAAGESKDPRMTIPKATRQIFWRIM
HHHCCCCCCEEHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHH
IFYIGAIAVIGLLLPYTDPHLLAGEVTDVAVSPFTLVLKRAGVAAAAAVMNAVILTSVLS
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
AGNSGLYASTRMLYALAREGKAPRILGRTSRRGVPVPALIVTTLVGAACFATSLVGSGQA
CCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCE
YTWLVNISGLCGFIAWIGIAICHIQFRRAFQAQGHDLSELPYRARWYPAGPIVAGVLCVI
EEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCEECCCCHHHHHHHHHH
VTLGQGRDAVLSGDVTDMIVAYISIPVFLALWVGHKIVTKAPHADLSTADLHHD
HHCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHCCHHEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]